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The map label for this gene is pbuX [H]

Identifier: 77458954

GI number: 77458954

Start: 3145843

End: 3147183

Strand: Direct

Name: pbuX [H]

Synonym: Pfl01_2729

Alternate gene names: 77458954

Gene position: 3145843-3147183 (Clockwise)

Preceding gene: 77458952

Following gene: 77458955

Centisome position: 48.86

GC content: 60.1

Gene sequence:

>1341_bases
ATGACCACACAACGCATTCATCCGGTGGACGAGGTTTTGCCACTGCGCCAGTTGTTCACGTTTGGCTTGCAGCATGTTCT
GGTGATGTACGCGGGAGCGGTGGCGGTGCCGCTGATTCTTGGCAGCGCGATGGGGCTGACCTCGGCGCAAGTCGTGTTGC
TGATCAACGCCAACCTGTTGACCTCTGGTGTGGCGACGCTGATTCAAACCCTCGGTTTCTGGAAGTTCGGCGCCCGCCTG
CCGCTGATTCAGGGCTGCTCGTTCATTGCCCTGGCGCCGATGATCATGATCGGCAAGGAGTTCGGTCTCAGCCAGATTTT
CGGTGCGGTGATCGCGGCGGGATTTATCACCGTTGCGCTGGCACCGGTGTTCAGCCGCTTGCTGCGGTTTTTTCCGCCGG
TGGTGATTGGCAGTCTGATCACCATTATCGGCATCTCGCTGATGCCGGCGGCGGCGATCTGGCTGGGCGGTGGCAATCCC
GATTCGGCAGATTTTGGCAATCCCGCCAACCTGTTGCTCGGTTTGGCCACGGTCAGTGTGACGCTGGTGATCTACGCCAG
ATTCAAGGGCTTCATCGGCAACCTCAGCGTGCTGATTGGCCTCTTTGTCGGCAGCCTGATCGCAGCGGCTTGCGGCATGA
CGCACTTCAATCGGGTCAGCGAAGCGGCCTGGTTTGAGTTGAGTGCGCCGATGGCTTTCGGCGCGCCGGAATTCGCGCCG
GTGCCGATTCTGATCATGACCCTGGCGATGCTGGTCATCATGGCCGAGACCACCGGCAACTGTCTGGCGATCGGCAAATT
GACCGGCAAACCGACCACGCAACAAACCCTCGGCAACGCATTCCGCGCCGATGGCTTGTCGACCATGCTCGGTGGCTTGT
TCAACAGCTTTCCTTACAACGCCTTTACTCAGAACACCGGCTTGATTGCGCTCTCCAACGTTAAAAGCCGCTTCGTTGTG
GCCGCTGCCGGGGCAATCATGGTGCTGATGGGCCTGTTCCCGAAACTCGGCGCGTTGATCGCCGCAGTGCCGACGCCGGT
GCTCGGTGGCTGCGCGATTGTGATGTTCGGCATGACCACGGTGGCGGGGATTCAGGAACTGTCACGGGTGCAATTCGAGG
GCACGCGCAACGGCATTATCGTCGCCGTGTCAGTGAGTGCCGGGGTGCTGCCGATGTCCTTTCCGGCGCTGTTCGAACAC
GTCGGCCCGACCCTGAAACTGGTGCTCGACAGCGGGATTTTCCTCGGAGCGATCACCGCCATCGTCCTCAACGTTCTGCT
CAACGATGAAAAAAAACCGACCGAAACCATCGGCGCTACATCGGCTGAACTGGCCGACTGA

Upstream 100 bases:

>100_bases
ATGGCCCCGCTTCAAACGATCTCCGGGGCGGATGCACCTTTCAAACGCCTTGGGCATGCCCGCAATCTCAACAGATGCCG
CACCTTCAGGAGCGTGGGAA

Downstream 100 bases:

>100_bases
CTTTTGTTTTCCACTGCCCTGGAGTTACCCATGAATCAATTGACTGAACTCATCCCGGCTGGCATCAGCGCGCTTGATCT
GACGTTACTGCGCCAGACCA

Product: xanthine/uracil permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTTQRIHPVDEVLPLRQLFTFGLQHVLVMYAGAVAVPLILGSAMGLTSAQVVLLINANLLTSGVATLIQTLGFWKFGARL
PLIQGCSFIALAPMIMIGKEFGLSQIFGAVIAAGFITVALAPVFSRLLRFFPPVVIGSLITIIGISLMPAAAIWLGGGNP
DSADFGNPANLLLGLATVSVTLVIYARFKGFIGNLSVLIGLFVGSLIAAACGMTHFNRVSEAAWFELSAPMAFGAPEFAP
VPILIMTLAMLVIMAETTGNCLAIGKLTGKPTTQQTLGNAFRADGLSTMLGGLFNSFPYNAFTQNTGLIALSNVKSRFVV
AAAGAIMVLMGLFPKLGALIAAVPTPVLGGCAIVMFGMTTVAGIQELSRVQFEGTRNGIIVAVSVSAGVLPMSFPALFEH
VGPTLKLVLDSGIFLGAITAIVLNVLLNDEKKPTETIGATSAELAD

Sequences:

>Translated_446_residues
MTTQRIHPVDEVLPLRQLFTFGLQHVLVMYAGAVAVPLILGSAMGLTSAQVVLLINANLLTSGVATLIQTLGFWKFGARL
PLIQGCSFIALAPMIMIGKEFGLSQIFGAVIAAGFITVALAPVFSRLLRFFPPVVIGSLITIIGISLMPAAAIWLGGGNP
DSADFGNPANLLLGLATVSVTLVIYARFKGFIGNLSVLIGLFVGSLIAAACGMTHFNRVSEAAWFELSAPMAFGAPEFAP
VPILIMTLAMLVIMAETTGNCLAIGKLTGKPTTQQTLGNAFRADGLSTMLGGLFNSFPYNAFTQNTGLIALSNVKSRFVV
AAAGAIMVLMGLFPKLGALIAAVPTPVLGGCAIVMFGMTTVAGIQELSRVQFEGTRNGIIVAVSVSAGVLPMSFPALFEH
VGPTLKLVLDSGIFLGAITAIVLNVLLNDEKKPTETIGATSAELAD
>Mature_445_residues
TTQRIHPVDEVLPLRQLFTFGLQHVLVMYAGAVAVPLILGSAMGLTSAQVVLLINANLLTSGVATLIQTLGFWKFGARLP
LIQGCSFIALAPMIMIGKEFGLSQIFGAVIAAGFITVALAPVFSRLLRFFPPVVIGSLITIIGISLMPAAAIWLGGGNPD
SADFGNPANLLLGLATVSVTLVIYARFKGFIGNLSVLIGLFVGSLIAAACGMTHFNRVSEAAWFELSAPMAFGAPEFAPV
PILIMTLAMLVIMAETTGNCLAIGKLTGKPTTQQTLGNAFRADGLSTMLGGLFNSFPYNAFTQNTGLIALSNVKSRFVVA
AAGAIMVLMGLFPKLGALIAAVPTPVLGGCAIVMFGMTTVAGIQELSRVQFEGTRNGIIVAVSVSAGVLPMSFPALFEHV
GPTLKLVLDSGIFLGAITAIVLNVLLNDEKKPTETIGATSAELAD

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=504, Percent_Identity=22.8174603174603, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI40316845, Length=504, Percent_Identity=22.8174603174603, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI44680143, Length=216, Percent_Identity=26.8518518518519, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI44680145, Length=216, Percent_Identity=26.8518518518519, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI87082181, Length=441, Percent_Identity=40.8163265306122, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1790087, Length=448, Percent_Identity=29.0178571428571, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI87082178, Length=460, Percent_Identity=26.7391304347826, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI87081818, Length=398, Percent_Identity=29.6482412060301, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788843, Length=400, Percent_Identity=28, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17558856, Length=460, Percent_Identity=24.1304347826087, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71993493, Length=441, Percent_Identity=22.9024943310658, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17542260, Length=183, Percent_Identity=27.8688524590164, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17542262, Length=428, Percent_Identity=21.2616822429907, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=433, Percent_Identity=21.9399538106236, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356175, Length=435, Percent_Identity=22.7586206896552, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46380; Mature: 46249

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQRIHPVDEVLPLRQLFTFGLQHVLVMYAGAVAVPLILGSAMGLTSAQVVLLINANLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHH
TSGVATLIQTLGFWKFGARLPLIQGCSFIALAPMIMIGKEFGLSQIFGAVIAAGFITVAL
HHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
APVFSRLLRFFPPVVIGSLITIIGISLMPAAAIWLGGGNPDSADFGNPANLLLGLATVSV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHH
TLVIYARFKGFIGNLSVLIGLFVGSLIAAACGMTHFNRVSEAAWFELSAPMAFGAPEFAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEECCCCCCCCCCCCC
VPILIMTLAMLVIMAETTGNCLAIGKLTGKPTTQQTLGNAFRADGLSTMLGGLFNSFPYN
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCC
AFTQNTGLIALSNVKSRFVVAAAGAIMVLMGLFPKLGALIAAVPTPVLGGCAIVMFGMTT
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VAGIQELSRVQFEGTRNGIIVAVSVSAGVLPMSFPALFEHVGPTLKLVLDSGIFLGAITA
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEHHHHCCHHHHHHHH
IVLNVLLNDEKKPTETIGATSAELAD
HHHHHHHCCCCCCHHHHCCCCHHCCC
>Mature Secondary Structure 
TTQRIHPVDEVLPLRQLFTFGLQHVLVMYAGAVAVPLILGSAMGLTSAQVVLLINANLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHH
TSGVATLIQTLGFWKFGARLPLIQGCSFIALAPMIMIGKEFGLSQIFGAVIAAGFITVAL
HHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
APVFSRLLRFFPPVVIGSLITIIGISLMPAAAIWLGGGNPDSADFGNPANLLLGLATVSV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHH
TLVIYARFKGFIGNLSVLIGLFVGSLIAAACGMTHFNRVSEAAWFELSAPMAFGAPEFAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEECCCCCCCCCCCCC
VPILIMTLAMLVIMAETTGNCLAIGKLTGKPTTQQTLGNAFRADGLSTMLGGLFNSFPYN
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCC
AFTQNTGLIALSNVKSRFVVAAAGAIMVLMGLFPKLGALIAAVPTPVLGGCAIVMFGMTT
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VAGIQELSRVQFEGTRNGIIVAVSVSAGVLPMSFPALFEHVGPTLKLVLDSGIFLGAITA
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEHHHHCCHHHHHHHH
IVLNVLLNDEKKPTETIGATSAELAD
HHHHHHHCCCCCCHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]