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The map label for this gene is cynR [H]

Identifier: 73538946

GI number: 73538946

Start: 1862590

End: 1863510

Strand: Reverse

Name: cynR [H]

Synonym: Reut_B5121

Alternate gene names: 73538946

Gene position: 1863510-1862590 (Counterclockwise)

Preceding gene: 73538949

Following gene: 73538945

Centisome position: 68.36

GC content: 65.91

Gene sequence:

>921_bases
ATGCGTGAGATCAATCAGCAGCGCTTGCGGTACTTTCGTGAAGTCCTCGCGCAGGGCACGATCCGTGGGGCGGCGGACAG
TCTCAATACCGCGCCGTCGGTCATCACCCGGCAGATCCGGCTACTGGAAGAAGAGCTTGGCGCCACGCTGTTCGAGCGCG
AGCCGCGCGGCTTGCGGCCAACGGCGGCGGCTGCGCATTTGATCGAGTTCTGGCGCGGGTACCGTTCTCACCAGGAGAAG
CTCGAAGACCAGTTGCATGCGCTCAAGGGTCTGCAGCAAGGCGAAGTCCAGCTGGCCATGAGCGAGGGCTACGTGGATCC
GCTGGTCAACGAGGTGCTGGCCCCGTTTTGCGCGCAGTACCCGAAGCTCGACGTCCGGCTGGAGATCCTGCCGGTCGACG
ACGTTCTGAACGAAGTGGCAGAGAGCCGTGCGCACATCGGCCTTGCCTACAATCCGCCGCCGCATCCGCGCATCGAATAC
CGTGCGAGCGCGCCGCAGCCGGTCGTGCTGCTGGTCCGGCACGATCACCCGCTGGCGTTGCGCGGCGGACCGGCCAGCGT
GGCGGACTTGCAGTCCTACCCGCTCGCGATGATGCCGGCATCGTTTGGCGTCGGGCACGCGCTGCAGATGCTGGAGTTTG
CCGAGAACATCCGGATCCGCCCGACGCTGGTCAGCAACTCCCTGACGGCGCTCAAGCAGTTCGTCGCCTACGAAAACTTC
ATGACGCTGATCGGCGAGTTCGCCGCGTATCGCGAGATCGCGGCCGGCACCCTTGCGGCGGTGCCGCTCGATCATCCGCT
GTTCCAGGGCACGCAGGCACGGCTGCTGGTCAAGGCCGGCCGGCCCTTGCCGGCGGCGGCGCTTGCGATGCTGGACCATA
TCTCGCGCAAGATGTCGATCTTCGCCGGTAGCGGAACGTAG

Upstream 100 bases:

>100_bases
AGCCCGCCCCCTTACGCGGCAGCGCGTCCATCGAGCAAACGCTGCCTGCTTCAGGTAAGGTGGCGCATCGCCCGCTCATC
GATTCAGTGGATGTCCTCCT

Downstream 100 bases:

>100_bases
CTTTCGCTGCCGGTTTGCAGAGCAAATCGGAAAGGCTCGCGGGTGCAACGCCTGCCGAGCGCTCCCGTCAAGCGATAAGC
CACTCCGCCATGGCCGGTTA

Product: regulatory protein LysR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MREINQQRLRYFREVLAQGTIRGAADSLNTAPSVITRQIRLLEEELGATLFEREPRGLRPTAAAAHLIEFWRGYRSHQEK
LEDQLHALKGLQQGEVQLAMSEGYVDPLVNEVLAPFCAQYPKLDVRLEILPVDDVLNEVAESRAHIGLAYNPPPHPRIEY
RASAPQPVVLLVRHDHPLALRGGPASVADLQSYPLAMMPASFGVGHALQMLEFAENIRIRPTLVSNSLTALKQFVAYENF
MTLIGEFAAYREIAAGTLAAVPLDHPLFQGTQARLLVKAGRPLPAAALAMLDHISRKMSIFAGSGT

Sequences:

>Translated_306_residues
MREINQQRLRYFREVLAQGTIRGAADSLNTAPSVITRQIRLLEEELGATLFEREPRGLRPTAAAAHLIEFWRGYRSHQEK
LEDQLHALKGLQQGEVQLAMSEGYVDPLVNEVLAPFCAQYPKLDVRLEILPVDDVLNEVAESRAHIGLAYNPPPHPRIEY
RASAPQPVVLLVRHDHPLALRGGPASVADLQSYPLAMMPASFGVGHALQMLEFAENIRIRPTLVSNSLTALKQFVAYENF
MTLIGEFAAYREIAAGTLAAVPLDHPLFQGTQARLLVKAGRPLPAAALAMLDHISRKMSIFAGSGT
>Mature_306_residues
MREINQQRLRYFREVLAQGTIRGAADSLNTAPSVITRQIRLLEEELGATLFEREPRGLRPTAAAAHLIEFWRGYRSHQEK
LEDQLHALKGLQQGEVQLAMSEGYVDPLVNEVLAPFCAQYPKLDVRLEILPVDDVLNEVAESRAHIGLAYNPPPHPRIEY
RASAPQPVVLLVRHDHPLALRGGPASVADLQSYPLAMMPASFGVGHALQMLEFAENIRIRPTLVSNSLTALKQFVAYENF
MTLIGEFAAYREIAAGTLAAVPLDHPLFQGTQARLLVKAGRPLPAAALAMLDHISRKMSIFAGSGT

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=304, Percent_Identity=26.6447368421053, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787601, Length=248, Percent_Identity=23.7903225806452, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33790; Mature: 33790

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50931 HTH_LYSR ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREINQQRLRYFREVLAQGTIRGAADSLNTAPSVITRQIRLLEEELGATLFEREPRGLRP
CCCCCHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCH
TAAAAHLIEFWRGYRSHQEKLEDQLHALKGLQQGEVQLAMSEGYVDPLVNEVLAPFCAQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHC
PKLDVRLEILPVDDVLNEVAESRAHIGLAYNPPPHPRIEYRASAPQPVVLLVRHDHPLAL
CCCCEEEEEECHHHHHHHHHHHHHCEEEEECCCCCCCEEEECCCCCCEEEEEECCCCEEE
RGGPASVADLQSYPLAMMPASFGVGHALQMLEFAENIRIRPTLVSNSLTALKQFVAYENF
CCCCCCHHHHHHCCEEECCCCCCHHHHHHHHHHHHCCEECEEHHHHHHHHHHHHHHHHHH
MTLIGEFAAYREIAAGTLAAVPLDHPLFQGTQARLLVKAGRPLPAAALAMLDHISRKMSI
HHHHHHHHHHHHHHHHHHEECCCCCCHHCCCHHEEEEECCCCCHHHHHHHHHHHHHHHHH
FAGSGT
EECCCC
>Mature Secondary Structure
MREINQQRLRYFREVLAQGTIRGAADSLNTAPSVITRQIRLLEEELGATLFEREPRGLRP
CCCCCHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCH
TAAAAHLIEFWRGYRSHQEKLEDQLHALKGLQQGEVQLAMSEGYVDPLVNEVLAPFCAQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHC
PKLDVRLEILPVDDVLNEVAESRAHIGLAYNPPPHPRIEYRASAPQPVVLLVRHDHPLAL
CCCCEEEEEECHHHHHHHHHHHHHCEEEEECCCCCCCEEEECCCCCCEEEEEECCCCEEE
RGGPASVADLQSYPLAMMPASFGVGHALQMLEFAENIRIRPTLVSNSLTALKQFVAYENF
CCCCCCHHHHHHCCEEECCCCCCHHHHHHHHHHHHCCEECEEHHHHHHHHHHHHHHHHHH
MTLIGEFAAYREIAAGTLAAVPLDHPLFQGTQARLLVKAGRPLPAAALAMLDHISRKMSI
HHHHHHHHHHHHHHHHHHEECCCCCCHHCCCHHEEEEECCCCCHHHHHHHHHHHHHHHHH
FAGSGT
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]