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The map label for this gene is acoC [H]

Identifier: 73539374

GI number: 73539374

Start: 2358699

End: 2359811

Strand: Direct

Name: acoC [H]

Synonym: Reut_B5552

Alternate gene names: 73539374

Gene position: 2358699-2359811 (Clockwise)

Preceding gene: 73539373

Following gene: 73539375

Centisome position: 86.52

GC content: 66.4

Gene sequence:

>1113_bases
ATGGCCGCAGCAATTACCCCGATCGTGATGCCCAAGTGGGGCCTGTCGATGAAGGAAGGCACTATCAACGAGTGGCTCGT
CGACGAGGGCGCCCAAATATCGGTGGGCATGCCGATCCTTGATGTGGAAACCGACAAGATCGCCAACGCCGTCGAGGCGC
CCGATGCCGGCACCTTGCGCCGCAAGGTAGCCAGCGTGGGGGACGTGCTGCCGGTCAAGGCCCTGCTCGGTGTGCTGGCG
CCTGCGGAGGTGAGCGATGCGGAAATCGATGCCTATATTGCGGCTTACGAAACGCCGGCGGACGACGGCGACGAAGAGGA
AGCCGGACCCGCGTACCAATACGCCGACGTCGACGGCATCCGCGTCCGCTACGCCCGGAGGGGCGACGCGGGGCCGGCGG
TGCTCTTCGTCCACGGATTTGGCGGTGACCTGGATAACTGGCTGTTCAACCTTGACGCCCTTGCCGATGCGTACACGGTG
GTCGCGCTGGACCTCCCCGCTCACGGACAGACGTCGCCGCGGCTCGCGGGTACGACGCTGGCGGAGATGGCCGGCTTTGT
AGCACGCTTCCTGGATGTGACGGGCATCGACGCGGCGCATGTGGTCGGGCATTCGATGGGCGGGGGCATTGCCGCGCAGC
TTGCCGTCGATGCGCCGCAGCGCGTGCTCTCGGTGGCGCTGGTCTCGCCGGTCGGCATGGGCGAGGAGATCAACAGCGGC
TATACCGAAGGCTTCGTCAACGCGCAGTCGCGCCGGGACCTGAAGCCCGTGATCGAGCTGCTGTTCGCCAACCCGGACCT
CGTCAGCCGGCAGATGCTCGATGACCTGCTGCGCTACAAGCGGCTCGACGGCGTGCAGGAAGCATTGTCGGCGATCGGCT
ACAGCTTGTTCGCGCGAGGCAGGCAGCGCGAGCAGCCGGCGCAGCGGCTGGCTGATACGGGCAAGCGCACGCTCGTGGTG
TGGGGCGCAAAGGACCAGATCATCCCGAGTACCCACGCGCAGAACGCGCCGGCAGGCGCCACGGTGAAGGTGTTCGACGA
CGCCGGACACATGAGCCAGATGGAAAAGGCCGGCGACTTCAATGCGCTGTTGCGCACACACCTGGCCGGTTGA

Upstream 100 bases:

>100_bases
CGCCGGTTCCGTTTTCGCCGACGCTCGAAGACCTGTATATCCCCAGCGCCGCGCACGTCGTGGAAGCGGTGCGCAAGACC
ATGAAGGGAGGCAAGCACTG

Downstream 100 bases:

>100_bases
TGCCGGATCGCGGACGGCGGCCACGCCGTCCGCGCCGGCCTGCTATCGTGTGGCAGGTCACCGCCAGGACGAATTCCATG
CCATTCGTATTTGTCGAACC

Product: branched-chain alpha-keto acid dehydrogenase subunit E2

Products: NA

Alternate protein names: Acetoin dehydrogenase E2 component; Dihydrolipoamide acetyltransferase component of acetoin cleaving system; Fast-migrating protein; FMP [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MAAAITPIVMPKWGLSMKEGTINEWLVDEGAQISVGMPILDVETDKIANAVEAPDAGTLRRKVASVGDVLPVKALLGVLA
PAEVSDAEIDAYIAAYETPADDGDEEEAGPAYQYADVDGIRVRYARRGDAGPAVLFVHGFGGDLDNWLFNLDALADAYTV
VALDLPAHGQTSPRLAGTTLAEMAGFVARFLDVTGIDAAHVVGHSMGGGIAAQLAVDAPQRVLSVALVSPVGMGEEINSG
YTEGFVNAQSRRDLKPVIELLFANPDLVSRQMLDDLLRYKRLDGVQEALSAIGYSLFARGRQREQPAQRLADTGKRTLVV
WGAKDQIIPSTHAQNAPAGATVKVFDDAGHMSQMEKAGDFNALLRTHLAG

Sequences:

>Translated_370_residues
MAAAITPIVMPKWGLSMKEGTINEWLVDEGAQISVGMPILDVETDKIANAVEAPDAGTLRRKVASVGDVLPVKALLGVLA
PAEVSDAEIDAYIAAYETPADDGDEEEAGPAYQYADVDGIRVRYARRGDAGPAVLFVHGFGGDLDNWLFNLDALADAYTV
VALDLPAHGQTSPRLAGTTLAEMAGFVARFLDVTGIDAAHVVGHSMGGGIAAQLAVDAPQRVLSVALVSPVGMGEEINSG
YTEGFVNAQSRRDLKPVIELLFANPDLVSRQMLDDLLRYKRLDGVQEALSAIGYSLFARGRQREQPAQRLADTGKRTLVV
WGAKDQIIPSTHAQNAPAGATVKVFDDAGHMSQMEKAGDFNALLRTHLAG
>Mature_369_residues
AAAITPIVMPKWGLSMKEGTINEWLVDEGAQISVGMPILDVETDKIANAVEAPDAGTLRRKVASVGDVLPVKALLGVLAP
AEVSDAEIDAYIAAYETPADDGDEEEAGPAYQYADVDGIRVRYARRGDAGPAVLFVHGFGGDLDNWLFNLDALADAYTVV
ALDLPAHGQTSPRLAGTTLAEMAGFVARFLDVTGIDAAHVVGHSMGGGIAAQLAVDAPQRVLSVALVSPVGMGEEINSGY
TEGFVNAQSRRDLKPVIELLFANPDLVSRQMLDDLLRYKRLDGVQEALSAIGYSLFARGRQREQPAQRLADTGKRTLVVW
GAKDQIIPSTHAQNAPAGATVKVFDDAGHMSQMEKAGDFNALLRTHLAG

Specific function: Dihydrolipoamide acetyltransferase involved in acetoin catabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI189027141, Length=269, Percent_Identity=24.5353159851301, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87081721, Length=278, Percent_Identity=27.6978417266187, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000073
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00364 Biotin_lipoyl [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 39241; Mature: 39110

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAITPIVMPKWGLSMKEGTINEWLVDEGAQISVGMPILDVETDKIANAVEAPDAGTLR
CCCCCCCEECCCCCCCCCCCCCHHHHHCCCCEEEECCEEEECCHHHHHHHHCCCCCHHHH
RKVASVGDVLPVKALLGVLAPAEVSDAEIDAYIAAYETPADDGDEEEAGPAYQYADVDGI
HHHHHHCCHHHHHHHHHHCCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCEEECCCCCE
RVRYARRGDAGPAVLFVHGFGGDLDNWLFNLDALADAYTVVALDLPAHGQTSPRLAGTTL
EEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHH
AEMAGFVARFLDVTGIDAAHVVGHSMGGGIAAQLAVDAPQRVLSVALVSPVGMGEEINSG
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHCCC
YTEGFVNAQSRRDLKPVIELLFANPDLVSRQMLDDLLRYKRLDGVQEALSAIGYSLFARG
CHHCCCCCHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC
RQREQPAQRLADTGKRTLVVWGAKDQIIPSTHAQNAPAGATVKVFDDAGHMSQMEKAGDF
CCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCCH
NALLRTHLAG
HHHHHHHCCC
>Mature Secondary Structure 
AAAITPIVMPKWGLSMKEGTINEWLVDEGAQISVGMPILDVETDKIANAVEAPDAGTLR
CCCCCCEECCCCCCCCCCCCCHHHHHCCCCEEEECCEEEECCHHHHHHHHCCCCCHHHH
RKVASVGDVLPVKALLGVLAPAEVSDAEIDAYIAAYETPADDGDEEEAGPAYQYADVDGI
HHHHHHCCHHHHHHHHHHCCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCEEECCCCCE
RVRYARRGDAGPAVLFVHGFGGDLDNWLFNLDALADAYTVVALDLPAHGQTSPRLAGTTL
EEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHH
AEMAGFVARFLDVTGIDAAHVVGHSMGGGIAAQLAVDAPQRVLSVALVSPVGMGEEINSG
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHCCC
YTEGFVNAQSRRDLKPVIELLFANPDLVSRQMLDDLLRYKRLDGVQEALSAIGYSLFARG
CHHCCCCCHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC
RQREQPAQRLADTGKRTLVVWGAKDQIIPSTHAQNAPAGATVKVFDDAGHMSQMEKAGDF
CCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCCH
NALLRTHLAG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2061286 [H]