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The map label for this gene is lon [H]

Identifier: 77459917

GI number: 77459917

Start: 4181812

End: 4184208

Strand: Reverse

Name: lon [H]

Synonym: Pfl01_3695

Alternate gene names: 77459917

Gene position: 4184208-4181812 (Counterclockwise)

Preceding gene: 77459918

Following gene: 77459916

Centisome position: 64.99

GC content: 57.99

Gene sequence:

>2397_bases
ATGAAGACCACCATCGAATTGCCTCTCCTGCCATTGCGTGATGTCGTTGTGTATCCGCACATGGTTATCCCGCTGTTCGT
GGGGCGCGAGAAATCCATCGAAGCCCTCGAGGCTGCGATGACGGGCGACAAGCAGATCCTGCTGCTGGCCCAGAGAAACC
CGGCTGACGACGATCCCGGTGAAGAAGCTCTCTATCGCGTAGGTACTATCGCCACTGTTCTGCAGTTGCTGAAGCTGCCG
GACGGCACCGTCAAGGTTCTGGTCGAGGGCGAGCAGCGTGGTGCTGTCGAGCGCTTCAGCGAAGTTGATGGCCACTGCCG
TGCTGAAGTGTCGCTGATCGACGAAGTCGACGCCGCCGAGCGCGAATCCGAAGTGTTCGTGCGCAGCCTGCTGTCGCAGT
TCGAACAATATGTGCAGCTGGGCAAGAAAGTCCCGGCTGAAGTCCTGTCGTCGCTCAACAGCATCGACGAGCCTGGCCGC
CTGGTAGACACCATGGCCGCGCACATGGCGCTGAAGATCGAGCAGAAGCAGGAAATCCTCGAAATCATCGATTTGTCGGC
CCGGGTCGAGCACGTTCTGGCCTTGCTGGACGCCGAGATCGACCTGCTGCAAGTCGAAAAACGCATTCGTGGCCGCGTCA
AAAAGCAAATGGAGCGCAGTCAGCGCGAGTACTACCTGAACGAGCAGATGAAGGCCATTCAGAAAGAACTCGGCGACAGC
GACGAAGGCCACAACGAAATCGAAGACCTGAAAAAGCGCATCGACGCTGCCGGTCTGCCGAAAGATGCCCTGGCCAAGGC
CACTGCCGAGCTGAACAAGCTCAAGCAAATGTCGCCGATGTCCGCCGAAGCCACCGTGGTGCGCTCGTACATCGACTGGC
TGGTTCAAGTGCCGTGGAAGGCTCAGAGCAAGGTACGTCTGGACCTGGCCCGTGCCGAAGACATTCTCGACGCCGATCAC
TACGGCCTGGAAGAGGTCAAGGAACGCATCCTTGAATACCTCGCCGTGCAGAAACGCGTGAAAAAGATCCGTGGCCCGGT
GTTGTGCCTGGTCGGTCCTCCAGGCGTGGGTAAAACCTCGCTGGCCGAGTCGATCGCCCATGCCACCAACCGCAAATTCG
TGCGCATGGCCCTCGGTGGCGTGCGTGATGAAGCGGAAATCCGTGGTCACCGTCGGACTTACATCGGTTCGATGCCAGGA
AGATTGATTCAAAAGATGACAAAAGTGGGTGTGCGCAACCCGCTGTTCCTGCTCGATGAAATCGACAAAATGGGCAGCGA
CATGCGTGGCGACCCGGCGTCGGCGTTGCTGGAAGTGCTCGATCCTGAGCAGAACCACAACTTCAACGACCACTATCTGG
AAGTCGATTACGACCTCTCGGATGTGATGTTCCTGTGCACCTCGAACTCGATGAACATTCCACCGGCGCTGCTGGACCGG
ATGGAAGTCATCCGTCTGCCGGGCTACACCGAAGACGAGAAGATCAACATCGCGGTCAAGTACCTGTCGCCAAAACAGAT
TGCAGCCAATGGCCTGAAGAAGGGCGAGCTGGAATTCGACGAAGAAGCGATCCGCGACATCATCCGTTACTACACCCGCG
AAGCCGGTGTACGTGGCCTCGAGCGGCAGATTGCCAAGGTCTGCCGCAAGGCGGTCAAAGAGCACGCGCTGGAAAAACGT
TTCTCGGTAAAAGTGACAGCTGATCTGCTGGAGCATTTCCTCGGCGTTCGCAAGTTCCGCTACGGTCTGGCCGAGCAACA
GGATCAGATCGGTCAAGTGACCGGCCTGGCCTGGACTCAGGTGGGCGGCGAACTGCTGACCATCGAAGCCGCCGTGGTGC
CGGGTAAAGGTCAACTGATCAAGACCGGTTCGCTGGGTGACGTAATGGTCGAATCGATCACTGCGGCCCTGACCGTGGTG
CGTAGCCGTGCCAAGAGCCTGGGCATTCCCCTGGACTTCCACGAGAAGCGCGACACGCACATCCACATGCCGGAAGGTGC
TACGCCGAAAGACGGCCCGAGCGCCGGTGTAGGCATGTGTACTGCGCTGGTGTCGGCTTTGACGGGGATTCCTGTGCGTG
CCGATGTTGCCATGACCGGCGAGATCACCCTGCGTGGTCAGGTTCTTGCCATTGGCGGTCTGAAGGAAAAACTGCTGGCC
GCTCACCGTGGCGGAATCAAGACTGTGATTATTCCGGAAGAGAACGTGCGCGATCTGAAGGAGATTCCTGACAATATCAA
GCAGGATCTGCAGATCAAACCGGTTAAATGGATTGACGAGGTCCTGCAAATTGCGCTGCAATACGCGCCGGAGCCCTTGC
CGGATGTGGCTCCGGAGATAGTTGCCAAGGACGAAAAACGTGAGTCTGACTCTAAGGAAAGAATTAGCACGCATTAA

Upstream 100 bases:

>100_bases
CATCCGCTTTGCGCTTGTTTTTTTTCAAGTCAGCCCCCATCTTGGTTTCAAGTTTAATTCCATCTGATTACGGCCGTATG
GCCGCCGTAGAGGCGAAATC

Downstream 100 bases:

>100_bases
TACGCTTTTGCCTGGGGGGCTTCCTTGACAGCTTTTTAGAGCCCTTGTTATAAAGCGGCTCTTAAGTGTCTGTAGGCCAT
TCAGCACTCGTTTTTGCTTT

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 798; Mature: 798

Protein sequence:

>798_residues
MKTTIELPLLPLRDVVVYPHMVIPLFVGREKSIEALEAAMTGDKQILLLAQRNPADDDPGEEALYRVGTIATVLQLLKLP
DGTVKVLVEGEQRGAVERFSEVDGHCRAEVSLIDEVDAAERESEVFVRSLLSQFEQYVQLGKKVPAEVLSSLNSIDEPGR
LVDTMAAHMALKIEQKQEILEIIDLSARVEHVLALLDAEIDLLQVEKRIRGRVKKQMERSQREYYLNEQMKAIQKELGDS
DEGHNEIEDLKKRIDAAGLPKDALAKATAELNKLKQMSPMSAEATVVRSYIDWLVQVPWKAQSKVRLDLARAEDILDADH
YGLEEVKERILEYLAVQKRVKKIRGPVLCLVGPPGVGKTSLAESIAHATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPG
RLIQKMTKVGVRNPLFLLDEIDKMGSDMRGDPASALLEVLDPEQNHNFNDHYLEVDYDLSDVMFLCTSNSMNIPPALLDR
MEVIRLPGYTEDEKINIAVKYLSPKQIAANGLKKGELEFDEEAIRDIIRYYTREAGVRGLERQIAKVCRKAVKEHALEKR
FSVKVTADLLEHFLGVRKFRYGLAEQQDQIGQVTGLAWTQVGGELLTIEAAVVPGKGQLIKTGSLGDVMVESITAALTVV
RSRAKSLGIPLDFHEKRDTHIHMPEGATPKDGPSAGVGMCTALVSALTGIPVRADVAMTGEITLRGQVLAIGGLKEKLLA
AHRGGIKTVIIPEENVRDLKEIPDNIKQDLQIKPVKWIDEVLQIALQYAPEPLPDVAPEIVAKDEKRESDSKERISTH

Sequences:

