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The map label for this gene is mmlH [H]

Identifier: 77457631

GI number: 77457631

Start: 1575295

End: 1576581

Strand: Direct

Name: mmlH [H]

Synonym: Pfl01_1404

Alternate gene names: 77457631

Gene position: 1575295-1576581 (Clockwise)

Preceding gene: 77457629

Following gene: 77457632

Centisome position: 24.47

GC content: 61.46

Gene sequence:

>1287_bases
ATGAGTGCGCCCGACACCCTCGACCTCCCCAAGACTGCGGCCCGTCTCGGCCCGTTCGACTGGTATCGCAACATCAATCA
GCAGGAGCGCCGGACCTTCTGGAGCTGCAAGATCGGCTACGGTCTGGACGGCATGGACACCCAGATGCTCAGCTTCGTGG
TGCCGACCCTGATCGCAATGTGGGGCATCACCACCGGCGAAGCCGGCCTGATCCACACCAGCACCCTGATCGCTTCGGCC
ATCGGCGGTTGGGTGGCGGGAATTCTCTCCGACCGCATCGGCCGCGTGCGCACCCTGCAACTGACGGTGCTGTGGTTTGC
CTTCTTCACTTTCCTTTGCGGCTTTGCCCAGAACTACGAACAGCTGTTGATTGCCCGCACCTTGATGGGCTTCGGTTTCG
GCGGTGAATGGACCGCCGGTGCGGTGCTGATCGGTGAAGTGATCCGGGCCAAGGACCGCGGCAAGGCGGTGGGCATGGTG
CAATCCGGCTGGGCCTTGGGTTGGGGCCTGACGGCGATTCTGTATGCGCTGCTGTTTTCGGTGCTGCCACCGGAAGACGC
CTGGCGCGCACTGTTCATCCTTGGCATCGTGCCGGCGGTGTTCGTGATTTTCGTCCGCCGTCTGGTGAAAGATCCGGAGA
TCTACCGCGAAGCCAAGGCCAGACAAACCCCGGAAAGCCCTTCGAAGTTCTACGAGATTTTCGCCCCCGGCATGCTCTTC
ACCACGATTCGTGCCTCGCTGCTGACCACCGGCGCCCTCGGCGGTTATTACGCGATTACCTCCTGGCTGCCGACTTTTCT
GAAAAACGAACGCGGTTTGAGCGTACTCGGCACCGGCGGTTATCTGGCGATGGTGATCATCGGTTCCTACGCCGGTTATG
TGATCAGCGCCTATTTGACCGACCTGTTGGGCCGCAAGAAGAACTTCATCCTGTTCGCCGTCGGCTCGTTCACCATCGTT
CTGCTCTACACCCAATTGCCGGTCAGCAACGGCGTGATGCTGTGGCTGGGTTTCCCGCTGGGCTTTTTCGCCTCGGGGAT
TTTCAGTGGGATGGGCGCGTTTCTCACCGAGTTGTTTCCAACCCGGATTCGTGGCTCGGGGCAGGGCTTCTGCTACAACA
TCGGTCGGGCGCTGGCGGCTTTGTTCCCGCTGCTGATCGGCCTGCTCAGTCAGAAGGTGCCACTGAGCGTAGGCATCGGT
GCCTTTGCGGCGGTGTCCTACGGGGTGGTGATCCTCGCGGCGTTGAGCCTGCCGGAAACCCGTGGCAAGCAACTGGACGC
GCAGTAA

Upstream 100 bases:

>100_bases
CGCGACCGGGTGACGCACCCAAGAATCGACGCATCCGGTTCCCACGATAGGCGTCGTCGGAGCTTCGAACAAGACCAATA
AAAGCCTGCGGAGACATGCC

Downstream 100 bases:

>100_bases
CTGATAACCTGCGACAACGCCCTACGATAAAAAAAGACAAAAGCTACAGGAGTGTTCACCATGAGCCGCCTGCTATTGAA
CTGTGACATCGGCGAGAGCT

Product: general substrate transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSAPDTLDLPKTAARLGPFDWYRNINQQERRTFWSCKIGYGLDGMDTQMLSFVVPTLIAMWGITTGEAGLIHTSTLIASA
IGGWVAGILSDRIGRVRTLQLTVLWFAFFTFLCGFAQNYEQLLIARTLMGFGFGGEWTAGAVLIGEVIRAKDRGKAVGMV
QSGWALGWGLTAILYALLFSVLPPEDAWRALFILGIVPAVFVIFVRRLVKDPEIYREAKARQTPESPSKFYEIFAPGMLF
TTIRASLLTTGALGGYYAITSWLPTFLKNERGLSVLGTGGYLAMVIIGSYAGYVISAYLTDLLGRKKNFILFAVGSFTIV
LLYTQLPVSNGVMLWLGFPLGFFASGIFSGMGAFLTELFPTRIRGSGQGFCYNIGRALAALFPLLIGLLSQKVPLSVGIG
AFAAVSYGVVILAALSLPETRGKQLDAQ

Sequences:

