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The map label for this gene is pdhR [H]

Identifier: 73539271

GI number: 73539271

Start: 2240988

End: 2241731

Strand: Direct

Name: pdhR [H]

Synonym: Reut_B5449

Alternate gene names: 73539271

Gene position: 2240988-2241731 (Clockwise)

Preceding gene: 73539265

Following gene: 73539275

Centisome position: 82.2

GC content: 67.07

Gene sequence:

>744_bases
ATGGCAACGCACACGCAATCGCACGGACGGGGCAGGGGACGCGTCGAAGCGGTAATGCGGCAAATCGAAACCGCCTTGCT
GGATGGCACCTGGCCCGCGGGCGCGCGCTTGCCGGCCGAGCGCGATTTGGCAGAGCAATACGACGTGGCCCGCAATACCG
TGCGCGAAGCCATTCAGCGCCTGGCCGCACGCGGGTTGCTGCAAAGCCGGCGCGGCGCCGGGGTCTACGTGACCGACCAG
TTGAGATCAGGCATCGCCTCGCCATGGGGCCAGCTCGTAGCCGACCATCCGGCGCTGCGTGACGACATCCTCGAATTCCG
CCGCGTGCTGGAAGGCGCCACGGCCTACTTCGCCGCACTGCGTGGCGACGATGAAGACCGCAAGCGCATCCGCGGCCTGA
TGGCTGAACTTGAACGTGCGCGCATGGTTGACGACAAACAGGCCGAGGCAGAGGCCGACACGCGCCTGCACGACGCCATC
GCGCAGGCCTCGCACAACACCATGTTCCTGCACCTGCATACCAGCGTCATCAGCATGCTGCGCGAACACATCACCATCAG
CGGCACCGGCCTGCGCGAAGAGGGCGAGGCCACGTCGGCGCTCTTGCTGCTGCAGCACCGTACCGTGTGCGACGCTATCT
GCGCGCGCCGCCCGGAAGAAGCGCGCACGGCGATGCAGACGCATATCGATTTCGTGCGGACGTGGGTGGAGAACGGGGGC
GGGGCGGACAGGAGCGTGGACTAG

Upstream 100 bases:

>100_bases
TCGGGCGCATAATTCCCGCTTCCGCGCTACAGTACAAATTGGTTGGACCAATTCAAGCGGACATCACATTGGCATGACGG
GGATCGGCAAGGGGAGAGGA

Downstream 100 bases:

>100_bases
CGCGCGGCCATGGCAGGGGTCACGCGGCTCCGTCTTGGATCAAACCAGCCCGGCAGTAGACAACTCTCGCTTGAGATACG
CATAGAAGATCGGCCCCGCA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MATHTQSHGRGRGRVEAVMRQIETALLDGTWPAGARLPAERDLAEQYDVARNTVREAIQRLAARGLLQSRRGAGVYVTDQ
LRSGIASPWGQLVADHPALRDDILEFRRVLEGATAYFAALRGDDEDRKRIRGLMAELERARMVDDKQAEAEADTRLHDAI
AQASHNTMFLHLHTSVISMLREHITISGTGLREEGEATSALLLLQHRTVCDAICARRPEEARTAMQTHIDFVRTWVENGG
GADRSVD

Sequences:

>Translated_247_residues
MATHTQSHGRGRGRVEAVMRQIETALLDGTWPAGARLPAERDLAEQYDVARNTVREAIQRLAARGLLQSRRGAGVYVTDQ
LRSGIASPWGQLVADHPALRDDILEFRRVLEGATAYFAALRGDDEDRKRIRGLMAELERARMVDDKQAEAEADTRLHDAI
AQASHNTMFLHLHTSVISMLREHITISGTGLREEGEATSALLLLQHRTVCDAICARRPEEARTAMQTHIDFVRTWVENGG
GADRSVD
>Mature_246_residues
ATHTQSHGRGRGRVEAVMRQIETALLDGTWPAGARLPAERDLAEQYDVARNTVREAIQRLAARGLLQSRRGAGVYVTDQL
RSGIASPWGQLVADHPALRDDILEFRRVLEGATAYFAALRGDDEDRKRIRGLMAELERARMVDDKQAEAEADTRLHDAIA
QASHNTMFLHLHTSVISMLREHITISGTGLREEGEATSALLLLQHRTVCDAICARRPEEARTAMQTHIDFVRTWVENGGG
ADRSVD

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=218, Percent_Identity=40.8256880733945, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1790032, Length=215, Percent_Identity=36.7441860465116, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790780, Length=236, Percent_Identity=30.0847457627119, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1789353, Length=226, Percent_Identity=27.8761061946903, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI48994955, Length=198, Percent_Identity=28.2828282828283, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789621, Length=226, Percent_Identity=26.5486725663717, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082208, Length=227, Percent_Identity=27.3127753303965, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI48994961, Length=205, Percent_Identity=26.3414634146341, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 27450; Mature: 27319

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHTQSHGRGRGRVEAVMRQIETALLDGTWPAGARLPAERDLAEQYDVARNTVREAIQR
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAARGLLQSRRGAGVYVTDQLRSGIASPWGQLVADHPALRDDILEFRRVLEGATAYFAAL
HHHHHHHHHCCCCCEEEHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RGDDEDRKRIRGLMAELERARMVDDKQAEAEADTRLHDAIAQASHNTMFLHLHTSVISML
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHH
REHITISGTGLREEGEATSALLLLQHRTVCDAICARRPEEARTAMQTHIDFVRTWVENGG
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
GADRSVD
CCCCCCC
>Mature Secondary Structure 
ATHTQSHGRGRGRVEAVMRQIETALLDGTWPAGARLPAERDLAEQYDVARNTVREAIQR
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAARGLLQSRRGAGVYVTDQLRSGIASPWGQLVADHPALRDDILEFRRVLEGATAYFAAL
HHHHHHHHHCCCCCEEEHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RGDDEDRKRIRGLMAELERARMVDDKQAEAEADTRLHDAIAQASHNTMFLHLHTSVISML
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHH
REHITISGTGLREEGEATSALLLLQHRTVCDAICARRPEEARTAMQTHIDFVRTWVENGG
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
GADRSVD
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]