Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 73542551

GI number: 73542551

Start: 3139051

End: 3140403

Strand: Direct

Name: accC [H]

Synonym: Reut_A2866

Alternate gene names: 73542551

Gene position: 3139051-3140403 (Clockwise)

Preceding gene: 73542550

Following gene: 73542552

Centisome position: 82.46

GC content: 64.01

Gene sequence:

>1353_bases
ATGTTTGAAAAAATTCTGATCGCGAACCGCGGTGAAATTGCCCTTCGCATCCAGCGCGCCTGCCGCGAGCTGGGCATCAA
GACCGTGGTGGTGTACTCGGAAGCCGACAAGGAAGCCAAGTACGTGAAGCTGGCCGACGAAGCCGTGTGTATCGGCCCGG
CCCCGTCGCCGCTGTCCTACCTGAACATGCCTGCCATCATTTCGGCCGCCGAAGTGACCGACGCGCAGGCGATCCACCCG
GGCTACGGCTTCCTGTCCGAAAACGCCGACTTTGCCGAGCGCGTGGAGAAGTCCGGCTTCGTCTTCATCGGCCCGACCGC
CGAGAGCATCCGCCTGATGGGCGACAAGGTCTCGGCCAAGCAGGCCATGATCAAGGCCGGCGTGCCGTGCGTGCCGGGCT
CGGAAGGCGCACTGCCTGACGATCCCGCCGAAATCGTCGCGGCGGCGCGCCGCGTGGGCTACCCGGTCATCATCAAGGCT
GCCGGCGGTGGTGGCGGCCGCGGCATGCGCGTGGTGCACACCGAGGCCGCGCTGGTCAACGCCGTCAACATGACGCGCGA
AGAAGCCGGCCGTGCCTTCGGCAACCCCGAGGTCTACATGGAGAAGTTCCTGGAGAATCCGCGCCACGTGGAGATCCAGA
TCCTTGCCGACCAGCACAAGCAAGCTATCTGGCTGGGCGAGCGCGACTGCTCGATGCAGCGACGCCACCAGAAGGTGATC
GAGGAAGCGCCCGCGCCGCACATTCCGCGCCGCCTGATCGAACGCATCGGCGACCGCTGCGCGGAGGCTTGCCGCAAGAT
GGGCTACCGTGGCGCCGGCACGTTCGAATTCCTGTACGAGAACAACGAGTTCTACTTCATCGAGATGAACACGCGCGTGC
AGGTCGAGCACCCGGTCACCGAAATGATCACGGGCATCGACATCGTGCAGGAACAGATCCGCATCGCATTTGGCGAGAAG
CTGCGCTACCGCCAGAAGGATGTGCAGTTCCGTGGCCATGCGATCGAATGCCGCGTGAATGCCGAGGACCCGTTCAAGTT
CATTCCGTCCCCGGGCCGCATCACCGCCTGGCACATGCCCGGTGGCCCCGGCGTACGCGTCGACTCGCACGCGTATGATG
GTTACTTCGTCCCGCCGAATTATGATTCGATGATCGGCAAGATCATCACCTACGGCGCTACCCGCGAGCAGGCGATTGCC
CGCATGCGGATCGCGCTGTCGGAGATGGTGGTGGACGGTATCCAGACCAACGTGCCGCTGCACCGGGAGCTGATGATGGA
CGCCAACTTCGTCGAAGGCGGCACCAGCATCCACTATCTCGAGCATCGCCTCGCGCAGCGCGAGAAAGCCTGA

Upstream 100 bases:

>100_bases
GCCATGAAGCGGCCCCTGGCCCCGCCAGTTTCCCGGCCGCGCACCCCGCGTGCCGCGGCGGCACCTGGCGGGACCGCTCC
CGTTCTCGCAGAGAGAGACC

Downstream 100 bases:

>100_bases
CGCGGCGACTGCCGCACCTGCTGTACAAAAGGAAGCCCGTGGCCTTTCAGGAATGTGTGATCGAAGTGGCGCAGGACCAG
GCCGAAGCCTGGTCTGACGC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFEKILIANRGEIALRIQRACRELGIKTVVVYSEADKEAKYVKLADEAVCIGPAPSPLSYLNMPAIISAAEVTDAQAIHP
GYGFLSENADFAERVEKSGFVFIGPTAESIRLMGDKVSAKQAMIKAGVPCVPGSEGALPDDPAEIVAAARRVGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPEVYMEKFLENPRHVEIQILADQHKQAIWLGERDCSMQRRHQKVI
EEAPAPHIPRRLIERIGDRCAEACRKMGYRGAGTFEFLYENNEFYFIEMNTRVQVEHPVTEMITGIDIVQEQIRIAFGEK
LRYRQKDVQFRGHAIECRVNAEDPFKFIPSPGRITAWHMPGGPGVRVDSHAYDGYFVPPNYDSMIGKIITYGATREQAIA
RMRIALSEMVVDGIQTNVPLHRELMMDANFVEGGTSIHYLEHRLAQREKA

Sequences:

