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The map label for this gene is algA [H]

Identifier: 77457176

GI number: 77457176

Start: 1104584

End: 1106035

Strand: Reverse

Name: algA [H]

Synonym: Pfl01_0949

Alternate gene names: 77457176

Gene position: 1106035-1104584 (Counterclockwise)

Preceding gene: 77457177

Following gene: 77457173

Centisome position: 17.18

GC content: 61.16

Gene sequence:

>1452_bases
ATGATTCCGGTGATCTTGTCAGGTGGTAGCGGCTCACGTCTTTGGCCGCTTTCGCGCAAGCAGTTTCCCAAGCAGTTCCT
CGCCCTGACCGGCGAACACACACTGTTCCAGCAAACCCTCGAGCGTCTGGTGTTCGAAGGCATGGACACCCCGATCGTGG
TCTGCAACAAGGATCACCGCTTCATCGTCAACGAGCAGTTGGCCAGCCGCAATCTGGAATGCCAACGCATCCTGATGGAA
CCGTTCGGGCGCAATACCGCGCCGGCCGTGGCGCTGACCGCGATGATGCTGGTCAATGAAGGTCGCGACGAACTGATGCT
GGTGCTGCCGGCCGACCACGTTCTGGAGGACCAGAAAGCCCTGCAACGCGCCCTGGCCCTGGCCACCGTCGCCGCCGAAA
ACGGCGAGATGGTGCTGTTCGGCGTACCGGCCACCAAACCGGAAACCGGTTACGGCTACATCAAGTCCACCGGTGATTCG
CTGCTGCCGGAAGGCGTCAGCCGTGTTTCGCACTTCGTGGAAAAACCCGACGTCAAACGCGCCACCGAGTACGTTGAGTC
CGGCGGTTACTACTGGAACAGCGGCATGTTCCTGTTCCGCGCCAGCCGCTTCCTCGAAGAGCTGAAAAAGCACGATCCGG
ACATCTACGACACCTGCCTGCTGACCCTCGAGCGCAGCCAGCAGGATGCCGACACCGTCACCCTGGACGAAGCCACCTTC
GCCTGCTGCCCGGACAACTCCATCGACTATTCCGTGATGGAAAAAACCCAGCGCGCCTGCGTGGTACCGCTGACCGCCGG
CTGGAGCGATGTCGGTTGCTGGTCGTCGCTGTGGGAGGTCAACGAAAAGGACGCCAACGGCAACGTCAGCAAGGGCGACG
TGGTGATCCAGGACAGCAAGAACTGCATGATCCACGGCAACGGCAAACTGGTGTCGGTGATCGGTCTGGAAAACATCGTC
GTCGTCGAAACCAAGGACGCCATGATGATCGCCCACAAGGACAAGGTTCAGGGCGTGAAGCAGATGGTCAACACCCTCAA
CGCCCAGGGCCGCAGCGAAACCCAGAACCACTGCGAGGTGTACCGTCCGTGGGGCTCGTACGACTCGGTGGACATGGGCG
GCCGCTTCCAGGTCAAGCACATCTCGGTCAAGCCGGGCGCGTGCCTGTCACTGCAGATGCACCACCACCGCGCCGAACAC
TGGATCGTGGTCAGCGGCACCGCCGAAGTGACCTGCGACGAGAACGTGTTTCTGCTCACTGAAAACCAGTCGACCTACAT
CCCGATCGCCTCGGTGCATCGCCTGCGCAACCCGGGCAAGATCCCGCTGGAAATCATCGAAGTGCAGTCGGGCTCGTACC
TGGGTGAAGACGACATCGAGCGCTTCGAAGATATCTACGGGCGCTCGACCCCGATCGAACGCGGCGTGTCGGTGAAAACC
ATCGCGCAGTAA

Upstream 100 bases:

>100_bases
GAAACCGGGCAGCCGTCGCTGCCCGGTACGGAACAACAACAAGAGTGAAACGACACAACGTTCGTGGCTCTGACCCAATC
GATTTTATGGAGTAAACAAT

Downstream 100 bases:

>100_bases
GCGTTCCGTAAAACAAGAAGCCCCCGTCCAGCCCGCTGTGTCCCCTATCCGCAGCGGGTTGGGCGGGGGCTTTTTTTACT
TCAGCCAAACGACTGCTGCC

Product: mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MIPVILSGGSGSRLWPLSRKQFPKQFLALTGEHTLFQQTLERLVFEGMDTPIVVCNKDHRFIVNEQLASRNLECQRILME
PFGRNTAPAVALTAMMLVNEGRDELMLVLPADHVLEDQKALQRALALATVAAENGEMVLFGVPATKPETGYGYIKSTGDS
LLPEGVSRVSHFVEKPDVKRATEYVESGGYYWNSGMFLFRASRFLEELKKHDPDIYDTCLLTLERSQQDADTVTLDEATF
ACCPDNSIDYSVMEKTQRACVVPLTAGWSDVGCWSSLWEVNEKDANGNVSKGDVVIQDSKNCMIHGNGKLVSVIGLENIV
VVETKDAMMIAHKDKVQGVKQMVNTLNAQGRSETQNHCEVYRPWGSYDSVDMGGRFQVKHISVKPGACLSLQMHHHRAEH
WIVVSGTAEVTCDENVFLLTENQSTYIPIASVHRLRNPGKIPLEIIEVQSGSYLGEDDIERFEDIYGRSTPIERGVSVKT
IAQ

Sequences:

>Translated_483_residues
MIPVILSGGSGSRLWPLSRKQFPKQFLALTGEHTLFQQTLERLVFEGMDTPIVVCNKDHRFIVNEQLASRNLECQRILME
PFGRNTAPAVALTAMMLVNEGRDELMLVLPADHVLEDQKALQRALALATVAAENGEMVLFGVPATKPETGYGYIKSTGDS
LLPEGVSRVSHFVEKPDVKRATEYVESGGYYWNSGMFLFRASRFLEELKKHDPDIYDTCLLTLERSQQDADTVTLDEATF
ACCPDNSIDYSVMEKTQRACVVPLTAGWSDVGCWSSLWEVNEKDANGNVSKGDVVIQDSKNCMIHGNGKLVSVIGLENIV
VVETKDAMMIAHKDKVQGVKQMVNTLNAQGRSETQNHCEVYRPWGSYDSVDMGGRFQVKHISVKPGACLSLQMHHHRAEH
WIVVSGTAEVTCDENVFLLTENQSTYIPIASVHRLRNPGKIPLEIIEVQSGSYLGEDDIERFEDIYGRSTPIERGVSVKT
IAQ
>Mature_483_residues
MIPVILSGGSGSRLWPLSRKQFPKQFLALTGEHTLFQQTLERLVFEGMDTPIVVCNKDHRFIVNEQLASRNLECQRILME
PFGRNTAPAVALTAMMLVNEGRDELMLVLPADHVLEDQKALQRALALATVAAENGEMVLFGVPATKPETGYGYIKSTGDS
LLPEGVSRVSHFVEKPDVKRATEYVESGGYYWNSGMFLFRASRFLEELKKHDPDIYDTCLLTLERSQQDADTVTLDEATF
ACCPDNSIDYSVMEKTQRACVVPLTAGWSDVGCWSSLWEVNEKDANGNVSKGDVVIQDSKNCMIHGNGKLVSVIGLENIV
VVETKDAMMIAHKDKVQGVKQMVNTLNAQGRSETQNHCEVYRPWGSYDSVDMGGRFQVKHISVKPGACLSLQMHHHRAEH
WIVVSGTAEVTCDENVFLLTENQSTYIPIASVHRLRNPGKIPLEIIEVQSGSYLGEDDIERFEDIYGRSTPIERGVSVKT
IAQ

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=474, Percent_Identity=53.1645569620253, Blast_Score=505, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 53768; Mature: 53768

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPVILSGGSGSRLWPLSRKQFPKQFLALTGEHTLFQQTLERLVFEGMDTPIVVCNKDHR
CCEEEEECCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCE
FIVNEQLASRNLECQRILMEPFGRNTAPAVALTAMMLVNEGRDELMLVLPADHVLEDQKA
EEEEHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHH
LQRALALATVAAENGEMVLFGVPATKPETGYGYIKSTGDSLLPEGVSRVSHFVEKPDVKR
HHHHHHHHHEEECCCCEEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCHHH
ATEYVESGGYYWNSGMFLFRASRFLEELKKHDPDIYDTCLLTLERSQQDADTVTLDEATF
HHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCEE
ACCPDNSIDYSVMEKTQRACVVPLTAGWSDVGCWSSLWEVNEKDANGNVSKGDVVIQDSK
EECCCCCCCHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEECCC
NCMIHGNGKLVSVIGLENIVVVETKDAMMIAHKDKVQGVKQMVNTLNAQGRSETQNHCEV
CEEEECCCCEEEEEECCCEEEEEECCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEE
YRPWGSYDSVDMGGRFQVKHISVKPGACLSLQMHHHRAEHWIVVSGTAEVTCDENVFLLT
ECCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCEEEEEECCEEEEECCCEEEEE
ENQSTYIPIASVHRLRNPGKIPLEIIEVQSGSYLGEDDIERFEDIYGRSTPIERGVSVKT
CCCCCEEEHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHCCCCEEE
IAQ
ECC
>Mature Secondary Structure
MIPVILSGGSGSRLWPLSRKQFPKQFLALTGEHTLFQQTLERLVFEGMDTPIVVCNKDHR
CCEEEEECCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCE
FIVNEQLASRNLECQRILMEPFGRNTAPAVALTAMMLVNEGRDELMLVLPADHVLEDQKA
EEEEHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHH
LQRALALATVAAENGEMVLFGVPATKPETGYGYIKSTGDSLLPEGVSRVSHFVEKPDVKR
HHHHHHHHHEEECCCCEEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCHHH
ATEYVESGGYYWNSGMFLFRASRFLEELKKHDPDIYDTCLLTLERSQQDADTVTLDEATF
HHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCEE
ACCPDNSIDYSVMEKTQRACVVPLTAGWSDVGCWSSLWEVNEKDANGNVSKGDVVIQDSK
EECCCCCCCHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEECCC
NCMIHGNGKLVSVIGLENIVVVETKDAMMIAHKDKVQGVKQMVNTLNAQGRSETQNHCEV
CEEEECCCCEEEEEECCCEEEEEECCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEE
YRPWGSYDSVDMGGRFQVKHISVKPGACLSLQMHHHRAEHWIVVSGTAEVTCDENVFLLT
ECCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCEEEEEECCEEEEECCCEEEEE
ENQSTYIPIASVHRLRNPGKIPLEIIEVQSGSYLGEDDIERFEDIYGRSTPIERGVSVKT
CCCCCEEEHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHCCCCEEE
IAQ
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12775688 [H]