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The map label for this gene is mcpB [H]

Identifier: 77457279

GI number: 77457279

Start: 1219171

End: 1220793

Strand: Direct

Name: mcpB [H]

Synonym: Pfl01_1052

Alternate gene names: 77457279

Gene position: 1219171-1220793 (Clockwise)

Preceding gene: 77457278

Following gene: 77457280

Centisome position: 18.94

GC content: 61.37

Gene sequence:

>1623_bases
GTGAAGAACTGGACGTTGCGCCAACGCATTTTGGCGAGCTTTGCGGTGATTATCGCCATCATGCTGCTGATGGTGGTCGT
CTCGTATTCGCGGCTGCTGAAGATCGAAGCCAGTGAAAACAGCGTCCGTGACGACGCGATTCCCGGCGTCTATTACAGCT
CGATGATTCGTGGCGCGTGGGTCGACAGCTACCTGCAGACCCAGGAACTGCTGGGGCTCAAGGAAGGGCAGGGCATCAGC
AGTGAAGACGCGGCCGATTACAAGGCTTTCGAATCTCGGCTTCAGGAACAGATGGCCAATTACCGTGGCACGGTGGTCAC
GGACGAGGACAAGCTCGAATTCGCGGCGTTCGAGAAGTATCACGATGCCTACCTGAAAATTCAGGATGCGGTGCTCGATC
TGCACAAGCGAAATCTGGAAGCGGATGCGGTCAAGCTGTTCCACGAGCAACTGACTCCGACCTGGTACTCGGGCCGGATG
AAGCTCAACGACATCATCAGCGAAAACAAGAGAGTCGCCGACCAGGCCATGGCCAACATCGACGAGGCCGTGGCGGCAGC
CAAAGTCAGCATGTTTGTGTCGCTGGTGGTGGCGGTGCTGGCCGCCGGTTTCTGTGGTCTGTTGCTGATGCGCGCGATCA
TGGCGCCGATGAACCGTATCGTGCAGATCCTCGACATCATGCGCACCGGCGATCTGAGCAGCCGCTTGAATCTCGAGCGC
AAGGACGAGTTCGGCGCCGTGGAAACCGGCTTCAACGACATGATGACCGAGCTCACCTCGCTGGTGTCCCAGGCCCAGCG
CTCGTCGGTGCAGGTCACCACCTCGGTGACCGAGATCGCTGCGACCTCCAAGCAACAGCAAGCCACCGCCACCGAAACCG
CTGCGACCACCACTGAAATCGGCGCGACGTCTCGCGAAATTGCGGCGACCTCCCGCGATCTCGTACGCACGATGACCGAA
GTCTCCACCGCCGCCGATCAGGCCTCGGTGCTGGCCGGTTCCGGGCAGCAAGGCCTGGCGCGGATGGAAGACACCATGCA
TTCGGTGATGGGCGCGGCGGATCTGGTGAACGCCAAACTGGCGATCCTCAACGAGAAGGCCGGCAACATCAATCAGGTGG
TGGTGACCATCGTCAAGGTCGCCGACCAGACCAACCTGCTGTCCCTGAACGCTGCGATCGAAGCGGAGAAGGCCGGCGAA
TACGGTCGCGGTTTTGCCGTGGTCGCCACCGAAGTGCGGCGTCTGGCGGATCAGACCGCTGTTGCCACGTATGACATCGA
ACAGATGGTCCGCGAGATCCAGTCGGCGGTGTCCGCCGGGGTGATGGGCATGGACAAGTTCTCCGAGGAAGTGCGTCGCG
GCATGGCTGAAGTGCAGCAGGTCGGCGAGCAGCTGTCGCAGATCATCCATCAGGTGCAGGCGCTGGCGCCGCGGGTATTG
ATGGTCAACGAAGGCATGCAGGCCCAGGCCACCGGCGCCGAGCAGATCAACCATGCGCTGGTGCAGCTGGGTGATGCCAG
CAGCCAGACCGTCGAGTCGTTGCGTCAGGCCAGTTTCGCCATCGACGAACTGAGCCAGGTGGCCGTGGGCCTGCGCAGCG
GCGTTTCGCGATTCAAAGTCTGA

