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The map label for this gene is serA [H]

Identifier: 77465449

GI number: 77465449

Start: 517543

End: 518538

Strand: Reverse

Name: serA [H]

Synonym: RSP_3447

Alternate gene names: 77465449

Gene position: 518538-517543 (Counterclockwise)

Preceding gene: 77465450

Following gene: 77465448

Centisome position: 54.99

GC content: 75.2

Gene sequence:

>996_bases
ATGAACTGTCTGATCGTCCAACCCATCCACGAAGCGGGTCTCGCCGCCCTGCGCGCGGCCGGGATCGCGCCCATCCTCTG
CCCGGCGCCCGACATGGCGACGGTGGCGCGCCACATGGCCGGCATCGACGCCGTCATCACCCGCGACGCGGGCCTCGATG
CCGCGGCCTTCGCCGCGGGCGACCGGCTCCGGGCGGTGGTGGTCCATGGCGCGGGCCACGATCCGGTGGACAAGGAGGCC
GCGGCGCGCAGGGGCGTGGTCGTGGCCAACACCCCGGGCGCCAACGCGCGCTCGGTGGCCGAACTGGCCGTGGGCCTCGC
GCTTGCGGTGGCCCGCCGCATCCCCGCCGCCGACCGCGCCCTGCGGGAGGGGAAGACGGGCTTTCGCGAATCCGCCCGCT
TCTCGGAACTGCGGGGGCGCACCGCGCTGGTCGTGGGCTGGGGGGCCAGCGGCCGCGAGACCGGGCGGATGCTGGCGCAG
GCCTTCGACATGCGCCTCCTCGTCCATTCGCCGCGCGTGCCGCGGATCGAGGGGGGCGAGCGGGTGGCGAGCCTTGCCGA
AGGGCTGGCCGCGGCCGACCTCGTGTCGCTCCACACGCCGCTCCGCCCCGAGACCCACCACATGATGGATGCGCGCGCCT
TTGCCGCCATGCGGCCGGGCGCCATCCTTATCAACATGGCCCGCGCGGGCCTCGTGGACGAGGCGGCGCTGCTCGAAGCG
GTGGCCTCTGGCCATCTCGGCGGCGCGGGGCTCGACGTCTGCTCGCCCGGCGCGCCCTCGGGCCCGCTGGCCGCGCACGG
CAACGTGGTCTTCACGCCCCATCTCGGTGGCACGACCGAGGAGGCGCTCCGCCGCGTGGCCCTCGAGGCCGTGCGCCATG
TCATCACCGCGCTCGAGGGCCGTCTGCCCGAGACCGCGATCAACCCCGACGTCTGGCGCGTGGAATCCCGCAGCCCCGCG
TCCGCCGCAACCGAGGTCGGAGGGACCCAAGCATGA

Upstream 100 bases:

>100_bases
CGGTCGAGGCTGGGCTGCGGGCCCATCTCGAACATGCGCGCGACGCCGTGCTCCTCCGTCTGCGCCGCGCTGCCGCGGCG
ACCGCTTCCGCGAGTGCCTC

Downstream 100 bases:

>100_bases
CCGATCTGCCCCTGGCTGAGGACGCCCCCGCCCGCGCCATCCGCAGCACCATCGACCGGGTGCTGGCCGAGGTGAACGCG
CTTTCCGAGGGCGGCCCCGG

Product: putative dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MNCLIVQPIHEAGLAALRAAGIAPILCPAPDMATVARHMAGIDAVITRDAGLDAAAFAAGDRLRAVVVHGAGHDPVDKEA
AARRGVVVANTPGANARSVAELAVGLALAVARRIPAADRALREGKTGFRESARFSELRGRTALVVGWGASGRETGRMLAQ
AFDMRLLVHSPRVPRIEGGERVASLAEGLAAADLVSLHTPLRPETHHMMDARAFAAMRPGAILINMARAGLVDEAALLEA
VASGHLGGAGLDVCSPGAPSGPLAAHGNVVFTPHLGGTTEEALRRVALEAVRHVITALEGRLPETAINPDVWRVESRSPA
SAATEVGGTQA

Sequences:

