Click here to switch to the map view.

The map label for this gene is divL [H]

Identifier: 77465233

GI number: 77465233

Start: 275582

End: 277681

Strand: Reverse

Name: divL [H]

Synonym: RSP_3217

Alternate gene names: 77465233

Gene position: 277681-275582 (Counterclockwise)

Preceding gene: 77465241

Following gene: 77465232

Centisome position: 29.45

GC content: 66.29

Gene sequence:

>2100_bases
ATGTCATGGACAATCGATGCCAGAGGGCATGGGCCGATTCCGCTGAACAAGTGGCTCTGGCGCTCCTATATCAAGGCCGC
CCTCGTTCCGCTGCTGCTGATCGAATTCGGCTTCGTCGGCGTCTATCTCATCACGAGCCAGGTGGTCTACGACCGGAGCG
CCTCGGCAATCACCCGCATTTCCGAAACGACTTTGCGCGACGATTCAACCCGCGAGGCGGATATCATCGCCCACAGGTTG
CAGAGCATCAGCGCCACCACCCGGATCTTCTCCGAAGAAACCGCCCGTGCGCTCGCCGCGCCTGCTACGGTGTCGGAGGA
GGAAAAGGCGCGCCACCGCCTCTCGCCCGAGGGGGTCTTCTACACGACGAAGGACACGGGCGGAGCGGCCGTCTTCTATT
CCGGAATTGTCCCGATAGGCGAGGCCGAGCGCGAAAAGGTCTGGCGCACGGCGCGGCTCGATCCCTTGATGAAATCCATC
AAGGACAGCGATCCCCTGATTGCCCAGCTTTATCTGAATACATGGGATTCCTATAACCGGATCTATCCCTACTTCGACGT
GCTCGACATCTACCCGCCGAAGATGGATATCCCGAGTTACAATTTCTACTACGAGGCCGATCGCGCGCACAATCCGGCGG
GCGGGGCGGTCTGGACCGATGCCTATGTGGATCCGGCCGGAGAGGGCTGGATGGTCTCCTCGATCGCGCCGGTCTACGGG
CCGGACCGGCTCGAAGCGGTGGTGGGCATCGACGTCACCATCAAGACGATTGTCGAACAGGTGCTCGACATCAAGATGCC
GGGCGACGGCTTTGCCGTCCTCATCGGGCGCGACGGCACGATCCTGGCCCTCCCGCCGAAGGGCGAGGATCGGCTGGGGA
TGAGCGAGCTCATCGGCCACACCTATGCCGAGGCGATCCTTCAGGACACGTTCAAGCCCGCCGAGTTCAACATCTTCCGC
AGGCCCGATCTGGCGTCCATCGCGCTCCAGATGCAGGCCGAGCCGGCGGGCGTCTCGAAGGTCGATCTGCAGGAGCCGAT
GATCGCCGCATGGTCCACCGTCGCGGGGCCGAACTGGCGCCTCCTTCTGCTCACGAGCGAACGGAGCCTGCTCACCGAGG
CCACGAACCTGCGCGACCAGCTGGGATTCGTCAGCACGAGCATCGTGGCGATCCTCGTCCTCTTCTACGCGGGCTTCTTC
GCCTATCTCTGGCGCCGGTCGGTCGCGATGAGCGCGCGCGTGGCCCGGCCGCTCGGGGATCTCGAGCAGCGGATGGTCCT
CATCAGCGAGGGCGGCACCGTCCCCCCCTCGGCGCCGTTCGAGATCCAGGAACTGCAGACCGTGGGCGAGCATCTCGCCA
CCATGGGCGACAAGCTCGACGCGGCGAACCGCGCCAAGTCCAGCTTCCTGTCCTCCATGAGCCACGAGCTGCGCACGCCA
CTGACCGCGATCATCGGCTATGCCGAGCTGCTCGAAGCCTCGGAAGGCCGCAAGCTCGACGGGGAGCGGCTGCAGCAGGT
GCAGGCGATCTCGACGGCGGGCTGGACGCTGGTGAAGCTGGTGGATGCGGTGCTGGAACTCAGCCGGCTCGAACATCGCG
ACCTGCGCCTCGCGACCAGCTCGATGGATCTGATGCCGCTGATCGAGGAGGCGCTCGGCCGCGCGCGGCCCGACGCGGAG
CGCATGCGCGTGACGCTGCGCCTCATCGCGCCCGAGACGCCGCTGCCGTCGGTGGTGAGCGATCCGGCGCTCCTCCGGCG
CATCCTCGACCAGCTTCTGTCGAACGCGGTCAAATACAACCTGCCCGGCGGCCTCGTGGAGGTCAGCTTCGGCCTCGAGG
CGCCCGACACGGTGGATCTGTCGATCCGCGACACCGGCCCCGGCATCCCGACGGACCGGCAGGCCGAGGTGTTTCAGGCC
TTCCAGCGGCTCGGGCACGAGAACGGCGCCATCAGCGGCGCGGGCATCGGCATGACCATCGCGCAGCGGTTGGCCGAGGT
CAGCGGCTGCCGTCTCAGCCTCGAGAGCACCCCGGGCAAGGGCACGGTCTTCCTGCTCCGCATCCCGCGCACCCGTCAGG
GCGCGCCAGGCACCGCCTGA

Upstream 100 bases:

>100_bases
CCACAGCTCCTCTCTCTTGGTGCGAAATCTTTACAGGTTGGGGGCACACAGCTAGCTAAAATCGTCGCGTCGCGTCTCAG
GTTCCCGGGAATCACCGCTC

Downstream 100 bases:

>100_bases
TCTCACCGCAGCGCCCGGACGGGTGCGCAGCTTCGGCACGATTCCTGCAGGAGGCCCCCGGACCGAACCGAAAGGGAGAC
CCGGATGTCCTGCACCCCCT

Product: Cache sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 698

Protein sequence:

>699_residues
MSWTIDARGHGPIPLNKWLWRSYIKAALVPLLLIEFGFVGVYLITSQVVYDRSASAITRISETTLRDDSTREADIIAHRL
QSISATTRIFSEETARALAAPATVSEEEKARHRLSPEGVFYTTKDTGGAAVFYSGIVPIGEAEREKVWRTARLDPLMKSI
KDSDPLIAQLYLNTWDSYNRIYPYFDVLDIYPPKMDIPSYNFYYEADRAHNPAGGAVWTDAYVDPAGEGWMVSSIAPVYG
PDRLEAVVGIDVTIKTIVEQVLDIKMPGDGFAVLIGRDGTILALPPKGEDRLGMSELIGHTYAEAILQDTFKPAEFNIFR
RPDLASIALQMQAEPAGVSKVDLQEPMIAAWSTVAGPNWRLLLLTSERSLLTEATNLRDQLGFVSTSIVAILVLFYAGFF
AYLWRRSVAMSARVARPLGDLEQRMVLISEGGTVPPSAPFEIQELQTVGEHLATMGDKLDAANRAKSSFLSSMSHELRTP
LTAIIGYAELLEASEGRKLDGERLQQVQAISTAGWTLVKLVDAVLELSRLEHRDLRLATSSMDLMPLIEEALGRARPDAE
RMRVTLRLIAPETPLPSVVSDPALLRRILDQLLSNAVKYNLPGGLVEVSFGLEAPDTVDLSIRDTGPGIPTDRQAEVFQA
FQRLGHENGAISGAGIGMTIAQRLAEVSGCRLSLESTPGKGTVFLLRIPRTRQGAPGTA

Sequences:

>Translated_699_residues
MSWTIDARGHGPIPLNKWLWRSYIKAALVPLLLIEFGFVGVYLITSQVVYDRSASAITRISETTLRDDSTREADIIAHRL
QSISATTRIFSEETARALAAPATVSEEEKARHRLSPEGVFYTTKDTGGAAVFYSGIVPIGEAEREKVWRTARLDPLMKSI
KDSDPLIAQLYLNTWDSYNRIYPYFDVLDIYPPKMDIPSYNFYYEADRAHNPAGGAVWTDAYVDPAGEGWMVSSIAPVYG
PDRLEAVVGIDVTIKTIVEQVLDIKMPGDGFAVLIGRDGTILALPPKGEDRLGMSELIGHTYAEAILQDTFKPAEFNIFR
RPDLASIALQMQAEPAGVSKVDLQEPMIAAWSTVAGPNWRLLLLTSERSLLTEATNLRDQLGFVSTSIVAILVLFYAGFF
AYLWRRSVAMSARVARPLGDLEQRMVLISEGGTVPPSAPFEIQELQTVGEHLATMGDKLDAANRAKSSFLSSMSHELRTP
LTAIIGYAELLEASEGRKLDGERLQQVQAISTAGWTLVKLVDAVLELSRLEHRDLRLATSSMDLMPLIEEALGRARPDAE
RMRVTLRLIAPETPLPSVVSDPALLRRILDQLLSNAVKYNLPGGLVEVSFGLEAPDTVDLSIRDTGPGIPTDRQAEVFQA
FQRLGHENGAISGAGIGMTIAQRLAEVSGCRLSLESTPGKGTVFLLRIPRTRQGAPGTA
>Mature_698_residues
SWTIDARGHGPIPLNKWLWRSYIKAALVPLLLIEFGFVGVYLITSQVVYDRSASAITRISETTLRDDSTREADIIAHRLQ
SISATTRIFSEETARALAAPATVSEEEKARHRLSPEGVFYTTKDTGGAAVFYSGIVPIGEAEREKVWRTARLDPLMKSIK
DSDPLIAQLYLNTWDSYNRIYPYFDVLDIYPPKMDIPSYNFYYEADRAHNPAGGAVWTDAYVDPAGEGWMVSSIAPVYGP
DRLEAVVGIDVTIKTIVEQVLDIKMPGDGFAVLIGRDGTILALPPKGEDRLGMSELIGHTYAEAILQDTFKPAEFNIFRR
PDLASIALQMQAEPAGVSKVDLQEPMIAAWSTVAGPNWRLLLLTSERSLLTEATNLRDQLGFVSTSIVAILVLFYAGFFA
YLWRRSVAMSARVARPLGDLEQRMVLISEGGTVPPSAPFEIQELQTVGEHLATMGDKLDAANRAKSSFLSSMSHELRTPL
TAIIGYAELLEASEGRKLDGERLQQVQAISTAGWTLVKLVDAVLELSRLEHRDLRLATSSMDLMPLIEEALGRARPDAER
MRVTLRLIAPETPLPSVVSDPALLRRILDQLLSNAVKYNLPGGLVEVSFGLEAPDTVDLSIRDTGPGIPTDRQAEVFQAF
QRLGHENGAISGAGIGMTIAQRLAEVSGCRLSLESTPGKGTVFLLRIPRTRQGAPGTA

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=272, Percent_Identity=30.5147058823529, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI87081816, Length=262, Percent_Identity=33.206106870229, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=31.2757201646091, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788713, Length=258, Percent_Identity=31.0077519379845, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1789149, Length=259, Percent_Identity=32.4324324324324, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1788393, Length=258, Percent_Identity=29.8449612403101, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=29.4871794871795, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI87082128, Length=282, Percent_Identity=26.5957446808511, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=29.6803652968037, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788549, Length=288, Percent_Identity=25.3472222222222, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790861, Length=248, Percent_Identity=27.8225806451613, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=253, Percent_Identity=26.8774703557312, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790346, Length=249, Percent_Identity=26.5060240963855, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=253, Percent_Identity=21.7391304347826, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790551, Length=318, Percent_Identity=21.6981132075472, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1786783, Length=340, Percent_Identity=23.5294117647059, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1789403, Length=240, Percent_Identity=26.25, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1787894, Length=252, Percent_Identity=25.3968253968254, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76660; Mature: 76528

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWTIDARGHGPIPLNKWLWRSYIKAALVPLLLIEFGFVGVYLITSQVVYDRSASAITRI
CCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SETTLRDDSTREADIIAHRLQSISATTRIFSEETARALAAPATVSEEEKARHRLSPEGVF
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEE
YTTKDTGGAAVFYSGIVPIGEAEREKVWRTARLDPLMKSIKDSDPLIAQLYLNTWDSYNR
EEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCC
IYPYFDVLDIYPPKMDIPSYNFYYEADRAHNPAGGAVWTDAYVDPAGEGWMVSSIAPVYG
CCCCHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCEEECCEECCCCCCEEEECCCCCCC
PDRLEAVVGIDVTIKTIVEQVLDIKMPGDGFAVLIGRDGTILALPPKGEDRLGMSELIGH
CCHHHEEEECCEEHHHHHHHHHCCCCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHHHH
TYAEAILQDTFKPAEFNIFRRPDLASIALQMQAEPAGVSKVDLQEPMIAAWSTVAGPNWR
HHHHHHHHHCCCCCCEEEECCCCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCEE
LLLLTSERSLLTEATNLRDQLGFVSTSIVAILVLFYAGFFAYLWRRSVAMSARVARPLGD
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LEQRMVLISEGGTVPPSAPFEIQELQTVGEHLATMGDKLDAANRAKSSFLSSMSHELRTP
HHHCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCH
LTAIIGYAELLEASEGRKLDGERLQQVQAISTAGWTLVKLVDAVLELSRLEHRDLRLATS
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECC
SMDLMPLIEEALGRARPDAERMRVTLRLIAPETPLPSVVSDPALLRRILDQLLSNAVKYN
CCHHHHHHHHHHHCCCCCHHHEEEEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHEEEC
LPGGLVEVSFGLEAPDTVDLSIRDTGPGIPTDRQAEVFQAFQRLGHENGAISGAGIGMTI
CCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHH
AQRLAEVSGCRLSLESTPGKGTVFLLRIPRTRQGAPGTA
HHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SWTIDARGHGPIPLNKWLWRSYIKAALVPLLLIEFGFVGVYLITSQVVYDRSASAITRI
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SETTLRDDSTREADIIAHRLQSISATTRIFSEETARALAAPATVSEEEKARHRLSPEGVF
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEE
YTTKDTGGAAVFYSGIVPIGEAEREKVWRTARLDPLMKSIKDSDPLIAQLYLNTWDSYNR
EEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCC
IYPYFDVLDIYPPKMDIPSYNFYYEADRAHNPAGGAVWTDAYVDPAGEGWMVSSIAPVYG
CCCCHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCEEECCEECCCCCCEEEECCCCCCC
PDRLEAVVGIDVTIKTIVEQVLDIKMPGDGFAVLIGRDGTILALPPKGEDRLGMSELIGH
CCHHHEEEECCEEHHHHHHHHHCCCCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHHHH
TYAEAILQDTFKPAEFNIFRRPDLASIALQMQAEPAGVSKVDLQEPMIAAWSTVAGPNWR
HHHHHHHHHCCCCCCEEEECCCCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCEE
LLLLTSERSLLTEATNLRDQLGFVSTSIVAILVLFYAGFFAYLWRRSVAMSARVARPLGD
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LEQRMVLISEGGTVPPSAPFEIQELQTVGEHLATMGDKLDAANRAKSSFLSSMSHELRTP
HHHCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCH
LTAIIGYAELLEASEGRKLDGERLQQVQAISTAGWTLVKLVDAVLELSRLEHRDLRLATS
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECC
SMDLMPLIEEALGRARPDAERMRVTLRLIAPETPLPSVVSDPALLRRILDQLLSNAVKYN
CCHHHHHHHHHHHCCCCCHHHEEEEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHEEEC
LPGGLVEVSFGLEAPDTVDLSIRDTGPGIPTDRQAEVFQAFQRLGHENGAISGAGIGMTI
CCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHH
AQRLAEVSGCRLSLESTPGKGTVFLLRIPRTRQGAPGTA
HHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647 [H]