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The map label for this gene is fadE12 [H]

Identifier: 73538346

GI number: 73538346

Start: 1189793

End: 1190959

Strand: Reverse

Name: fadE12 [H]

Synonym: Reut_B4519

Alternate gene names: 73538346

Gene position: 1190959-1189793 (Counterclockwise)

Preceding gene: 73538347

Following gene: 73538345

Centisome position: 43.69

GC content: 63.75

Gene sequence:

>1167_bases
ATGAATTTCGATCTCTCCGCCGAACAGCAGTCGATCGTTGAAGCCGTGCAGCAGGTCTGCGGCCAGTTCGACATGGAATA
CTGGAACAAGCTGGACGTCTCCCACACCTATCCGCACGAGTTCTACAAGACGCTGTGCGAAGGCGGCTGGCTCGGCGTTG
CCATGCCGGAACAGTATGGCGGTGCGGGTCTGGGCATCCTGGAAGCAGCCCTCGTTATGCAGACCATCTCGGAGTCCGGC
GCGGGCATGAGCGGCGCTTCGGCGGTGCACATGAACGTGTTCGGCCTGAACCCGGTGGTGGTGTTCGGCACCGACGAGCA
AAAGGCGCGCTTCCTGCCGCCGCTGATCGCCGGCAAGGAGAAGGCCTGCTTTGGCGTGACCGAGCCCGACGCGGGCCTCG
ACACCACCAAGCTCAAGACCTTCGCGCGCAAGGTGGAGGGCGGCTATTCGGTGACGGGACGCAAGATCTGGATCTCCACC
GCTCAGGTCGCGGACCGCATGCTGCTGCTGGCGCGCACCACGCCGCTCGAATCGGTGAAGAAGCCGACCGAAGGCCTGTC
GCTGTTCTATACGAAGGTCGACCGCAGCAAGATCGAAATCCGCGAGATCGACAAGATGGGCCGCTCGGCCGTCGATACCA
ATATGCTGTTCATCGACGACCTGTTCATCCCCGAGGAAGACCGTATCGGCGAGGAAGGGCGTGGCTTCGAGTACATCCTG
CACGGCCTGAACCCCGAGCGCATCCTGATCGCCGCCGAGGCCATCGGCCTGGGCCGCGCGGCGCTGGCCATTGCTACGCA
GTATGCAAAGGAGCGCGTGGTGTTCGGCCGGCCTATCGGCATGAACCAGGGCGTGCAGCACCCGCTCGCACAGGCGTGGA
TGCAGCTTGAAGCGGCCAACCTGATGATGTTGAAGGCTGCCGCGCGCTACGACGCGGGCGAGTCCTGCGGCGCCGAGGCC
AACACTGCCAAATACCTCGCAGCCGAAGCTGGCCACAATGCTTGCCAGACTGCCATCCTGACGCTTGGCGGCATGGGCTA
TTCGCGCGAATACCGCGTGGAGCGGTTGCTGCGCGAGTCGTATATCCCGCGCATCGCGCCGGTGAGCCCGCAGCTCATCA
TGTGCTTTATCGCCGAGCGCGTGCTGGGCTTGCCGAAGTCGTACTGA

Upstream 100 bases:

>100_bases
CGAGCTGGGCCAGTTTGTCACGGCGGAACTGCAGAAGTGGTCGCGTCTGGTGAAGGATGCGGGAATCCAGCCGGAATAAG
AAAGCACAAGGAACACCGAT

Downstream 100 bases:

