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The map label for this gene is edd [H]

Identifier: 73539152

GI number: 73539152

Start: 2095705

End: 2097540

Strand: Direct

Name: edd [H]

Synonym: Reut_B5330

Alternate gene names: 73539152

Gene position: 2095705-2097540 (Clockwise)

Preceding gene: 73539145

Following gene: 73539158

Centisome position: 76.87

GC content: 67.32

Gene sequence:

>1836_bases
ATGCCACGTCACCCAGTACTCGAACGGGTCACGGCCCGCATCGTCTCGCGCAGCGGCCCTTCGCGTCAGGCCTACCTTGA
CCGCACCCGCGCCATGGCGGGCCAGAAAGTCGAGCGCAGCCAGATTTCCTGTACCAACCTCGCGCACGCCATCGCCGCTA
TGCCGGACGAGGCGAAGATCCGGCTCAAGGCCGACGAGCGGCCCAACCTGGCGATCGTCTCGTCTTACAACGACATGCTG
TCGGCGCACCAACCGCTGGCGGCCTTCCCGAAGTGGCTCAAGGAGGCCGCGCTGGAAGCCGGCGGCACGGCGCAGTTCGC
CGGCGGCACGCCTGCCATGTGCGACGGCGTAACCCAGGGCCAGGACGGCATGGACCTGTCACTGTTCTCGCGCGATGTGA
TCGCATTGGCCACGGCGGTGGCACTGTCGCACCAGATGTTCGACGGCGCGCTGTATCTCGGCGTCTGCGACAAGATCGTG
CCAGGGCTGGTGATGGGCGCGCTGTCGTTTGGCCACCTGCCGGCGGTGTTCGTGCCGGGCGGCCCCATGACCACCGGCAT
GAGCAATGACGAGAAGGCGCATGTGCGCCAGCTCTATGCCGAAGGCAAGATCGGCCGCAAGGAGCTGCTCGAGGCCGAGA
CACGTTCCTATCATAGCCCCGGCACGTGCACGTTCTACGGCACCGCCAACTCCAACCAGATGCTGATGGAAATGATGGGC
CTGCATCTGCCGGGCACGGCCTTCATCAATCCCAACACGCCGCTGCGCGAAGCGCTGACACGCGAATCGGCCCGGCAGGC
CTTGCGCCTCGTGCATGGCGGCGAACGGTATACGCCTGTGGCCGACGTGCTCGACGAGCGCGCCTTCGTCAACGGCATCG
TGGGCCTGCTGGCCACGGGCGGTTCGACCAATCACACGCTGCACCTGATCGCCATGGCACGCGTGGCCGGCATCGTACTG
ACGTGGGACGATTTCGATGAACTGTCGGCCGCGGTGCCGCTGCTCGCGCGCGTCTACCCGAACGGCAAGGCCGACGTAAA
CCAGTTCCAGGCGGCCGGCGGACTGTCGGTGGTGATTCGCGGTCTGCTCGAACTCGGCCTGCTGCATGACGATGTCAACA
CGGTGGTCGGCCGCGGGCTGGAGGCCTATACGCGCGAGCCCGTGCTGCGCGATGGCAAGCTCGAATGGACGGATGGGCCC
AAGGCCTCGCTCGACGACACGATCGTGCGCGGCCCGGCGCAGCCGTTCGCGGCGGACGGTGGCATCAAGGTGCTCGACGG
CAGGCTCGGGCGTGCGGTCATCAAGACTTCTGCAGTGAAGCGGGAACACCAGGTCGTGGAAGCGCCTGCGATCGTGTTCG
AGCACCAGGACGACGTGATCGCGGCATTCAAGCGCGGCGAGCTCGAGCGCGATTTCGTCGCAGTGCTGCCGTGGCAAGGC
CCGGCATCGTGCGGCATGCCGGAGTTGCACAAGCTCACGCCGACGCTGACGGTGCTGCAGGACCGAGGCTTCCATGTCGC
GCTTGTGACGGATGGACGCATGTCGGGCGCATCGGGCAAGGTGCCGGCGGCCATTCACGTCTGTCCGGAGGCGCTGAACG
GTGGCGGTATTGGGCGCGTGCGTACCGGCGACATGGTGCGCGTGGATGCGCCGGCCGGTGTGCTGACCGTGCTGGTGGCA
GATGCCGAGTGGGACGCGCGCGAATCCGCACGCCCCGACCTGCGGGCCAATCGCCATGGCGTCGGACGCGACCTGTTCGC
GACCTTCCGCCGCAACGTCAGTGATGCCGAAGCGGGCGCCTGCACGCTGTTCGCCGACGAAGACGCGCGCGACTGA

