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The map label for this gene is ffh [H]

Identifier: 77457245

GI number: 77457245

Start: 1182821

End: 1184197

Strand: Direct

Name: ffh [H]

Synonym: Pfl01_1018

Alternate gene names: 77457245

Gene position: 1182821-1184197 (Clockwise)

Preceding gene: 77457241

Following gene: 77457246

Centisome position: 18.37

GC content: 59.77

Gene sequence:

>1377_bases
ATGTTTGAAAACTTAACCGACCGTCTCTCGCAGACGCTGCGCCATGTCACCGGCAAGGCGAAACTGACCGAGGACAACAT
CAAAGACACCCTGCGCGAAGTGCGCATGGCGTTGCTCGAAGCCGACGTGGCCCTGCCTGTGGTCAAGGACTTCGTCAATT
CGGTCAAGGAGCGTGCTGTCGGCACCGAGGTGTCGCGCAGCCTGACGCCGGGCCAGGCGTTCGTGAAGATCGTCCAGGCC
GAACTCGAAAGCCTGATGGGCGCGGCCAACGAAGACTTGAACCTGAGCGCCGTGCCGCCTGCCGTCATTCTGATGGCCGG
TCTGCAGGGTGCGGGTAAAACCACCACCGCCGGCAAACTGGCGCGCTTCCTTAAAGAGCGCAAGAAGAAGTCGGTCATGG
TCGTGTCGGCGGACATCTACCGCCCTGCTGCTATTAAACAGCTGGAAACCCTGGCCAACGACATCGGTGTGACGTTCTTC
CCGTCCGACCTGAGCCAGAAGCCGGTCGACATCGCCAACGCGGCTATTAAAGAAGCAAAACTGAAATTCATCGACGTGGT
CATCGTCGACACCGCCGGTCGTCTGCACATCGACGAAGAGATGATGGGCGAAATCAAGGCGCTGCACGCCGCGATCAACC
CGGTCGAAACCCTGTTCGTGGTCGATGCCATGACCGGTCAGGACGCGGCCAACACGGCCAAGGCTTTCGGTGATGCGCTG
CCGCTGACCGGTGTGATCCTGACCAAGGTCGACGGTGATGCCCGTGGTGGTGCCGCGCTGTCCGTTCGTGCGATTACCGG
CAAGCCGATCAAGTTCATCGGTATGGGCGAGAAGAGCGAAGCGCTCGATCCGTTCCATCCTGAGCGGATCGCTTCGCGTA
TCCTCGGCATGGGCGACGTGCTCAGCCTGATCGAACAGGCTGAAGCGACTCTCGATAAGGAAAAGGCCGACAAGCTTGCT
AAAAAGCTGAAGAAGGGCAAGGGCTTCGACCTCGAAGACTTCCGCGATCAGCTGCAACAGATGAAGAACATGGGCGGCCT
CGGCGGGCTCATGGACAAGCTGCCGAACATCGGCGGCGTCAATCTCTCGCAAATGGGCAATGCCCAGAATGCCGCAGAGA
AGCAGTTCAAGCAGATGGAAGCCATCATCAACTCCATGACCCCGGCCGAGCGCCGCGACCCTGAGCTGATCAGCGGTTCG
CGCAAACGCCGGATCGCCCTCGGTTCCGGCACCCAGGTGCAGGACATCGGTCGCTTGATCAAGCAGCACAAGCAGATGCA
GAAGATGATGAAGAAATTCTCCGCCAAGGGCGGAATGGCGAAAATGATGCGCGGCATGGGCGGAATGTTGCCCGGCGGCG
GCATGCCAAAGATGTAA

Upstream 100 bases:

>100_bases
AATCCGCGACCTGCCCACGCCGCAGGCTCGCCGAGCACATGTTGATTCCGGTCTGGGCCGCCATTATCCCGGTCTACACA
GGGCCTGAAAGGATCGCGCA

Downstream 100 bases:

>100_bases
AAGAACTCGCCGGTCGTCGCACCGGCGCAGTCCCGCAAGGAAGCGGGATCCACAGCAAACCCGCACTCGGCGGGAGCTGA
CCGGCCGTGTTAAACGACGG

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MFENLTDRLSQTLRHVTGKAKLTEDNIKDTLREVRMALLEADVALPVVKDFVNSVKERAVGTEVSRSLTPGQAFVKIVQA
ELESLMGAANEDLNLSAVPPAVILMAGLQGAGKTTTAGKLARFLKERKKKSVMVVSADIYRPAAIKQLETLANDIGVTFF
PSDLSQKPVDIANAAIKEAKLKFIDVVIVDTAGRLHIDEEMMGEIKALHAAINPVETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRAITGKPIKFIGMGEKSEALDPFHPERIASRILGMGDVLSLIEQAEATLDKEKADKLA
KKLKKGKGFDLEDFRDQLQQMKNMGGLGGLMDKLPNIGGVNLSQMGNAQNAAEKQFKQMEAIINSMTPAERRDPELISGS
RKRRIALGSGTQVQDIGRLIKQHKQMQKMMKKFSAKGGMAKMMRGMGGMLPGGGMPKM

Sequences:

