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The map label for this gene is gyaR [H]

Identifier: 73538467

GI number: 73538467

Start: 1326513

End: 1327505

Strand: Direct

Name: gyaR [H]

Synonym: Reut_B4640

Alternate gene names: 73538467

Gene position: 1326513-1327505 (Clockwise)

Preceding gene: 73538463

Following gene: 73538468

Centisome position: 48.66

GC content: 69.49

Gene sequence:

>993_bases
ATGGATGGCGTTCCTATACTCGGCCCATCGACAACCGCTCCAAGACGCCTGCCAGTGAAACCCGCCATCCTGCTCACCCA
GCCCGTAGTTCCCAGTCTCGAAGCCGGCCTCAAGGCAGCCTACGAGATCCACCGCCTGTATGCCGCCGCATCGCCCGACG
CGCTGATCGACGAAGTCGGGCCGCGCATCGAGGGCGTCGTCACGGGCGGCTCGCTCGGCCTGAAGGAATCCGTGATGCGA
CGGTTGCCGGCACTCAAGATCGTCGCGGTGTCCGGCGTCGGCACCGATGCGGTCGACCTGCCCTACGCACGCGGGCGTGG
CATCCACGTCACCACTACGCCCGATGTGCTGACAGCCGATGTCGCCGATCAGGCCATCGGGCTGCTGATCGCGGTGTACC
GCCGGTTGACCGAAGCAGAGCGCTACGTGCGCGCCGGACAGTGGGGCAAGGCGCCGTTGCCGCTCGCGCGCCGTTTCAGC
GGCAAGCGCGTGGGCATCGTCGGACTGGGCCGCGTGGGCCTTGCGATTGCGGTTCGTGCCGCGGCGTTTGGCTGCCCGGT
TTCTTACACCGACCTGCGTGCGATTCCCGATGTGCCCTACACCTTCCTGCCGGACATTGCCGCCCTTGCCTCCCATTGCG
ACGCGCTGGTACTGGCCGCATCGGCCGACGGCGCGAAGCCGGTGGTCGACGCCGCCGTGCTCGATGCGCTGGGACCCGAC
GGCGTGCTGATCAACGTGGCGCGCGGCCGGCTCGTGGACGAGCCCGAGGTGGTGCGTGCGCTCGAAGCGGGCCGCATCGC
GGGCGCCGGGCTAGACGTGTTCGCCGACGAGCCGGCCGTACCACCCGCCCTGCTCGCCATGGACAACGTCGTGATCCAGC
CGCACCGTGCCAGCGCCACGTGGGAGACCCGCGATGCGATGGGCGAGATCGTGCTCGCCAACCTGCGCGCCTGCCTTGCC
GGCGAACGCCCGCCTGCGACGGTGATGGCGTAG

Upstream 100 bases:

>100_bases
CTCGCCCACGGCGATAAAGCAGCGCAATTGGTTCAGATCCGGAATCATTGCATCATGCCAATAGTTGGATTGATCGATGC
AAACTATAGCTTAGACATGC

Downstream 100 bases:

>100_bases
CACGCATCAACCGGTCATCGCATCCCCCTTCATGGATCAGGGCGCCGTCATAGAGCGCCCGGACAAAATTCAGGAGACAC
CATGCAACATCGCGCATTTC

Product: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MDGVPILGPSTTAPRRLPVKPAILLTQPVVPSLEAGLKAAYEIHRLYAAASPDALIDEVGPRIEGVVTGGSLGLKESVMR
RLPALKIVAVSGVGTDAVDLPYARGRGIHVTTTPDVLTADVADQAIGLLIAVYRRLTEAERYVRAGQWGKAPLPLARRFS
GKRVGIVGLGRVGLAIAVRAAAFGCPVSYTDLRAIPDVPYTFLPDIAALASHCDALVLAASADGAKPVVDAAVLDALGPD
GVLINVARGRLVDEPEVVRALEAGRIAGAGLDVFADEPAVPPALLAMDNVVIQPHRASATWETRDAMGEIVLANLRACLA
GERPPATVMA

Sequences:

