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The map label for this gene is fabG [C]

Identifier: 73538679

GI number: 73538679

Start: 1563089

End: 1563799

Strand: Reverse

Name: fabG [C]

Synonym: Reut_B4854

Alternate gene names: 73538679

Gene position: 1563799-1563089 (Counterclockwise)

Preceding gene: 73538682

Following gene: 73538678

Centisome position: 57.36

GC content: 67.51

Gene sequence:

>711_bases
ATGGAAGCCGCCATTCGTCATGTCGTGATCACCGGCGCCGCCGGCGCCTTGGGCCGCGCAGTAGCCAGCCGCTTTGCCGG
GGAGGGCTGCCGGCTGGCCCTGATCGACCGTGACCTCCAGCACCTGCAAAGCGTCTTCGCCCATCCCGATGCGGACGGCG
GCATGTTGCTGCGCGAGGCCGATGTCACCTCGGATACCGGCATGTCCCGCGTCGGTGCGGAGATCCTGGATACCTTCGGT
GCCGTGGACGTCGTGGTCCATGTGGCCGGCGGCTTCGAGATGGGCGAGGCCACGCACGCCATCAGCCGCGAGTCATGGAT
GCGCATGATGGACCTGAACGCGTGGTCATTCATCGCCGTAACGCGGCCGTTCATCCCCGCCATGCTCGCACGAGGCAGCG
GCAAGGTCGTTGCCGTCACGGCGCGCAGTGCGGCGGCGGGCGTGGCTTCGATGGGCGCATACTGCGCGTCAAAGAGCGCG
CTGCAGCGGCTCGTTGAAAGCCTGTCGCGCGAGGTACGCGCCGGCGGCGTGAACGTCAACAGCATTGCGCCCGGAGTGCT
CGATACGCCGGCCAACCGGGGGGACATGCCGGGGACGGATCCTTCAGTGTGGGTGTCGACGGGAGCGGCTGCACGGATGG
TATCCATGCTGGCATCCGATGCGGCGGCCATGGTGCATGGGCAGCACTGGGTGCTGGATGGATTGAGCTAG

Upstream 100 bases:

>100_bases
CGCAAGGATTCCGCTCTGTACAGTTCAGCCGACATCCGCATTTCCCTTTGCGTGCCGCCCGACTATGGTGAAGGCAGTCC
TTCGCTACGGGAGCCCGAAG

Downstream 100 bases:

>100_bases
GGGCCGGAGACCGCCACGGTGTTTGCCCCCGCTCCCATCGTTTGCCATTCGGGTTGAGGATCGCCGGTCGCGGTGCCAGA
ATTCCAGCATTGCGCGATCG

Product: Short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MEAAIRHVVITGAAGALGRAVASRFAGEGCRLALIDRDLQHLQSVFAHPDADGGMLLREADVTSDTGMSRVGAEILDTFG
AVDVVVHVAGGFEMGEATHAISRESWMRMMDLNAWSFIAVTRPFIPAMLARGSGKVVAVTARSAAAGVASMGAYCASKSA
LQRLVESLSREVRAGGVNVNSIAPGVLDTPANRGDMPGTDPSVWVSTGAAARMVSMLASDAAAMVHGQHWVLDGLS

Sequences:

>Translated_236_residues
MEAAIRHVVITGAAGALGRAVASRFAGEGCRLALIDRDLQHLQSVFAHPDADGGMLLREADVTSDTGMSRVGAEILDTFG
AVDVVVHVAGGFEMGEATHAISRESWMRMMDLNAWSFIAVTRPFIPAMLARGSGKVVAVTARSAAAGVASMGAYCASKSA
LQRLVESLSREVRAGGVNVNSIAPGVLDTPANRGDMPGTDPSVWVSTGAAARMVSMLASDAAAMVHGQHWVLDGLS
>Mature_236_residues
MEAAIRHVVITGAAGALGRAVASRFAGEGCRLALIDRDLQHLQSVFAHPDADGGMLLREADVTSDTGMSRVGAEILDTFG
AVDVVVHVAGGFEMGEATHAISRESWMRMMDLNAWSFIAVTRPFIPAMLARGSGKVVAVTARSAAAGVASMGAYCASKSA
LQRLVESLSREVRAGGVNVNSIAPGVLDTPANRGDMPGTDPSVWVSTGAAARMVSMLASDAAAMVHGQHWVLDGLS

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI157739938, Length=203, Percent_Identity=27.5862068965517, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI66933014, Length=225, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI20149619, Length=197, Percent_Identity=29.4416243654822, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4503817, Length=195, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI7706318, Length=186, Percent_Identity=27.9569892473118, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI5031737, Length=249, Percent_Identity=26.1044176706827, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=27.8947368421053, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI32483357, Length=239, Percent_Identity=24.6861924686192, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=235, Percent_Identity=25.9574468085106, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787820, Length=180, Percent_Identity=23.3333333333333, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786812, Length=214, Percent_Identity=26.6355140186916, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787905, Length=187, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87082100, Length=249, Percent_Identity=26.5060240963855, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=247, Percent_Identity=25.9109311740891, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17567345, Length=192, Percent_Identity=30.7291666666667, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=191, Percent_Identity=29.3193717277487, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=25.1012145748988, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=189, Percent_Identity=29.1005291005291, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=196, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=254, Percent_Identity=25.1968503937008, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=244, Percent_Identity=24.1803278688525, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=214, Percent_Identity=25.7009345794392, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=197, Percent_Identity=25.8883248730964, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=193, Percent_Identity=28.4974093264249, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=185, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=187, Percent_Identity=26.7379679144385, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=194, Percent_Identity=26.8041237113402, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=192, Percent_Identity=26.0416666666667, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21358495, Length=197, Percent_Identity=26.3959390862944, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356301, Length=191, Percent_Identity=28.7958115183246, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=28.8, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357041, Length=245, Percent_Identity=26.530612244898, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355631, Length=169, Percent_Identity=27.810650887574, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571526, Length=243, Percent_Identity=27.5720164609054, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=29.0155440414508, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281364892, Length=191, Percent_Identity=26.1780104712042, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24443; Mature: 24443

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAAIRHVVITGAAGALGRAVASRFAGEGCRLALIDRDLQHLQSVFAHPDADGGMLLREA
CCCHHEEEEEECCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCCCCCEEEEEC
DVTSDTGMSRVGAEILDTFGAVDVVVHVAGGFEMGEATHAISRESWMRMMDLNAWSFIAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
TRPFIPAMLARGSGKVVAVTARSAAAGVASMGAYCASKSALQRLVESLSREVRAGGVNVN
HHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SIAPGVLDTPANRGDMPGTDPSVWVSTGAAARMVSMLASDAAAMVHGQHWVLDGLS
HCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEECCCC
>Mature Secondary Structure
MEAAIRHVVITGAAGALGRAVASRFAGEGCRLALIDRDLQHLQSVFAHPDADGGMLLREA
CCCHHEEEEEECCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCCCCCEEEEEC
DVTSDTGMSRVGAEILDTFGAVDVVVHVAGGFEMGEATHAISRESWMRMMDLNAWSFIAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
TRPFIPAMLARGSGKVVAVTARSAAAGVASMGAYCASKSALQRLVESLSREVRAGGVNVN
HHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SIAPGVLDTPANRGDMPGTDPSVWVSTGAAARMVSMLASDAAAMVHGQHWVLDGLS
HCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]