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The map label for this gene is yusP [H]

Identifier: 73537452

GI number: 73537452

Start: 186400

End: 187998

Strand: Direct

Name: yusP [H]

Synonym: Reut_B3617

Alternate gene names: 73537452

Gene position: 186400-187998 (Clockwise)

Preceding gene: 73537449

Following gene: 73537453

Centisome position: 6.84

GC content: 65.17

Gene sequence:

>1599_bases
ATGACGTCGACGGCACAATCCGGGCATGGCAGCGGACAGGTTCTCCCGTTCCGCGAATCGCTGCTTGCCATGTTGGGGGT
GGCCTTTGTGTCGATGCTGGTGGCCCTTGACCAGACCGTGGTCGGTACGGCACTGCCAACGGTTGTCGCCGAGCTCCAGG
GCTTCGAGTACTACGCGTGGGTAGCGACGTCTTACCTGCTGCTGTCGGTGATTACCGTGCCGATCTTCGGGCGCCTCGGC
GATTACTATGGCCGCAAGCCTTTCGTGCTGGCTTCCATCGTCGTGTTCTCGGTGGCGTCCGCGCTGTGCGGCATGGCGAC
GAGCATGCCCTTCCTCGTGGCTGCGCGCGGACTGCAGGGAATCGGGGGCGGCATGCTGGTCGGCACGGCGTTCGCGTGCA
TCCCAGATCTGTTTCCGGATTCGCACGTGAGGCTGCGCTGGCAGGTTCTGATGAGTGCGGCGTTTGGCGTGGCGAATGCA
ATCGGGCCGTCGCTGGGCGGCATACTCACGGAGTGGTACGGCTGGCGCGCCGTGTTCTATGTCAACCTGCCGGTGGGGGT
GCTGAGCCTGTGGTTCGTGTGGCGCTACCTGCCGCACCTGCGCCAGCAATCGCATTCCGGCCCGATCCGGGTCGACTGGC
TGGGTGCCTTGCTGATCGGCGTGGGGCTCGGCTGCATGCAGATGAGTGTCGAGCTGCTACCGCAGCGTGGCGTCGATTGG
CTGACCGCAGGGCTGCTTGCCGTCGCTGTCGCGGCGCTGGTCGGGTTGTGGCAATGGGAACGCCGCTGTGCCAATCCGAT
CCTGCCGCTGGACATGTTCCGCAACCCCGGCGTGGCGCCGCTGCTCCAGCTCGCCGTGCTGGTCGGGTTCACGATGTTTG
CGGTGCTGATCTATGCACCGCTGCTGCTGCAGGGGGGCTTTGGCTATTCGCCGCGCGATGCTGGGCTGTTGGTAACGCCG
CTGGTGGTGTGCATCACGGTCGGCAGTATCGTGAACGGTCGCATCATCACGCGCATCCGCCGTCCTAACGCGATGTTGTT
CGCCGGCTTTGGCATGCTGGCCGCCGGATGCCTGGCCCTGTCTCAGGCCACGCGCGGCATGCCCCATTCGCTGCTGCTCG
CGATCATGTTGGTTGCCGGTTTCGGGCTTGGCTTCATCATGCCAAACCTCACGGTGTTTGCGCAGCAGACAGTGGGCCGG
GAACATCTTGGTATCGCTACCGCGATGCTGCAGTCGCTACGGATGGTAGGGGGCATGATCGGTACGGCGATGGTCGGCAC
GATGGTATCGCGCTCCTATACCGCAGGTGTGGAGCAGTCGCTTGCGGCCGTCAATGCGCAGGGCTGGCTCACGCGCATGG
CCGATCCGCAGGTGCTGATCGATAAGGCCGCGCAGGCAGGATTGCTGACCGAACTGCAGCAGGCAGGGCACAATGGCGCC
TTGCTGCTGGAGCAGGCGCGTGTGTCCCTGGTGACTGCAATTCATTTCGGGCTGGTAATTGCCGCAGCGGCAGCGTTGAT
AGGCCTGTGGCGCGCGCGGCGCGTGCCGCCGGTCAGGCTCGTGCGAGCCGGCCAGCAGCCGGCCATGGCGGCTGACTAG

Upstream 100 bases:

>100_bases
GGTGTACGGCCCTTCGTAATCCTGCTCGTTTTTATCGTCAGAATATTCCGCCAACCCGTCCTATAATGATTGACATTACA
ACGATTGATCGGGCAATAAA

Downstream 100 bases:

>100_bases
AGCACTGGCTGCACGGCGTGCTTGGCATGCCGTGTCATTGGATACGGGAGATTGGATGGAACTGGAGCGACAAAGCCTTG
CGGTACTGCAGCAGTTCGGG

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MTSTAQSGHGSGQVLPFRESLLAMLGVAFVSMLVALDQTVVGTALPTVVAELQGFEYYAWVATSYLLLSVITVPIFGRLG
DYYGRKPFVLASIVVFSVASALCGMATSMPFLVAARGLQGIGGGMLVGTAFACIPDLFPDSHVRLRWQVLMSAAFGVANA
IGPSLGGILTEWYGWRAVFYVNLPVGVLSLWFVWRYLPHLRQQSHSGPIRVDWLGALLIGVGLGCMQMSVELLPQRGVDW
LTAGLLAVAVAALVGLWQWERRCANPILPLDMFRNPGVAPLLQLAVLVGFTMFAVLIYAPLLLQGGFGYSPRDAGLLVTP
LVVCITVGSIVNGRIITRIRRPNAMLFAGFGMLAAGCLALSQATRGMPHSLLLAIMLVAGFGLGFIMPNLTVFAQQTVGR
EHLGIATAMLQSLRMVGGMIGTAMVGTMVSRSYTAGVEQSLAAVNAQGWLTRMADPQVLIDKAAQAGLLTELQQAGHNGA
LLLEQARVSLVTAIHFGLVIAAAAALIGLWRARRVPPVRLVRAGQQPAMAAD