>Translated_330_residues
MDGVPILGPSTTAPRRLPVKPAILLTQPVVPSLEAGLKAAYEIHRLYAAASPDALIDEVGPRIEGVVTGGSLGLKESVMR
RLPALKIVAVSGVGTDAVDLPYARGRGIHVTTTPDVLTADVADQAIGLLIAVYRRLTEAERYVRAGQWGKAPLPLARRFS
GKRVGIVGLGRVGLAIAVRAAAFGCPVSYTDLRAIPDVPYTFLPDIAALASHCDALVLAASADGAKPVVDAAVLDALGPD
GVLINVARGRLVDEPEVVRALEAGRIAGAGLDVFADEPAVPPALLAMDNVVIQPHRASATWETRDAMGEIVLANLRACLA
GERPPATVMA
>Mature_330_residues
MDGVPILGPSTTAPRRLPVKPAILLTQPVVPSLEAGLKAAYEIHRLYAAASPDALIDEVGPRIEGVVTGGSLGLKESVMR
RLPALKIVAVSGVGTDAVDLPYARGRGIHVTTTPDVLTADVADQAIGLLIAVYRRLTEAERYVRAGQWGKAPLPLARRFS
GKRVGIVGLGRVGLAIAVRAAAFGCPVSYTDLRAIPDVPYTFLPDIAALASHCDALVLAASADGAKPVVDAAVLDALGPD
GVLINVARGRLVDEPEVVRALEAGRIAGAGLDVFADEPAVPPALLAMDNVVIQPHRASATWETRDAMGEIVLANLRACLA
GERPPATVMA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=37.3015873015873, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI23308577, Length=269, Percent_Identity=30.4832713754647, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI4557497, Length=292, Percent_Identity=28.7671232876712, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI61743967, Length=292, Percent_Identity=28.7671232876712, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580578, Length=302, Percent_Identity=27.4834437086093, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4557499, Length=302, Percent_Identity=27.4834437086093, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=28.1021897810219, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI87082289, Length=314, Percent_Identity=31.5286624203822, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789279, Length=244, Percent_Identity=31.1475409836066, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787645, Length=268, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=220, Percent_Identity=27.7272727272727, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25147481, Length=279, Percent_Identity=25.8064516129032, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=240, Percent_Identity=29.1666666666667, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322116, Length=335, Percent_Identity=26.2686567164179, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=320, Percent_Identity=25.9375, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=217, Percent_Identity=24.4239631336406, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=34.8242811501597, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=34.8242811501597, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=34.8242811501597, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=34.8242811501597, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=34.8242811501597, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28571528, Length=254, Percent_Identity=38.1889763779528, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574286, Length=249, Percent_Identity=34.5381526104418, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI62472511, Length=290, Percent_Identity=28.6206896551724, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646446, Length=290, Percent_Identity=28.6206896551724, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24646448, Length=290, Percent_Identity=28.6206896551724, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24646452, Length=290, Percent_Identity=28.6206896551724, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24646450, Length=290, Percent_Identity=28.6206896551724, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24585516, Length=246, Percent_Identity=30.4878048780488, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19921140, Length=230, Percent_Identity=27.8260869565217, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34268; Mature: 34268

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGVPILGPSTTAPRRLPVKPAILLTQPVVPSLEAGLKAAYEIHRLYAAASPDALIDEVG
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
PRIEGVVTGGSLGLKESVMRRLPALKIVAVSGVGTDAVDLPYARGRGIHVTTTPDVLTAD
CCEEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCEEHH
VADQAIGLLIAVYRRLTEAERYVRAGQWGKAPLPLARRFSGKRVGIVGLGRVGLAIAVRA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEEEEEECHHHHHHHHHH
AAFGCPVSYTDLRAIPDVPYTFLPDIAALASHCDALVLAASADGAKPVVDAAVLDALGPD
HHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCC
GVLINVARGRLVDEPEVVRALEAGRIAGAGLDVFADEPAVPPALLAMDNVVIQPHRASAT
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHCCEEECCCCCCCC
WETRDAMGEIVLANLRACLAGERPPATVMA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDGVPILGPSTTAPRRLPVKPAILLTQPVVPSLEAGLKAAYEIHRLYAAASPDALIDEVG
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
PRIEGVVTGGSLGLKESVMRRLPALKIVAVSGVGTDAVDLPYARGRGIHVTTTPDVLTAD
CCEEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCEEHH
VADQAIGLLIAVYRRLTEAERYVRAGQWGKAPLPLARRFSGKRVGIVGLGRVGLAIAVRA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEEEEEECHHHHHHHHHH
AAFGCPVSYTDLRAIPDVPYTFLPDIAALASHCDALVLAASADGAKPVVDAAVLDALGPD
HHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCC
GVLINVARGRLVDEPEVVRALEAGRIAGAGLDVFADEPAVPPALLAMDNVVIQPHRASAT
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHCCEEECCCCCCCC
WETRDAMGEIVLANLRACLAGERPPATVMA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA