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The map label for this gene is accB [H]

Identifier: 73542550

GI number: 73542550

Start: 3138397

End: 3138861

Strand: Direct

Name: accB [H]

Synonym: Reut_A2865

Alternate gene names: 73542550

Gene position: 3138397-3138861 (Clockwise)

Preceding gene: 73542549

Following gene: 73542551

Centisome position: 82.45

GC content: 65.38

Gene sequence:

>465_bases
ATGGACCTGCGCAAGCTGAAGACGCTGATCGACCTGGTGGCCGAATCCGGCATCTCGGAGCTGGAAGTCACTGAAGGCGA
CGGCAAGGTTCGTATCGTCAAGCAACCGCCGCAAGTCATCGCCGCGCCGATGGCCATGCCGCAAATGCAGGCGCTGCCGG
TCATGCCCGCCGCTGCTCCGGCAGCCAGCGCCCCGGCAGCCGCTGAAGCGGCCGCCCCGCAGCTTCCCGCCGGTCACATC
GTGACCTCGCCGATGGTCGGCACCTTCTACCGTGCACCGTCGCCGGGCGCCGCGCCGTTCGTCAACGTCGGGGACTCGGT
CAAGGAAGGCCAGACCGTCTGCATCATCGAAGCCATGAAGCTGCTCAACGAGATCGAGTGCGACAAGGCCGGCGTCATCA
AGGAAATCCTGGTCGAAAACGGCCAGGCGGTGGAATACGGCCAGCCGCTGTTCGTCATCGGCTAA

Upstream 100 bases:

>100_bases
CAAGCACGGCGGGCGCGGAGAGCGGGTGGCCGTACCGACGATTTCTTCCGCCGCTGCCCGCGAGGGCATGCCCGGACAAC
CTGATTCAGGAGGATAGAAG

Downstream 100 bases:

>100_bases
TGCTGCCCGGCATGCCGCGCCGCCCTGCCCCCCCGGGCTGCGGCCTGCCGGATGTCGTGGATGTTCGCACGTTGCGAACC
GCATCCCTTGCCATGAAGCG

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MDLRKLKTLIDLVAESGISELEVTEGDGKVRIVKQPPQVIAAPMAMPQMQALPVMPAAAPAASAPAAAEAAAPQLPAGHI
VTSPMVGTFYRAPSPGAAPFVNVGDSVKEGQTVCIIEAMKLLNEIECDKAGVIKEILVENGQAVEYGQPLFVIG

Sequences:

>Translated_154_residues
MDLRKLKTLIDLVAESGISELEVTEGDGKVRIVKQPPQVIAAPMAMPQMQALPVMPAAAPAASAPAAAEAAAPQLPAGHI
VTSPMVGTFYRAPSPGAAPFVNVGDSVKEGQTVCIIEAMKLLNEIECDKAGVIKEILVENGQAVEYGQPLFVIG
>Mature_154_residues
MDLRKLKTLIDLVAESGISELEVTEGDGKVRIVKQPPQVIAAPMAMPQMQALPVMPAAAPAASAPAAAEAAAPQLPAGHI
VTSPMVGTFYRAPSPGAAPFVNVGDSVKEGQTVCIIEAMKLLNEIECDKAGVIKEILVENGQAVEYGQPLFVIG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=161, Percent_Identity=53.416149068323, Blast_Score=161, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 15985; Mature: 15985

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRKLKTLIDLVAESGISELEVTEGDGKVRIVKQPPQVIAAPMAMPQMQALPVMPAAAP
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCHHHHCCCCCCCCCCCCCCCCCCCC
AASAPAAAEAAAPQLPAGHIVTSPMVGTFYRAPSPGAAPFVNVGDSVKEGQTVCIIEAMK
CCCCCCCHHHCCCCCCCCCEECCCCCHHEECCCCCCCCCEECCCCCCCCCCEEHHHHHHH
LLNEIECDKAGVIKEILVENGQAVEYGQPLFVIG
HHHHHCCCCHHHHHHHHHCCCCEEECCCEEEEEC
>Mature Secondary Structure
MDLRKLKTLIDLVAESGISELEVTEGDGKVRIVKQPPQVIAAPMAMPQMQALPVMPAAAP
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCHHHHCCCCCCCCCCCCCCCCCCCC
AASAPAAAEAAAPQLPAGHIVTSPMVGTFYRAPSPGAAPFVNVGDSVKEGQTVCIIEAMK
CCCCCCCHHHCCCCCCCCCEECCCCCHHEECCCCCCCCCEECCCCCCCCCCEEHHHHHHH
LLNEIECDKAGVIKEILVENGQAVEYGQPLFVIG
HHHHHCCCCHHHHHHHHHCCCCEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]