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The map label for this gene is ybhO [H]

Identifier: 73538436

GI number: 73538436

Start: 1296300

End: 1297553

Strand: Reverse

Name: ybhO [H]

Synonym: Reut_B4609

Alternate gene names: 73538436

Gene position: 1297553-1296300 (Counterclockwise)

Preceding gene: 73538437

Following gene: 73538435

Centisome position: 47.6

GC content: 65.07

Gene sequence:

>1254_bases
ATGGACCACGGATGGACGACGGGCAACCGGTTTCGCTTACTGGAGAACGGGGAGGAATACTTCCCCAGGCTGATTGCGGC
CCTGAACGCCGCGCATACCAGTGTGCTGCTGGAAACGTTCATCCTGGCCGAGGATGACGTCGGTTGCCGGCTCGCCGAAG
CGCTGGCCGCCGCAGCGCGACGGGGCGTGCAGGTAGCGCTGACCGTCGATGGTTTCGGATCGGCCGATCTGTCTGCCGAC
TATATGGTGAGGTTGACGCAGGCAGGCGTTGCGGTGCGCATGTTCTCGCCGGGCCGCCGGCTGTTGGGCAAACGTGCCAA
TCTCTTCCGCCGGTTGCACCGCAAGCTGGTGGCCATCGACGCATCCGTCGCGTTCGTCGGCGGGATCAACCTGTGCGTCG
ATCATCTTGTCCAGGCAAGCCCCATCGCCAAACAGGACTACGCGGTGGAGGTACAAGGGCCCGCTGCAGAAGCCATCCAC
AGGTTCATGCTGGAAGCGATTGGCGCCGGGGCCAAATGGCCACAGGCCATGCGCTGGCGGCGTCCGGCGGCGCGCGGCAA
CGCGGCTTTTGACGCTGACTTGCCAGGTGCCGCCTTGCTTGTGACACGGGACAACCGGGCACATCGGAGCGACATCGAGC
GGCACTACCTGATGGCGATCCGCGCGGCGCGGCGCGAGATCGTCATTGCCAATGCGTACTTCCTGCCCGGCTATCGCCTG
CTGCAGGCGATCTGCGCCGCGGCGCAGCGCGGCGTCGATGTGAGGCTGATCTTGCAAGGCAGGCCGGACATGGTGTGGGT
CAAGCGCACCGTCGACATGTTGTACGCCCACTTGCGTGAATCGGGTGTGCGGATTTTCGAGTACTGCGAGCGTCCCAACC
ATAGCAAGGTGGCCGTGGTGGACGATGACTGGGCCACGGTGGGATCGAGCAATCTCGATCCCCTGAGCCTGTCGCTGAAC
CTCGAAGCCAATCTCGTGATTCGCGATGGCGCGTTCGTCGCCACGCTAAAGGACACCCTGCGCGACCTGATGGTCCGCAG
TTGCACGGAGATATCCGCCGTCGAGCGCGGACAGGGCGCGTGGTGGCATGGCATCGCCACGCCGCTGATCTTCCACTTCC
TGCGCAAGTTTCCCGCCTGGGCCGGATGGCTGCCGGCCCATACGCCCCGGTTGGTGTCGCCGGAGATTCCGGCGGCCGGC
GTTGCGCCGCCGGCAGACATGGCCGTGCACAACGTTCAACGGGATGGCTCATGA

Upstream 100 bases:

>100_bases
AGGCTGACCATGGGCACGCCCGGGCGGCGGCGGCGACGCCGGATTCGCCACCCGTGACGTCGACATGCGCGAATGGCACC
AATCCTGCTAGTTGCCGGAA

Downstream 100 bases:

>100_bases
CAAGCACTACCGCTCTGCGCCGTGCGTTTCGACGCGGCATCCGCTGGTCGACCATCAAACGCGTGAGCGGCATCTTATTC
GCGGCGCTGGTCGTTTACCT

Product: cardiolipin synthase 2

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDHGWTTGNRFRLLENGEEYFPRLIAALNAAHTSVLLETFILAEDDVGCRLAEALAAAARRGVQVALTVDGFGSADLSAD
YMVRLTQAGVAVRMFSPGRRLLGKRANLFRRLHRKLVAIDASVAFVGGINLCVDHLVQASPIAKQDYAVEVQGPAAEAIH
RFMLEAIGAGAKWPQAMRWRRPAARGNAAFDADLPGAALLVTRDNRAHRSDIERHYLMAIRAARREIVIANAYFLPGYRL
LQAICAAAQRGVDVRLILQGRPDMVWVKRTVDMLYAHLRESGVRIFEYCERPNHSKVAVVDDDWATVGSSNLDPLSLSLN
LEANLVIRDGAFVATLKDTLRDLMVRSCTEISAVERGQGAWWHGIATPLIFHFLRKFPAWAGWLPAHTPRLVSPEIPAAG
VAPPADMAVHNVQRDGS

