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The map label for this gene is accC [H]

Identifier: 77456846

GI number: 77456846

Start: 726625

End: 727983

Strand: Reverse

Name: accC [H]

Synonym: Pfl01_0618

Alternate gene names: 77456846

Gene position: 727983-726625 (Counterclockwise)

Preceding gene: 77456847

Following gene: 77456845

Centisome position: 11.31

GC content: 60.85

Gene sequence:

>1359_bases
ATGACTGCGAAGTTGGAAAAAGTTCTGATCGCTAACCGCGGTGAGATCGCCCTGCGGATTCTGCGTGCCTGCAAAGAGAT
GGGCATCAAGACCGTCGCCGTTTACTCCAAGGCCGACAAAGAGCTGATGCACCTGGGTCTGGCAGACGAATCCGTCTGCA
TCGGCCCGGCTTCTGCCGCGCACTCCTACCTGCACATCCCGGCAATCATTGCGGCCGCTGAAGTGACTGGCGCTACCGCC
ATTCACCCAGGCTACGGTTTCCTCGCGGAAAACGCCGACTTTGCCGAGCAGGTCGAGAACTCCGGCTTCGCCTTCATCGG
CCCGAAAGCCGAAACCATTCGCCTGATGGGCGACAAGGTATCGGCCAAGCACGCGATGATCGAAGCGGGCGTGCCAACCG
TTCCAGGTTCCGACGGCCCGCTGCCGGAAGACGAGGAAACGGCGCTGCGCATCGGTCGTGAAGTCGGCTATCCGGTGATC
ATCAAGGCCGCCGGCGGCGGTGGTGGTCGCGGCATGCGTGTGGTGCACAAGGAAGAAGACCTGATCGCCTCGGCAAAGCT
GACCCGCTCCGAAGCTGGCGCGGCGTTCGGCAACCCGATGGTCTATCTGGAAAAATTCCTGACCAATCCGCGTCACGTCG
AAGTGCAGGTTCTGTCCGACGGCCAGGGCAACGCCATCCATCTGGGCGACCGCGATTGCTCGCTGCAACGCCGTCACCAG
AAAGTTCTCGAAGAAGCACCGGCACCGGGCATCGATGAGAACGCGCGCAAGGAAGTCCTGGCCCGCTGCGTCAAGGCGTG
CATCGACATCGGCTACCGTGGCGCCGGCACCTTCGAGTTCCTGTACGAGAACGGTCGTTTCTACTTCATCGAAATGAACA
CCCGTGTTCAGGTGGAGCACCCGGTTTCGGAAATGGTCACCGGTATCGACATCGTCAAGGAGATGCTCAGCATCGCCGCT
GGCAACAAGCTGTCGTATACCCAGGATGATGTGGTGATCCGCGGTCACTCGCTGGAATGCCGGATCAACGCCGAAGACCC
GAAAACCTTCATGCCGAGCCCGGGCACGGTCAAGCATTTCCACGCACCAGGCGGCAACGGCGTTCGCGTCGATTCGCACC
TGTACAGCGGTTATGCCGTTCCGCCGAACTACGACTCGCTGATCGGCAAGCTGATCACTTACGGCGCGACCCGCGACGAA
GCCATGGCCCGCATGCGCAATGCCCTGGACGAAATCGTGGTCGACGGGATCAAGACCAACATCCCGCTGCACCGTGATCT
GACCCGCGACGAAGGCTTCTGCAAAGGGGGCGTGAACATTCACTACCTCGAGCACAAGCTGGCTGGCGAGAAGCACTAA

Upstream 100 bases:

>100_bases
AAACCAGCGGTGTGATCGAGTCCATCCTCGTCGAAGACGGCCAGCCGGTTGAGTACGACCAACCGCTGTTCACCATCGTT
TGAACTGCGGAGAGCCTTTG

Downstream 100 bases:

>100_bases
GCTTCAGCCCGCACCTGACAAGGCCGCCTTCGGGCGGCTTTGTTGTTTCCGAAGGTTTCATCTGCTCACACATTCCCCGC
TCCCACAAAACCGTCGCGCT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTAKLEKVLIANRGEIALRILRACKEMGIKTVAVYSKADKELMHLGLADESVCIGPASAAHSYLHIPAIIAAAEVTGATA
IHPGYGFLAENADFAEQVENSGFAFIGPKAETIRLMGDKVSAKHAMIEAGVPTVPGSDGPLPEDEETALRIGREVGYPVI
IKAAGGGGGRGMRVVHKEEDLIASAKLTRSEAGAAFGNPMVYLEKFLTNPRHVEVQVLSDGQGNAIHLGDRDCSLQRRHQ
KVLEEAPAPGIDENARKEVLARCVKACIDIGYRGAGTFEFLYENGRFYFIEMNTRVQVEHPVSEMVTGIDIVKEMLSIAA
GNKLSYTQDDVVIRGHSLECRINAEDPKTFMPSPGTVKHFHAPGGNGVRVDSHLYSGYAVPPNYDSLIGKLITYGATRDE
AMARMRNALDEIVVDGIKTNIPLHRDLTRDEGFCKGGVNIHYLEHKLAGEKH

Sequences:

>Translated_452_residues
MTAKLEKVLIANRGEIALRILRACKEMGIKTVAVYSKADKELMHLGLADESVCIGPASAAHSYLHIPAIIAAAEVTGATA
IHPGYGFLAENADFAEQVENSGFAFIGPKAETIRLMGDKVSAKHAMIEAGVPTVPGSDGPLPEDEETALRIGREVGYPVI
IKAAGGGGGRGMRVVHKEEDLIASAKLTRSEAGAAFGNPMVYLEKFLTNPRHVEVQVLSDGQGNAIHLGDRDCSLQRRHQ
KVLEEAPAPGIDENARKEVLARCVKACIDIGYRGAGTFEFLYENGRFYFIEMNTRVQVEHPVSEMVTGIDIVKEMLSIAA
GNKLSYTQDDVVIRGHSLECRINAEDPKTFMPSPGTVKHFHAPGGNGVRVDSHLYSGYAVPPNYDSLIGKLITYGATRDE
AMARMRNALDEIVVDGIKTNIPLHRDLTRDEGFCKGGVNIHYLEHKLAGEKH
>Mature_451_residues
TAKLEKVLIANRGEIALRILRACKEMGIKTVAVYSKADKELMHLGLADESVCIGPASAAHSYLHIPAIIAAAEVTGATAI
HPGYGFLAENADFAEQVENSGFAFIGPKAETIRLMGDKVSAKHAMIEAGVPTVPGSDGPLPEDEETALRIGREVGYPVII
KAAGGGGGRGMRVVHKEEDLIASAKLTRSEAGAAFGNPMVYLEKFLTNPRHVEVQVLSDGQGNAIHLGDRDCSLQRRHQK
VLEEAPAPGIDENARKEVLARCVKACIDIGYRGAGTFEFLYENGRFYFIEMNTRVQVEHPVSEMVTGIDIVKEMLSIAAG
NKLSYTQDDVVIRGHSLECRINAEDPKTFMPSPGTVKHFHAPGGNGVRVDSHLYSGYAVPPNYDSLIGKLITYGATRDEA
MARMRNALDEIVVDGIKTNIPLHRDLTRDEGFCKGGVNIHYLEHKLAGEKH

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=47.1783295711061, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=47.1783295711061, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=47.1783295711061, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=45.0226244343891, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=45.413870246085, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=45.413870246085, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=45.413870246085, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=31.8982387475538, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=31.8982387475538, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=31.8982387475538, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=31.8982387475538, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=31.8982387475538, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI134142062, Length=515, Percent_Identity=30.2912621359223, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=69.7516930022573, Blast_Score=632, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=192, Percent_Identity=25, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=444, Percent_Identity=46.3963963963964, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71987519, Length=444, Percent_Identity=44.8198198198198, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=43.7777777777778, Blast_Score=359, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=29.0766208251473, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=29.0766208251473, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI133931226, Length=496, Percent_Identity=27.6209677419355, Blast_Score=189, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=46.0850111856823, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319685, Length=442, Percent_Identity=43.6651583710407, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=46.0850111856823, Blast_Score=352, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6324343, Length=526, Percent_Identity=30.4182509505703, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323863, Length=461, Percent_Identity=31.4533622559653, Blast_Score=209, Evalue=5e-55,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=47.6510067114094, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=47.6510067114094, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=47.6510067114094, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=47.6510067114094, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=47.6510067114094, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=47.6510067114094, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=47.6510067114094, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=47.6510067114094, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=47.6510067114094, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=47.6510067114094, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=42.7293064876958, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=42.2982885085575, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24586458, Length=511, Percent_Identity=28.9628180039139, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI161076409, Length=511, Percent_Identity=28.9628180039139, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI161076407, Length=511, Percent_Identity=28.9628180039139, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24586460, Length=511, Percent_Identity=28.9628180039139, Blast_Score=204, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48973; Mature: 48841

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKLEKVLIANRGEIALRILRACKEMGIKTVAVYSKADKELMHLGLADESVCIGPASAA
CCCCCCCCEECCCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCCCCCEEECCHHHH
HSYLHIPAIIAAAEVTGATAIHPGYGFLAENADFAEQVENSGFAFIGPKAETIRLMGDKV
CCEEEHHHHHHHHHHCCCEEECCCCCEEECCCHHHHHHHCCCEEEECCCCEEEEEECCCH
SAKHAMIEAGVPTVPGSDGPLPEDEETALRIGREVGYPVIIKAAGGGGGRGMRVVHKEED
HHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCH
LIASAKLTRSEAGAAFGNPMVYLEKFLTNPRHVEVQVLSDGQGNAIHLGDRDCSLQRRHQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHH
KVLEEAPAPGIDENARKEVLARCVKACIDIGYRGAGTFEFLYENGRFYFIEMNTRVQVEH
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECC
PVSEMVTGIDIVKEMLSIAAGNKLSYTQDDVVIRGHSLECRINAEDPKTFMPSPGTVKHF
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCEEEE
HAPGGNGVRVDSHLYSGYAVPPNYDSLIGKLITYGATRDEAMARMRNALDEIVVDGIKTN
ECCCCCCEEECCCEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHCC
IPLHRDLTRDEGFCKGGVNIHYLEHKLAGEKH
CCCCCCCCCCCCCEECCCEEEEEEHHHCCCCC
>Mature Secondary Structure 
TAKLEKVLIANRGEIALRILRACKEMGIKTVAVYSKADKELMHLGLADESVCIGPASAA
CCCCCCCEECCCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCCCCCEEECCHHHH
HSYLHIPAIIAAAEVTGATAIHPGYGFLAENADFAEQVENSGFAFIGPKAETIRLMGDKV
CCEEEHHHHHHHHHHCCCEEECCCCCEEECCCHHHHHHHCCCEEEECCCCEEEEEECCCH
SAKHAMIEAGVPTVPGSDGPLPEDEETALRIGREVGYPVIIKAAGGGGGRGMRVVHKEED
HHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCH
LIASAKLTRSEAGAAFGNPMVYLEKFLTNPRHVEVQVLSDGQGNAIHLGDRDCSLQRRHQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHH
KVLEEAPAPGIDENARKEVLARCVKACIDIGYRGAGTFEFLYENGRFYFIEMNTRVQVEH
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECC
PVSEMVTGIDIVKEMLSIAAGNKLSYTQDDVVIRGHSLECRINAEDPKTFMPSPGTVKHF
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCEEEE
HAPGGNGVRVDSHLYSGYAVPPNYDSLIGKLITYGATRDEAMARMRNALDEIVVDGIKTN
ECCCCCCEEECCCEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHCC
IPLHRDLTRDEGFCKGGVNIHYLEHKLAGEKH
CCCCCCCCCCCCCEECCCEEEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]