Sequences:

>Translated_532_residues
MTSTAQSGHGSGQVLPFRESLLAMLGVAFVSMLVALDQTVVGTALPTVVAELQGFEYYAWVATSYLLLSVITVPIFGRLG
DYYGRKPFVLASIVVFSVASALCGMATSMPFLVAARGLQGIGGGMLVGTAFACIPDLFPDSHVRLRWQVLMSAAFGVANA
IGPSLGGILTEWYGWRAVFYVNLPVGVLSLWFVWRYLPHLRQQSHSGPIRVDWLGALLIGVGLGCMQMSVELLPQRGVDW
LTAGLLAVAVAALVGLWQWERRCANPILPLDMFRNPGVAPLLQLAVLVGFTMFAVLIYAPLLLQGGFGYSPRDAGLLVTP
LVVCITVGSIVNGRIITRIRRPNAMLFAGFGMLAAGCLALSQATRGMPHSLLLAIMLVAGFGLGFIMPNLTVFAQQTVGR
EHLGIATAMLQSLRMVGGMIGTAMVGTMVSRSYTAGVEQSLAAVNAQGWLTRMADPQVLIDKAAQAGLLTELQQAGHNGA
LLLEQARVSLVTAIHFGLVIAAAAALIGLWRARRVPPVRLVRAGQQPAMAAD
>Mature_531_residues
TSTAQSGHGSGQVLPFRESLLAMLGVAFVSMLVALDQTVVGTALPTVVAELQGFEYYAWVATSYLLLSVITVPIFGRLGD
YYGRKPFVLASIVVFSVASALCGMATSMPFLVAARGLQGIGGGMLVGTAFACIPDLFPDSHVRLRWQVLMSAAFGVANAI
GPSLGGILTEWYGWRAVFYVNLPVGVLSLWFVWRYLPHLRQQSHSGPIRVDWLGALLIGVGLGCMQMSVELLPQRGVDWL
TAGLLAVAVAALVGLWQWERRCANPILPLDMFRNPGVAPLLQLAVLVGFTMFAVLIYAPLLLQGGFGYSPRDAGLLVTPL
VVCITVGSIVNGRIITRIRRPNAMLFAGFGMLAAGCLALSQATRGMPHSLLLAIMLVAGFGLGFIMPNLTVFAQQTVGRE
HLGIATAMLQSLRMVGGMIGTAMVGTMVSRSYTAGVEQSLAAVNAQGWLTRMADPQVLIDKAAQAGLLTELQQAGHNGAL
LLEQARVSLVTAIHFGLVIAAAAALIGLWRARRVPPVRLVRAGQQPAMAAD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=314, Percent_Identity=30.2547770700637, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789042, Length=431, Percent_Identity=26.9141531322506, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87081983, Length=438, Percent_Identity=28.310502283105, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788710, Length=486, Percent_Identity=23.4567901234568, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788392, Length=322, Percent_Identity=28.8819875776398, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1790146, Length=168, Percent_Identity=27.9761904761905, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6319770, Length=434, Percent_Identity=24.8847926267281, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322958, Length=486, Percent_Identity=22.4279835390947, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323735, Length=321, Percent_Identity=26.1682242990654, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=32.6666666666667, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325455, Length=154, Percent_Identity=27.9220779220779, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324954, Length=396, Percent_Identity=22.7272727272727, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56503; Mature: 56372

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TSTAQSGHGSGQVLPFRESLLAMLGVAFVSMLVALDQTVVGTALPTVVAELQGFEYYAW
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VATSYLLLSVITVPIFGRLGDYYGRKPFVLASIVVFSVASALCGMATSMPFLVAARGLQG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCC
IGGGMLVGTAFACIPDLFPDSHVRLRWQVLMSAAFGVANAIGPSLGGILTEWYGWRAVFY
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEEE
VNLPVGVLSLWFVWRYLPHLRQQSHSGPIRVDWLGALLIGVGLGCMQMSVELLPQRGVDW
EECCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LTAGLLAVAVAALVGLWQWERRCANPILPLDMFRNPGVAPLLQLAVLVGFTMFAVLIYAP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLLQGGFGYSPRDAGLLVTPLVVCITVGSIVNGRIITRIRRPNAMLFAGFGMLAAGCLAL
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHEEEECCCCEEEECHHHHHHHHHHH
SQATRGMPHSLLLAIMLVAGFGLGFIMPNLTVFAQQTVGREHLGIATAMLQSLRMVGGMI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
GTAMVGTMVSRSYTAGVEQSLAAVNAQGWLTRMADPQVLIDKAAQAGLLTELQQAGHNGA
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
LLLEQARVSLVTAIHFGLVIAAAAALIGLWRARRVPPVRLVRAGQQPAMAAD
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]