Upstream 100 bases:

>100_bases
TTTCATGAGCGAAAGGCCAGAGCGCGGCAAACCGTCTTATAAATGAAACACCGCCCTCAGCTATACTCCCCCGCATTTCG
ACCCGCCCCGAGGACTGACT

Downstream 100 bases:

>100_bases
TGAGCGAAATCACCGCCAAACGCAGCGCTGCACCGGTGGCGAAGCAGGCGTTGTTTCTGCTGTTTCGCATCGGCAGCGAA
CGCTACGCCCTGCGCGCCAC

Product: chemotaxis sensory transducer

Products: NA

Alternate protein names: H3 [H]

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MKNWTLRQRILASFAVIIAIMLLMVVVSYSRLLKIEASENSVRDDAIPGVYYSSMIRGAWVDSYLQTQELLGLKEGQGIS
SEDAADYKAFESRLQEQMANYRGTVVTDEDKLEFAAFEKYHDAYLKIQDAVLDLHKRNLEADAVKLFHEQLTPTWYSGRM
KLNDIISENKRVADQAMANIDEAVAAAKVSMFVSLVVAVLAAGFCGLLLMRAIMAPMNRIVQILDIMRTGDLSSRLNLER
KDEFGAVETGFNDMMTELTSLVSQAQRSSVQVTTSVTEIAATSKQQQATATETAATTTEIGATSREIAATSRDLVRTMTE
VSTAADQASVLAGSGQQGLARMEDTMHSVMGAADLVNAKLAILNEKAGNINQVVVTIVKVADQTNLLSLNAAIEAEKAGE
YGRGFAVVATEVRRLADQTAVATYDIEQMVREIQSAVSAGVMGMDKFSEEVRRGMAEVQQVGEQLSQIIHQVQALAPRVL
MVNEGMQAQATGAEQINHALVQLGDASSQTVESLRQASFAIDELSQVAVGLRSGVSRFKV

Sequences:

>Translated_540_residues
MKNWTLRQRILASFAVIIAIMLLMVVVSYSRLLKIEASENSVRDDAIPGVYYSSMIRGAWVDSYLQTQELLGLKEGQGIS
SEDAADYKAFESRLQEQMANYRGTVVTDEDKLEFAAFEKYHDAYLKIQDAVLDLHKRNLEADAVKLFHEQLTPTWYSGRM
KLNDIISENKRVADQAMANIDEAVAAAKVSMFVSLVVAVLAAGFCGLLLMRAIMAPMNRIVQILDIMRTGDLSSRLNLER
KDEFGAVETGFNDMMTELTSLVSQAQRSSVQVTTSVTEIAATSKQQQATATETAATTTEIGATSREIAATSRDLVRTMTE
VSTAADQASVLAGSGQQGLARMEDTMHSVMGAADLVNAKLAILNEKAGNINQVVVTIVKVADQTNLLSLNAAIEAEKAGE
YGRGFAVVATEVRRLADQTAVATYDIEQMVREIQSAVSAGVMGMDKFSEEVRRGMAEVQQVGEQLSQIIHQVQALAPRVL
MVNEGMQAQATGAEQINHALVQLGDASSQTVESLRQASFAIDELSQVAVGLRSGVSRFKV
>Mature_540_residues
MKNWTLRQRILASFAVIIAIMLLMVVVSYSRLLKIEASENSVRDDAIPGVYYSSMIRGAWVDSYLQTQELLGLKEGQGIS
SEDAADYKAFESRLQEQMANYRGTVVTDEDKLEFAAFEKYHDAYLKIQDAVLDLHKRNLEADAVKLFHEQLTPTWYSGRM
KLNDIISENKRVADQAMANIDEAVAAAKVSMFVSLVVAVLAAGFCGLLLMRAIMAPMNRIVQILDIMRTGDLSSRLNLER
KDEFGAVETGFNDMMTELTSLVSQAQRSSVQVTTSVTEIAATSKQQQATATETAATTTEIGATSREIAATSRDLVRTMTE
VSTAADQASVLAGSGQQGLARMEDTMHSVMGAADLVNAKLAILNEKAGNINQVVVTIVKVADQTNLLSLNAAIEAEKAGE
YGRGFAVVATEVRRLADQTAVATYDIEQMVREIQSAVSAGVMGMDKFSEEVRRGMAEVQQVGEQLSQIIHQVQALAPRVL
MVNEGMQAQATGAEQINHALVQLGDASSQTVESLRQASFAIDELSQVAVGLRSGVSRFKV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=403, Percent_Identity=26.302729528536, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1787690, Length=457, Percent_Identity=23.6323851203501, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788194, Length=332, Percent_Identity=27.710843373494, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788195, Length=239, Percent_Identity=30.5439330543933, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1789453, Length=365, Percent_Identity=23.8356164383562, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 58754; Mature: 58754