>Translated_458_residues
MFENLTDRLSQTLRHVTGKAKLTEDNIKDTLREVRMALLEADVALPVVKDFVNSVKERAVGTEVSRSLTPGQAFVKIVQA
ELESLMGAANEDLNLSAVPPAVILMAGLQGAGKTTTAGKLARFLKERKKKSVMVVSADIYRPAAIKQLETLANDIGVTFF
PSDLSQKPVDIANAAIKEAKLKFIDVVIVDTAGRLHIDEEMMGEIKALHAAINPVETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRAITGKPIKFIGMGEKSEALDPFHPERIASRILGMGDVLSLIEQAEATLDKEKADKLA
KKLKKGKGFDLEDFRDQLQQMKNMGGLGGLMDKLPNIGGVNLSQMGNAQNAAEKQFKQMEAIINSMTPAERRDPELISGS
RKRRIALGSGTQVQDIGRLIKQHKQMQKMMKKFSAKGGMAKMMRGMGGMLPGGGMPKM
>Mature_458_residues
MFENLTDRLSQTLRHVTGKAKLTEDNIKDTLREVRMALLEADVALPVVKDFVNSVKERAVGTEVSRSLTPGQAFVKIVQA
ELESLMGAANEDLNLSAVPPAVILMAGLQGAGKTTTAGKLARFLKERKKKSVMVVSADIYRPAAIKQLETLANDIGVTFF
PSDLSQKPVDIANAAIKEAKLKFIDVVIVDTAGRLHIDEEMMGEIKALHAAINPVETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRAITGKPIKFIGMGEKSEALDPFHPERIASRILGMGDVLSLIEQAEATLDKEKADKLA
KKLKKGKGFDLEDFRDQLQQMKNMGGLGGLMDKLPNIGGVNLSQMGNAQNAAEKQFKQMEAIINSMTPAERRDPELISGS
RKRRIALGSGTQVQDIGRLIKQHKQMQKMMKKFSAKGGMAKMMRGMGGMLPGGGMPKM

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=465, Percent_Identity=33.1182795698925, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI226371618, Length=367, Percent_Identity=35.4223433242507, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=40.625, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI23308697, Length=302, Percent_Identity=28.1456953642384, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI295424842, Length=302, Percent_Identity=28.1456953642384, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1788963, Length=456, Percent_Identity=71.7105263157895, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=36.6533864541833, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=440, Percent_Identity=30.2272727272727, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=290, Percent_Identity=30, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=445, Percent_Identity=33.2584269662921, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6320498, Length=317, Percent_Identity=29.3375394321767, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17647949, Length=458, Percent_Identity=31.8777292576419, Blast_Score=194, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24641198, Length=202, Percent_Identity=31.6831683168317, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49362; Mature: 49362

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLTDRLSQTLRHVTGKAKLTEDNIKDTLREVRMALLEADVALPVVKDFVNSVKERAV
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTEVSRSLTPGQAFVKIVQAELESLMGAANEDLNLSAVPPAVILMAGLQGAGKTTTAGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHH
ARFLKERKKKSVMVVSADIYRPAAIKQLETLANDIGVTFFPSDLSQKPVDIANAAIKEAK
HHHHHHHHHCCEEEEECCHHCHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHH
LKFIDVVIVDTAGRLHIDEEMMGEIKALHAAINPVETLFVVDAMTGQDAANTAKAFGDAL
HHEEEEEEEECCCCEEECHHHHHHHHHHHHHHCHHHHHHEEECCCCCCHHHHHHHHHCCC
PLTGVILTKVDGDARGGAALSVRAITGKPIKFIGMGEKSEALDPFHPERIASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEQAEATLDKEKADKLAKKLKKGKGFDLEDFRDQLQQMKNMGGLGGLMDKLPNIGGV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCC
NLSQMGNAQNAAEKQFKQMEAIINSMTPAERRDPELISGSRKRRIALGSGTQVQDIGRLI
CHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEECCCCCHHHHHHHH
KQHKQMQKMMKKFSAKGGMAKMMRGMGGMLPGGGMPKM
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MFENLTDRLSQTLRHVTGKAKLTEDNIKDTLREVRMALLEADVALPVVKDFVNSVKERAV
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTEVSRSLTPGQAFVKIVQAELESLMGAANEDLNLSAVPPAVILMAGLQGAGKTTTAGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHH
ARFLKERKKKSVMVVSADIYRPAAIKQLETLANDIGVTFFPSDLSQKPVDIANAAIKEAK
HHHHHHHHHCCEEEEECCHHCHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHH
LKFIDVVIVDTAGRLHIDEEMMGEIKALHAAINPVETLFVVDAMTGQDAANTAKAFGDAL
HHEEEEEEEECCCCEEECHHHHHHHHHHHHHHCHHHHHHEEECCCCCCHHHHHHHHHCCC
PLTGVILTKVDGDARGGAALSVRAITGKPIKFIGMGEKSEALDPFHPERIASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEQAEATLDKEKADKLAKKLKKGKGFDLEDFRDQLQQMKNMGGLGGLMDKLPNIGGV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCC
NLSQMGNAQNAAEKQFKQMEAIINSMTPAERRDPELISGSRKRRIALGSGTQVQDIGRLI
CHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEECCCCCHHHHHHHH
KQHKQMQKMMKKFSAKGGMAKMMRGMGGMLPGGGMPKM
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]