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The map label for this gene is rnd [H]

Identifier: 77457615

GI number: 77457615

Start: 1561967

End: 1563100

Strand: Direct

Name: rnd [H]

Synonym: Pfl01_1388

Alternate gene names: 77457615

Gene position: 1561967-1563100 (Clockwise)

Preceding gene: 77457614

Following gene: 77457616

Centisome position: 24.26

GC content: 64.37

Gene sequence:

>1134_bases
GTGGCCATCGATATTCACTGGATTCGCGACAACGATAGCCTCGCGCAGTTTTGCGCCGAGTGGCAGCAGCTGCCGTTCGT
TGCCCTCGACACCGAATTCATGCGGGTCGACACCTTCTATCCGATTGCCGGCCTGTTGCAGGTCGGCGACGGCAAACGCG
CCTACCTGATCGACCCGCTGACCATCAACGCCTGGCAGCCCTTGGCCGCGTTGCTGGAAAACCCGGCGGTGCTCAAAGTC
CTGCACGCCTGCAGCGAAGACCTCGAAGTCCTGCTGCGCCTGACCGGCAGCCTGCCGGCGCCGCTGTTCGACACCCAACT
GGCCGCTGCCTACCTGAACCTCGGGTTCTCGATGGGCTATTCGCGTCTGGTGCAGGAAGTGCTGGGCATCGAACTGCCGA
AGGGCGAAACCCGGTCCGACTGGTTGCAGCGTCCGTTGTCCGACACGCAAATCAGCTATGCCGCCGAAGACGCCGTGCAT
CTGGCGGAGGTTTTCGTACAACTGCGTCCGAAACTGTCCGACGACAAATTCGCCTGGGTGCTGGAGGACGGCGCCGAACT
GGTCGCCAACCTGCGCCGCGAGACCGATCCGTACGAGGTGTATCGCGAGGCCAAACTGGCGTGGAAGCTGTCTCGCGCCC
AACTGGCTGTGCTGCGCGAATTGTGCGCCTGGCGTGAGCGCGAGGCCCGCGCCCGCGACCTGCCGCGCAATCGCATCGTG
CGTGAACACTCGCTGTGGCCGCTGGCCCGGACCCAACCGGACAACCTCAGCGCGCTGGGCAAGATCGAAGACATGCACCC
GCGTACCGTGCGTCAGGACGGCGAGTTTCTGCTTGATCTGATCAAGCGCTCTGGCAGTGTGGGGCCTGATCAATGGCCGC
CAGCCGTGCCGGAGCCGTTGCCGATCGAAGCCGCCGCGCTGATCAAACAGCTGCGGGCGCTCGGTCAGGCCGAAGCCGAA
CGTCTGGGCATCGCGCCGGAACTGATGCTGCGCAAGAAAACCCTCGAAGCGCTGGTCAAAAGCGGCTTCCCCGAGGGCCC
TTACCAATTGCCTGATTCGCTGCGTGGCTGGCGCCGCGAATTGATGGGCCAGAAGCTGCTCGACAGCCTGGCCACCGCCG
GAGAACAGCCTTGA

Upstream 100 bases:

>100_bases
TTCCCACAGGCAGGAGATTTCATCAAGCTCTTGCCCTGTAGAGGCGCGGAAAGCGCCGGTGGCGATATATACTGCGCGCC
ATTCTTGAAGGGAGAGCCGT

Downstream 100 bases:

>100_bases
AACGTATTTGTTCCATTTATCAAAGTTCGAAGAAAAGCGGCATGTACCTGTACGTGCTCAAGAGCGATGCGCTGGAGCGC
GTGCCGGAAGGCCTGATGGC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAIDIHWIRDNDSLAQFCAEWQQLPFVALDTEFMRVDTFYPIAGLLQVGDGKRAYLIDPLTINAWQPLAALLENPAVLKV
LHACSEDLEVLLRLTGSLPAPLFDTQLAAAYLNLGFSMGYSRLVQEVLGIELPKGETRSDWLQRPLSDTQISYAAEDAVH
LAEVFVQLRPKLSDDKFAWVLEDGAELVANLRRETDPYEVYREAKLAWKLSRAQLAVLRELCAWREREARARDLPRNRIV
REHSLWPLARTQPDNLSALGKIEDMHPRTVRQDGEFLLDLIKRSGSVGPDQWPPAVPEPLPIEAAALIKQLRALGQAEAE
RLGIAPELMLRKKTLEALVKSGFPEGPYQLPDSLRGWRRELMGQKLLDSLATAGEQP

Sequences:

