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The map label for this gene is hexR [H]

Identifier: 77461862

GI number: 77461862

Start: 6321608

End: 6322474

Strand: Reverse

Name: hexR [H]

Synonym: Pfl01_5642

Alternate gene names: 77461862

Gene position: 6322474-6321608 (Counterclockwise)

Preceding gene: 77461863

Following gene: 77461860

Centisome position: 98.2

GC content: 62.63

Gene sequence:

>867_bases
TTGAATCTGCTGCAACACATCGCCCAGTCACGTCACCTGTTACGCAAGTCGGAGCTCAAGGTCGCCGACCACGTGCTGCT
TGACCCTGCGGCGGTGATGCACAGTTCCATGGCCGACCTGGCCCACAGCGTCGGCATCAGCGAGCCGACCATCGTGCGCT
TCTGCCGGGCCATTGGTTGCTCCGGTTTCCAGGATCTGAAACTCAAGCTCGCGCAAAGCCTCGCGGCCGGCGCCAGCTTC
GGTCAGTTCGCGATCCATGAAGACGATTCCGTCGCCGACTACAGCCTGAAAATCTTCGACACCACCTTGCACACGCTGAT
GGAGGTTCGCGAAAAGCTCGATCCTCTGGAGCTGCAACGGGCGGTGACGCTGATGTCCCAGGCCCAGCGCGTCGAGTTCT
ATGGTTTTGGTGCGTCGGGCGCGGTGGCGGCGGATGCGCAGCACAAGTTCTTCCGTCTGCTGCTGACGGCAGCGGCGTAT
TCCGACCCGCACATGCAGGCGATGTCGGCGGTGACGCTGAAGCCCACCGACGTGGCGATCTGCATTTCCCAGTCCGGCCG
CTCCAAAGACCTGCTGATCACCGCCAACCTCGTTCGCGAGAGCGGGGCGTCGCTGATTACCTTGTGCCCGAGCCAGACGC
CGCTGGCCGAGCTGTCGACCGTCAACCTGGCGATCGACGTTCACGAAGACACCGAAATCTACACCCCGTTGACTTCGCGT
ATCGCTCACCTGGTGGTGATCGACGTATTGGCGATGGGCGTGGCCATGGCGCGCGGGCCGAGCCTGGTCAACCACCTCAA
GAGCGTCAAGCGCAGCCTGCGCAGCTTGCGGCTGTCGCCAAAATCGGTAAAAGCGCTGGACGACTGA

Upstream 100 bases:

>100_bases
TTGAGCAGGCAAAAAGCCGATTCATGTAGTATAACTACAAGCTTGCTACATCCCCGGCATCTGGCCAAAGCACATCTTTC
CATAACAAGAGTCCAGCCCC

Downstream 100 bases:

>100_bases
TTGTCTTGGGGTGACGGCAATCTTCATCTGCCTGTAACCCCGACGAAGCTAAACCGTCATCCCCCAAGCCTATCGTGAAA
CTCCCGTAATCGCCTTGGGA

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNLLQHIAQSRHLLRKSELKVADHVLLDPAAVMHSSMADLAHSVGISEPTIVRFCRAIGCSGFQDLKLKLAQSLAAGASF
GQFAIHEDDSVADYSLKIFDTTLHTLMEVREKLDPLELQRAVTLMSQAQRVEFYGFGASGAVAADAQHKFFRLLLTAAAY
SDPHMQAMSAVTLKPTDVAICISQSGRSKDLLITANLVRESGASLITLCPSQTPLAELSTVNLAIDVHEDTEIYTPLTSR
IAHLVVIDVLAMGVAMARGPSLVNHLKSVKRSLRSLRLSPKSVKALDD

Sequences:

>Translated_288_residues
MNLLQHIAQSRHLLRKSELKVADHVLLDPAAVMHSSMADLAHSVGISEPTIVRFCRAIGCSGFQDLKLKLAQSLAAGASF
GQFAIHEDDSVADYSLKIFDTTLHTLMEVREKLDPLELQRAVTLMSQAQRVEFYGFGASGAVAADAQHKFFRLLLTAAAY
SDPHMQAMSAVTLKPTDVAICISQSGRSKDLLITANLVRESGASLITLCPSQTPLAELSTVNLAIDVHEDTEIYTPLTSR
IAHLVVIDVLAMGVAMARGPSLVNHLKSVKRSLRSLRLSPKSVKALDD
>Mature_288_residues
MNLLQHIAQSRHLLRKSELKVADHVLLDPAAVMHSSMADLAHSVGISEPTIVRFCRAIGCSGFQDLKLKLAQSLAAGASF
GQFAIHEDDSVADYSLKIFDTTLHTLMEVREKLDPLELQRAVTLMSQAQRVEFYGFGASGAVAADAQHKFFRLLLTAAAY
SDPHMQAMSAVTLKPTDVAICISQSGRSKDLLITANLVRESGASLITLCPSQTPLAELSTVNLAIDVHEDTEIYTPLTSR
IAHLVVIDVLAMGVAMARGPSLVNHLKSVKRSLRSLRLSPKSVKALDD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=288, Percent_Identity=43.4027777777778, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI87082369, Length=256, Percent_Identity=27.34375, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788767, Length=294, Percent_Identity=27.2108843537415, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082130, Length=215, Percent_Identity=29.3023255813954, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31207; Mature: 31207

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLQHIAQSRHLLRKSELKVADHVLLDPAAVMHSSMADLAHSVGISEPTIVRFCRAIGC
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
SGFQDLKLKLAQSLAAGASFGQFAIHEDDSVADYSLKIFDTTLHTLMEVREKLDPLELQR
CCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHHH
AVTLMSQAQRVEFYGFGASGAVAADAQHKFFRLLLTAAAYSDPHMQAMSAVTLKPTDVAI
HHHHHHHHHHEEEEECCCCCCEECHHHHHHHHHHHHHHHCCCHHHHHHHHEEECCCCEEE
CISQSGRSKDLLITANLVRESGASLITLCPSQTPLAELSTVNLAIDVHEDTEIYTPLTSR
EEECCCCCCEEEEEHHHHHHCCCCEEEECCCCCCCHHHEEEEEEEEECCCCCEECCHHHH
IAHLVVIDVLAMGVAMARGPSLVNHLKSVKRSLRSLRLSPKSVKALDD
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure
MNLLQHIAQSRHLLRKSELKVADHVLLDPAAVMHSSMADLAHSVGISEPTIVRFCRAIGC
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
SGFQDLKLKLAQSLAAGASFGQFAIHEDDSVADYSLKIFDTTLHTLMEVREKLDPLELQR
CCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHHH
AVTLMSQAQRVEFYGFGASGAVAADAQHKFFRLLLTAAAYSDPHMQAMSAVTLKPTDVAI
HHHHHHHHHHEEEEECCCCCCEECHHHHHHHHHHHHHHHCCCHHHHHHHHEEECCCCEEE
CISQSGRSKDLLITANLVRESGASLITLCPSQTPLAELSTVNLAIDVHEDTEIYTPLTSR
EEECCCCCCEEEEEHHHHHHCCCCEEEECCCCCCCHHHEEEEEEEEECCCCCEECCHHHH
IAHLVVIDVLAMGVAMARGPSLVNHLKSVKRSLRSLRLSPKSVKALDD
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]