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The map label for this gene is ymxG [H]

Identifier: 78043889

GI number: 78043889

Start: 1021851

End: 1023080

Strand: Direct

Name: ymxG [H]

Synonym: CHY_1148

Alternate gene names: 78043889

Gene position: 1021851-1023080 (Clockwise)

Preceding gene: 78044170

Following gene: 78043988

Centisome position: 42.55

GC content: 40.24

Gene sequence:

>1230_bases
ATGATCCATGTTACCACCTTACCTAACAAAATAACCGTTCTGGTAGAAGAGATTCCCTACATTCGTTCCGCGGCCATTGG
CTTGTGGTTTAAAGTTGGTTCCCGTCATGAACGTAGGGACGAAAGCGGAATTTCTCATTTCATTGAACACATGATGTTTA
AGGGCACTGTTAATCGTACCGCAAAAGAAATAGCTGAATCTCTGGACCAGGTAGGCGGACAGTTAAACGCCTTTACTACC
AAGGAGTATACCTGTTACTATGCCCGGGTTTTAGACGAGCATACCCTTTTGGCCTTAGAAATTCTTCACGATATGGTTTT
TAATTCCAAATTTGCCGAGGAAGACATTGAAAAAGAAAAAAACGTGGTAATTGAAGAAATTAGAATGTATGAAGATGCGC
CCGACGAGCTAATTCACGATCTCCTGACCGAAGTAATGTGGAACAACCATCCTTTAGGGCGCCCTATTTTGGGTGAAATT
CAGGATATAGAGAGTTTAACCCGGGAAAAAGTAGTAAATTATTATAAAAGATACTATACTCCGGATAATTTAATTATTGC
GGTGGCCGGAAGGGTAAATTACCAACAGCTTTTGGATAAAATAATGGAGTTATTTGGGAGTATCCAGGGGGAACAAAAAG
GTGATAAAATAACGATTCCCGAGTTTAATTTACATAGCTTTAGCCGTCGTAAAGATTCCGAACAGGTTCATTTATGTTTG
GGAACGAAAGGCTATGCCATTAATGATGATCGGATTTATGGCCTAAACATCCTCAGCACAATTTTAGGGGGAGGGATTAG
TTCAAGGCTTTTCCAAGAGTTACGGGAACGACACGGTTTGGTTTATTCCGTTTATTCTTATACCACAGCTTATCAAGATG
CAGGTTTATTTGGAATTTATGCCGGTCTCGGCCCGAATAAAGTAAATGAAGCTTTAGAACTTATCCAAAAGCAGTTGAAG
GAGTTAAAAACCGGTGACATTTCAGCAGAGGAAGTAGAGCGGGCCCGGCAGCAAATTAAGGGTAACCTCTTACTGAGCTT
AGAAAGTGTTACCACGCGGATGTCCCGTCTGGCTAAATCGTTTTTATATCATGGTAAGATCATTTCTCCTGAAGAAATTG
TTGAAAAGGTTTTTAATGTTTCCCTGGAAGATATAAAGGCTATGGCTGAGGAAATTTCGGATTTAAACAATTTTACCAAA
GTTTCAATAGGTCCGTGGGAAGGCTTTTAA

Upstream 100 bases:

>100_bases
TATTGAAGACAGTGATTCCTTTGTTCGGGCATTATTTTTTTTAAATGGTGCATTTTTGGCCGAGCAAAATTTACAAAAAG
TAAGATGATGGAGGTTTAGT

Downstream 100 bases:

>100_bases
TTTAGGTTCTAAGGCTTTTGGGGCAGGCATAAAATAAAACCGGAAGGGGACCTTTATGCTTGCCTTTTTACTTATTTTAA
TTATTTTTTTATTTTTTTTA

Product: M16 family peptidase

Products: NA

Alternate protein names: ORFP [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MIHVTTLPNKITVLVEEIPYIRSAAIGLWFKVGSRHERRDESGISHFIEHMMFKGTVNRTAKEIAESLDQVGGQLNAFTT
KEYTCYYARVLDEHTLLALEILHDMVFNSKFAEEDIEKEKNVVIEEIRMYEDAPDELIHDLLTEVMWNNHPLGRPILGEI
QDIESLTREKVVNYYKRYYTPDNLIIAVAGRVNYQQLLDKIMELFGSIQGEQKGDKITIPEFNLHSFSRRKDSEQVHLCL
GTKGYAINDDRIYGLNILSTILGGGISSRLFQELRERHGLVYSVYSYTTAYQDAGLFGIYAGLGPNKVNEALELIQKQLK
ELKTGDISAEEVERARQQIKGNLLLSLESVTTRMSRLAKSFLYHGKIISPEEIVEKVFNVSLEDIKAMAEEISDLNNFTK
VSIGPWEGF

Sequences:

>Translated_409_residues
MIHVTTLPNKITVLVEEIPYIRSAAIGLWFKVGSRHERRDESGISHFIEHMMFKGTVNRTAKEIAESLDQVGGQLNAFTT
KEYTCYYARVLDEHTLLALEILHDMVFNSKFAEEDIEKEKNVVIEEIRMYEDAPDELIHDLLTEVMWNNHPLGRPILGEI
QDIESLTREKVVNYYKRYYTPDNLIIAVAGRVNYQQLLDKIMELFGSIQGEQKGDKITIPEFNLHSFSRRKDSEQVHLCL
GTKGYAINDDRIYGLNILSTILGGGISSRLFQELRERHGLVYSVYSYTTAYQDAGLFGIYAGLGPNKVNEALELIQKQLK
ELKTGDISAEEVERARQQIKGNLLLSLESVTTRMSRLAKSFLYHGKIISPEEIVEKVFNVSLEDIKAMAEEISDLNNFTK
VSIGPWEGF
>Mature_409_residues
MIHVTTLPNKITVLVEEIPYIRSAAIGLWFKVGSRHERRDESGISHFIEHMMFKGTVNRTAKEIAESLDQVGGQLNAFTT
KEYTCYYARVLDEHTLLALEILHDMVFNSKFAEEDIEKEKNVVIEEIRMYEDAPDELIHDLLTEVMWNNHPLGRPILGEI
QDIESLTREKVVNYYKRYYTPDNLIIAVAGRVNYQQLLDKIMELFGSIQGEQKGDKITIPEFNLHSFSRRKDSEQVHLCL
GTKGYAINDDRIYGLNILSTILGGGISSRLFQELRERHGLVYSVYSYTTAYQDAGLFGIYAGLGPNKVNEALELIQKQLK
ELKTGDISAEEVERARQQIKGNLLLSLESVTTRMSRLAKSFLYHGKIISPEEIVEKVFNVSLEDIKAMAEEISDLNNFTK
VSIGPWEGF

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=414, Percent_Identity=30.1932367149758, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI46593007, Length=411, Percent_Identity=24.5742092457421, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI24308013, Length=420, Percent_Identity=25.2380952380952, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI50592988, Length=395, Percent_Identity=21.0126582278481, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI155969707, Length=239, Percent_Identity=26.7782426778243, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1787770, Length=204, Percent_Identity=23.0392156862745, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71999683, Length=405, Percent_Identity=27.9012345679012, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17553678, Length=423, Percent_Identity=25.531914893617, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17510601, Length=427, Percent_Identity=23.4192037470726, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17569737, Length=393, Percent_Identity=22.3918575063613, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323192, Length=406, Percent_Identity=32.2660098522167, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6321813, Length=423, Percent_Identity=26.0047281323877, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6323421, Length=210, Percent_Identity=25.2380952380952, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357875, Length=396, Percent_Identity=28.5353535353535, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24646943, Length=396, Percent_Identity=28.5353535353535, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI19921772, Length=423, Percent_Identity=23.6406619385343, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24665395, Length=417, Percent_Identity=21.8225419664269, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 46703; Mature: 46703

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHVTTLPNKITVLVEEIPYIRSAAIGLWFKVGSRHERRDESGISHFIEHMMFKGTVNRT
CEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AKEIAESLDQVGGQLNAFTTKEYTCYYARVLDEHTLLALEILHDMVFNSKFAEEDIEKEK
HHHHHHHHHHHCCCEECEECCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
NVVIEEIRMYEDAPDELIHDLLTEVMWNNHPLGRPILGEIQDIESLTREKVVNYYKRYYT
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PDNLIIAVAGRVNYQQLLDKIMELFGSIQGEQKGDKITIPEFNLHSFSRRKDSEQVHLCL
CCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHCCCCCCEEEEE
GTKGYAINDDRIYGLNILSTILGGGISSRLFQELRERHGLVYSVYSYTTAYQDAGLFGIY
CCCCEEECCCCEEHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCEEEE
AGLGPNKVNEALELIQKQLKELKTGDISAEEVERARQQIKGNLLLSLESVTTRMSRLAKS
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHH
FLYHGKIISPEEIVEKVFNVSLEDIKAMAEEISDLNNFTKVSIGPWEGF
HHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCCC
>Mature Secondary Structure
MIHVTTLPNKITVLVEEIPYIRSAAIGLWFKVGSRHERRDESGISHFIEHMMFKGTVNRT
CEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AKEIAESLDQVGGQLNAFTTKEYTCYYARVLDEHTLLALEILHDMVFNSKFAEEDIEKEK
HHHHHHHHHHHCCCEECEECCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
NVVIEEIRMYEDAPDELIHDLLTEVMWNNHPLGRPILGEIQDIESLTREKVVNYYKRYYT
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PDNLIIAVAGRVNYQQLLDKIMELFGSIQGEQKGDKITIPEFNLHSFSRRKDSEQVHLCL
CCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHCCCCCCEEEEE
GTKGYAINDDRIYGLNILSTILGGGISSRLFQELRERHGLVYSVYSYTTAYQDAGLFGIY
CCCCEEECCCCEEHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCEEEE
AGLGPNKVNEALELIQKQLKELKTGDISAEEVERARQQIKGNLLLSLESVTTRMSRLAKS
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHH
FLYHGKIISPEEIVEKVFNVSLEDIKAMAEEISDLNNFTKVSIGPWEGF
HHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 8098035 [H]