Sequences:

>Translated_417_residues
MDHGWTTGNRFRLLENGEEYFPRLIAALNAAHTSVLLETFILAEDDVGCRLAEALAAAARRGVQVALTVDGFGSADLSAD
YMVRLTQAGVAVRMFSPGRRLLGKRANLFRRLHRKLVAIDASVAFVGGINLCVDHLVQASPIAKQDYAVEVQGPAAEAIH
RFMLEAIGAGAKWPQAMRWRRPAARGNAAFDADLPGAALLVTRDNRAHRSDIERHYLMAIRAARREIVIANAYFLPGYRL
LQAICAAAQRGVDVRLILQGRPDMVWVKRTVDMLYAHLRESGVRIFEYCERPNHSKVAVVDDDWATVGSSNLDPLSLSLN
LEANLVIRDGAFVATLKDTLRDLMVRSCTEISAVERGQGAWWHGIATPLIFHFLRKFPAWAGWLPAHTPRLVSPEIPAAG
VAPPADMAVHNVQRDGS
>Mature_417_residues
MDHGWTTGNRFRLLENGEEYFPRLIAALNAAHTSVLLETFILAEDDVGCRLAEALAAAARRGVQVALTVDGFGSADLSAD
YMVRLTQAGVAVRMFSPGRRLLGKRANLFRRLHRKLVAIDASVAFVGGINLCVDHLVQASPIAKQDYAVEVQGPAAEAIH
RFMLEAIGAGAKWPQAMRWRRPAARGNAAFDADLPGAALLVTRDNRAHRSDIERHYLMAIRAARREIVIANAYFLPGYRL
LQAICAAAQRGVDVRLILQGRPDMVWVKRTVDMLYAHLRESGVRIFEYCERPNHSKVAVVDDDWATVGSSNLDPLSLSLN
LEANLVIRDGAFVATLKDTLRDLMVRSCTEISAVERGQGAWWHGIATPLIFHFLRKFPAWAGWLPAHTPRLVSPEIPAAG
VAPPADMAVHNVQRDGS

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=408, Percent_Identity=50.2450980392157, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1787502, Length=348, Percent_Identity=29.0229885057471, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 45884; Mature: 45884

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHGWTTGNRFRLLENGEEYFPRLIAALNAAHTSVLLETFILAEDDVGCRLAEALAAAAR
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RGVQVALTVDGFGSADLSADYMVRLTQAGVAVRMFSPGRRLLGKRANLFRRLHRKLVAID
CCEEEEEEECCCCCCCCCHHHHEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
ASVAFVGGINLCVDHLVQASPIAKQDYAVEVQGPAAEAIHRFMLEAIGAGAKWPQAMRWR
CHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHC
RPAARGNAAFDADLPGAALLVTRDNRAHRSDIERHYLMAIRAARREIVIANAYFLPGYRL
CCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEECCHHHH
LQAICAAAQRGVDVRLILQGRPDMVWVKRTVDMLYAHLRESGVRIFEYCERPNHSKVAVV
HHHHHHHHHCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEE
DDDWATVGSSNLDPLSLSLNLEANLVIRDGAFVATLKDTLRDLMVRSCTEISAVERGQGA
CCCCCCCCCCCCCCEEEEEEEEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
WWHGIATPLIFHFLRKFPAWAGWLPAHTPRLVSPEIPAAGVAPPADMAVHNVQRDGS
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MDHGWTTGNRFRLLENGEEYFPRLIAALNAAHTSVLLETFILAEDDVGCRLAEALAAAAR
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RGVQVALTVDGFGSADLSADYMVRLTQAGVAVRMFSPGRRLLGKRANLFRRLHRKLVAID
CCEEEEEEECCCCCCCCCHHHHEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHC
ASVAFVGGINLCVDHLVQASPIAKQDYAVEVQGPAAEAIHRFMLEAIGAGAKWPQAMRWR
CHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHC
RPAARGNAAFDADLPGAALLVTRDNRAHRSDIERHYLMAIRAARREIVIANAYFLPGYRL
CCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEECCHHHH
LQAICAAAQRGVDVRLILQGRPDMVWVKRTVDMLYAHLRESGVRIFEYCERPNHSKVAVV
HHHHHHHHHCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEE
DDDWATVGSSNLDPLSLSLNLEANLVIRDGAFVATLKDTLRDLMVRSCTEISAVERGQGA
CCCCCCCCCCCCCCEEEEEEEEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
WWHGIATPLIFHFLRKFPAWAGWLPAHTPRLVSPEIPAAGVAPPADMAVHNVQRDGS
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]