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The map label for this gene is fdhA [H]

Identifier: 73538649

GI number: 73538649

Start: 1527386

End: 1528582

Strand: Reverse

Name: fdhA [H]

Synonym: Reut_B4824

Alternate gene names: 73538649

Gene position: 1528582-1527386 (Counterclockwise)

Preceding gene: 73538650

Following gene: 73538647

Centisome position: 56.07

GC content: 65.25

Gene sequence:

>1197_bases
ATGAGCAGCAACCGAGGCGTCGTATATCTTGGGCCGGGCCAGGTCGAGGTACAGAAGATCGACTATCCGAAAATGGTCGA
TCCCAGCGGCCGGGCCATTGGCCATGGCGTGATCCTCAAGGTCGTGACCACGAACATCTGCGGGTCGGACCAGCACATGG
TGCGCGGCCGCACGACCGCACCGACCGGCCTTGTGCTCGGTCACGAGATCACCGGCGAGGTCATCGAAATCGGCCGCGAC
GTCGAGACGCTGAAGCTTGGCGATCTGGTGTCTGTGCCGTTCAATGTCGCGTGCGGCCGCTGCGCGATGTGCAAGGAGCA
GCACACCGGCGTCTGTCTTACCGTCAACCCGTCGCGCGCGGGGGGAGCTTACGGGTACGTCGACATGGGCGGCTGGATCG
GCGGGCAGTCCGAGTACGTGATGGTGCCGTATGCCGACTTCAACCTGCTGAGATTTCCCGACCGCGACCAGGCGATGGCG
AAGATCCGCGATCTCACCTGCCTGTCGGACATCCTGCCGACGGGCTATCACGGTGCCGTCACCGCGGGCGTGAAGCCTGG
CTCGACGGTCTATATCGCCGGCGCGGGCCCGGTAGGCATGGCTGCCGCCGCATCAGCCCGCCTGCTTGGCGCAGCCTGCA
CCATCGTCGGCGACATGAACCCGGCGCGTCTCGCGCACGCGAAGGCGATGGGCTTTGAAGTCGTGGACCTGTCGAAGGAC
GCAACGCTCGGCGAGCAGATCGCCGAGATTCTCGGTACGCCCGAGATCGACTGCGCGGTGGACTGCGTCGGCTTCGAGGC
GCATGGCCACGGCTCGTCCGGCTACGTGGAGGAGGCGCCTGCCACGGTGCTCAATTCGCTGATGGAAATCACGCGGCCCG
CCGGGGCGATCGGCATCCCGGGCCTCTACGTAACGGATGATCCGGGCGCCCAGGATGCAGCGGCGCAGCGCGGCAGCCTC
AGCATCCGCTTCGGCCTCGGCTGGGCGAAGTCGCACTCGTTCCATACGGGCCAGACGCCGGTCCTCAAGTACAACCGCAA
CCTGATGCAGGCGATCCTTCACAATCGTTTGCCGATTGCCGAAATCGTCAATGTGACGGTCATCCCCCTTGATCAGGCGC
CGGAAGGCTACAAGCAGTTCGATGGCGGCGCGCCACGCAAATTCGTCATTGATCCGCACGGGCTGTTGGCGGCCTGA

Upstream 100 bases:

>100_bases
CCCGCGCCGGCATCCCCGAATACGCTCGAAGACGCTGCCGCGCATGCCACGCCGATCGCCGTGGCTGCGGCACGATTCAA
CAAGACATGGAGACAACGCG

Downstream 100 bases:

>100_bases
CCATTAGCGCAGAAACAAAACGGGCGGTCGATTTGCGGCCGCCCGTTTTGCCGTTTGAGGCAGTGTGCTTCACTGCCGCT
TCCCCCGAACGCTCACGCGT

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: FALDH; FDH [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSSNRGVVYLGPGQVEVQKIDYPKMVDPSGRAIGHGVILKVVTTNICGSDQHMVRGRTTAPTGLVLGHEITGEVIEIGRD
VETLKLGDLVSVPFNVACGRCAMCKEQHTGVCLTVNPSRAGGAYGYVDMGGWIGGQSEYVMVPYADFNLLRFPDRDQAMA
KIRDLTCLSDILPTGYHGAVTAGVKPGSTVYIAGAGPVGMAAAASARLLGAACTIVGDMNPARLAHAKAMGFEVVDLSKD
ATLGEQIAEILGTPEIDCAVDCVGFEAHGHGSSGYVEEAPATVLNSLMEITRPAGAIGIPGLYVTDDPGAQDAAAQRGSL
SIRFGLGWAKSHSFHTGQTPVLKYNRNLMQAILHNRLPIAEIVNVTVIPLDQAPEGYKQFDGGAPRKFVIDPHGLLAA

Sequences:

>Translated_398_residues
MSSNRGVVYLGPGQVEVQKIDYPKMVDPSGRAIGHGVILKVVTTNICGSDQHMVRGRTTAPTGLVLGHEITGEVIEIGRD
VETLKLGDLVSVPFNVACGRCAMCKEQHTGVCLTVNPSRAGGAYGYVDMGGWIGGQSEYVMVPYADFNLLRFPDRDQAMA
KIRDLTCLSDILPTGYHGAVTAGVKPGSTVYIAGAGPVGMAAAASARLLGAACTIVGDMNPARLAHAKAMGFEVVDLSKD
ATLGEQIAEILGTPEIDCAVDCVGFEAHGHGSSGYVEEAPATVLNSLMEITRPAGAIGIPGLYVTDDPGAQDAAAQRGSL
SIRFGLGWAKSHSFHTGQTPVLKYNRNLMQAILHNRLPIAEIVNVTVIPLDQAPEGYKQFDGGAPRKFVIDPHGLLAA
>Mature_397_residues
SSNRGVVYLGPGQVEVQKIDYPKMVDPSGRAIGHGVILKVVTTNICGSDQHMVRGRTTAPTGLVLGHEITGEVIEIGRDV
ETLKLGDLVSVPFNVACGRCAMCKEQHTGVCLTVNPSRAGGAYGYVDMGGWIGGQSEYVMVPYADFNLLRFPDRDQAMAK
IRDLTCLSDILPTGYHGAVTAGVKPGSTVYIAGAGPVGMAAAASARLLGAACTIVGDMNPARLAHAKAMGFEVVDLSKDA
TLGEQIAEILGTPEIDCAVDCVGFEAHGHGSSGYVEEAPATVLNSLMEITRPAGAIGIPGLYVTDDPGAQDAAAQRGSLS
IRFGLGWAKSHSFHTGQTPVLKYNRNLMQAILHNRLPIAEIVNVTVIPLDQAPEGYKQFDGGAPRKFVIDPHGLLAA

Specific function: Catalyzes the oxidation of long-chain alcohols but is inactive against ethanol [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=204, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI34577061, Length=206, Percent_Identity=33.495145631068, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4501929, Length=205, Percent_Identity=33.1707317073171, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI156627571, Length=280, Percent_Identity=28.2142857142857, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI71743840, Length=226, Percent_Identity=30.5309734513274, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI262073058, Length=226, Percent_Identity=30.5309734513274, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI71565154, Length=212, Percent_Identity=29.7169811320755, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4501939, Length=206, Percent_Identity=30.0970873786408, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI156523966, Length=206, Percent_Identity=30.0970873786408, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786825, Length=400, Percent_Identity=33, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1790045, Length=249, Percent_Identity=30.9236947791165, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790718, Length=269, Percent_Identity=27.5092936802974, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082125, Length=243, Percent_Identity=32.9218106995885, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788073, Length=256, Percent_Identity=29.6875, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI226510992, Length=227, Percent_Identity=33.4801762114537, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787863, Length=217, Percent_Identity=31.7972350230415, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081918, Length=208, Percent_Identity=32.6923076923077, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=235, Percent_Identity=28.936170212766, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=238, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=273, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=273, Percent_Identity=30.7692307692308, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=276, Percent_Identity=30.4347826086957, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=259, Percent_Identity=25.4826254826255, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17137530, Length=246, Percent_Identity=30.0813008130081, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17737895, Length=213, Percent_Identity=30.0469483568075, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR014184
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.2.1.46 [H]

Molecular weight: Translated: 41773; Mature: 41642

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNRGVVYLGPGQVEVQKIDYPKMVDPSGRAIGHGVILKVVTTNICGSDQHMVRGRTTA
CCCCCCEEEECCCEEEEEECCCCCCCCCCCCEECCEEEEEEEEECCCCCCCCEEECCCCC
PTGLVLGHEITGEVIEIGRDVETLKLGDLVSVPFNVACGRCAMCKEQHTGVCLTVNPSRA
CCCEEECCCCCCHHHHHCCCEEEEEECCEEECCCCCCCCCHHHHHCCCCCEEEEECCCCC
GGAYGYVDMGGWIGGQSEYVMVPYADFNLLRFPDRDQAMAKIRDLTCLSDILPTGYHGAV
CCCEEEEECCCEECCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEE
TAGVKPGSTVYIAGAGPVGMAAAASARLLGAACTIVGDMNPARLAHAKAMGFEVVDLSKD
EECCCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEEECCCHHHHHHHHHCCEEEEECCCC
ATLGEQIAEILGTPEIDCAVDCVGFEAHGHGSSGYVEEAPATVLNSLMEITRPAGAIGIP
CHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
GLYVTDDPGAQDAAAQRGSLSIRFGLGWAKSHSFHTGQTPVLKYNRNLMQAILHNRLPIA
EEEEECCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCHH
EIVNVTVIPLDQAPEGYKQFDGGAPRKFVIDPHGLLAA
HHCEEEEEECCCCCCHHHHCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
SSNRGVVYLGPGQVEVQKIDYPKMVDPSGRAIGHGVILKVVTTNICGSDQHMVRGRTTA
CCCCCEEEECCCEEEEEECCCCCCCCCCCCEECCEEEEEEEEECCCCCCCCEEECCCCC
PTGLVLGHEITGEVIEIGRDVETLKLGDLVSVPFNVACGRCAMCKEQHTGVCLTVNPSRA
CCCEEECCCCCCHHHHHCCCEEEEEECCEEECCCCCCCCCHHHHHCCCCCEEEEECCCCC
GGAYGYVDMGGWIGGQSEYVMVPYADFNLLRFPDRDQAMAKIRDLTCLSDILPTGYHGAV
CCCEEEEECCCEECCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEE
TAGVKPGSTVYIAGAGPVGMAAAASARLLGAACTIVGDMNPARLAHAKAMGFEVVDLSKD
EECCCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEEECCCHHHHHHHHHCCEEEEECCCC
ATLGEQIAEILGTPEIDCAVDCVGFEAHGHGSSGYVEEAPATVLNSLMEITRPAGAIGIP
CHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
GLYVTDDPGAQDAAAQRGSLSIRFGLGWAKSHSFHTGQTPVLKYNRNLMQAILHNRLPIA
EEEEECCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCHH
EIVNVTVIPLDQAPEGYKQFDGGAPRKFVIDPHGLLAA
HHCEEEEEECCCCCCHHHHCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]