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The map label for this gene is tipA [H]

Identifier: 77454664

GI number: 77454664

Start: 94036

End: 94461

Strand: Direct

Name: tipA [H]

Synonym: pREL1_0097

Alternate gene names: 77454664

Gene position: 94036-94461 (Clockwise)

Preceding gene: 77454662

Following gene: 77454666

Centisome position: 34.63

GC content: 61.27

Gene sequence:

>426_bases
ATGGGTGACGACGACGGCATGCATATGCAGATTGGGCAGGTCGCGCACCGCACCGAGTTGTCCATCCGCACCGTGCGGCA
TTACGACGACGTCGGATTGGTCGTTCCCTCGGAGAGAAGCGTCGGCGGTTTCCGTCTCTACACCGAAGCCGATGTCGAAC
GCCTACTGGTTATTCGGCGTATGAAGCCACTCGGATTCACCCTCGCCGAAATGAAAGGCCTACTCGATGCGCTCGACGTC
GTCAACGACGACTCGGCTACCGAGAAAGAGCGCTCCGAGGCGGAGGACTTCATCAACGAATGCCACGGCAAGGCCTCGGA
GAGCTGCACCACGCTTCGGCGGCAATTGGCGTACGCCGAGGAACTGACCGAACTGCTCGCAGCGCGAAGCGCGACCTCGG
GTTCATCGTCGCCGGCATCTCTCTGA

Upstream 100 bases:

>100_bases
GTCTGGTCCGATGCGGGTGCTCGCTAGAGTGGTCACCGAGCGCGGGCGCAAACATCTGCCCGTCATTCAAGGCCGGGTAG
ATGGATGTGGAGGTGCACCG

Downstream 100 bases:

>100_bases
TCCGGGAGCGCGCCGGCGGAGTAGGCCCCGCACCAGGGCGGGTCGAGGCTCTCCGTCCAGATATTCGGATGGCCTCCGGT
CTGTGAACTATTATTGCGCA

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MGDDDGMHMQIGQVAHRTELSIRTVRHYDDVGLVVPSERSVGGFRLYTEADVERLLVIRRMKPLGFTLAEMKGLLDALDV
VNDDSATEKERSEAEDFINECHGKASESCTTLRRQLAYAEELTELLAARSATSGSSSPASL

Sequences:

>Translated_141_residues
MGDDDGMHMQIGQVAHRTELSIRTVRHYDDVGLVVPSERSVGGFRLYTEADVERLLVIRRMKPLGFTLAEMKGLLDALDV
VNDDSATEKERSEAEDFINECHGKASESCTTLRRQLAYAEELTELLAARSATSGSSSPASL
>Mature_140_residues
GDDDGMHMQIGQVAHRTELSIRTVRHYDDVGLVVPSERSVGGFRLYTEADVERLLVIRRMKPLGFTLAEMKGLLDALDVV
NDDSATEKERSEAEDFINECHGKASESCTTLRRQLAYAEELTELLAARSATSGSSSPASL

Specific function: Transcriptional activator. Is activated when bound to the antibiotic thiostrepton [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 15516; Mature: 15384

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDDDGMHMQIGQVAHRTELSIRTVRHYDDVGLVVPSERSVGGFRLYTEADVERLLVIRR
CCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEECHHHHHHHHHHHH
MKPLGFTLAEMKGLLDALDVVNDDSATEKERSEAEDFINECHGKASESCTTLRRQLAYAE
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ELTELLAARSATSGSSSPASL
HHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
GDDDGMHMQIGQVAHRTELSIRTVRHYDDVGLVVPSERSVGGFRLYTEADVERLLVIRR
CCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEECHHHHHHHHHHHH
MKPLGFTLAEMKGLLDALDVVNDDSATEKERSEAEDFINECHGKASESCTTLRRQLAYAE
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ELTELLAARSATSGSSSPASL
HHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]