>Translated_331_residues
MNCLIVQPIHEAGLAALRAAGIAPILCPAPDMATVARHMAGIDAVITRDAGLDAAAFAAGDRLRAVVVHGAGHDPVDKEA
AARRGVVVANTPGANARSVAELAVGLALAVARRIPAADRALREGKTGFRESARFSELRGRTALVVGWGASGRETGRMLAQ
AFDMRLLVHSPRVPRIEGGERVASLAEGLAAADLVSLHTPLRPETHHMMDARAFAAMRPGAILINMARAGLVDEAALLEA
VASGHLGGAGLDVCSPGAPSGPLAAHGNVVFTPHLGGTTEEALRRVALEAVRHVITALEGRLPETAINPDVWRVESRSPA
SAATEVGGTQA
>Mature_331_residues
MNCLIVQPIHEAGLAALRAAGIAPILCPAPDMATVARHMAGIDAVITRDAGLDAAAFAAGDRLRAVVVHGAGHDPVDKEA
AARRGVVVANTPGANARSVAELAVGLALAVARRIPAADRALREGKTGFRESARFSELRGRTALVVGWGASGRETGRMLAQ
AFDMRLLVHSPRVPRIEGGERVASLAEGLAAADLVSLHTPLRPETHHMMDARAFAAMRPGAILINMARAGLVDEAALLEA
VASGHLGGAGLDVCSPGAPSGPLAAHGNVVFTPHLGGTTEEALRRVALEAVRHVITALEGRLPETAINPDVWRVESRSPA
SAATEVGGTQA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=271, Percent_Identity=35.4243542435424, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI145580578, Length=272, Percent_Identity=35.2941176470588, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI4557499, Length=272, Percent_Identity=35.2941176470588, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI61743967, Length=269, Percent_Identity=34.9442379182156, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI4557497, Length=269, Percent_Identity=34.9442379182156, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI145580575, Length=280, Percent_Identity=35, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI6912396, Length=254, Percent_Identity=30.7086614173228, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1789279, Length=334, Percent_Identity=32.0359281437126, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87082289, Length=271, Percent_Identity=31.3653136531365, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787645, Length=255, Percent_Identity=30.5882352941176, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788660, Length=249, Percent_Identity=30.5220883534137, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=277, Percent_Identity=33.9350180505415, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=257, Percent_Identity=29.9610894941634, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=333, Percent_Identity=30.3303303303303, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=249, Percent_Identity=35.3413654618474, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324055, Length=267, Percent_Identity=30.3370786516854, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=299, Percent_Identity=25.752508361204, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921140, Length=280, Percent_Identity=36.4285714285714, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24585516, Length=299, Percent_Identity=28.0936454849498, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646446, Length=283, Percent_Identity=32.8621908127208, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24646448, Length=283, Percent_Identity=32.8621908127208, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24646452, Length=283, Percent_Identity=32.8621908127208, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24646450, Length=283, Percent_Identity=32.8621908127208, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI62472511, Length=280, Percent_Identity=32.8571428571429, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45552429, Length=263, Percent_Identity=29.6577946768061, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585514, Length=263, Percent_Identity=29.6577946768061, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28574282, Length=263, Percent_Identity=29.6577946768061, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28574284, Length=263, Percent_Identity=29.6577946768061, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45551003, Length=263, Percent_Identity=29.6577946768061, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28571528, Length=307, Percent_Identity=30.2931596091205, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI28574286, Length=253, Percent_Identity=30.4347826086957, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34076; Mature: 34076

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCLIVQPIHEAGLAALRAAGIAPILCPAPDMATVARHMAGIDAVITRDAGLDAAAFAAG
CCEEEECCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHCCHHEEECCCCCCHHHHHCC
DRLRAVVVHGAGHDPVDKEAAARRGVVVANTPGANARSVAELAVGLALAVARRIPAADRA
CCEEEEEEECCCCCCCCHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
LREGKTGFRESARFSELRGRTALVVGWGASGRETGRMLAQAFDMRLLVHSPRVPRIEGGE
HHHCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHEECCCCCCCCCCHH
RVASLAEGLAAADLVSLHTPLRPETHHMMDARAFAAMRPGAILINMARAGLVDEAALLEA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHH
VASGHLGGAGLDVCSPGAPSGPLAAHGNVVFTPHLGGTTEEALRRVALEAVRHVITALEG
HHCCCCCCCCCCCCCCCCCCCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
RLPETAINPDVWRVESRSPASAATEVGGTQA
CCCCCCCCCCEEEECCCCCCHHHHHCCCCCC
>Mature Secondary Structure
MNCLIVQPIHEAGLAALRAAGIAPILCPAPDMATVARHMAGIDAVITRDAGLDAAAFAAG
CCEEEECCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHCCHHEEECCCCCCHHHHHCC
DRLRAVVVHGAGHDPVDKEAAARRGVVVANTPGANARSVAELAVGLALAVARRIPAADRA
CCEEEEEEECCCCCCCCHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
LREGKTGFRESARFSELRGRTALVVGWGASGRETGRMLAQAFDMRLLVHSPRVPRIEGGE
HHHCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHEECCCCCCCCCCHH
RVASLAEGLAAADLVSLHTPLRPETHHMMDARAFAAMRPGAILINMARAGLVDEAALLEA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHH
VASGHLGGAGLDVCSPGAPSGPLAAHGNVVFTPHLGGTTEEALRRVALEAVRHVITALEG
HHCCCCCCCCCCCCCCCCCCCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
RLPETAINPDVWRVESRSPASAATEVGGTQA
CCCCCCCCCCEEEECCCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]