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The map label for this gene is yngG [H]

Identifier: 73538024

GI number: 73538024

Start: 835199

End: 836164

Strand: Reverse

Name: yngG [H]

Synonym: Reut_B4194

Alternate gene names: 73538024

Gene position: 836164-835199 (Counterclockwise)

Preceding gene: 73538025

Following gene: 73538023

Centisome position: 30.67

GC content: 71.12

Gene sequence:

>966_bases
ATGACGGCGACGCGTTCGCCCGTCGGCGTGGTGGTCAGTGAAGCGGGGCTGTGCGACGGTCTGCAGTCGCTGCGCCAACG
GCTGCCAGCCGCCGCCCGCCAGGCATGGATTTCCGCCGAAGCGGCCGCGGGCGTGCGCGATATCGAAGTCGGCACGCTTG
CCGCTTTCGGTGTGCTGCCGCAGACGGCCGACTTGTCGGAAGCGGTGGCACATGCGCTCGCGGTTCCGGGACTGACGGTT
GCGGCCCGCGTGCCCAATTTCATGGGCGCCGAACGCGCCCTTGCTGCCGGCGTGCACCGGATCGCCTTGCCCGTCTTCGC
CGACGAAGCCGACAGCCTGCGCCACATGAACCGCACCCATGCCCAGATGCTGCGAGAGGTGCGCCGGATCGCCCAGCGCA
TCGGCGCCGTGCCGCGCCAGGCACGCCCGCGCCTGCAGGTGCGGCTGGAGATGGCATTCGGCTGCGCGCTCACCGGGCCG
GCGGATGAAGCCGCCATTGCCTGCCTGGCCGAAACGCTGGCGGCGGCCGGCGCCGACGACATTGTCCTGTGCGATACGGC
TGGCTGCGCCGATCCCCGGCAGGTGCGCCGGCTGACGCAGGCGGTCTGGCTGGCCGTGGGCGTGGAGGGGGCGCCGGGCA
TCCACCTGCTCAATACGCGTGGACTCGGCCTGGCCAACGCACTGGCTGCCGTCGAGGCCGGCATGACCGTCGTCCATGCC
TCGCTTGGCGGACTCGGCGGCAACGTGGTCACCGAGGACCTTGCGTTCCTGCTGGAATCGATCGGCATCCCTACCGGCAT
CGACCTCGACGCACTGATCGCCGCGCGCACGTGCGTGGCGCAGTACCTGCCCGGCGTGGTGCTGCAGGGCTGCACCCCCG
TGGCCGGCCTGCCGGCGGGCTTCCGTGGGCAGCCTCCGGAGAGCGTAACGAAGCCTTGCCCTATGGCCTCCGAAGCACCA
AAGTAG

Upstream 100 bases:

>100_bases
TGGAGTACGCGATGTCTCGCGAAGGGGTGTGGAGCGCCGGCGCCGGGGAGATCGTCCGGTCATTTGCGGCGCAGCATCAT
GCCACGGACGAGGCAGCATC

Downstream 100 bases:

>100_bases
AACGTGGGCCGGCGGGGCCGGTCAGCCACGGGAGACTGCTCATGGGTAAAAAGAAACAGGAAAAGTACGGTACCAATGAT
GCCGGGGGGGGTGCTGGCAC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTATRSPVGVVVSEAGLCDGLQSLRQRLPAAARQAWISAEAAAGVRDIEVGTLAAFGVLPQTADLSEAVAHALAVPGLTV
AARVPNFMGAERALAAGVHRIALPVFADEADSLRHMNRTHAQMLREVRRIAQRIGAVPRQARPRLQVRLEMAFGCALTGP
ADEAAIACLAETLAAAGADDIVLCDTAGCADPRQVRRLTQAVWLAVGVEGAPGIHLLNTRGLGLANALAAVEAGMTVVHA
SLGGLGGNVVTEDLAFLLESIGIPTGIDLDALIAARTCVAQYLPGVVLQGCTPVAGLPAGFRGQPPESVTKPCPMASEAP
K

