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The map label for this gene is degP [H]

Identifier: 73539383

GI number: 73539383

Start: 2377600

End: 2379066

Strand: Direct

Name: degP [H]

Synonym: Reut_B5561

Alternate gene names: 73539383

Gene position: 2377600-2379066 (Clockwise)

Preceding gene: 73539380

Following gene: 73539384

Centisome position: 87.21

GC content: 65.37

Gene sequence:

>1467_bases
ATGATTCGCCAGACCATTGCACGTACCGCCATTGGCATTGCTGCACTCGCCGCCATTGGTGGAGGCTATGCCTACCTGCA
GAAGGAAGTCATAACGCCGGGGTACGCCGCATCCGCGCCGGCGGTCTCGGCCGCACCCGCGCAAGCCGCTGCGGTGGCGA
CGCCGATGGATTTCTCCGGCATCGTCGACCAGTATGGCCCAGCCGTGGTCAATATCAGCGTGACCGCGCGTGCGCAGCGC
ACCGCTATGCAGGCACCGTCCGGCATGGACCCCGACGATCCGCTGTTCCAGTTCTTCAAGCGTTTTGGGCCCCAGTTCCA
GGGGCCGCAGAGCGGTCAGCAACTGGTCAAGGGCCTGGGTTCCGGCTTTATCGTGAGCCCGGATGGTCTGATCCTGACCA
ACGCGCACGTCGTGGATGGCGCGCAGGAGGTCACTGTGAAGCTGACCGACCGGCGCGAGTTCAAGGCCAAGGTGCTGGGC
ACGGACCCGCAGACCGACGTGGCCGTGATCCGCATCGATGCCAAAGACCTGCCCACGGTCCGGCTCGGCGACCCGGCACG
CGTGAAGGTTGGTGAGCCCGTACTGGCCATCGGCTCGCCTTACGGATTCGAGAACACGGTGACCGCCGGTATCGTCAGCG
CCAAGTCGCGCTCACTGCCTGACGACACCTATGTGCCGTTCATCCAGACCGACGTGGCCGTGAACCCTGGCAATTCCGGA
GGCCCCTTGTTCAACCAGCGCGGCGAGGTGATCGGCATCAATTCGCAGATCTACAGCCAGACCGGCGGCTACCAGGGGTT
GTCGTTCGCAATTCCGATCAACGTCGCGACCAAGGTCGAACAGCAGCTCGTGGCGCACGGCAAGGTCACGCGCGGCCGTC
TAGGCATCTCGGTGCAGGAAGTCAACCAAGCGCTCGCGCAGTCGTTCGGCCTGCCCAAGCCGTCGGGTGCGCTCGTGAAT
TCGGTCGAGGCTGACAGCCCCGCTGCCAAGGCGGGCGTAAAGCCTGGCGATGTCATCGTGCAACTCGACGACGACGTGAT
CGACCACTCCGGAGACTTGCCTGAGCACGTTGCCGATATCAAGCCGGGCACGCAGACCACGCTGAAGATCATCCGCAAGG
GCCAGCCGATGACGCTCGCGGTGAAGGTGGGCGCCGCCAAGGAGGAATCGGTCGCGCAGAAGGGTAACGACAGTCAGGCC
GGCGGACGGCTGGGCCTGGCCGTCCGCTCGCTGACGCCTTCGGAACGGCGCGAAAGCGGGATCGATGGCGGACTCGTGGT
GGAGGATGTCGCCGGCCCGGCTGCGCGCGTGGGCATCCAGCCGGGCGACGTGATCCTGTCGCTCAACGGCACGCCGATTA
CGTCGGCCGACCAACTGCGCGCTCTGGTTGCCAAATCCGGCAAGCAGGTGGCACTCCTGGTGCAGCGCGATGAGGCGCGC
ATCTTCATTCCGCTCGACCTCGGCTGA

Upstream 100 bases:

>100_bases
ATCTTTAAGGCTGTCTTAAGTCTCGCTGTTTAGCATCTACCGTGTCGCGCCACGCCGCTATCGGCAACGGCGCAGGAACA
GATCGGGGAAAGGAGATTCC

Downstream 100 bases:

>100_bases
TCGCTGCAAGCGTTTACCGATAAGGCTTTGGGGGCGTTCGCGGGTCGTATGCAGGGGGGTAAACGGCGGCGTATACGAAG
CGTATACGGGCCGTATACGA

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MIRQTIARTAIGIAALAAIGGGYAYLQKEVITPGYAASAPAVSAAPAQAAAVATPMDFSGIVDQYGPAVVNISVTARAQR
TAMQAPSGMDPDDPLFQFFKRFGPQFQGPQSGQQLVKGLGSGFIVSPDGLILTNAHVVDGAQEVTVKLTDRREFKAKVLG
TDPQTDVAVIRIDAKDLPTVRLGDPARVKVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSG
GPLFNQRGEVIGINSQIYSQTGGYQGLSFAIPINVATKVEQQLVAHGKVTRGRLGISVQEVNQALAQSFGLPKPSGALVN
SVEADSPAAKAGVKPGDVIVQLDDDVIDHSGDLPEHVADIKPGTQTTLKIIRKGQPMTLAVKVGAAKEESVAQKGNDSQA
GGRLGLAVRSLTPSERRESGIDGGLVVEDVAGPAARVGIQPGDVILSLNGTPITSADQLRALVAKSGKQVALLVQRDEAR
IFIPLDLG

Sequences:

>Translated_488_residues
MIRQTIARTAIGIAALAAIGGGYAYLQKEVITPGYAASAPAVSAAPAQAAAVATPMDFSGIVDQYGPAVVNISVTARAQR
TAMQAPSGMDPDDPLFQFFKRFGPQFQGPQSGQQLVKGLGSGFIVSPDGLILTNAHVVDGAQEVTVKLTDRREFKAKVLG
TDPQTDVAVIRIDAKDLPTVRLGDPARVKVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSG
GPLFNQRGEVIGINSQIYSQTGGYQGLSFAIPINVATKVEQQLVAHGKVTRGRLGISVQEVNQALAQSFGLPKPSGALVN
SVEADSPAAKAGVKPGDVIVQLDDDVIDHSGDLPEHVADIKPGTQTTLKIIRKGQPMTLAVKVGAAKEESVAQKGNDSQA
GGRLGLAVRSLTPSERRESGIDGGLVVEDVAGPAARVGIQPGDVILSLNGTPITSADQLRALVAKSGKQVALLVQRDEAR
IFIPLDLG
>Mature_488_residues
MIRQTIARTAIGIAALAAIGGGYAYLQKEVITPGYAASAPAVSAAPAQAAAVATPMDFSGIVDQYGPAVVNISVTARAQR
TAMQAPSGMDPDDPLFQFFKRFGPQFQGPQSGQQLVKGLGSGFIVSPDGLILTNAHVVDGAQEVTVKLTDRREFKAKVLG
TDPQTDVAVIRIDAKDLPTVRLGDPARVKVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSG
GPLFNQRGEVIGINSQIYSQTGGYQGLSFAIPINVATKVEQQLVAHGKVTRGRLGISVQEVNQALAQSFGLPKPSGALVN
SVEADSPAAKAGVKPGDVIVQLDDDVIDHSGDLPEHVADIKPGTQTTLKIIRKGQPMTLAVKVGAAKEESVAQKGNDSQA
GGRLGLAVRSLTPSERRESGIDGGLVVEDVAGPAARVGIQPGDVILSLNGTPITSADQLRALVAKSGKQVALLVQRDEAR
IFIPLDLG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI7019477, Length=290, Percent_Identity=37.2413793103448, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4506141, Length=299, Percent_Identity=34.7826086956522, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI22129776, Length=276, Percent_Identity=36.231884057971, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=36.8, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1786356, Length=372, Percent_Identity=38.1720430107527, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI1789629, Length=454, Percent_Identity=34.1409691629956, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1789630, Length=280, Percent_Identity=37.8571428571429, Blast_Score=178, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24646839, Length=272, Percent_Identity=36.0294117647059, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50632; Mature: 50632

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRQTIARTAIGIAALAAIGGGYAYLQKEVITPGYAASAPAVSAAPAQAAAVATPMDFSG
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHEEECCCCHHH
IVDQYGPAVVNISVTARAQRTAMQAPSGMDPDDPLFQFFKRFGPQFQGPQSGQQLVKGLG
HHHHCCCEEEEEEEECHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCC
SGFIVSPDGLILTNAHVVDGAQEVTVKLTDRREFKAKVLGTDPQTDVAVIRIDAKDLPTV
CCEEECCCCEEEECCEEECCCEEEEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCEE
RLGDPARVKVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSG
ECCCCCEEEECCCEEEECCCCCCCCCHHHHEEECCCCCCCCCCCCCEEEEEEEECCCCCC
GPLFNQRGEVIGINSQIYSQTGGYQGLSFAIPINVATKVEQQLVAHGKVTRGRLGISVQE
CCCCCCCCCEEEECHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCHHH
VNQALAQSFGLPKPSGALVNSVEADSPAAKAGVKPGDVIVQLDDDVIDHSGDLPEHVADI
HHHHHHHHCCCCCCCCHHEECCCCCCCHHHCCCCCCCEEEEECCCHHCCCCCCHHHHHHC
KPGTQTTLKIIRKGQPMTLAVKVGAAKEESVAQKGNDSQAGGRLGLAVRSLTPSERRESG
CCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHCC
IDGGLVVEDVAGPAARVGIQPGDVILSLNGTPITSADQLRALVAKSGKQVALLVQRDEAR
CCCCEEEECCCCCHHEECCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCE
IFIPLDLG
EEEEECCC
>Mature Secondary Structure
MIRQTIARTAIGIAALAAIGGGYAYLQKEVITPGYAASAPAVSAAPAQAAAVATPMDFSG
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHEEECCCCHHH
IVDQYGPAVVNISVTARAQRTAMQAPSGMDPDDPLFQFFKRFGPQFQGPQSGQQLVKGLG
HHHHCCCEEEEEEEECHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCC
SGFIVSPDGLILTNAHVVDGAQEVTVKLTDRREFKAKVLGTDPQTDVAVIRIDAKDLPTV
CCEEECCCCEEEECCEEECCCEEEEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCEE
RLGDPARVKVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSG
ECCCCCEEEECCCEEEECCCCCCCCCHHHHEEECCCCCCCCCCCCCEEEEEEEECCCCCC
GPLFNQRGEVIGINSQIYSQTGGYQGLSFAIPINVATKVEQQLVAHGKVTRGRLGISVQE
CCCCCCCCCEEEECHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCHHH
VNQALAQSFGLPKPSGALVNSVEADSPAAKAGVKPGDVIVQLDDDVIDHSGDLPEHVADI
HHHHHHHHCCCCCCCCHHEECCCCCCCHHHCCCCCCCEEEEECCCHHCCCCCCHHHHHHC
KPGTQTTLKIIRKGQPMTLAVKVGAAKEESVAQKGNDSQAGGRLGLAVRSLTPSERRESG
CCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHCC
IDGGLVVEDVAGPAARVGIQPGDVILSLNGTPITSADQLRALVAKSGKQVALLVQRDEAR
CCCCEEEECCCCCHHEECCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCE
IFIPLDLG
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]