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The map label for this gene is chaA [C]

Identifier: 73538228

GI number: 73538228

Start: 1056198

End: 1057283

Strand: Direct

Name: chaA [C]

Synonym: Reut_B4399

Alternate gene names: 73538228

Gene position: 1056198-1057283 (Clockwise)

Preceding gene: 73538227

Following gene: 73538231

Centisome position: 38.74

GC content: 67.13

Gene sequence:

>1086_bases
ATGGCACTGACTTCCAACAAGCTGCCGGCGTGGACCGTGTGGGCCCCGCTTGCCGCGGCGGCGATTCTCGCCGCCGGACT
TGGCTTGCCCACCCAGGGCTGGCTGATCATGCTGATGGCGCCCGCGCTGGCCGGCGCGGTGTTCGCCGCCGTACATCATG
CGGAAGTGGTCGCCCATAAGGTCGGAGAACCGTTCGGCACGCTGGTGCTCGCCATTGCGGTGACCGTGATCGAGGTTGCG
TTGATCGTCTCCGTAATGCTGTCATCCGGGCCTGAGAAAGCCGGCCTTGCGCGTGACACGGTGTTCGCCGCGGTCATGCT
GATCTGCAATGGCATCGTCGGTCTATGCCTGTTCGTCGGCGGGCTGCACCATCGCGAGCAGGTGTTCCAGGCACCGGGCG
CAAATGCCGCCATGGCTGTGCTGGCTGCGCTGCTGGTGCTGACCATGGTGCTGCCCAACTACACCAGCAGTTCGCCGGGC
CCGGTGCTCACGCCCGCGCAACTTGGCTTTGCCGGCGTGATGTCGCTCGTGCTGTATGGCTCGTTCGTGTTCGTGCAGAC
CGTGCGCCACCGCGACTATTTCCTTGCGGAAGGCAGCTCGGACGAGAACGTCCACGCCCCGCCCCCGCCAGGCCGTGTGG
CTGCGATCAGCGGTTTGCTGCTGGTGGTCTGCCTGGTGCTCGTCGTCGGTCTGGCCAAGCTGCTGTCGCCGTCGGTGGAG
GCCGCCGTGTTGCGTGCCGGCGCGCCCGCCGCGGTGGTCGGAATCATCATCGCGGCCATGGTGCTGCTGCCCGAAGGCCT
GGCCGCGTTGCGCGCGGCGCGAGCGGACCGGCTCCAGACGAGCCTGAACCTCGCGCTCGGCTCCGCACTGGCCAGCATCG
GCCTGACCATTCCGGCCGTGGCGGCAGTCTTCATCTGGATCGGGCAACCGCTCGAACTCGGACTCGGCGCCAAGGAAACG
GTGCTGCTGATGCTGACGCTGGTGGTGTCGTCGCTCACGCTGGGCAGGGGCCGAACCACGATCCTGCAAGGTGTCGTGCA
CCTTGTGATCCTGGCCGCCTACCTGTTCCTGTCGGTAGTGCCCTGA

Upstream 100 bases:

>100_bases
GGCGCCAGCCACCCTTCTGCTTCGTGCCGGGCATCAATCACCCGCACGTCTCGATGCCGCCGCCCGGCGGCCACATAAAA
CTAGAAAGGAAAAAACAGGG

Downstream 100 bases:

>100_bases
ACGGACACTCCCGCTGGCTCACGCGCGACGGTAGTGCGCGAGCTTGTCTTCATCGAGCGCGAGGCCCAGTCCCGGGCCTG
CGGGCAGGTGCAGGCTGAAA

Product: Sodium/calcium exchanger membrane region

Products: Na (I) [Periplasm]; Ca (II) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MALTSNKLPAWTVWAPLAAAAILAAGLGLPTQGWLIMLMAPALAGAVFAAVHHAEVVAHKVGEPFGTLVLAIAVTVIEVA
LIVSVMLSSGPEKAGLARDTVFAAVMLICNGIVGLCLFVGGLHHREQVFQAPGANAAMAVLAALLVLTMVLPNYTSSSPG
PVLTPAQLGFAGVMSLVLYGSFVFVQTVRHRDYFLAEGSSDENVHAPPPPGRVAAISGLLLVVCLVLVVGLAKLLSPSVE
AAVLRAGAPAAVVGIIIAAMVLLPEGLAALRAARADRLQTSLNLALGSALASIGLTIPAVAAVFIWIGQPLELGLGAKET
VLLMLTLVVSSLTLGRGRTTILQGVVHLVILAAYLFLSVVP

