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The map label for this gene is moeA [H]

Identifier: 73537926

GI number: 73537926

Start: 738524

End: 739744

Strand: Direct

Name: moeA [H]

Synonym: Reut_B4093

Alternate gene names: 73537926

Gene position: 738524-739744 (Clockwise)

Preceding gene: 73537925

Following gene: 73537927

Centisome position: 27.09

GC content: 69.21

Gene sequence:

>1221_bases
ATGCTGAGCTTCGACGAGGCACAGGCAATCTTCGCCAATGCCGCAGAGCCGGTGCGCGAGACCGAAACCTTATGGCTGGG
GCTGGCAACCGGCCGCGTGCTGGCCAGCGACCTAGTCGCCGTGACCGACACGCCGTCGGCCGACCGCAGTGCGATGGATG
GCTATGCGGTGCGTTGCGAGGACTGGCAGGGTGGCGCATGCCTGCCTGTGCAGCAGGTGGTGTACGCCGGCACCCGGCCG
CAGGCGCTGCGTCCCGCCCCTGCCATCCGCATTTACACGGGCGCGGTGATCCCTGCCGGGGCCGATGCCGTGGTCGCGCA
GGAAGATGCCGAGGAAAATTTTCGCGGCGTAACCTGTAACCGAACGCCGCTCGTTGGCCAGCATATCCGCCGCCAGGGCG
AGGATGTCCGCCGTGGCGAGATGCTGCTGCCAGCCGGAACGCTGATCGAAGCCGGCCATATTGCCGCGCTGGCCTCGCAG
GGGCTTGTCCATGTGCCGGTCTGCCGGCTGGTCGAAATTGCCATCCTGACGTCTGGCGACGAGGTGGCGGCCAACGATGA
ACCGCACGACGTATACCAGGTGCATGACGTCAACGGGCCGATGCTCGAGTCGCTCGTGCAGTCCATGGGAGCCGTCGTGC
GCTGCCACCGCCATGTGCGTGACGACGAGCGCGTGCTGCACCATGCATTGCGCGAGCTGGCCGGCCATGCCGACCTTGTC
CTCGTGACCGGGGGTGCGTCGGTCGGCCAGCGTGATCTGGTGGCCGCGGCGCTGGCCTCGGCTGGCGGCGAGCTGCTTTG
CCGCGGCGTCAACATGCGGCCCGGCAAGCCGGTGACGATCGGACGCCTGCGCGGCAAGCCCGTGGTCTGCCTGCCGGGCA
ATCCGGCGGCGGCCTATACCACCTTTGCGCTGCTGGTGACGCCGTTGCTGCGCCGGCTGCAAGGCCGGACCCGGCTGTTC
CCGCCGGTGAGCCGGGTCCGCGCGGCACTGGCCGGCGGACGCGTGCCGCCGTGCGATGCGTTCTGGCGGGTGGGAGAGGT
TGGCTACTCCGGCGACCCTGGCAGCCAGGAAGGCCTGGTCCACGTCGCCGCGCAGCAGGGCGCAGCCGCCGTGTCGGCGC
TCGGGCAGGCCAGCGGCTTTGTCCGGGTAGGTCCGCAGAACGCCGGCCAGCTCCACCATGTGTCGTTGCCGTACTATGAT
CTCCATCGTTGGCTTGGCTAA

Upstream 100 bases:

>100_bases
TTAGCTTTTGCCGGAAGGACGGCTATGTCGAATATACCGGCGCAGCATTCGATGACAGCTGCGGTCCTCAGGCCGAAGGT
GTTCTCGAAGGAGCGGCAGC

Downstream 100 bases:

>100_bases
GGACTGCCTGCGGACGGAGACCCGGCGCCCAGGTGCCCGGGAAGGCGCAACCAGATCGGCCAGCGAGGGGAGCGCGGCGT
GAAACTCTATGAAAAACTGG

Product: molybdopterin binding domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLSFDEAQAIFANAAEPVRETETLWLGLATGRVLASDLVAVTDTPSADRSAMDGYAVRCEDWQGGACLPVQQVVYAGTRP
QALRPAPAIRIYTGAVIPAGADAVVAQEDAEENFRGVTCNRTPLVGQHIRRQGEDVRRGEMLLPAGTLIEAGHIAALASQ
GLVHVPVCRLVEIAILTSGDEVAANDEPHDVYQVHDVNGPMLESLVQSMGAVVRCHRHVRDDERVLHHALRELAGHADLV
LVTGGASVGQRDLVAAALASAGGELLCRGVNMRPGKPVTIGRLRGKPVVCLPGNPAAAYTTFALLVTPLLRRLQGRTRLF
PPVSRVRAALAGGRVPPCDAFWRVGEVGYSGDPGSQEGLVHVAAQQGAAAVSALGQASGFVRVGPQNAGQLHHVSLPYYD
LHRWLG

Sequences:

