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The map label for this gene is fabG [H]

Identifier: 73538550

GI number: 73538550

Start: 1425081

End: 1425821

Strand: Direct

Name: fabG [H]

Synonym: Reut_B4725

Alternate gene names: 73538550

Gene position: 1425081-1425821 (Clockwise)

Preceding gene: 73538549

Following gene: 73538552

Centisome position: 52.27

GC content: 63.83

Gene sequence:

>741_bases
ATGACATCCAGCCAATCGCAGCCCAAGGTTGCCCTGGTCATTGGCGCAGGCGATTCCACTGGCGGGGCCATTGCCAGGCG
TTTTGCCCGCGAAGGCTATATCGCCTGCGTCACTCGCCGCGACGCGGACAAACTGCAACCACTCGTCGACAGTATTCGCG
CCGAAGGCGGCCAGGCGTTCGGCTACGGCAGCGATGCGCGCAAGGAAGACGCGGTGGCGGCATTGTTCGAGCAGATCGAA
TCCGAGCATGGGCCGGTCGAGGTTCTCGTGTTCAACATTGGCGCCAACGTACCTTCAAGCATCCTCGAAGAGACTCCGCG
CAAGTACTTCAAGATCTGGGAGATGGCCTGCTTCAGCGGCTTCCTCAACGCCCAGGCGGCGGCCCGCCGGATGGTCGCGC
GCGGCCGGGGCACCATCCTGTTCACGGGCGCCACGGCCGCGTTGCGCGGTGCGGCAAACTTTGCCGCGTTTGCCGGGGCA
AAACACGCGCTGCGCGCGCTGGCGCAAAGCATGGCCCGCGAGCTGGGCCCACAAAACATCCACGTCGCGCATGTGGTCGT
GGACGGCGCCATCGACACCGCGTTCATCCGCGATACGTTTCCCGAACGCTACGCGCTCAAGGACCAGGATGGCATCCTGA
ACCCCGAGCACATCGCAGAGAACTACTGGTACCTGCATAGCCAGCCGCGCGATGCCTGGACTTTTGAGCTGGACCTGCGC
CCTTACATGGAACGCTGGTAA

Upstream 100 bases:

>100_bases
GAATCAAAAGGCTGATCGCTTCCGGCTCCAGTTGCTTGACACCTCGCGACCCGTAACTTAACGTTCGTTCACTAAACGGA
CGTAGACCAAAGGAGACTCC

Downstream 100 bases:

>100_bases
GACGTCGCGCACAGCCGAAGGATGAGGGGCAACGGCAAGCGGCCTCGCCCCGATCAATATCCACGAGCGATCTCGCGCAA
CACCGCGCGCTGCCGCTCGT

Product: Short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MTSSQSQPKVALVIGAGDSTGGAIARRFAREGYIACVTRRDADKLQPLVDSIRAEGGQAFGYGSDARKEDAVAALFEQIE
SEHGPVEVLVFNIGANVPSSILEETPRKYFKIWEMACFSGFLNAQAAARRMVARGRGTILFTGATAALRGAANFAAFAGA
KHALRALAQSMARELGPQNIHVAHVVVDGAIDTAFIRDTFPERYALKDQDGILNPEHIAENYWYLHSQPRDAWTFELDLR
PYMERW

Sequences:

>Translated_246_residues
MTSSQSQPKVALVIGAGDSTGGAIARRFAREGYIACVTRRDADKLQPLVDSIRAEGGQAFGYGSDARKEDAVAALFEQIE
SEHGPVEVLVFNIGANVPSSILEETPRKYFKIWEMACFSGFLNAQAAARRMVARGRGTILFTGATAALRGAANFAAFAGA
KHALRALAQSMARELGPQNIHVAHVVVDGAIDTAFIRDTFPERYALKDQDGILNPEHIAENYWYLHSQPRDAWTFELDLR
PYMERW
>Mature_245_residues
TSSQSQPKVALVIGAGDSTGGAIARRFAREGYIACVTRRDADKLQPLVDSIRAEGGQAFGYGSDARKEDAVAALFEQIES
EHGPVEVLVFNIGANVPSSILEETPRKYFKIWEMACFSGFLNAQAAARRMVARGRGTILFTGATAALRGAANFAAFAGAK
HALRALAQSMARELGPQNIHVAHVVVDGAIDTAFIRDTFPERYALKDQDGILNPEHIAENYWYLHSQPRDAWTFELDLRP
YMERW

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=191, Percent_Identity=30.3664921465969, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI109715829, Length=246, Percent_Identity=23.9837398373984, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI40254992, Length=194, Percent_Identity=25.7731958762887, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787905, Length=232, Percent_Identity=32.3275862068966, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789057, Length=224, Percent_Identity=25.8928571428571, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787335, Length=191, Percent_Identity=28.7958115183246, Blast_Score=65, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640492, Length=209, Percent_Identity=29.1866028708134, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281364892, Length=172, Percent_Identity=29.6511627906977, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24641232, Length=250, Percent_Identity=28.4, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355319, Length=198, Percent_Identity=25.2525252525253, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 27003; Mature: 26872

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSQSQPKVALVIGAGDSTGGAIARRFAREGYIACVTRRDADKLQPLVDSIRAEGGQAF
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCC
GYGSDARKEDAVAALFEQIESEHGPVEVLVFNIGANVPSSILEETPRKYFKIWEMACFSG
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLNAQAAARRMVARGRGTILFTGATAALRGAANFAAFAGAKHALRALAQSMARELGPQNI
HHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
HVAHVVVDGAIDTAFIRDTFPERYALKDQDGILNPEHIAENYWYLHSQPRDAWTFELDLR
EEEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCEEEEEECC
PYMERW
HHHHCC
>Mature Secondary Structure 
TSSQSQPKVALVIGAGDSTGGAIARRFAREGYIACVTRRDADKLQPLVDSIRAEGGQAF
CCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCC
GYGSDARKEDAVAALFEQIESEHGPVEVLVFNIGANVPSSILEETPRKYFKIWEMACFSG
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLNAQAAARRMVARGRGTILFTGATAALRGAANFAAFAGAKHALRALAQSMARELGPQNI
HHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
HVAHVVVDGAIDTAFIRDTFPERYALKDQDGILNPEHIAENYWYLHSQPRDAWTFELDLR
EEEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCEEEEEECC
PYMERW
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7623658; 12788972 [H]