Sequences:

>Translated_321_residues
MTATRSPVGVVVSEAGLCDGLQSLRQRLPAAARQAWISAEAAAGVRDIEVGTLAAFGVLPQTADLSEAVAHALAVPGLTV
AARVPNFMGAERALAAGVHRIALPVFADEADSLRHMNRTHAQMLREVRRIAQRIGAVPRQARPRLQVRLEMAFGCALTGP
ADEAAIACLAETLAAAGADDIVLCDTAGCADPRQVRRLTQAVWLAVGVEGAPGIHLLNTRGLGLANALAAVEAGMTVVHA
SLGGLGGNVVTEDLAFLLESIGIPTGIDLDALIAARTCVAQYLPGVVLQGCTPVAGLPAGFRGQPPESVTKPCPMASEAP
K
>Mature_320_residues
TATRSPVGVVVSEAGLCDGLQSLRQRLPAAARQAWISAEAAAGVRDIEVGTLAAFGVLPQTADLSEAVAHALAVPGLTVA
ARVPNFMGAERALAAGVHRIALPVFADEADSLRHMNRTHAQMLREVRRIAQRIGAVPRQARPRLQVRLEMAFGCALTGPA
DEAAIACLAETLAAAGADDIVLCDTAGCADPRQVRRLTQAVWLAVGVEGAPGIHLLNTRGLGLANALAAVEAGMTVVHAS
LGGLGGNVVTEDLAFLLESIGIPTGIDLDALIAARTCVAQYLPGVVLQGCTPVAGLPAGFRGQPPESVTKPCPMASEAPK

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=289, Percent_Identity=29.4117647058824, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI109150427, Length=278, Percent_Identity=28.0575539568345, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI109150422, Length=278, Percent_Identity=28.0575539568345, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI260654708, Length=126, Percent_Identity=34.9206349206349, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17510563, Length=272, Percent_Identity=28.3088235294118, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24582381, Length=290, Percent_Identity=31.0344827586207, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32948; Mature: 32816

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATRSPVGVVVSEAGLCDGLQSLRQRLPAAARQAWISAEAAAGVRDIEVGTLAAFGVLP
CCCCCCCCEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
QTADLSEAVAHALAVPGLTVAARVPNFMGAERALAAGVHRIALPVFADEADSLRHMNRTH
CCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AQMLREVRRIAQRIGAVPRQARPRLQVRLEMAFGCALTGPADEAAIACLAETLAAAGADD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHCEEECCCCHHHHHHHHHHHHHHCCCCC
IVLCDTAGCADPRQVRRLTQAVWLAVGVEGAPGIHLLNTRGLGLANALAAVEAGMTVVHA
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
SLGGLGGNVVTEDLAFLLESIGIPTGIDLDALIAARTCVAQYLPGVVLQGCTPVAGLPAG
HHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCC
FRGQPPESVTKPCPMASEAPK
CCCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TATRSPVGVVVSEAGLCDGLQSLRQRLPAAARQAWISAEAAAGVRDIEVGTLAAFGVLP
CCCCCCCEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
QTADLSEAVAHALAVPGLTVAARVPNFMGAERALAAGVHRIALPVFADEADSLRHMNRTH
CCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AQMLREVRRIAQRIGAVPRQARPRLQVRLEMAFGCALTGPADEAAIACLAETLAAAGADD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHCEEECCCCHHHHHHHHHHHHHHCCCCC
IVLCDTAGCADPRQVRRLTQAVWLAVGVEGAPGIHLLNTRGLGLANALAAVEAGMTVVHA
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
SLGGLGGNVVTEDLAFLLESIGIPTGIDLDALIAARTCVAQYLPGVVLQGCTPVAGLPAG
HHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCC
FRGQPPESVTKPCPMASEAPK
CCCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]