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The map label for this gene is ctrA [H]

Identifier: 73537889

GI number: 73537889

Start: 695736

End: 696563

Strand: Reverse

Name: ctrA [H]

Synonym: Reut_B4056

Alternate gene names: 73537889

Gene position: 696563-695736 (Counterclockwise)

Preceding gene: 73537894

Following gene: 73537888

Centisome position: 25.55

GC content: 64.61

Gene sequence:

>828_bases
ATGCCTGACCCCATGAATATCGCACTGCTGAGCGGTCAGTCCGCGCATCTGAAAGCCGTTCCCGAATTGCTGGCGCGCGC
CGGCTTCCGATGCAACGTGTTTGCTTCCACTCGTGCGCTCATCCAGGGCGTCAGCCTTGCCTCGTACGATATGCTGCTGA
TCCATGACGAACTGCCCGACACAGCGGCGATTGACGTCATCCGCACTGTACGGTGCGCGCGCTCGCGCGATCTGCCGATC
ATGATGCTGGGCGGCAACGGTAGCGAGGAGGCCCTCGTCGAAGCGCTCGACGCGGGCGCCGACGACTACCTGAGCGGTCC
GCAGAGTACGCGGGTCCTTCTGGCGCGAATGGCCGCACTGCGCCGCCGCGCCACAGGGGACCGTCAACGTCAGGGGCTGT
TGGCGCGCGCGGGCCCGTACCAGCTCAACAGCGTCGGCCGCTTCGCAACGCTGCACGGCGAGCGCATAACACTGACCCCA
AAGGAGTTCGATCTGGCCATGCTGCTGTTCACCAATGCCGGCCGGGTACTCGCTAACCGCCGCATCGAACAGGCCATCTG
GCACCATGAACTGCCGCCCTTGTCGCGTGCGCTGGCCGGGTTGATGTCGCGCCTGCGCAAGACCTTGCGACTCAGTCCCG
AGAATGGCATTTCGATCACGGTGGTCTATGCCCATGGCTATCGCCTCGACATCCATGAGGACAGCCCGACCCACCCACGG
AAACACGGCAATCCGGCGTTAGCTCAGCAGCAGCCTGATCTTCACACTGGCCTGCTGGCCGACGATCGGGCCCACGGAGT
GCGCCCCGTAACGGATTCGGCGTGCTAG

Upstream 100 bases:

>100_bases
GGAATCGGATTTGTCCGATTGTTCCGCCGCGTTTGCCTTTATACGCTCTCGACTCAGCACCTTCCGGCAAACCGACTTTT
CTCATTTCCGCCGCCACTGT

Downstream 100 bases:

>100_bases
GTGGCGCTTGTGCGCTGCTGCCGACGGATAAAGTGGCAGTACAGATGTGTCTGCCGGAAACATTTGACATTGAGAGGTAA
CCGGCATTTACGAGTTCAGC

Product: response regulator receiver:transcriptional regulatory protein, C-terminal

Products: NA

Alternate protein names: Response regulator SokA [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPDPMNIALLSGQSAHLKAVPELLARAGFRCNVFASTRALIQGVSLASYDMLLIHDELPDTAAIDVIRTVRCARSRDLPI
MMLGGNGSEEALVEALDAGADDYLSGPQSTRVLLARMAALRRRATGDRQRQGLLARAGPYQLNSVGRFATLHGERITLTP
KEFDLAMLLFTNAGRVLANRRIEQAIWHHELPPLSRALAGLMSRLRKTLRLSPENGISITVVYAHGYRLDIHEDSPTHPR
KHGNPALAQQQPDLHTGLLADDRAHGVRPVTDSAC

Sequences:

>Translated_275_residues
MPDPMNIALLSGQSAHLKAVPELLARAGFRCNVFASTRALIQGVSLASYDMLLIHDELPDTAAIDVIRTVRCARSRDLPI
MMLGGNGSEEALVEALDAGADDYLSGPQSTRVLLARMAALRRRATGDRQRQGLLARAGPYQLNSVGRFATLHGERITLTP
KEFDLAMLLFTNAGRVLANRRIEQAIWHHELPPLSRALAGLMSRLRKTLRLSPENGISITVVYAHGYRLDIHEDSPTHPR
KHGNPALAQQQPDLHTGLLADDRAHGVRPVTDSAC
>Mature_274_residues
PDPMNIALLSGQSAHLKAVPELLARAGFRCNVFASTRALIQGVSLASYDMLLIHDELPDTAAIDVIRTVRCARSRDLPIM
MLGGNGSEEALVEALDAGADDYLSGPQSTRVLLARMAALRRRATGDRQRQGLLARAGPYQLNSVGRFATLHGERITLTPK
EFDLAMLLFTNAGRVLANRRIEQAIWHHELPPLSRALAGLMSRLRKTLRLSPENGISITVVYAHGYRLDIHEDSPTHPRK
HGNPALAQQQPDLHTGLLADDRAHGVRPVTDSAC

Specific function: Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=206, Percent_Identity=33.495145631068, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786784, Length=214, Percent_Identity=31.3084112149533, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786911, Length=181, Percent_Identity=31.4917127071823, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787375, Length=187, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI2367329, Length=157, Percent_Identity=31.8471337579618, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788394, Length=182, Percent_Identity=29.6703296703297, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789809, Length=209, Percent_Identity=25.8373205741627, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786599, Length=181, Percent_Identity=27.6243093922652, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=24.6753246753247, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790860, Length=198, Percent_Identity=26.2626262626263, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082012, Length=205, Percent_Identity=28.2926829268293, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 30061; Mature: 29930

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDPMNIALLSGQSAHLKAVPELLARAGFRCNVFASTRALIQGVSLASYDMLLIHDELPD
CCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCEEEEEEECCCCC
TAAIDVIRTVRCARSRDLPIMMLGGNGSEEALVEALDAGADDYLSGPQSTRVLLARMAAL
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHH
RRRATGDRQRQGLLARAGPYQLNSVGRFATLHGERITLTPKEFDLAMLLFTNAGRVLANR
HHHCCCCHHHCCCEECCCCCCCCCCCCEEEECCCEEEECCCHHCEEEEEEECCCHHHHHH
RIEQAIWHHELPPLSRALAGLMSRLRKTLRLSPENGISITVVYAHGYRLDIHEDSPTHPR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEEEECCCCCCCCC
KHGNPALAQQQPDLHTGLLADDRAHGVRPVTDSAC
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PDPMNIALLSGQSAHLKAVPELLARAGFRCNVFASTRALIQGVSLASYDMLLIHDELPD
CCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCEEEEEEECCCCC
TAAIDVIRTVRCARSRDLPIMMLGGNGSEEALVEALDAGADDYLSGPQSTRVLLARMAAL
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHH
RRRATGDRQRQGLLARAGPYQLNSVGRFATLHGERITLTPKEFDLAMLLFTNAGRVLANR
HHHCCCCHHHCCCEECCCCCCCCCCCCEEEECCCEEEECCCHHCEEEEEEECCCHHHHHH
RIEQAIWHHELPPLSRALAGLMSRLRKTLRLSPENGISITVVYAHGYRLDIHEDSPTHPR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEEEECCCCCCCCC
KHGNPALAQQQPDLHTGLLADDRAHGVRPVTDSAC
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8548829 [H]