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The map label for this gene is clpP [H]

Identifier: 77459919

GI number: 77459919

Start: 4185768

End: 4186403

Strand: Reverse

Name: clpP [H]

Synonym: Pfl01_3697

Alternate gene names: 77459919

Gene position: 4186403-4185768 (Counterclockwise)

Preceding gene: 77459920

Following gene: 77459918

Centisome position: 65.02

GC content: 56.13

Gene sequence:

>636_bases
ATGTTCCGTAATTCCTATATTCAGCAGAACTCTGATATCCAGGCCGCCGGCGGCCTGGTCCCGATGGTTGTCGAGCAATC
TGCTCGTGGCGAGCGCGCCTATGACATCTACTCGCGTCTTCTTAAGGAACGAGTGATCTTTCTGGTGGGTCCTGTAGAGG
ACTACATGGCCAACCTGATTTGCGCGCAATTGCTGTTCCTTGAAGCGGAAAACCCGGACAAGGACATCCATCTTTATATC
AACTCCCCGGGCGGTTCGGTGACAGCGGGCATGTCGATCTACGACACCATGCAGTTCATCAAGCCAAACGTATCAACTAC
CTGTATCGGTCAGGCGTGCAGCATGGGCGCGTTCCTGCTGACGGCCGGTGCACCTGGCAAGCGTTTCTGCCTGCCGAACT
CGCGCGTGATGATTCACCAGCCGCTGGGCGGTTTCCAGGGGCAGGCGTCGGACATCGAAATCCATGCCAAGGAAATCCTC
TTCATCCGCGAGCGTCTCAACACGCTGATGGCCAAGCACAGCGGCCGTACGCTTGAAGAAATCGAGCGCGACACCAACCG
CGACAACTTCATGAGTGCAGAAGCTGCGAAGGAATACGGTCTGATCGACGAAGTGATCAACCAGCGCCCAGCTTAA

Upstream 100 bases:

>100_bases
CCGACTGATTGTTTTTGCGTTAGAAGCACACACCATAAGCCAGCCTTCGAGCTGGCTTATGCGTATTCAAGACATGACTA
TTTGGGAGTGACTGCAGAGC

Downstream 100 bases:

>100_bases
AATAAGCAACTCAAAATAGGCTTGGTCGGCGCGTCTGATCAGCGGCGGGCTTGAAAAAGCCCGCAATAGCCTTCATCTTG
TGTTGCAAGCCTATCGGATT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MFRNSYIQQNSDIQAAGGLVPMVVEQSARGERAYDIYSRLLKERVIFLVGPVEDYMANLICAQLLFLEAENPDKDIHLYI
NSPGGSVTAGMSIYDTMQFIKPNVSTTCIGQACSMGAFLLTAGAPGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAKEIL
FIRERLNTLMAKHSGRTLEEIERDTNRDNFMSAEAAKEYGLIDEVINQRPA

Sequences:

>Translated_211_residues
MFRNSYIQQNSDIQAAGGLVPMVVEQSARGERAYDIYSRLLKERVIFLVGPVEDYMANLICAQLLFLEAENPDKDIHLYI
NSPGGSVTAGMSIYDTMQFIKPNVSTTCIGQACSMGAFLLTAGAPGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAKEIL
FIRERLNTLMAKHSGRTLEEIERDTNRDNFMSAEAAKEYGLIDEVINQRPA
>Mature_211_residues
MFRNSYIQQNSDIQAAGGLVPMVVEQSARGERAYDIYSRLLKERVIFLVGPVEDYMANLICAQLLFLEAENPDKDIHLYI
NSPGGSVTAGMSIYDTMQFIKPNVSTTCIGQACSMGAFLLTAGAPGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAKEIL
FIRERLNTLMAKHSGRTLEEIERDTNRDNFMSAEAAKEYGLIDEVINQRPA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=55.7291666666667, Blast_Score=237, Evalue=5e-63,
Organism=Escherichia coli, GI1786641, Length=205, Percent_Identity=72.1951219512195, Blast_Score=320, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=54.3010752688172, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=59.8958333333333, Blast_Score=253, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23450; Mature: 23450

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRNSYIQQNSDIQAAGGLVPMVVEQSARGERAYDIYSRLLKERVIFLVGPVEDYMANLI
CCCCCCCCCCCCCCCCCCEEHEEHHHCCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHH
CAQLLFLEAENPDKDIHLYINSPGGSVTAGMSIYDTMQFIKPNVSTTCIGQACSMGAFLL
HHHHHHHCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCCCHHHHHHHHCCCEEEE
TAGAPGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAKEILFIRERLNTLMAKHSGRTLEE
ECCCCCCEEECCCCCEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
IERDTNRDNFMSAEAAKEYGLIDEVINQRPA
HHHHCCCCHHHHHHHHHHCCHHHHHHHCCCC
>Mature Secondary Structure
MFRNSYIQQNSDIQAAGGLVPMVVEQSARGERAYDIYSRLLKERVIFLVGPVEDYMANLI
CCCCCCCCCCCCCCCCCCEEHEEHHHCCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHH
CAQLLFLEAENPDKDIHLYINSPGGSVTAGMSIYDTMQFIKPNVSTTCIGQACSMGAFLL
HHHHHHHCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCCCHHHHHHHHCCCEEEE
TAGAPGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAKEILFIRERLNTLMAKHSGRTLEE
ECCCCCCEEECCCCCEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
IERDTNRDNFMSAEAAKEYGLIDEVINQRPA
HHHHCCCCHHHHHHHHHHCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA