Click here to switch to the map view.

The map label for this gene is argH1 [H]

Identifier: 73537655

GI number: 73537655

Start: 425031

End: 426560

Strand: Reverse

Name: argH1 [H]

Synonym: Reut_B3820

Alternate gene names: 73537655

Gene position: 426560-425031 (Counterclockwise)

Preceding gene: 73537656

Following gene: 73537654

Centisome position: 15.65

GC content: 59.54

Gene sequence:

>1530_bases
ATGGAATCTGCCTCACTTAATGCCATGACATCCTCCACTTCCCACGAAACACTGCTTGCCGAAGCCCGGCTAAGCTCGCC
CCCGGCCTCCCGGCTTACCAAGCACTACGCCCTGCCGGGACTGGAGCGCGAGCGCAGGCAGTTCCACGAGTTTGTCGCCG
TCGATCTTGCCCATACCACCATGCTGGTGGAACAGGGCATTGTTTCCACAGCTACCGGACGCGCAATCCTGGAGCAGTTA
CTGGCCATTCGCGACATGGAACCTTCGGATTTTCCAGTTGATGCGCGCAAAGGCAGCTTCCTGTTGCAGATGGAGTCGTA
TCTCTTCAGCGCGATTGGCGAGGATGTCGGTGGGCAGATGCACACAGGCCGCAGCCGGATTGACCAGGGCGCTACCGTAC
GCCGGCTGTATAAGCGCAATCGCATTCTGGATGTGATGGACCGGCTGAACGAGTTTCAGGATGCAGTCGCCGAGCAAGCG
CGCCGCCACGCTCACACCATCATGCCCGGCTACACGCATATGCAGCAGGCACAGCCTTGGGTCTTCGGGCACTATCTCCT
CAGTTTCAGCTCTCGCCTGCATGACAGCTTTGAGCGTCTCGCTCAGGCCTACGGGCGCGTCAACCGCAATCCATTGGGGA
CGGTCGGCCTTGCGGGCACGTCGTGGCCGCTCAACCGCGAGCGGACCACGGAACTGCTCGGCTTCGACGGTCTGGTCGAA
AACTCCAAGCTGGGTCGCGAAGCTTTTGACGCCGCAGATGCCATCTGCGCACTTTCTTTCATCATGGCCGACTTGAACGA
TCTGGCTACCGATCTCCATATTTGGTCCAGCACCGAATTTGGACTGGTTGAATGCGATGACAGCTACTGTGGCACGAGCA
GCATCTTCCCCCAGAAGAAGAACCCAGTAGCTTTGGAGACCATCAGGAAGGCTGCCGGCCCCGCAGTAACGTGGCTTGGC
GCTGCGCTGGCGACTTTCCGGGCCGAGGGGACTGGGGACCAAGCGATGCGAACCGTCTCTCACATCGATGAAGCGTTCTC
AACGACTGAGAGCATGCTGGATCTGTTCACAGGAGTCATCGAAACGCTGATCGTGCATCGGGACCGCATGGCCGAATCGC
TCAAGGGTAGTTGGTGCACGGCAAGCAACCTCGCGGATGTAATCGTGCGTGAGCGTGGCCTTTCCTTCCGCCAAGTGCAC
CACATCGTCGCCCGTGCAGTCCGCAATTGCGTGGCTCAAGGCCTGAGCCCAAATGAATTGACCAGTGCTCGTCTCGACGA
AGCCGCGTTCGAAACGGCTGGAGTCCGTCTCCGACTGAGCGACTGTGCAGTTCAGGAGGCGCTCGATCCACGTCGGTTTG
TCGAGACCCGGATTACCGATGGAAGCGTCGGGCCGCATCAGGTTGCACGATTGCTCGAGCATGCCGCGCAGGAGCGCGCA
GCAGACCGACAATGGGTGAGTATGGCGCGCACCCATTTGGATCGTTCGCAACGGATGCTCATCGAGGCCGTTGTCAAACT
CGTTGCTTAA

Upstream 100 bases:

>100_bases
GACCGTCGCACCAAGCCTCTGTGCGAGCACAAGAATCCCTTATGCGCGTCCAACCCTGTCTGTAGTTGTGACTGCCTGAC
CAAGAATTCATCATCTCGTC

Downstream 100 bases:

>100_bases
AGGAGACGCAGGTTATGTTGAAGTCTGTTGCAGTAGTTGTGTCGATCGCCGCACTTTCCATGGGTGTTCGTGCGGAGACC
TATCCTTCAAAGCCCATCAT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 1; Arginosuccinase 1 [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MESASLNAMTSSTSHETLLAEARLSSPPASRLTKHYALPGLERERRQFHEFVAVDLAHTTMLVEQGIVSTATGRAILEQL
LAIRDMEPSDFPVDARKGSFLLQMESYLFSAIGEDVGGQMHTGRSRIDQGATVRRLYKRNRILDVMDRLNEFQDAVAEQA
RRHAHTIMPGYTHMQQAQPWVFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGTVGLAGTSWPLNRERTTELLGFDGLVE
NSKLGREAFDAADAICALSFIMADLNDLATDLHIWSSTEFGLVECDDSYCGTSSIFPQKKNPVALETIRKAAGPAVTWLG
AALATFRAEGTGDQAMRTVSHIDEAFSTTESMLDLFTGVIETLIVHRDRMAESLKGSWCTASNLADVIVRERGLSFRQVH
HIVARAVRNCVAQGLSPNELTSARLDEAAFETAGVRLRLSDCAVQEALDPRRFVETRITDGSVGPHQVARLLEHAAQERA
ADRQWVSMARTHLDRSQRMLIEAVVKLVA

Sequences:

>Translated_509_residues
MESASLNAMTSSTSHETLLAEARLSSPPASRLTKHYALPGLERERRQFHEFVAVDLAHTTMLVEQGIVSTATGRAILEQL
LAIRDMEPSDFPVDARKGSFLLQMESYLFSAIGEDVGGQMHTGRSRIDQGATVRRLYKRNRILDVMDRLNEFQDAVAEQA
RRHAHTIMPGYTHMQQAQPWVFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGTVGLAGTSWPLNRERTTELLGFDGLVE
NSKLGREAFDAADAICALSFIMADLNDLATDLHIWSSTEFGLVECDDSYCGTSSIFPQKKNPVALETIRKAAGPAVTWLG
AALATFRAEGTGDQAMRTVSHIDEAFSTTESMLDLFTGVIETLIVHRDRMAESLKGSWCTASNLADVIVRERGLSFRQVH
HIVARAVRNCVAQGLSPNELTSARLDEAAFETAGVRLRLSDCAVQEALDPRRFVETRITDGSVGPHQVARLLEHAAQERA
ADRQWVSMARTHLDRSQRMLIEAVVKLVA
>Mature_509_residues
MESASLNAMTSSTSHETLLAEARLSSPPASRLTKHYALPGLERERRQFHEFVAVDLAHTTMLVEQGIVSTATGRAILEQL
LAIRDMEPSDFPVDARKGSFLLQMESYLFSAIGEDVGGQMHTGRSRIDQGATVRRLYKRNRILDVMDRLNEFQDAVAEQA
RRHAHTIMPGYTHMQQAQPWVFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGTVGLAGTSWPLNRERTTELLGFDGLVE
NSKLGREAFDAADAICALSFIMADLNDLATDLHIWSSTEFGLVECDDSYCGTSSIFPQKKNPVALETIRKAAGPAVTWLG
AALATFRAEGTGDQAMRTVSHIDEAFSTTESMLDLFTGVIETLIVHRDRMAESLKGSWCTASNLADVIVRERGLSFRQVH
HIVARAVRNCVAQGLSPNELTSARLDEAAFETAGVRLRLSDCAVQEALDPRRFVETRITDGSVGPHQVARLLEHAAQERA
ADRQWVSMARTHLDRSQRMLIEAVVKLVA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=307, Percent_Identity=33.2247557003257, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI68303542, Length=307, Percent_Identity=33.2247557003257, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI68303547, Length=305, Percent_Identity=33.4426229508197, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI68303549, Length=307, Percent_Identity=31.2703583061889, Blast_Score=130, Evalue=4e-30,
Organism=Escherichia coli, GI1790398, Length=375, Percent_Identity=30.9333333333333, Blast_Score=167, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6321806, Length=343, Percent_Identity=34.1107871720117, Blast_Score=173, Evalue=7e-44,
Organism=Drosophila melanogaster, GI221473854, Length=319, Percent_Identity=33.5423197492163, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI78706858, Length=319, Percent_Identity=33.5423197492163, Blast_Score=161, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 56416; Mature: 56416

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESASLNAMTSSTSHETLLAEARLSSPPASRLTKHYALPGLERERRQFHEFVAVDLAHTT
CCCCCCCHHHCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
MLVEQGIVSTATGRAILEQLLAIRDMEPSDFPVDARKGSFLLQMESYLFSAIGEDVGGQM
HHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
HTGRSRIDQGATVRRLYKRNRILDVMDRLNEFQDAVAEQARRHAHTIMPGYTHMQQAQPW
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCH
VFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGTVGLAGTSWPLNRERTTELLGFDGLVE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHHHCCCCCCC
NSKLGREAFDAADAICALSFIMADLNDLATDLHIWSSTEFGLVECDDSYCGTSSIFPQKK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCCCCCCCCCC
NPVALETIRKAAGPAVTWLGAALATFRAEGTGDQAMRTVSHIDEAFSTTESMLDLFTGVI
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLIVHRDRMAESLKGSWCTASNLADVIVRERGLSFRQVHHIVARAVRNCVAQGLSPNEL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHH
TSARLDEAAFETAGVRLRLSDCAVQEALDPRRFVETRITDGSVGPHQVARLLEHAAQERA
HHHHHHHHHHHHCCCEEEHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ADRQWVSMARTHLDRSQRMLIEAVVKLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MESASLNAMTSSTSHETLLAEARLSSPPASRLTKHYALPGLERERRQFHEFVAVDLAHTT
CCCCCCCHHHCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
MLVEQGIVSTATGRAILEQLLAIRDMEPSDFPVDARKGSFLLQMESYLFSAIGEDVGGQM
HHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
HTGRSRIDQGATVRRLYKRNRILDVMDRLNEFQDAVAEQARRHAHTIMPGYTHMQQAQPW
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCH
VFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGTVGLAGTSWPLNRERTTELLGFDGLVE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHHHCCCCCCC
NSKLGREAFDAADAICALSFIMADLNDLATDLHIWSSTEFGLVECDDSYCGTSSIFPQKK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCCCCCCCCCC
NPVALETIRKAAGPAVTWLGAALATFRAEGTGDQAMRTVSHIDEAFSTTESMLDLFTGVI
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLIVHRDRMAESLKGSWCTASNLADVIVRERGLSFRQVHHIVARAVRNCVAQGLSPNEL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHH
TSARLDEAAFETAGVRLRLSDCAVQEALDPRRFVETRITDGSVGPHQVARLLEHAAQERA
HHHHHHHHHHHHCCCEEEHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ADRQWVSMARTHLDRSQRMLIEAVVKLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA