Click here to switch to the map view.

The map label for this gene is glxR [H]

Identifier: 73539354

GI number: 73539354

Start: 2332472

End: 2333350

Strand: Direct

Name: glxR [H]

Synonym: Reut_B5532

Alternate gene names: 73539354

Gene position: 2332472-2333350 (Clockwise)

Preceding gene: 73539350

Following gene: 73539356

Centisome position: 85.56

GC content: 67.35

Gene sequence:

>879_bases
ATGGCGGTGGGATTCATCGGACTCGGTGTCATGGGGCAGCCCATGGCGCTCAATCTGGCGCGAGCCGGCACGCCGCTGGT
GGTGTGGAACCGCTCGGGCGGGAAATACGAGCCTCTGGTCGAGGCGGGCGCCGCGGTGGCGGACAGCCCGGCGGATGTGT
TCACTTGCGCCGGCGTGGTGATCCTGATGCTGGCGAACGACCGGGCCAACGACGAGGCACTGGGCCGCGGCACGCCAGAC
TTTGCCGCACGGGTTCGCGAACGAACGATCGTGCATATGGGGACCACTTCGACTGCGTACTCGCATGGGCTGGAGGCTGA
CATCCGTCTGGCGGGCGGCCAGTATGTCGAAGCACCCGTGTCGGGCTCGCGCAAGCCGGCGGAGGCCGGCCAGCTCGTCG
CCATGCTCGCGGGCGACCCGGCAGCCATGGAGCAGGTGCGGCCGCTGCTAGCGCCGATGTGCCGTGAGGCGATTTCCTGC
GGCGCTGTGCCGAACGCGCTGACGATGAAGCTTGCGGTCAACGTGTTCCTGATCACGATGGTCACCGGGTTGGCGGAGGC
CATGCATTTTGCTGAACGCCACGGGCTCGACCCGGCGCATTTCATGGCCGTGGCCAATGCGAGTCCGATGGCAAGCGATG
TGTCGCGCTTCAAGGTGGCAAAGCTGGCCGCGCGCGACTTCTCGGTGCAGGCCGCCATTACCGATGTGCTGAAGAACAGC
CGGCTCGTTACCGAGGCCGCGAGGGCAGCGGGAATGGCATCGCCGCTGCTTGATGTCTGCCATGCGCTGTACGGCGAGAC
CGAAGCGCTGGGACTCGGCCAGGATGACATGGCGGCCGTGATCCGCGCGTTGGAGCAGCGCACGGCGCAGCTCGGCTGA

Upstream 100 bases:

>100_bases
TTTCGCAGGGGCGCACCGCTGTCGCCTGCACAATCGTTCAAGACAGTCTCCGCATGGCTTTGTACGCTTGCACCAATGCT
AACGCTAACCGGAGACGCAC

Downstream 100 bases:

>100_bases
GGGCGCTTACGTCGCCGAAGTCGTTTCGCGCGGCAGCTCCAGGACCCATTCGCGGAACGCCTCGAGTGCTTCCGACGGCG
GCCGGCCCTCGGGATAGGCA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MAVGFIGLGVMGQPMALNLARAGTPLVVWNRSGGKYEPLVEAGAAVADSPADVFTCAGVVILMLANDRANDEALGRGTPD
FAARVRERTIVHMGTTSTAYSHGLEADIRLAGGQYVEAPVSGSRKPAEAGQLVAMLAGDPAAMEQVRPLLAPMCREAISC
GAVPNALTMKLAVNVFLITMVTGLAEAMHFAERHGLDPAHFMAVANASPMASDVSRFKVAKLAARDFSVQAAITDVLKNS
RLVTEAARAAGMASPLLDVCHALYGETEALGLGQDDMAAVIRALEQRTAQLG

Sequences:

>Translated_292_residues
MAVGFIGLGVMGQPMALNLARAGTPLVVWNRSGGKYEPLVEAGAAVADSPADVFTCAGVVILMLANDRANDEALGRGTPD
FAARVRERTIVHMGTTSTAYSHGLEADIRLAGGQYVEAPVSGSRKPAEAGQLVAMLAGDPAAMEQVRPLLAPMCREAISC
GAVPNALTMKLAVNVFLITMVTGLAEAMHFAERHGLDPAHFMAVANASPMASDVSRFKVAKLAARDFSVQAAITDVLKNS
RLVTEAARAAGMASPLLDVCHALYGETEALGLGQDDMAAVIRALEQRTAQLG
>Mature_291_residues
AVGFIGLGVMGQPMALNLARAGTPLVVWNRSGGKYEPLVEAGAAVADSPADVFTCAGVVILMLANDRANDEALGRGTPDF
AARVRERTIVHMGTTSTAYSHGLEADIRLAGGQYVEAPVSGSRKPAEAGQLVAMLAGDPAAMEQVRPLLAPMCREAISCG
AVPNALTMKLAVNVFLITMVTGLAEAMHFAERHGLDPAHFMAVANASPMASDVSRFKVAKLAARDFSVQAAITDVLKNSR
LVTEAARAAGMASPLLDVCHALYGETEALGLGQDDMAAVIRALEQRTAQLG

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=26.9503546099291, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI23308751, Length=295, Percent_Identity=29.4915254237288, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786719, Length=285, Percent_Identity=29.1228070175439, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI145693186, Length=281, Percent_Identity=27.0462633451957, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1790315, Length=284, Percent_Identity=26.7605633802817, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574115, Length=279, Percent_Identity=27.9569892473118, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24655230, Length=293, Percent_Identity=29.3515358361775, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19922568, Length=293, Percent_Identity=29.3515358361775, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30396; Mature: 30265

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVGFIGLGVMGQPMALNLARAGTPLVVWNRSGGKYEPLVEAGAAVADSPADVFTCAGVV
CCEEEEECCCCCCCCEEEHHCCCCCEEEEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHH
ILMLANDRANDEALGRGTPDFAARVRERTIVHMGTTSTAYSHGLEADIRLAGGQYVEAPV
HEEECCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHCCCCCEEEECCCCEEECCC
SGSRKPAEAGQLVAMLAGDPAAMEQVRPLLAPMCREAISCGAVPNALTMKLAVNVFLITM
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VTGLAEAMHFAERHGLDPAHFMAVANASPMASDVSRFKVAKLAARDFSVQAAITDVLKNS
HHHHHHHHHHHHHHCCCHHHHHEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
RLVTEAARAAGMASPLLDVCHALYGETEALGLGQDDMAAVIRALEQRTAQLG
HHHHHHHHHHCCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVGFIGLGVMGQPMALNLARAGTPLVVWNRSGGKYEPLVEAGAAVADSPADVFTCAGVV
CEEEEECCCCCCCCEEEHHCCCCCEEEEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHH
ILMLANDRANDEALGRGTPDFAARVRERTIVHMGTTSTAYSHGLEADIRLAGGQYVEAPV
HEEECCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHCCCCCEEEECCCCEEECCC
SGSRKPAEAGQLVAMLAGDPAAMEQVRPLLAPMCREAISCGAVPNALTMKLAVNVFLITM
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VTGLAEAMHFAERHGLDPAHFMAVANASPMASDVSRFKVAKLAARDFSVQAAITDVLKNS
HHHHHHHHHHHHHHCCCHHHHHEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
RLVTEAARAAGMASPLLDVCHALYGETEALGLGQDDMAAVIRALEQRTAQLG
HHHHHHHHHHCCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]