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The map label for this gene is fabG2 [H]

Identifier: 73537399

GI number: 73537399

Start: 119397

End: 120182

Strand: Direct

Name: fabG2 [H]

Synonym: Reut_B3564

Alternate gene names: 73537399

Gene position: 119397-120182 (Clockwise)

Preceding gene: 73537396

Following gene: 73537400

Centisome position: 4.38

GC content: 66.79

Gene sequence:

>786_bases
ATGGAACTCAATGCATCGGTATCGGCTATCGTGACCGGCGGCGCTTCGGGCCTGGGTGCGGCGACGGCGCGCGCGCTGGC
CGCGCACGGTGTGCGCGTCGCGCTGTTTGACCTCAATGTCGAAAAGGGCGAAGCACTGGCTCGCGAACTGGGCGGCGTGT
TTTGCCAGGTCAACGTGACCTCGGAAGCGGAAGTCGAAGCCGGCTTTGCCAAGGCACGCGCCGCCATCGGCCAGGAACGC
ATCCTGGTCAACTGCGCGGGCACCGGCAACGCGATCAAGACCGCGTCGCGCTCGAAGGAAGACCCGTCGCAGATCAAGTT
CTTCCCGACCGACGCGTTCGAACGCATCGTCCAGATCAACCTGATCGGCACGTTCCGCTGCATCGCGCGCTCGGCGGCCG
GCATGCTGACGCTGGACCACACTGCAAGCGGCGACCGCGGCGTGATCATCAGCACCGCCTCGGTGGCGGCGCAGGACGGC
CAGATCGGCCAGGCGTCGTACTCGGCATCGAAGGCGGGCGTGGTTGGCATGACGCTGCCGATCGCACGCGATCTCTCCGG
GGAAGGTATCCGGGTCAACACCATCCTGCCGGGCATCTTCAACACGCCGCTGCTGCAAGGCGCACCCGAGAACGTCAAGG
CCGCGCTGGGCGCCTCGGTGCCGTTCCCGAAGCGCCTGGGCCAGCCCCAAGAGTTTGCCTCGCTCGCGGTCGAGATGTGC
CGCAACGGCTATTTCAATGGCGAGTCCGTGCGACTGGACGGCGCCATTCGCATGGCACCGCGCTGA

Upstream 100 bases:

>100_bases
ACCCGCTCCGGCGCCGTGCTGCGCCGGTTTCAGACACCAACTTCGGGCCTGCCGCTCGCGCGGCGCGGGCCTGCAAAAAA
CAGACGGAAGGAACTCGGCA

Downstream 100 bases:

>100_bases
TCGGAACGGCAAGCATCCACAGATGACGGCTGCGGCCCGGCCTGGCCGGGCCGTTTCTGCATATAAGAAGAGGAGACGTC
GATGGATTTCAGCTACCTGG

Product: Short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MELNASVSAIVTGGASGLGAATARALAAHGVRVALFDLNVEKGEALARELGGVFCQVNVTSEAEVEAGFAKARAAIGQER
ILVNCAGTGNAIKTASRSKEDPSQIKFFPTDAFERIVQINLIGTFRCIARSAAGMLTLDHTASGDRGVIISTASVAAQDG
QIGQASYSASKAGVVGMTLPIARDLSGEGIRVNTILPGIFNTPLLQGAPENVKAALGASVPFPKRLGQPQEFASLAVEMC
RNGYFNGESVRLDGAIRMAPR

Sequences:

>Translated_261_residues
MELNASVSAIVTGGASGLGAATARALAAHGVRVALFDLNVEKGEALARELGGVFCQVNVTSEAEVEAGFAKARAAIGQER
ILVNCAGTGNAIKTASRSKEDPSQIKFFPTDAFERIVQINLIGTFRCIARSAAGMLTLDHTASGDRGVIISTASVAAQDG
QIGQASYSASKAGVVGMTLPIARDLSGEGIRVNTILPGIFNTPLLQGAPENVKAALGASVPFPKRLGQPQEFASLAVEMC
RNGYFNGESVRLDGAIRMAPR
>Mature_261_residues
MELNASVSAIVTGGASGLGAATARALAAHGVRVALFDLNVEKGEALARELGGVFCQVNVTSEAEVEAGFAKARAAIGQER
ILVNCAGTGNAIKTASRSKEDPSQIKFFPTDAFERIVQINLIGTFRCIARSAAGMLTLDHTASGDRGVIISTASVAAQDG
QIGQASYSASKAGVVGMTLPIARDLSGEGIRVNTILPGIFNTPLLQGAPENVKAALGASVPFPKRLGQPQEFASLAVEMC
RNGYFNGESVRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=254, Percent_Identity=50, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=47.4509803921569, Blast_Score=204, Evalue=4e-53,
Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=31.5175097276265, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=27.8884462151394, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI31542939, Length=250, Percent_Identity=30, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI59889578, Length=236, Percent_Identity=29.2372881355932, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI224922801, Length=185, Percent_Identity=31.8918918918919, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=30.7086614173228, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=27.8625954198473, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789057, Length=217, Percent_Identity=30.8755760368664, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787905, Length=239, Percent_Identity=30.9623430962343, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790717, Length=262, Percent_Identity=25.5725190839695, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=29.4573643410853, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI2367175, Length=261, Percent_Identity=29.8850574712644, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1789378, Length=241, Percent_Identity=28.6307053941909, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789208, Length=256, Percent_Identity=28.515625, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=49.2, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=30.1158301158301, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=31.1284046692607, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17563726, Length=272, Percent_Identity=26.8382352941176, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=268, Percent_Identity=26.865671641791, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=204, Percent_Identity=27.9411764705882, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=51.9685039370079, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=31.7647058823529, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355319, Length=253, Percent_Identity=29.2490118577075, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26972; Mature: 26972

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNASVSAIVTGGASGLGAATARALAAHGVRVALFDLNVEKGEALARELGGVFCQVNVT
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHCCEEEEEEEC
SEAEVEAGFAKARAAIGQERILVNCAGTGNAIKTASRSKEDPSQIKFFPTDAFERIVQIN
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCCCHHHEEEEECHHHHHEEEEE
LIGTFRCIARSAAGMLTLDHTASGDRGVIISTASVAAQDGQIGQASYSASKAGVVGMTLP
EHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCEECCCCCCCCCCCCCCCCCEEEEEEC
IARDLSGEGIRVNTILPGIFNTPLLQGAPENVKAALGASVPFPKRLGQPQEFASLAVEMC
HHCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCHHHCCCHHHHHHHHHHHH
RNGYFNGESVRLDGAIRMAPR
HCCCCCCCEEEECCEEEECCC
>Mature Secondary Structure
MELNASVSAIVTGGASGLGAATARALAAHGVRVALFDLNVEKGEALARELGGVFCQVNVT
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHCCEEEEEEEC
SEAEVEAGFAKARAAIGQERILVNCAGTGNAIKTASRSKEDPSQIKFFPTDAFERIVQIN
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCCCHHHEEEEECHHHHHEEEEE
LIGTFRCIARSAAGMLTLDHTASGDRGVIISTASVAAQDGQIGQASYSASKAGVVGMTLP
EHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCEECCCCCCCCCCCCCCCCCEEEEEEC
IARDLSGEGIRVNTILPGIFNTPLLQGAPENVKAALGASVPFPKRLGQPQEFASLAVEMC
HHCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCHHHCCCHHHHHHHHHHHH
RNGYFNGESVRLDGAIRMAPR
HCCCCCCCEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]