>100_bases
GCGAGGGATAGCGATGACGATGCCGAACGCGGGCACAACGCCCAAGGCCACCGGACCGCTCGCGGGCGTGCGCGTGGTCG
ATATGACCTCGGTCGGTATG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNFDLSAEQQSIVEAVQQVCGQFDMEYWNKLDVSHTYPHEFYKTLCEGGWLGVAMPEQYGGAGLGILEAALVMQTISESG
AGMSGASAVHMNVFGLNPVVVFGTDEQKARFLPPLIAGKEKACFGVTEPDAGLDTTKLKTFARKVEGGYSVTGRKIWIST
AQVADRMLLLARTTPLESVKKPTEGLSLFYTKVDRSKIEIREIDKMGRSAVDTNMLFIDDLFIPEEDRIGEEGRGFEYIL
HGLNPERILIAAEAIGLGRAALAIATQYAKERVVFGRPIGMNQGVQHPLAQAWMQLEAANLMMLKAAARYDAGESCGAEA
NTAKYLAAEAGHNACQTAILTLGGMGYSREYRVERLLRESYIPRIAPVSPQLIMCFIAERVLGLPKSY

Sequences:

>Translated_388_residues
MNFDLSAEQQSIVEAVQQVCGQFDMEYWNKLDVSHTYPHEFYKTLCEGGWLGVAMPEQYGGAGLGILEAALVMQTISESG
AGMSGASAVHMNVFGLNPVVVFGTDEQKARFLPPLIAGKEKACFGVTEPDAGLDTTKLKTFARKVEGGYSVTGRKIWIST
AQVADRMLLLARTTPLESVKKPTEGLSLFYTKVDRSKIEIREIDKMGRSAVDTNMLFIDDLFIPEEDRIGEEGRGFEYIL
HGLNPERILIAAEAIGLGRAALAIATQYAKERVVFGRPIGMNQGVQHPLAQAWMQLEAANLMMLKAAARYDAGESCGAEA
NTAKYLAAEAGHNACQTAILTLGGMGYSREYRVERLLRESYIPRIAPVSPQLIMCFIAERVLGLPKSY
>Mature_388_residues
MNFDLSAEQQSIVEAVQQVCGQFDMEYWNKLDVSHTYPHEFYKTLCEGGWLGVAMPEQYGGAGLGILEAALVMQTISESG
AGMSGASAVHMNVFGLNPVVVFGTDEQKARFLPPLIAGKEKACFGVTEPDAGLDTTKLKTFARKVEGGYSVTGRKIWIST
AQVADRMLLLARTTPLESVKKPTEGLSLFYTKVDRSKIEIREIDKMGRSAVDTNMLFIDDLFIPEEDRIGEEGRGFEYIL
HGLNPERILIAAEAIGLGRAALAIATQYAKERVVFGRPIGMNQGVQHPLAQAWMQLEAANLMMLKAAARYDAGESCGAEA
NTAKYLAAEAGHNACQTAILTLGGMGYSREYRVERLLRESYIPRIAPVSPQLIMCFIAERVLGLPKSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=28.9473684210526, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=28.9473684210526, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI4557233, Length=354, Percent_Identity=32.4858757062147, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4501859, Length=339, Percent_Identity=32.1533923303835, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI226958412, Length=364, Percent_Identity=29.1208791208791, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI226958414, Length=328, Percent_Identity=30.4878048780488, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4501857, Length=349, Percent_Identity=29.7994269340974, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI7656849, Length=372, Percent_Identity=28.2258064516129, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI76496475, Length=385, Percent_Identity=29.0909090909091, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4557235, Length=385, Percent_Identity=29.0909090909091, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI21361497, Length=354, Percent_Identity=27.683615819209, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI48976061, Length=307, Percent_Identity=28.6644951140065, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI211971008, Length=307, Percent_Identity=28.6644951140065, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI38505218, Length=274, Percent_Identity=29.1970802919708, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI7669494, Length=318, Percent_Identity=27.6729559748428, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4503943, Length=318, Percent_Identity=27.6729559748428, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=29.3193717277487, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=26.8929503916449, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI87082384, Length=296, Percent_Identity=29.3918918918919, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87081702, Length=374, Percent_Identity=25.9358288770053, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=30.2325581395349, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=32.2751322751323, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17569725, Length=389, Percent_Identity=31.1053984575836, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17538396, Length=366, Percent_Identity=28.9617486338798, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17506239, Length=336, Percent_Identity=29.1666666666667, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17508101, Length=379, Percent_Identity=27.9683377308707, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71990804, Length=314, Percent_Identity=30.2547770700637, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=29.2957746478873, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=27.2727272727273, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17505929, Length=343, Percent_Identity=27.6967930029155, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=28.9473684210526, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17533517, Length=392, Percent_Identity=25, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71985192, Length=289, Percent_Identity=27.3356401384083, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17534353, Length=302, Percent_Identity=26.158940397351, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=25.1824817518248, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=25.7142857142857, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562446, Length=291, Percent_Identity=26.4604810996564, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=261, Percent_Identity=29.5019157088123, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI86563383, Length=261, Percent_Identity=29.5019157088123, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356377, Length=354, Percent_Identity=31.9209039548023, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24666513, Length=378, Percent_Identity=30.4232804232804, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=29.1338582677165, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=31.4516129032258, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI281363737, Length=383, Percent_Identity=28.9817232375979, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI21355753, Length=342, Percent_Identity=28.0701754385965, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI19920834, Length=298, Percent_Identity=28.1879194630872, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42488; Mature: 42488

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDLSAEQQSIVEAVQQVCGQFDMEYWNKLDVSHTYPHEFYKTLCEGGWLGVAMPEQYG
CCCCCCCHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHCCCCEEEECCHHCC
GAGLGILEAALVMQTISESGAGMSGASAVHMNVFGLNPVVVFGTDEQKARFLPPLIAGKE
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEECCCCCCHHCCCHHHCCCC
KACFGVTEPDAGLDTTKLKTFARKVEGGYSVTGRKIWISTAQVADRMLLLARTTPLESVK
CCEECCCCCCCCCCHHHHHHHHHHHCCCCEECCCEEEEEHHHHHHHHHHHHCCCCHHHHH
KPTEGLSLFYTKVDRSKIEIREIDKMGRSAVDTNMLFIDDLFIPEEDRIGEEGRGFEYIL
CCCCCCEEEEEECCCCHHHHHHHHHHCCHHHCCCEEEEEEECCCCHHCCCCCCCCHHHHE
HGLNPERILIAAEAIGLGRAALAIATQYAKERVVFGRPIGMNQGVQHPLAQAWMQLEAAN
ECCCCCEEEEEEHHHCCCHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHH
LMMLKAAARYDAGESCGAEANTAKYLAAEAGHNACQTAILTLGGMGYSREYRVERLLRES
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YIPRIAPVSPQLIMCFIAERVLGLPKSY
CCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNFDLSAEQQSIVEAVQQVCGQFDMEYWNKLDVSHTYPHEFYKTLCEGGWLGVAMPEQYG
CCCCCCCHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHCCCCEEEECCHHCC
GAGLGILEAALVMQTISESGAGMSGASAVHMNVFGLNPVVVFGTDEQKARFLPPLIAGKE
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEECCCCCCHHCCCHHHCCCC
KACFGVTEPDAGLDTTKLKTFARKVEGGYSVTGRKIWISTAQVADRMLLLARTTPLESVK
CCEECCCCCCCCCCHHHHHHHHHHHCCCCEECCCEEEEEHHHHHHHHHHHHCCCCHHHHH
KPTEGLSLFYTKVDRSKIEIREIDKMGRSAVDTNMLFIDDLFIPEEDRIGEEGRGFEYIL
CCCCCCEEEEEECCCCHHHHHHHHHHCCHHHCCCEEEEEEECCCCHHCCCCCCCCHHHHE
HGLNPERILIAAEAIGLGRAALAIATQYAKERVVFGRPIGMNQGVQHPLAQAWMQLEAAN
ECCCCCEEEEEEHHHCCCHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHH
LMMLKAAARYDAGESCGAEANTAKYLAAEAGHNACQTAILTLGGMGYSREYRVERLLRES
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
YIPRIAPVSPQLIMCFIAERVLGLPKSY
CCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]