Sequences:

>Translated_361_residues
MALTSNKLPAWTVWAPLAAAAILAAGLGLPTQGWLIMLMAPALAGAVFAAVHHAEVVAHKVGEPFGTLVLAIAVTVIEVA
LIVSVMLSSGPEKAGLARDTVFAAVMLICNGIVGLCLFVGGLHHREQVFQAPGANAAMAVLAALLVLTMVLPNYTSSSPG
PVLTPAQLGFAGVMSLVLYGSFVFVQTVRHRDYFLAEGSSDENVHAPPPPGRVAAISGLLLVVCLVLVVGLAKLLSPSVE
AAVLRAGAPAAVVGIIIAAMVLLPEGLAALRAARADRLQTSLNLALGSALASIGLTIPAVAAVFIWIGQPLELGLGAKET
VLLMLTLVVSSLTLGRGRTTILQGVVHLVILAAYLFLSVVP
>Mature_360_residues
ALTSNKLPAWTVWAPLAAAAILAAGLGLPTQGWLIMLMAPALAGAVFAAVHHAEVVAHKVGEPFGTLVLAIAVTVIEVAL
IVSVMLSSGPEKAGLARDTVFAAVMLICNGIVGLCLFVGGLHHREQVFQAPGANAAMAVLAALLVLTMVLPNYTSSSPGP
VLTPAQLGFAGVMSLVLYGSFVFVQTVRHRDYFLAEGSSDENVHAPPPPGRVAAISGLLLVVCLVLVVGLAKLLSPSVEA
AVLRAGAPAAVVGIIIAAMVLLPEGLAALRAARADRLQTSLNLALGSALASIGLTIPAVAAVFIWIGQPLELGLGAKETV
LLMLTLVVSSLTLGRGRTTILQGVVHLVILAAYLFLSVVP

Specific function: Possible cation transporter [H]

COG id: COG0387

COG function: function code P; Ca2+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Escherichia coli, GI1787468, Length=311, Percent_Identity=32.7974276527331, Blast_Score=179, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004713
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 36878; Mature: 36747

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTSNKLPAWTVWAPLAAAAILAAGLGLPTQGWLIMLMAPALAGAVFAAVHHAEVVAHK
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGEPFGTLVLAIAVTVIEVALIVSVMLSSGPEKAGLARDTVFAAVMLICNGIVGLCLFVG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GLHHREQVFQAPGANAAMAVLAALLVLTMVLPNYTSSSPGPVLTPAQLGFAGVMSLVLYG
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
SFVFVQTVRHRDYFLAEGSSDENVHAPPPPGRVAAISGLLLVVCLVLVVGLAKLLSPSVE
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AAVLRAGAPAAVVGIIIAAMVLLPEGLAALRAARADRLQTSLNLALGSALASIGLTIPAV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AAVFIWIGQPLELGLGAKETVLLMLTLVVSSLTLGRGRTTILQGVVHLVILAAYLFLSVV
HHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
P
C
>Mature Secondary Structure 
ALTSNKLPAWTVWAPLAAAAILAAGLGLPTQGWLIMLMAPALAGAVFAAVHHAEVVAHK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGEPFGTLVLAIAVTVIEVALIVSVMLSSGPEKAGLARDTVFAAVMLICNGIVGLCLFVG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GLHHREQVFQAPGANAAMAVLAALLVLTMVLPNYTSSSPGPVLTPAQLGFAGVMSLVLYG
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
SFVFVQTVRHRDYFLAEGSSDENVHAPPPPGRVAAISGLLLVVCLVLVVGLAKLLSPSVE
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AAVLRAGAPAAVVGIIIAAMVLLPEGLAALRAARADRLQTSLNLALGSALASIGLTIPAV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AAVFIWIGQPLELGLGAKETVLLMLTLVVSSLTLGRGRTTILQGVVHLVILAAYLFLSVV
HHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm]; Ca (II) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + Proton [Periplasm] = Proton [Cytoplasm] + Na (I) [Periplasm] Ca (II) [Cytoplasm] + Proton [Periplasm] = Ca (II) [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]