>Translated_798_residues
MKTTIELPLLPLRDVVVYPHMVIPLFVGREKSIEALEAAMTGDKQILLLAQRNPADDDPGEEALYRVGTIATVLQLLKLP
DGTVKVLVEGEQRGAVERFSEVDGHCRAEVSLIDEVDAAERESEVFVRSLLSQFEQYVQLGKKVPAEVLSSLNSIDEPGR
LVDTMAAHMALKIEQKQEILEIIDLSARVEHVLALLDAEIDLLQVEKRIRGRVKKQMERSQREYYLNEQMKAIQKELGDS
DEGHNEIEDLKKRIDAAGLPKDALAKATAELNKLKQMSPMSAEATVVRSYIDWLVQVPWKAQSKVRLDLARAEDILDADH
YGLEEVKERILEYLAVQKRVKKIRGPVLCLVGPPGVGKTSLAESIAHATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPG
RLIQKMTKVGVRNPLFLLDEIDKMGSDMRGDPASALLEVLDPEQNHNFNDHYLEVDYDLSDVMFLCTSNSMNIPPALLDR
MEVIRLPGYTEDEKINIAVKYLSPKQIAANGLKKGELEFDEEAIRDIIRYYTREAGVRGLERQIAKVCRKAVKEHALEKR
FSVKVTADLLEHFLGVRKFRYGLAEQQDQIGQVTGLAWTQVGGELLTIEAAVVPGKGQLIKTGSLGDVMVESITAALTVV
RSRAKSLGIPLDFHEKRDTHIHMPEGATPKDGPSAGVGMCTALVSALTGIPVRADVAMTGEITLRGQVLAIGGLKEKLLA
AHRGGIKTVIIPEENVRDLKEIPDNIKQDLQIKPVKWIDEVLQIALQYAPEPLPDVAPEIVAKDEKRESDSKERISTH
>Mature_798_residues
MKTTIELPLLPLRDVVVYPHMVIPLFVGREKSIEALEAAMTGDKQILLLAQRNPADDDPGEEALYRVGTIATVLQLLKLP
DGTVKVLVEGEQRGAVERFSEVDGHCRAEVSLIDEVDAAERESEVFVRSLLSQFEQYVQLGKKVPAEVLSSLNSIDEPGR
LVDTMAAHMALKIEQKQEILEIIDLSARVEHVLALLDAEIDLLQVEKRIRGRVKKQMERSQREYYLNEQMKAIQKELGDS
DEGHNEIEDLKKRIDAAGLPKDALAKATAELNKLKQMSPMSAEATVVRSYIDWLVQVPWKAQSKVRLDLARAEDILDADH
YGLEEVKERILEYLAVQKRVKKIRGPVLCLVGPPGVGKTSLAESIAHATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPG
RLIQKMTKVGVRNPLFLLDEIDKMGSDMRGDPASALLEVLDPEQNHNFNDHYLEVDYDLSDVMFLCTSNSMNIPPALLDR
MEVIRLPGYTEDEKINIAVKYLSPKQIAANGLKKGELEFDEEAIRDIIRYYTREAGVRGLERQIAKVCRKAVKEHALEKR
FSVKVTADLLEHFLGVRKFRYGLAEQQDQIGQVTGLAWTQVGGELLTIEAAVVPGKGQLIKTGSLGDVMVESITAALTVV
RSRAKSLGIPLDFHEKRDTHIHMPEGATPKDGPSAGVGMCTALVSALTGIPVRADVAMTGEITLRGQVLAIGGLKEKLLA
AHRGGIKTVIIPEENVRDLKEIPDNIKQDLQIKPVKWIDEVLQIALQYAPEPLPDVAPEIVAKDEKRESDSKERISTH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=775, Percent_Identity=39.8709677419355, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI21396489, Length=642, Percent_Identity=41.2772585669782, Blast_Score=494, Evalue=1e-139,
Organism=Escherichia coli, GI1786643, Length=767, Percent_Identity=71.3168187744459, Blast_Score=1102, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=682, Percent_Identity=41.0557184750733, Blast_Score=482, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17556486, Length=789, Percent_Identity=32.1926489226869, Blast_Score=414, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6319449, Length=675, Percent_Identity=40.4444444444444, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI221513036, Length=625, Percent_Identity=44, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24666867, Length=625, Percent_Identity=44, Blast_Score=498, Evalue=1e-141,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88760; Mature: 88760

