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The map label for this gene is hepT [H]

Identifier: 78042835

GI number: 78042835

Start: 1072087

End: 1073067

Strand: Direct

Name: hepT [H]

Synonym: CHY_1206

Alternate gene names: 78042835

Gene position: 1072087-1073067 (Clockwise)

Preceding gene: 78043589

Following gene: 78044730

Centisome position: 44.64

GC content: 36.39

Gene sequence:

>981_bases
TTGCACAGTTTGGAAGACCAGGAAAAGAAATTGTTTGAACTTGTAAAAGAGGATTTAAGAAAAATTGAACAAGAGTTAAT
TAAAGAAGTTAGCGAAAGGAACGAATTTTTACACGACCCTGCCATGCACTTATTAAAAGCGGGAGGAAAAAGGTTAAGAC
CTGCTTTTGCTTTGTTGGCAGCAAAACTTGGCGATTATGATTTCGAGAAAGTTAAACCTTTAGCAGTGGCATTGGAACTT
ATTCATATGGCCACGTTAGTTCACGACGATGTTGTTGATAATTCCATGCTTCGCCGTGGGCTTCCCACGGTTAAAGCTAA
TTGGGGTAATAAGATGTCAATCCATATTGGTGACCGAATTTTTGCCAAATCCTTACTTTTAATCGATTCCTGTAAAAATA
ATTATGTGGCTAAAGTTTTAGCTGAGGTAAGTGTTAAAATGACTACCGGTGAAATTCAACAGTTAAACGGTGCAAAAAAC
ATTTCTACAAGTATTAAAGACTATTTAATAAAAATTAAAAGAAAAACAGCCCTATTATTATCCGCAAGCTGTGAACTTGG
TGGAGTTATGGCCAACGTTTCGCCCAGGGTTGTTAATGCGTTAAAACAGTATGGCTTATATGTTGGGATGGCTTTTCAAA
TTATCGATGATATTTTGGATTTTACTGCTGATGAAAAGGTTTTGGGAAAACCGGTTGGTAGTGATTTACGGCAAGGATTG
ATAACCTTACCTGTGCTCTTGGCTTTGAAAAGGGACAAAAAGCATGAGCTTTGGCGGGAGTTACAAAATCTTCCCCAAAA
TAATGCTAACATTGAGCAAATAATCAAAGAGATAAAATACCTTGGTGGTATAAGTGAAGCTTATGCCTGGGCAAAAAATT
ACATTGAAAAAGCAATTTCTGCCTTTGAATTGGTGCCAAAGTCACCAGTTAAAGATACTTTTTTAGAAATTGCCCAGTTT
ATCGTGCAAAGAAATTATTAA

Upstream 100 bases:

>100_bases
TTGGGGCAGGGGCTATGGCTGTCCCGAATACCGCCAGTTGGGGCTGGGGCAGCTTGAGGGGCGGACAACAAATACCCCAA
CCTTCCAAACCGGTGCAGTT

Downstream 100 bases:

>100_bases
ATGGTAGCAGGAAATTTGATTAATTTGTAGAAATAATTTGTGAAAACTGTATTTAATCCTTAGATAAAGGAGCGCGTTTA
GTATGTATTTAGTGGTTGTG

Product: heptaprenyl diphosphate synthase component II

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MHSLEDQEKKLFELVKEDLRKIEQELIKEVSERNEFLHDPAMHLLKAGGKRLRPAFALLAAKLGDYDFEKVKPLAVALEL
IHMATLVHDDVVDNSMLRRGLPTVKANWGNKMSIHIGDRIFAKSLLLIDSCKNNYVAKVLAEVSVKMTTGEIQQLNGAKN
ISTSIKDYLIKIKRKTALLLSASCELGGVMANVSPRVVNALKQYGLYVGMAFQIIDDILDFTADEKVLGKPVGSDLRQGL
ITLPVLLALKRDKKHELWRELQNLPQNNANIEQIIKEIKYLGGISEAYAWAKNYIEKAISAFELVPKSPVKDTFLEIAQF
IVQRNY

