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The map label for this gene is degP [H]

Identifier: 73538306

GI number: 73538306

Start: 1146200

End: 1147123

Strand: Reverse

Name: degP [H]

Synonym: Reut_B4479

Alternate gene names: 73538306

Gene position: 1147123-1146200 (Counterclockwise)

Preceding gene: 73538308

Following gene: 73538305

Centisome position: 42.08

GC content: 64.61

Gene sequence:

>924_bases
ATGAAGCGTGTGGCGATCTACAGATGGATCTCGGCCGGGCTGGCGCTTGCCGCCGTGGCAGTGCTGGCCTTTGCCTGGCA
TTTGCGACCGTCGCAGCGCGTGATTACGCAGGCCGATATCGACGCGGCGGTGCTGCACACGTTGCAGACCAAGAGCCTGC
CGTCACGCACGGCCCGCGCGGCCGAGGCGATTCGCGAGTCGGTGGTGGAGATCCGCAGCTTTTCGCCTGCAGACCCCAGT
GAGGAAGCGGCGTCCGCGCCGCGTGCGCGGCGTGATGCGCCGGCCACACGTCCGAAATCCTCCCAGCCATCTCGACGCAA
GCCGCACGACGAACTCGCCAAGGCCGCTCCGCCCGCAGGCACGGACGTACCGACAGAGAAGCGTGAAGCGAGTCACATCG
GTTCGGGCGTGGTCATCACCGAAAGCGGGCTCGTTCTGACCAGCTATCACGTCGTTGCCGATGCCAAGCGTGTGGAGGTC
ATGTTCCACGACGGCCAGACTTCCGAGGCTTCAGTGCTTCAGGCCATCCCCGAAAAAGACCTTGCCGTGGTCAAGCCGAA
GTCCATCCCCGACGACCTGCCGGCCGCGACGCTGGGCTCCAGCCGCAATCTCGCGCCGGGTGCGGAGGTCGTCGCGGTCG
GCTTCCCGTTCGGCATCGGGCCGTCGGTGTCGGCGGGCGTCGTATCGGGCCTTGATCGCCAGTTCATTTCGCCGGACGCC
AGGCAGAGCCTGGACAACCTCATCCAGTTTGATGCCGCGGCCAACCCCGGCAATTCCGGCGGGCCGCTGATCAATATGGA
TGGCGAAGTGGTGGGAATCGTCACGGCCATCCTCAATCCCAACAAGAGCGGTACATTCCTTGGCATCGGTTTTGCGGTGA
CGATCGAAAGTGCCGGCGTTTCCATCGGATCTTCTCCTTTCTGA

Upstream 100 bases:

>100_bases
GCATTTGCGGCCAGAGAAACTGCATGCTCTGCTCCTTGGCGCGTGGTTAAGAGGATGGTACTGTATTTTCAAGGGCGGCA
CGGGACCTCGGGAGTTGGCG

Downstream 100 bases:

>100_bases
AAGCGGAGGCCTATGAACGAGCAAGCCCGTGGCGCCATCGACAGCGCCGATCTGATGGAGCGCCTGCTGTACGAGGTGAA
ACGTGTGGTCGTCGGTCAGG

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MKRVAIYRWISAGLALAAVAVLAFAWHLRPSQRVITQADIDAAVLHTLQTKSLPSRTARAAEAIRESVVEIRSFSPADPS
EEAASAPRARRDAPATRPKSSQPSRRKPHDELAKAAPPAGTDVPTEKREASHIGSGVVITESGLVLTSYHVVADAKRVEV
MFHDGQTSEASVLQAIPEKDLAVVKPKSIPDDLPAATLGSSRNLAPGAEVVAVGFPFGIGPSVSAGVVSGLDRQFISPDA
RQSLDNLIQFDAAANPGNSGGPLINMDGEVVGIVTAILNPNKSGTFLGIGFAVTIESAGVSIGSSPF

Sequences:

>Translated_307_residues
MKRVAIYRWISAGLALAAVAVLAFAWHLRPSQRVITQADIDAAVLHTLQTKSLPSRTARAAEAIRESVVEIRSFSPADPS
EEAASAPRARRDAPATRPKSSQPSRRKPHDELAKAAPPAGTDVPTEKREASHIGSGVVITESGLVLTSYHVVADAKRVEV
MFHDGQTSEASVLQAIPEKDLAVVKPKSIPDDLPAATLGSSRNLAPGAEVVAVGFPFGIGPSVSAGVVSGLDRQFISPDA
RQSLDNLIQFDAAANPGNSGGPLINMDGEVVGIVTAILNPNKSGTFLGIGFAVTIESAGVSIGSSPF
>Mature_307_residues
MKRVAIYRWISAGLALAAVAVLAFAWHLRPSQRVITQADIDAAVLHTLQTKSLPSRTARAAEAIRESVVEIRSFSPADPS
EEAASAPRARRDAPATRPKSSQPSRRKPHDELAKAAPPAGTDVPTEKREASHIGSGVVITESGLVLTSYHVVADAKRVEV
MFHDGQTSEASVLQAIPEKDLAVVKPKSIPDDLPAATLGSSRNLAPGAEVVAVGFPFGIGPSVSAGVVSGLDRQFISPDA
RQSLDNLIQFDAAANPGNSGGPLINMDGEVVGIVTAILNPNKSGTFLGIGFAVTIESAGVSIGSSPF

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=185, Percent_Identity=38.3783783783784, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI22129776, Length=193, Percent_Identity=36.7875647668394, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI24308541, Length=142, Percent_Identity=40.1408450704225, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI7019477, Length=185, Percent_Identity=36.7567567567568, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786356, Length=162, Percent_Identity=41.358024691358, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1789629, Length=176, Percent_Identity=38.6363636363636, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1789630, Length=236, Percent_Identity=31.3559322033898, Blast_Score=100, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646839, Length=245, Percent_Identity=31.8367346938775, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 31957; Mature: 31957

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVAIYRWISAGLALAAVAVLAFAWHLRPSQRVITQADIDAAVLHTLQTKSLPSRTARA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHCCCCHHHHHH
AEAIRESVVEIRSFSPADPSEEAASAPRARRDAPATRPKSSQPSRRKPHDELAKAAPPAG
HHHHHHHHHHHHCCCCCCCCHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
TDVPTEKREASHIGSGVVITESGLVLTSYHVVADAKRVEVMFHDGQTSEASVLQAIPEKD
CCCCCCHHHHHHCCCCEEEECCCEEEEEEHHHCCCEEEEEEEECCCCCHHHHHHHCCCCC
LAVVKPKSIPDDLPAATLGSSRNLAPGAEVVAVGFPFGIGPSVSAGVVSGLDRQFISPDA
EEEECCCCCCCCCCHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHH
RQSLDNLIQFDAAANPGNSGGPLINMDGEVVGIVTAILNPNKSGTFLGIGFAVTIESAGV
HHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEEEHCCCCCCCCEEEEEEEEEEECCCC
SIGSSPF
CCCCCCC
>Mature Secondary Structure
MKRVAIYRWISAGLALAAVAVLAFAWHLRPSQRVITQADIDAAVLHTLQTKSLPSRTARA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHCCCCHHHHHH
AEAIRESVVEIRSFSPADPSEEAASAPRARRDAPATRPKSSQPSRRKPHDELAKAAPPAG
HHHHHHHHHHHHCCCCCCCCHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
TDVPTEKREASHIGSGVVITESGLVLTSYHVVADAKRVEVMFHDGQTSEASVLQAIPEKD
CCCCCCHHHHHHCCCCEEEECCCEEEEEEHHHCCCEEEEEEEECCCCCHHHHHHHCCCCC
LAVVKPKSIPDDLPAATLGSSRNLAPGAEVVAVGFPFGIGPSVSAGVVSGLDRQFISPDA
EEEECCCCCCCCCCHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHH
RQSLDNLIQFDAAANPGNSGGPLINMDGEVVGIVTAILNPNKSGTFLGIGFAVTIESAGV
HHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEEEHCCCCCCCCEEEEEEEEEEECCCC
SIGSSPF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]