Upstream 100 bases:

>100_bases
CAAAGCGTACCCGTTTCTGCGTGCCCACTGGCTGCGTCGCTCCACCGTGCAGCGTGCCGCGAAGTGCGCTAGGCTGGAAG
CAACCCCGCAGGAGAAACCT

Downstream 100 bases:

>100_bases
CTCAGCGAACTAGCCCGCGCGCCGCAACGGATTGGCGCGCGGATCGGGCGTTGCGGTCGGCGGTGTGGTGACCGGCGTGG
CGCCCGGGTCTGGCATGCGC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MPRHPVLERVTARIVSRSGPSRQAYLDRTRAMAGQKVERSQISCTNLAHAIAAMPDEAKIRLKADERPNLAIVSSYNDML
SAHQPLAAFPKWLKEAALEAGGTAQFAGGTPAMCDGVTQGQDGMDLSLFSRDVIALATAVALSHQMFDGALYLGVCDKIV
PGLVMGALSFGHLPAVFVPGGPMTTGMSNDEKAHVRQLYAEGKIGRKELLEAETRSYHSPGTCTFYGTANSNQMLMEMMG
LHLPGTAFINPNTPLREALTRESARQALRLVHGGERYTPVADVLDERAFVNGIVGLLATGGSTNHTLHLIAMARVAGIVL
TWDDFDELSAAVPLLARVYPNGKADVNQFQAAGGLSVVIRGLLELGLLHDDVNTVVGRGLEAYTREPVLRDGKLEWTDGP
KASLDDTIVRGPAQPFAADGGIKVLDGRLGRAVIKTSAVKREHQVVEAPAIVFEHQDDVIAAFKRGELERDFVAVLPWQG
PASCGMPELHKLTPTLTVLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEALNGGGIGRVRTGDMVRVDAPAGVLTVLVA
DAEWDARESARPDLRANRHGVGRDLFATFRRNVSDAEAGACTLFADEDARD

Sequences:

>Translated_611_residues
MPRHPVLERVTARIVSRSGPSRQAYLDRTRAMAGQKVERSQISCTNLAHAIAAMPDEAKIRLKADERPNLAIVSSYNDML
SAHQPLAAFPKWLKEAALEAGGTAQFAGGTPAMCDGVTQGQDGMDLSLFSRDVIALATAVALSHQMFDGALYLGVCDKIV
PGLVMGALSFGHLPAVFVPGGPMTTGMSNDEKAHVRQLYAEGKIGRKELLEAETRSYHSPGTCTFYGTANSNQMLMEMMG
LHLPGTAFINPNTPLREALTRESARQALRLVHGGERYTPVADVLDERAFVNGIVGLLATGGSTNHTLHLIAMARVAGIVL
TWDDFDELSAAVPLLARVYPNGKADVNQFQAAGGLSVVIRGLLELGLLHDDVNTVVGRGLEAYTREPVLRDGKLEWTDGP
KASLDDTIVRGPAQPFAADGGIKVLDGRLGRAVIKTSAVKREHQVVEAPAIVFEHQDDVIAAFKRGELERDFVAVLPWQG
PASCGMPELHKLTPTLTVLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEALNGGGIGRVRTGDMVRVDAPAGVLTVLVA
DAEWDARESARPDLRANRHGVGRDLFATFRRNVSDAEAGACTLFADEDARD
>Mature_610_residues
PRHPVLERVTARIVSRSGPSRQAYLDRTRAMAGQKVERSQISCTNLAHAIAAMPDEAKIRLKADERPNLAIVSSYNDMLS
AHQPLAAFPKWLKEAALEAGGTAQFAGGTPAMCDGVTQGQDGMDLSLFSRDVIALATAVALSHQMFDGALYLGVCDKIVP
GLVMGALSFGHLPAVFVPGGPMTTGMSNDEKAHVRQLYAEGKIGRKELLEAETRSYHSPGTCTFYGTANSNQMLMEMMGL
HLPGTAFINPNTPLREALTRESARQALRLVHGGERYTPVADVLDERAFVNGIVGLLATGGSTNHTLHLIAMARVAGIVLT
WDDFDELSAAVPLLARVYPNGKADVNQFQAAGGLSVVIRGLLELGLLHDDVNTVVGRGLEAYTREPVLRDGKLEWTDGPK
ASLDDTIVRGPAQPFAADGGIKVLDGRLGRAVIKTSAVKREHQVVEAPAIVFEHQDDVIAAFKRGELERDFVAVLPWQGP
ASCGMPELHKLTPTLTVLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEALNGGGIGRVRTGDMVRVDAPAGVLTVLVAD
AEWDARESARPDLRANRHGVGRDLFATFRRNVSDAEAGACTLFADEDARD

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=60.1328903654485, Blast_Score=742, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=557, Percent_Identity=29.802513464991, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI2367371, Length=461, Percent_Identity=32.3210412147505, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1786464, Length=523, Percent_Identity=31.1663479923518, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322476, Length=533, Percent_Identity=31.1444652908068, Blast_Score=191, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65366; Mature: 65235

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRHPVLERVTARIVSRSGPSRQAYLDRTRAMAGQKVERSQISCTNLAHAIAAMPDEAKI
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEE
RLKADERPNLAIVSSYNDMLSAHQPLAAFPKWLKEAALEAGGTAQFAGGTPAMCDGVTQG
EEECCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHCCCCCC
QDGMDLSLFSRDVIALATAVALSHQMFDGALYLGVCDKIVPGLVMGALSFGHLPAVFVPG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMTTGMSNDEKAHVRQLYAEGKIGRKELLEAETRSYHSPGTCTFYGTANSNQMLMEMMG
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHC
LHLPGTAFINPNTPLREALTRESARQALRLVHGGERYTPVADVLDERAFVNGIVGLLATG
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GSTNHTLHLIAMARVAGIVLTWDDFDELSAAVPLLARVYPNGKADVNQFQAAGGLSVVIR
CCCCCHHHHEEHHHHCEEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHH
GLLELGLLHDDVNTVVGRGLEAYTREPVLRDGKLEWTDGPKASLDDTIVRGPAQPFAADG
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEECCCCCCCCCCHHHCCCCCCCCCCC
GIKVLDGRLGRAVIKTSAVKREHQVVEAPAIVFEHQDDVIAAFKRGELERDFVAVLPWQG
CEEEECCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHCCCCCCCEEEEECCCC
PASCGMPELHKLTPTLTVLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEALNGGGIGRV
CCCCCCCHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCCEEEEECHHHCCCCCCCEE
RTGDMVRVDAPAGVLTVLVADAEWDARESARPDLRANRHGVGRDLFATFRRNVSDAEAGA
ECCCEEEEECCCCEEEEEEECCCCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCE
CTLFADEDARD
EEEEECCCCCC
>Mature Secondary Structure 
PRHPVLERVTARIVSRSGPSRQAYLDRTRAMAGQKVERSQISCTNLAHAIAAMPDEAKI
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEE
RLKADERPNLAIVSSYNDMLSAHQPLAAFPKWLKEAALEAGGTAQFAGGTPAMCDGVTQG
EEECCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHCCCCCC
QDGMDLSLFSRDVIALATAVALSHQMFDGALYLGVCDKIVPGLVMGALSFGHLPAVFVPG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMTTGMSNDEKAHVRQLYAEGKIGRKELLEAETRSYHSPGTCTFYGTANSNQMLMEMMG
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHC
LHLPGTAFINPNTPLREALTRESARQALRLVHGGERYTPVADVLDERAFVNGIVGLLATG
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GSTNHTLHLIAMARVAGIVLTWDDFDELSAAVPLLARVYPNGKADVNQFQAAGGLSVVIR
CCCCCHHHHEEHHHHCEEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHH
GLLELGLLHDDVNTVVGRGLEAYTREPVLRDGKLEWTDGPKASLDDTIVRGPAQPFAADG
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEECCCCCCCCCCHHHCCCCCCCCCCC
GIKVLDGRLGRAVIKTSAVKREHQVVEAPAIVFEHQDDVIAAFKRGELERDFVAVLPWQG
CEEEECCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHCCCCCCCEEEEECCCC
PASCGMPELHKLTPTLTVLQDRGFHVALVTDGRMSGASGKVPAAIHVCPEALNGGGIGRV
CCCCCCCHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCCEEEEECHHHCCCCCCCEE
RTGDMVRVDAPAGVLTVLVADAEWDARESARPDLRANRHGVGRDLFATFRRNVSDAEAGA
ECCCEEEEECCCCEEEEEEECCCCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCE
CTLFADEDARD
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]