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The map label for this gene is pmrA [H]

Identifier: 73537882

GI number: 73537882

Start: 690674

End: 691369

Strand: Reverse

Name: pmrA [H]

Synonym: Reut_B4049

Alternate gene names: 73537882

Gene position: 691369-690674 (Counterclockwise)

Preceding gene: 73537885

Following gene: 73537881

Centisome position: 25.36

GC content: 67.1

Gene sequence:

>696_bases
TTGACGCAAACTTCAGGCCATGAAGACATTTCACGTCCGCCGCCCTGCCCGGCTTCGCCACGCAAGCCGCCCTGCTTTCG
CGCTCGCGCTGGCCGGTGCTGCGCTCGCGCTTGCGCTTGGCATCGCCGCGCCGGCACATGCCGACAAGGACGCCGATCGC
GCCCGCGCGGCGGTGCAGTCCGGGGAAATCCTGCCGCTGTCCCGCATTCTCGAAGCGGTTTCGCAGCGCACGTCAACGTT
CCCGTGCTGATTCTCACGGCGCGAGACAGCTGGACAGAGAAGGTTGAAGGCATCGACGCGGGCGCCGACGACTACCTGGC
CAAGCCGTTCCGCATGGAAGAATTGCAGGCGCGCATCCGCGCGTTGATTCGCCGCGCGCACGGCATGCCGGCCCCCGAAC
TGAGCTGCGGCTCCGTCCAGCTGAATCCGCGCGCCGGCACCGTGACCGTGGATGGCGCCGCCGTGGTGCTGACGGCGCAC
GAATTCAAGGTGCTCGACTACCTGATGCACCATCCGGGCGCCATCGTCAGCAAGTCCACGCTGACCGAACATATCTATGC
GCAGGACTTTGACCGCGACAGCAACACGATCGAAGTCTTCGTCGGCCGGCTGCGCCGCAAGCTCGGCGTGGACGTGATCG
AGACCGTGCGCGGCCAGGGCTACCGGCTGCGACCGCCCCCCGCGACCGGGAATTAA

Upstream 100 bases:

>100_bases
TGGTGCGACATGGCTGGACTCCTGATACGGTTGGCAAGCATTGTCGTGAACGGCACCTGAACGCTGGCTGAGGCATCCGT
TCAGCCTGCGTTCAGGCGTT

Downstream 100 bases:

>100_bases
GGCACCGCATGCGCAACTCTCTCGCGCTGCGCCTGTGGCCGCCATTTGGCTCGCCGCGGCGCTCGGCGCAAGCTGGTGGC
TCCTTTCCACGCTGTTCGAG

Product: response regulator receiver:transcriptional regulatory protein, C-terminal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MTQTSGHEDISRPPPCPASPRKPPCFRARAGRCCARACAWHRRAGTCRQGRRSRPRGGAVRGNPAAVPHSRSGFAAHVNV
PVLILTARDSWTEKVEGIDAGADDYLAKPFRMEELQARIRALIRRAHGMPAPELSCGSVQLNPRAGTVTVDGAAVVLTAH
EFKVLDYLMHHPGAIVSKSTLTEHIYAQDFDRDSNTIEVFVGRLRRKLGVDVIETVRGQGYRLRPPPATGN

Sequences:

>Translated_231_residues
MTQTSGHEDISRPPPCPASPRKPPCFRARAGRCCARACAWHRRAGTCRQGRRSRPRGGAVRGNPAAVPHSRSGFAAHVNV
PVLILTARDSWTEKVEGIDAGADDYLAKPFRMEELQARIRALIRRAHGMPAPELSCGSVQLNPRAGTVTVDGAAVVLTAH
EFKVLDYLMHHPGAIVSKSTLTEHIYAQDFDRDSNTIEVFVGRLRRKLGVDVIETVRGQGYRLRPPPATGN
>Mature_230_residues
TQTSGHEDISRPPPCPASPRKPPCFRARAGRCCARACAWHRRAGTCRQGRRSRPRGGAVRGNPAAVPHSRSGFAAHVNVP
VLILTARDSWTEKVEGIDAGADDYLAKPFRMEELQARIRALIRRAHGMPAPELSCGSVQLNPRAGTVTVDGAAVVLTAHE
FKVLDYLMHHPGAIVSKSTLTEHIYAQDFDRDSNTIEVFVGRLRRKLGVDVIETVRGQGYRLRPPPATGN

Specific function: Member of the two-component regulatory system pmrB/pmrA involved in regulation of virulence. Unphosphorylated pmrA represses extracellular enzyme genes. Phosphorylation of pmrA by pmrB relieves such repression, which leads to activation of extracellular e

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=143, Percent_Identity=47.5524475524476, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1787375, Length=148, Percent_Identity=41.8918918918919, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790552, Length=144, Percent_Identity=47.2222222222222, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1786784, Length=157, Percent_Identity=36.9426751592357, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI87082012, Length=145, Percent_Identity=37.9310344827586, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1786599, Length=150, Percent_Identity=36, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI2367329, Length=157, Percent_Identity=38.8535031847134, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790860, Length=161, Percent_Identity=35.4037267080745, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1786911, Length=153, Percent_Identity=34.640522875817, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789809, Length=158, Percent_Identity=32.9113924050633, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787229, Length=152, Percent_Identity=30.9210526315789, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790863, Length=160, Percent_Identity=27.5, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788394, Length=153, Percent_Identity=30.718954248366, Blast_Score=71, Evalue=5e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25254; Mature: 25123

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTSGHEDISRPPPCPASPRKPPCFRARAGRCCARACAWHRRAGTCRQGRRSRPRGGAV
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
RGNPAAVPHSRSGFAAHVNVPVLILTARDSWTEKVEGIDAGADDYLAKPFRMEELQARIR
CCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHCCCCCCHHHHCCCCCHHHHHHHHH
ALIRRAHGMPAPELSCGSVQLNPRAGTVTVDGAAVVLTAHEFKVLDYLMHHPGAIVSKST
HHHHHHCCCCCCCCCCCCEEECCCCCEEEECCEEEEEEHHHHHHHHHHHHCCCCCEEHHH
LTEHIYAQDFDRDSNTIEVFVGRLRRKLGVDVIETVRGQGYRLRPPPATGN
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHCCCCEEECCCCCCCC
>Mature Secondary Structure 
TQTSGHEDISRPPPCPASPRKPPCFRARAGRCCARACAWHRRAGTCRQGRRSRPRGGAV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
RGNPAAVPHSRSGFAAHVNVPVLILTARDSWTEKVEGIDAGADDYLAKPFRMEELQARIR
CCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHCCCCCCHHHHCCCCCHHHHHHHHH
ALIRRAHGMPAPELSCGSVQLNPRAGTVTVDGAAVVLTAHEFKVLDYLMHHPGAIVSKST
HHHHHHCCCCCCCCCCCCEEECCCCCEEEECCEEEEEEHHHHHHHHHHHHCCCCCEEHHH
LTEHIYAQDFDRDSNTIEVFVGRLRRKLGVDVIETVRGQGYRLRPPPATGN
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14617142 [H]