>Translated_450_residues
MFEKILIANRGEIALRIQRACRELGIKTVVVYSEADKEAKYVKLADEAVCIGPAPSPLSYLNMPAIISAAEVTDAQAIHP
GYGFLSENADFAERVEKSGFVFIGPTAESIRLMGDKVSAKQAMIKAGVPCVPGSEGALPDDPAEIVAAARRVGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPEVYMEKFLENPRHVEIQILADQHKQAIWLGERDCSMQRRHQKVI
EEAPAPHIPRRLIERIGDRCAEACRKMGYRGAGTFEFLYENNEFYFIEMNTRVQVEHPVTEMITGIDIVQEQIRIAFGEK
LRYRQKDVQFRGHAIECRVNAEDPFKFIPSPGRITAWHMPGGPGVRVDSHAYDGYFVPPNYDSMIGKIITYGATREQAIA
RMRIALSEMVVDGIQTNVPLHRELMMDANFVEGGTSIHYLEHRLAQREKA
>Mature_450_residues
MFEKILIANRGEIALRIQRACRELGIKTVVVYSEADKEAKYVKLADEAVCIGPAPSPLSYLNMPAIISAAEVTDAQAIHP
GYGFLSENADFAERVEKSGFVFIGPTAESIRLMGDKVSAKQAMIKAGVPCVPGSEGALPDDPAEIVAAARRVGYPVIIKA
AGGGGGRGMRVVHTEAALVNAVNMTREEAGRAFGNPEVYMEKFLENPRHVEIQILADQHKQAIWLGERDCSMQRRHQKVI
EEAPAPHIPRRLIERIGDRCAEACRKMGYRGAGTFEFLYENNEFYFIEMNTRVQVEHPVTEMITGIDIVQEQIRIAFGEK
LRYRQKDVQFRGHAIECRVNAEDPFKFIPSPGRITAWHMPGGPGVRVDSHAYDGYFVPPNYDSMIGKIITYGATREQAIA
RMRIALSEMVVDGIQTNVPLHRELMMDANFVEGGTSIHYLEHRLAQREKA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=461, Percent_Identity=47.939262472885, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI295821183, Length=461, Percent_Identity=47.939262472885, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI65506442, Length=461, Percent_Identity=47.939262472885, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=45.9090909090909, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=44.3946188340807, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=44.3946188340807, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=44.3946188340807, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI38679977, Length=520, Percent_Identity=32.8846153846154, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI38679967, Length=520, Percent_Identity=32.8846153846154, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI38679974, Length=520, Percent_Identity=32.8846153846154, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI38679960, Length=520, Percent_Identity=32.8846153846154, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI38679971, Length=520, Percent_Identity=32.8846153846154, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI134142062, Length=520, Percent_Identity=31.3461538461538, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=69.0423162583519, Blast_Score=615, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=46.9525959367946, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=46.4852607709751, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=44.0715883668904, Blast_Score=347, Evalue=5e-96,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=30.3030303030303, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=517, Percent_Identity=28.6266924564797, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71997168, Length=517, Percent_Identity=28.6266924564797, Blast_Score=197, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=42.4379232505643, Blast_Score=353, Evalue=4e-98,
Organism=Saccharomyces cerevisiae, GI6319695, Length=451, Percent_Identity=45.8980044345898, Blast_Score=341, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=451, Percent_Identity=46.7849223946785, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6323863, Length=479, Percent_Identity=32.776617954071, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324343, Length=526, Percent_Identity=29.8479087452471, Blast_Score=223, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24651757, Length=433, Percent_Identity=44.3418013856813, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=45.4954954954955, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=45.4954954954955, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=45.4954954954955, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=45.4954954954955, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=45.4954954954955, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=45.4954954954955, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24651759, Length=396, Percent_Identity=43.4343434343434, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI161076407, Length=511, Percent_Identity=30.7240704500978, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24586460, Length=511, Percent_Identity=30.7240704500978, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161076409, Length=511, Percent_Identity=30.7240704500978, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24586458, Length=511, Percent_Identity=30.7240704500978, Blast_Score=223, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50065; Mature: 50065

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKILIANRGEIALRIQRACRELGIKTVVVYSEADKEAKYVKLADEAVCIGPAPSPLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCEEEECCCCCCHHH
LNMPAIISAAEVTDAQAIHPGYGFLSENADFAERVEKSGFVFIGPTAESIRLMGDKVSAK
CCCCHHEEHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
QAMIKAGVPCVPGSEGALPDDPAEIVAAARRVGYPVIIKAAGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVNMTREEAGRAFGNPEVYMEKFLENPRHVEIQILADQHKQAIWLGERDCSMQRRHQKVI
HHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPHIPRRLIERIGDRCAEACRKMGYRGAGTFEFLYENNEFYFIEMNTRVQVEHPVT
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHH
EMITGIDIVQEQIRIAFGEKLRYRQKDVQFRGHAIECRVNAEDPFKFIPSPGRITAWHMP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCEEEEEEECCCCCCEECCCCCCEEEEECC
GGPGVRVDSHAYDGYFVPPNYDSMIGKIITYGATREQAIARMRIALSEMVVDGIQTNVPL
CCCCCEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
HRELMMDANFVEGGTSIHYLEHRLAQREKA
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFEKILIANRGEIALRIQRACRELGIKTVVVYSEADKEAKYVKLADEAVCIGPAPSPLSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCEEEECCCCCCHHH
LNMPAIISAAEVTDAQAIHPGYGFLSENADFAERVEKSGFVFIGPTAESIRLMGDKVSAK
CCCCHHEEHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
QAMIKAGVPCVPGSEGALPDDPAEIVAAARRVGYPVIIKAAGGGGGRGMRVVHTEAALVN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVNMTREEAGRAFGNPEVYMEKFLENPRHVEIQILADQHKQAIWLGERDCSMQRRHQKVI
HHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPHIPRRLIERIGDRCAEACRKMGYRGAGTFEFLYENNEFYFIEMNTRVQVEHPVT
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHH
EMITGIDIVQEQIRIAFGEKLRYRQKDVQFRGHAIECRVNAEDPFKFIPSPGRITAWHMP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCEEEEEEECCCCCCEECCCCCCEEEEECC
GGPGVRVDSHAYDGYFVPPNYDSMIGKIITYGATREQAIARMRIALSEMVVDGIQTNVPL
CCCCCEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
HRELMMDANFVEGGTSIHYLEHRLAQREKA
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]