>Translated_406_residues
MLSFDEAQAIFANAAEPVRETETLWLGLATGRVLASDLVAVTDTPSADRSAMDGYAVRCEDWQGGACLPVQQVVYAGTRP
QALRPAPAIRIYTGAVIPAGADAVVAQEDAEENFRGVTCNRTPLVGQHIRRQGEDVRRGEMLLPAGTLIEAGHIAALASQ
GLVHVPVCRLVEIAILTSGDEVAANDEPHDVYQVHDVNGPMLESLVQSMGAVVRCHRHVRDDERVLHHALRELAGHADLV
LVTGGASVGQRDLVAAALASAGGELLCRGVNMRPGKPVTIGRLRGKPVVCLPGNPAAAYTTFALLVTPLLRRLQGRTRLF
PPVSRVRAALAGGRVPPCDAFWRVGEVGYSGDPGSQEGLVHVAAQQGAAAVSALGQASGFVRVGPQNAGQLHHVSLPYYD
LHRWLG
>Mature_406_residues
MLSFDEAQAIFANAAEPVRETETLWLGLATGRVLASDLVAVTDTPSADRSAMDGYAVRCEDWQGGACLPVQQVVYAGTRP
QALRPAPAIRIYTGAVIPAGADAVVAQEDAEENFRGVTCNRTPLVGQHIRRQGEDVRRGEMLLPAGTLIEAGHIAALASQ
GLVHVPVCRLVEIAILTSGDEVAANDEPHDVYQVHDVNGPMLESLVQSMGAVVRCHRHVRDDERVLHHALRELAGHADLV
LVTGGASVGQRDLVAAALASAGGELLCRGVNMRPGKPVTIGRLRGKPVVCLPGNPAAAYTTFALLVTPLLRRLQGRTRLF
PPVSRVRAALAGGRVPPCDAFWRVGEVGYSGDPGSQEGLVHVAAQQGAAAVSALGQASGFVRVGPQNAGQLHHVSLPYYD
LHRWLG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=345, Percent_Identity=32.463768115942, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI10880983, Length=345, Percent_Identity=32.463768115942, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=36.5535248041775, Blast_Score=201, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI25147659, Length=386, Percent_Identity=30.3108808290155, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17562606, Length=312, Percent_Identity=27.2435897435897, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17136978, Length=332, Percent_Identity=25.9036144578313, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24638841, Length=332, Percent_Identity=25.9036144578313, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42947; Mature: 42947

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFDEAQAIFANAAEPVRETETLWLGLATGRVLASDLVAVTDTPSADRSAMDGYAVRCE
CCCCHHHHHHHHHCCCHHHHCCEEEEEEHHHHHHHHCEEEEECCCCCCCHHCCCEEEEEE
DWQGGACLPVQQVVYAGTRPQALRPAPAIRIYTGAVIPAGADAVVAQEDAEENFRGVTCN
CCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEECEEECCCCCEEEECCCHHHCCCCEECC
RTPLVGQHIRRQGEDVRRGEMLLPAGTLIEAGHIAALASQGLVHVPVCRLVEIAILTSGD
CCCCHHHHHHHCCCHHHCCCEECCCCCCCCCCHHHHHHHCCCEEHHHHHHEEEEEEECCC
EVAANDEPHDVYQVHDVNGPMLESLVQSMGAVVRCHRHVRDDERVLHHALRELAGHADLV
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEE
LVTGGASVGQRDLVAAALASAGGELLCRGVNMRPGKPVTIGRLRGKPVVCLPGNPAAAYT
EEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCEEEEECCCCHHHHH
TFALLVTPLLRRLQGRTRLFPPVSRVRAALAGGRVPPCDAFWRVGEVGYSGDPGSQEGLV
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEE
HVAAQQGAAAVSALGQASGFVRVGPQNAGQLHHVSLPYYDLHRWLG
EEEHHCCHHHHHHHHHCCCEEEECCCCCCCEEEEECCHHHHHHHCC
>Mature Secondary Structure
MLSFDEAQAIFANAAEPVRETETLWLGLATGRVLASDLVAVTDTPSADRSAMDGYAVRCE
CCCCHHHHHHHHHCCCHHHHCCEEEEEEHHHHHHHHCEEEEECCCCCCCHHCCCEEEEEE
DWQGGACLPVQQVVYAGTRPQALRPAPAIRIYTGAVIPAGADAVVAQEDAEENFRGVTCN
CCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEECEEECCCCCEEEECCCHHHCCCCEECC
RTPLVGQHIRRQGEDVRRGEMLLPAGTLIEAGHIAALASQGLVHVPVCRLVEIAILTSGD
CCCCHHHHHHHCCCHHHCCCEECCCCCCCCCCHHHHHHHCCCEEHHHHHHEEEEEEECCC
EVAANDEPHDVYQVHDVNGPMLESLVQSMGAVVRCHRHVRDDERVLHHALRELAGHADLV
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEE
LVTGGASVGQRDLVAAALASAGGELLCRGVNMRPGKPVTIGRLRGKPVVCLPGNPAAAYT
EEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCEEEEECCCCHHHHH
TFALLVTPLLRRLQGRTRLFPPVSRVRAALAGGRVPPCDAFWRVGEVGYSGDPGSQEGLV
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEE
HVAAQQGAAAVSALGQASGFVRVGPQNAGQLHHVSLPYYDLHRWLG
EEEHHCCHHHHHHHHHCCCEEEECCCCCCCEEEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]