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNWTLRQRILASFAVIIAIMLLMVVVSYSRLLKIEASENSVRDDAIPGVYYSSMIRGAW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHH
VDSYLQTQELLGLKEGQGISSEDAADYKAFESRLQEQMANYRGTVVTDEDKLEFAAFEKY
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHH
HDAYLKIQDAVLDLHKRNLEADAVKLFHEQLTPTWYSGRMKLNDIISENKRVADQAMANI
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHH
DEAVAAAKVSMFVSLVVAVLAAGFCGLLLMRAIMAPMNRIVQILDIMRTGDLSSRLNLER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCH
KDEFGAVETGFNDMMTELTSLVSQAQRSSVQVTTSVTEIAATSKQQQATATETAATTTEI
HHCCCCHHCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATSREIAATSRDLVRTMTEVSTAADQASVLAGSGQQGLARMEDTMHSVMGAADLVNAKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AILNEKAGNINQVVVTIVKVADQTNLLSLNAAIEAEKAGEYGRGFAVVATEVRRLADQTA
HEEECCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VATYDIEQMVREIQSAVSAGVMGMDKFSEEVRRGMAEVQQVGEQLSQIIHQVQALAPRVL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
MVNEGMQAQATGAEQINHALVQLGDASSQTVESLRQASFAIDELSQVAVGLRSGVSRFKV
EECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNWTLRQRILASFAVIIAIMLLMVVVSYSRLLKIEASENSVRDDAIPGVYYSSMIRGAW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHH
VDSYLQTQELLGLKEGQGISSEDAADYKAFESRLQEQMANYRGTVVTDEDKLEFAAFEKY
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHH
HDAYLKIQDAVLDLHKRNLEADAVKLFHEQLTPTWYSGRMKLNDIISENKRVADQAMANI
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHH
DEAVAAAKVSMFVSLVVAVLAAGFCGLLLMRAIMAPMNRIVQILDIMRTGDLSSRLNLER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCH
KDEFGAVETGFNDMMTELTSLVSQAQRSSVQVTTSVTEIAATSKQQQATATETAATTTEI
HHCCCCHHCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATSREIAATSRDLVRTMTEVSTAADQASVLAGSGQQGLARMEDTMHSVMGAADLVNAKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AILNEKAGNINQVVVTIVKVADQTNLLSLNAAIEAEKAGEYGRGFAVVATEVRRLADQTA
HEEECCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VATYDIEQMVREIQSAVSAGVMGMDKFSEEVRRGMAEVQQVGEQLSQIIHQVQALAPRVL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
MVNEGMQAQATGAEQINHALVQLGDASSQTVESLRQASFAIDELSQVAVGLRSGVSRFKV
EECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]