Sequences:

>Translated_326_residues
MHSLEDQEKKLFELVKEDLRKIEQELIKEVSERNEFLHDPAMHLLKAGGKRLRPAFALLAAKLGDYDFEKVKPLAVALEL
IHMATLVHDDVVDNSMLRRGLPTVKANWGNKMSIHIGDRIFAKSLLLIDSCKNNYVAKVLAEVSVKMTTGEIQQLNGAKN
ISTSIKDYLIKIKRKTALLLSASCELGGVMANVSPRVVNALKQYGLYVGMAFQIIDDILDFTADEKVLGKPVGSDLRQGL
ITLPVLLALKRDKKHELWRELQNLPQNNANIEQIIKEIKYLGGISEAYAWAKNYIEKAISAFELVPKSPVKDTFLEIAQF
IVQRNY
>Mature_326_residues
MHSLEDQEKKLFELVKEDLRKIEQELIKEVSERNEFLHDPAMHLLKAGGKRLRPAFALLAAKLGDYDFEKVKPLAVALEL
IHMATLVHDDVVDNSMLRRGLPTVKANWGNKMSIHIGDRIFAKSLLLIDSCKNNYVAKVLAEVSVKMTTGEIQQLNGAKN
ISTSIKDYLIKIKRKTALLLSASCELGGVMANVSPRVVNALKQYGLYVGMAFQIIDDILDFTADEKVLGKPVGSDLRQGL
ITLPVLLALKRDKKHELWRELQNLPQNNANIEQIIKEIKYLGGISEAYAWAKNYIEKAISAFELVPKSPVKDTFLEIAQF
IVQRNY

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=331, Percent_Identity=29.9093655589124, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1789578, Length=319, Percent_Identity=31.6614420062696, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1786623, Length=226, Percent_Identity=30.9734513274336, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17505681, Length=177, Percent_Identity=39.5480225988701, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319475, Length=300, Percent_Identity=29, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24651612, Length=315, Percent_Identity=29.8412698412698, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI281365769, Length=224, Percent_Identity=24.5535714285714, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24660002, Length=224, Percent_Identity=24.5535714285714, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 36720; Mature: 36720

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSLEDQEKKLFELVKEDLRKIEQELIKEVSERNEFLHDPAMHLLKAGGKRLRPAFALLA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AKLGDYDFEKVKPLAVALELIHMATLVHDDVVDNSMLRRGLPTVKANWGNKMSIHIGDRI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECHHH
FAKSLLLIDSCKNNYVAKVLAEVSVKMTTGEIQQLNGAKNISTSIKDYLIKIKRKTALLL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SASCELGGVMANVSPRVVNALKQYGLYVGMAFQIIDDILDFTADEKVLGKPVGSDLRQGL
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHH
ITLPVLLALKRDKKHELWRELQNLPQNNANIEQIIKEIKYLGGISEAYAWAKNYIEKAIS
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AFELVPKSPVKDTFLEIAQFIVQRNY
HHHHCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHSLEDQEKKLFELVKEDLRKIEQELIKEVSERNEFLHDPAMHLLKAGGKRLRPAFALLA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AKLGDYDFEKVKPLAVALELIHMATLVHDDVVDNSMLRRGLPTVKANWGNKMSIHIGDRI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECHHH
FAKSLLLIDSCKNNYVAKVLAEVSVKMTTGEIQQLNGAKNISTSIKDYLIKIKRKTALLL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SASCELGGVMANVSPRVVNALKQYGLYVGMAFQIIDDILDFTADEKVLGKPVGSDLRQGL
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHH
ITLPVLLALKRDKKHELWRELQNLPQNNANIEQIIKEIKYLGGISEAYAWAKNYIEKAIS
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AFELVPKSPVKDTFLEIAQFIVQRNY
HHHHCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]