>Translated_377_residues
MAIDIHWIRDNDSLAQFCAEWQQLPFVALDTEFMRVDTFYPIAGLLQVGDGKRAYLIDPLTINAWQPLAALLENPAVLKV
LHACSEDLEVLLRLTGSLPAPLFDTQLAAAYLNLGFSMGYSRLVQEVLGIELPKGETRSDWLQRPLSDTQISYAAEDAVH
LAEVFVQLRPKLSDDKFAWVLEDGAELVANLRRETDPYEVYREAKLAWKLSRAQLAVLRELCAWREREARARDLPRNRIV
REHSLWPLARTQPDNLSALGKIEDMHPRTVRQDGEFLLDLIKRSGSVGPDQWPPAVPEPLPIEAAALIKQLRALGQAEAE
RLGIAPELMLRKKTLEALVKSGFPEGPYQLPDSLRGWRRELMGQKLLDSLATAGEQP
>Mature_376_residues
AIDIHWIRDNDSLAQFCAEWQQLPFVALDTEFMRVDTFYPIAGLLQVGDGKRAYLIDPLTINAWQPLAALLENPAVLKVL
HACSEDLEVLLRLTGSLPAPLFDTQLAAAYLNLGFSMGYSRLVQEVLGIELPKGETRSDWLQRPLSDTQISYAAEDAVHL
AEVFVQLRPKLSDDKFAWVLEDGAELVANLRRETDPYEVYREAKLAWKLSRAQLAVLRELCAWREREARARDLPRNRIVR
EHSLWPLARTQPDNLSALGKIEDMHPRTVRQDGEFLLDLIKRSGSVGPDQWPPAVPEPLPIEAAALIKQLRALGQAEAER
LGIAPELMLRKKTLEALVKSGFPEGPYQLPDSLRGWRRELMGQKLLDSLATAGEQP

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=286, Percent_Identity=24.1258741258741, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI50301240, Length=286, Percent_Identity=24.1258741258741, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788105, Length=376, Percent_Identity=36.7021276595745, Blast_Score=221, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17531757, Length=263, Percent_Identity=28.5171102661597, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324574, Length=295, Percent_Identity=27.7966101694915, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI161078302, Length=284, Percent_Identity=25.3521126760563, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42490; Mature: 42359

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIDIHWIRDNDSLAQFCAEWQQLPFVALDTEFMRVDTFYPIAGLLQVGDGKRAYLIDPL
CEEEEEEECCCCHHHHHHHHHHHCCEEEECCHHHHHCCHHHHHHHHCCCCCCEEEEECCE
TINAWQPLAALLENPAVLKVLHACSEDLEVLLRLTGSLPAPLFDTQLAAAYLNLGFSMGY
EECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCH
SRLVQEVLGIELPKGETRSDWLQRPLSDTQISYAAEDAVHLAEVFVQLRPKLSDDKFAWV
HHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LEDGAELVANLRRETDPYEVYREAKLAWKLSRAQLAVLRELCAWREREARARDLPRNRIV
EHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
REHSLWPLARTQPDNLSALGKIEDMHPRTVRQDGEFLLDLIKRSGSVGPDQWPPAVPEPL
HHHCCCCCCCCCCCCHHHHHCHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PIEAAALIKQLRALGQAEAERLGIAPELMLRKKTLEALVKSGFPEGPYQLPDSLRGWRRE
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LMGQKLLDSLATAGEQP
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AIDIHWIRDNDSLAQFCAEWQQLPFVALDTEFMRVDTFYPIAGLLQVGDGKRAYLIDPL
EEEEEEECCCCHHHHHHHHHHHCCEEEECCHHHHHCCHHHHHHHHCCCCCCEEEEECCE
TINAWQPLAALLENPAVLKVLHACSEDLEVLLRLTGSLPAPLFDTQLAAAYLNLGFSMGY
EECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCH
SRLVQEVLGIELPKGETRSDWLQRPLSDTQISYAAEDAVHLAEVFVQLRPKLSDDKFAWV
HHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LEDGAELVANLRRETDPYEVYREAKLAWKLSRAQLAVLRELCAWREREARARDLPRNRIV
EHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
REHSLWPLARTQPDNLSALGKIEDMHPRTVRQDGEFLLDLIKRSGSVGPDQWPPAVPEPL
HHHCCCCCCCCCCCCHHHHHCHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PIEAAALIKQLRALGQAEAERLGIAPELMLRKKTLEALVKSGFPEGPYQLPDSLRGWRRE
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LMGQKLLDSLATAGEQP
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]