>Translated_428_residues
MSAPDTLDLPKTAARLGPFDWYRNINQQERRTFWSCKIGYGLDGMDTQMLSFVVPTLIAMWGITTGEAGLIHTSTLIASA
IGGWVAGILSDRIGRVRTLQLTVLWFAFFTFLCGFAQNYEQLLIARTLMGFGFGGEWTAGAVLIGEVIRAKDRGKAVGMV
QSGWALGWGLTAILYALLFSVLPPEDAWRALFILGIVPAVFVIFVRRLVKDPEIYREAKARQTPESPSKFYEIFAPGMLF
TTIRASLLTTGALGGYYAITSWLPTFLKNERGLSVLGTGGYLAMVIIGSYAGYVISAYLTDLLGRKKNFILFAVGSFTIV
LLYTQLPVSNGVMLWLGFPLGFFASGIFSGMGAFLTELFPTRIRGSGQGFCYNIGRALAALFPLLIGLLSQKVPLSVGIG
AFAAVSYGVVILAALSLPETRGKQLDAQ
>Mature_427_residues
SAPDTLDLPKTAARLGPFDWYRNINQQERRTFWSCKIGYGLDGMDTQMLSFVVPTLIAMWGITTGEAGLIHTSTLIASAI
GGWVAGILSDRIGRVRTLQLTVLWFAFFTFLCGFAQNYEQLLIARTLMGFGFGGEWTAGAVLIGEVIRAKDRGKAVGMVQ
SGWALGWGLTAILYALLFSVLPPEDAWRALFILGIVPAVFVIFVRRLVKDPEIYREAKARQTPESPSKFYEIFAPGMLFT
TIRASLLTTGALGGYYAITSWLPTFLKNERGLSVLGTGGYLAMVIIGSYAGYVISAYLTDLLGRKKNFILFAVGSFTIVL
LYTQLPVSNGVMLWLGFPLGFFASGIFSGMGAFLTELFPTRIRGSGQGFCYNIGRALAALFPLLIGLLSQKVPLSVGIGA
FAAVSYGVVILAALSLPETRGKQLDAQ

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=437, Percent_Identity=25.858123569794, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI213021148, Length=440, Percent_Identity=22.2727272727273, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI87082231, Length=454, Percent_Identity=25.7709251101322, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI87082404, Length=356, Percent_Identity=26.685393258427, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87081723, Length=372, Percent_Identity=26.0752688172043, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790550, Length=328, Percent_Identity=22.8658536585366, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082159, Length=366, Percent_Identity=25.6830601092896, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=433, Percent_Identity=25.635103926097, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46484; Mature: 46353

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPDTLDLPKTAARLGPFDWYRNINQQERRTFWSCKIGYGLDGMDTQMLSFVVPTLIAM
CCCCCCCCCCHHHHHCCCHHHHHCCCHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHH
WGITTGEAGLIHTSTLIASAIGGWVAGILSDRIGRVRTLQLTVLWFAFFTFLCGFAQNYE
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLLIARTLMGFGFGGEWTAGAVLIGEVIRAKDRGKAVGMVQSGWALGWGLTAILYALLFS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEECCHHCCCHHHHHHHHHHHHHHHH
VLPPEDAWRALFILGIVPAVFVIFVRRLVKDPEIYREAKARQTPESPSKFYEIFAPGMLF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCHHHH
TTIRASLLTTGALGGYYAITSWLPTFLKNERGLSVLGTGGYLAMVIIGSYAGYVISAYLT
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
DLLGRKKNFILFAVGSFTIVLLYTQLPVSNGVMLWLGFPLGFFASGIFSGMGAFLTELFP
HHHCCCCCEEEEEEHHHEEHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
TRIRGSGQGFCYNIGRALAALFPLLIGLLSQKVPLSVGIGAFAAVSYGVVILAALSLPET
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCHHHHHHHHHHHHHHHHHCCCCC
RGKQLDAQ
CCCCCCCC
>Mature Secondary Structure 
SAPDTLDLPKTAARLGPFDWYRNINQQERRTFWSCKIGYGLDGMDTQMLSFVVPTLIAM
CCCCCCCCCHHHHHCCCHHHHHCCCHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHH
WGITTGEAGLIHTSTLIASAIGGWVAGILSDRIGRVRTLQLTVLWFAFFTFLCGFAQNYE
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLLIARTLMGFGFGGEWTAGAVLIGEVIRAKDRGKAVGMVQSGWALGWGLTAILYALLFS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEECCHHCCCHHHHHHHHHHHHHHHH
VLPPEDAWRALFILGIVPAVFVIFVRRLVKDPEIYREAKARQTPESPSKFYEIFAPGMLF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHCCHHHH
TTIRASLLTTGALGGYYAITSWLPTFLKNERGLSVLGTGGYLAMVIIGSYAGYVISAYLT
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
DLLGRKKNFILFAVGSFTIVLLYTQLPVSNGVMLWLGFPLGFFASGIFSGMGAFLTELFP
HHHCCCCCEEEEEEHHHEEHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
TRIRGSGQGFCYNIGRALAALFPLLIGLLSQKVPLSVGIGAFAAVSYGVVILAALSLPET
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCHHHHHHHHHHHHHHHHHCCCCC
RGKQLDAQ
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]