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTIELPLLPLRDVVVYPHMVIPLFVGREKSIEALEAAMTGDKQILLLAQRNPADDDPG
CCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCH
EEALYRVGTIATVLQLLKLPDGTVKVLVEGEQRGAVERFSEVDGHCRAEVSLIDEVDAAE
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
RESEVFVRSLLSQFEQYVQLGKKVPAEVLSSLNSIDEPGRLVDTMAAHMALKIEQKQEIL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EIIDLSARVEHVLALLDAEIDLLQVEKRIRGRVKKQMERSQREYYLNEQMKAIQKELGDS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEGHNEIEDLKKRIDAAGLPKDALAKATAELNKLKQMSPMSAEATVVRSYIDWLVQVPWK
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
AQSKVRLDLARAEDILDADHYGLEEVKERILEYLAVQKRVKKIRGPVLCLVGPPGVGKTS
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
LAESIAHATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGRLIQKMTKVGVRNPLFLLDE
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHH
IDKMGSDMRGDPASALLEVLDPEQNHNFNDHYLEVDYDLSDVMFLCTSNSMNIPPALLDR
HHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHEEEEECCCCCCCHHHHHH
MEVIRLPGYTEDEKINIAVKYLSPKQIAANGLKKGELEFDEEAIRDIIRYYTREAGVRGL
HHHHCCCCCCCCCEEEEEEEECCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ERQIAKVCRKAVKEHALEKRFSVKVTADLLEHFLGVRKFRYGLAEQQDQIGQVTGLAWTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
VGGELLTIEAAVVPGKGQLIKTGSLGDVMVESITAALTVVRSRAKSLGIPLDFHEKRDTH
CCCEEEEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
IHMPEGATPKDGPSAGVGMCTALVSALTGIPVRADVAMTGEITLRGQVLAIGGLKEKLLA
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEEEEEEEECCHHHHHHH
AHRGGIKTVIIPEENVRDLKEIPDNIKQDLQIKPVKWIDEVLQIALQYAPEPLPDVAPEI
HHCCCCEEEEECCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHH
VAKDEKRESDSKERISTH
HCCCHHHCCCHHHHCCCC
>Mature Secondary Structure
MKTTIELPLLPLRDVVVYPHMVIPLFVGREKSIEALEAAMTGDKQILLLAQRNPADDDPG
CCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCH
EEALYRVGTIATVLQLLKLPDGTVKVLVEGEQRGAVERFSEVDGHCRAEVSLIDEVDAAE
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
RESEVFVRSLLSQFEQYVQLGKKVPAEVLSSLNSIDEPGRLVDTMAAHMALKIEQKQEIL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EIIDLSARVEHVLALLDAEIDLLQVEKRIRGRVKKQMERSQREYYLNEQMKAIQKELGDS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEGHNEIEDLKKRIDAAGLPKDALAKATAELNKLKQMSPMSAEATVVRSYIDWLVQVPWK
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
AQSKVRLDLARAEDILDADHYGLEEVKERILEYLAVQKRVKKIRGPVLCLVGPPGVGKTS
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
LAESIAHATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGRLIQKMTKVGVRNPLFLLDE
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHH
IDKMGSDMRGDPASALLEVLDPEQNHNFNDHYLEVDYDLSDVMFLCTSNSMNIPPALLDR
HHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHEEEEECCCCCCCHHHHHH
MEVIRLPGYTEDEKINIAVKYLSPKQIAANGLKKGELEFDEEAIRDIIRYYTREAGVRGL
HHHHCCCCCCCCCEEEEEEEECCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ERQIAKVCRKAVKEHALEKRFSVKVTADLLEHFLGVRKFRYGLAEQQDQIGQVTGLAWTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
VGGELLTIEAAVVPGKGQLIKTGSLGDVMVESITAALTVVRSRAKSLGIPLDFHEKRDTH
CCCEEEEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
IHMPEGATPKDGPSAGVGMCTALVSALTGIPVRADVAMTGEITLRGQVLAIGGLKEKLLA
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEEEEEEEECCHHHHHHH
AHRGGIKTVIIPEENVRDLKEIPDNIKQDLQIKPVKWIDEVLQIALQYAPEPLPDVAPEI
HHCCCCEEEEECCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHH
VAKDEKRESDSKERISTH
HCCCHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]