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The map label for this gene is pdhR [H]

Identifier: 77457204

GI number: 77457204

Start: 1137744

End: 1138403

Strand: Direct

Name: pdhR [H]

Synonym: Pfl01_0977

Alternate gene names: 77457204

Gene position: 1137744-1138403 (Clockwise)

Preceding gene: 77457203

Following gene: 77457205

Centisome position: 17.67

GC content: 62.12

Gene sequence:

>660_bases
ATGTCAGAAAACTCACTCTTGATAAAACGATCTCTGGTCGATCAGGCCCTGGACCAATTGCGCCAGCGCATCACCGATGG
CAGCTGGCAGGTCGGTCAGCGTCTGCCGACCGAGCCCGAGCTGTGCGCAGAACTCGGCATCAGCCGCAACACCGTGCGCG
AGGCGATGCGGGTGCTGGCGTTTTCCGGGTTGATCGAGATCCGTCAAGGTGACGGCAGTTACCTGCGGGCGGTGGTCGAT
CCGATGGACACGCTCAAGGCGCTGTCCAAATGCTCGCTGGACCAGGCCCGGGAGACCCGGCACATCCTTGAAGTCGAGGC
CATTGGCCTGGCGGCCTTGCGTCGTACCGATGAAGACCTCGTCGCGTTGCACGAGGCGCTGGGTGTTGCCGGCAGCCACT
ACCACGGCGACCTCGACAGTTACATCCGCTGCGATCTGGTGTTCCACCGCCGTCTGGTGGACGCCGCGCACAACCCCACC
CTCAGCGAGCTGTATCGCTATTTTTCCAGCATCGTCGGCGCGCAATTGCGCCAGACCCTGAACATCGTCCCCCGTCGACA
GGAAGTCTTCGATTTGCACGTCGCCTTGCTTGAGGCTGTCGAGCAGCGCGATCCGGAGCGGGCCAAAGCCCTGTCGAGGC
AGTTGATCAATGAACCTTGA

Upstream 100 bases:

>100_bases
CGGGTTTATTTTTGCCCGGATTTTGTCGGTTGCCCCGGCTGAACAATCTGACTACCCTGTCAGCAAATTCATCCCATGAT
TGGATGACAGGGCGAATTCC

Downstream 100 bases:

>100_bases
AACCGAGAAAACCATGTCCCGCCCAGAAGTTTCCCCAGCACCCGTTCGCAAGGCCGAGCTCGAAGAGTTGTTGATCGACG
CCGAAGCCGATGACGAGCAG

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSENSLLIKRSLVDQALDQLRQRITDGSWQVGQRLPTEPELCAELGISRNTVREAMRVLAFSGLIEIRQGDGSYLRAVVD
PMDTLKALSKCSLDQARETRHILEVEAIGLAALRRTDEDLVALHEALGVAGSHYHGDLDSYIRCDLVFHRRLVDAAHNPT
LSELYRYFSSIVGAQLRQTLNIVPRRQEVFDLHVALLEAVEQRDPERAKALSRQLINEP

Sequences:

>Translated_219_residues
MSENSLLIKRSLVDQALDQLRQRITDGSWQVGQRLPTEPELCAELGISRNTVREAMRVLAFSGLIEIRQGDGSYLRAVVD
PMDTLKALSKCSLDQARETRHILEVEAIGLAALRRTDEDLVALHEALGVAGSHYHGDLDSYIRCDLVFHRRLVDAAHNPT
LSELYRYFSSIVGAQLRQTLNIVPRRQEVFDLHVALLEAVEQRDPERAKALSRQLINEP
>Mature_218_residues
SENSLLIKRSLVDQALDQLRQRITDGSWQVGQRLPTEPELCAELGISRNTVREAMRVLAFSGLIEIRQGDGSYLRAVVDP
MDTLKALSKCSLDQARETRHILEVEAIGLAALRRTDEDLVALHEALGVAGSHYHGDLDSYIRCDLVFHRRLVDAAHNPTL
SELYRYFSSIVGAQLRQTLNIVPRRQEVFDLHVALLEAVEQRDPERAKALSRQLINEP

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=213, Percent_Identity=32.8638497652582, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1790032, Length=217, Percent_Identity=27.1889400921659, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1790780, Length=212, Percent_Identity=29.7169811320755, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI48994955, Length=218, Percent_Identity=27.9816513761468, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789353, Length=218, Percent_Identity=28.8990825688073, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789621, Length=220, Percent_Identity=26.3636363636364, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI48994961, Length=229, Percent_Identity=24.8908296943231, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 24703; Mature: 24571

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENSLLIKRSLVDQALDQLRQRITDGSWQVGQRLPTEPELCAELGISRNTVREAMRVLA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHH
FSGLIEIRQGDGSYLRAVVDPMDTLKALSKCSLDQARETRHILEVEAIGLAALRRTDEDL
HHHHHHEECCCCHHHHHHHCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCHHHH
VALHEALGVAGSHYHGDLDSYIRCDLVFHRRLVDAAHNPTLSELYRYFSSIVGAQLRQTL
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
NIVPRRQEVFDLHVALLEAVEQRDPERAKALSRQLINEP
HHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SENSLLIKRSLVDQALDQLRQRITDGSWQVGQRLPTEPELCAELGISRNTVREAMRVLA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHH
FSGLIEIRQGDGSYLRAVVDPMDTLKALSKCSLDQARETRHILEVEAIGLAALRRTDEDL
HHHHHHEECCCCHHHHHHHCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCHHHH
VALHEALGVAGSHYHGDLDSYIRCDLVFHRRLVDAAHNPTLSELYRYFSSIVGAQLRQTL
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
NIVPRRQEVFDLHVALLEAVEQRDPERAKALSRQLINEP
HHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]