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The map label for this gene is crt [H]

Identifier: 73541595

GI number: 73541595

Start: 2090794

End: 2091564

Strand: Reverse

Name: crt [H]

Synonym: Reut_A1906

Alternate gene names: 73541595

Gene position: 2091564-2090794 (Counterclockwise)

Preceding gene: 73541596

Following gene: 73541594

Centisome position: 54.95

GC content: 67.06

Gene sequence:

>771_bases
ATGGAACCCGTAATTGTGGAACGCGATGGCGACGTGGCCATCGTCACGCTGAATCGTCCCGCGCGCATGAACGCCGTCAA
CGATGCGCTGCGCGGCGGGCTGATTGATGCGCTGGCCCGGCTCAACGCCGATCCGGCCGTGCGCGCCCTGGTACTTGCAG
GGGCCGGCGAGCGCGCCTTCTGTGCCGGACAGGATCTTGATGAAGCAGCTGCGGTGACGTGGCAGCAGATCGTGCCGTGG
CTGAACCGTCAGCGGGCCATGTACCAATCCGTGCGCGATCTGGACAAGCCCTGCGTGGCAGCGGTGCGGGGCGTGGCCGC
CGGTGCGGGATTCCAGCTTGCGCTGTGCGCGGACTGGCGCCTGACGACGGCGGACAGCCGCTGGGGCCAGCCGGAGGTCA
AGGCCGGCCTGGCGAGCATCGTCGGCTCATACCTGATGACGCTGCACGTTGGGCATACCCACAACGTGCAGATGTCGCTG
TCGGGCGAACTGGTATCAGGGCAGCGGGCCTACGAGATCGGGCTGGTAACCGCCTTGCATGGCGAGGCGGAACTGATGGG
CGCCGCGCTGGCGCGTGCCCGGTCGCTGGCCGCCTTGCCGCCAACATCGGTCAGGCTGTCGAAACAACGGCTGCGGGCAA
TGACGCAGCCCGGGTTCGACGACGCATGCGTAGCGGGCATCCGCGCGCAGCTCGAATGCTATGCGGATGGCGAGCCGCAA
CGCGTGATGGCCGAATTTCTCGGCAAACGGAATGCAAGGGAGTCGCAATGA

Upstream 100 bases:

>100_bases
GGCACGCTGAAGTCGGTGGACATCAATCCGCTGATGGTGATGGCCGCCGGCGACGGCGTGGTGGCCGTGGACGCCGTGGT
GGAACTGCAAGGAGCCTGAC

Downstream 100 bases:

>100_bases
TCCAGTGGAACGAGCATCTCATCAACGGCGCGCGACGAGCCGTGCGCGAAGGGCGCACCGTTCGCATTCACGATGCCGCC
ACCGAAGCACCGCTCGGTGA

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MEPVIVERDGDVAIVTLNRPARMNAVNDALRGGLIDALARLNADPAVRALVLAGAGERAFCAGQDLDEAAAVTWQQIVPW
LNRQRAMYQSVRDLDKPCVAAVRGVAAGAGFQLALCADWRLTTADSRWGQPEVKAGLASIVGSYLMTLHVGHTHNVQMSL
SGELVSGQRAYEIGLVTALHGEAELMGAALARARSLAALPPTSVRLSKQRLRAMTQPGFDDACVAGIRAQLECYADGEPQ
RVMAEFLGKRNARESQ

Sequences:

>Translated_256_residues
MEPVIVERDGDVAIVTLNRPARMNAVNDALRGGLIDALARLNADPAVRALVLAGAGERAFCAGQDLDEAAAVTWQQIVPW
LNRQRAMYQSVRDLDKPCVAAVRGVAAGAGFQLALCADWRLTTADSRWGQPEVKAGLASIVGSYLMTLHVGHTHNVQMSL
SGELVSGQRAYEIGLVTALHGEAELMGAALARARSLAALPPTSVRLSKQRLRAMTQPGFDDACVAGIRAQLECYADGEPQ
RVMAEFLGKRNARESQ
>Mature_256_residues
MEPVIVERDGDVAIVTLNRPARMNAVNDALRGGLIDALARLNADPAVRALVLAGAGERAFCAGQDLDEAAAVTWQQIVPW
LNRQRAMYQSVRDLDKPCVAAVRGVAAGAGFQLALCADWRLTTADSRWGQPEVKAGLASIVGSYLMTLHVGHTHNVQMSL
SGELVSGQRAYEIGLVTALHGEAELMGAALARARSLAALPPTSVRLSKQRLRAMTQPGFDDACVAGIRAQLECYADGEPQ
RVMAEFLGKRNARESQ

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=257, Percent_Identity=28.7937743190661, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI37594469, Length=181, Percent_Identity=28.7292817679558, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI37594471, Length=181, Percent_Identity=28.7292817679558, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI20127408, Length=227, Percent_Identity=26.8722466960352, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4502327, Length=242, Percent_Identity=27.6859504132231, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI70995211, Length=212, Percent_Identity=27.8301886792453, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787659, Length=214, Percent_Identity=34.1121495327103, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI221142681, Length=216, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790281, Length=191, Percent_Identity=29.8429319371728, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87082183, Length=245, Percent_Identity=23.6734693877551, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787660, Length=218, Percent_Identity=33.0275229357798, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788597, Length=218, Percent_Identity=27.0642201834862, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25145438, Length=241, Percent_Identity=28.6307053941909, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17554946, Length=212, Percent_Identity=31.1320754716981, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=237, Percent_Identity=27.8481012658228, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17560910, Length=199, Percent_Identity=30.1507537688442, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17535521, Length=254, Percent_Identity=27.1653543307087, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17534483, Length=226, Percent_Identity=27.4336283185841, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17558304, Length=176, Percent_Identity=29.5454545454545, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144157, Length=191, Percent_Identity=26.7015706806283, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144160, Length=191, Percent_Identity=26.7015706806283, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=136, Percent_Identity=30.1470588235294, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=136, Percent_Identity=30.1470588235294, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17508953, Length=176, Percent_Identity=28.4090909090909, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=186, Percent_Identity=25.2688172043011, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=28.0487804878049, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=28.0487804878049, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653139, Length=214, Percent_Identity=28.9719626168224, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357171, Length=206, Percent_Identity=29.6116504854369, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24650670, Length=222, Percent_Identity=27.4774774774775, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24654903, Length=253, Percent_Identity=22.9249011857708, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19920382, Length=212, Percent_Identity=27.8301886792453, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 27398; Mature: 27398

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPVIVERDGDVAIVTLNRPARMNAVNDALRGGLIDALARLNADPAVRALVLAGAGERAF
CCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCEE
CAGQDLDEAAAVTWQQIVPWLNRQRAMYQSVRDLDKPCVAAVRGVAAGAGFQLALCADWR
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEECCE
LTTADSRWGQPEVKAGLASIVGSYLMTLHVGHTHNVQMSLSGELVSGQRAYEIGLVTALH
EECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEECCCCEEEEEEEEEEC
GEAELMGAALARARSLAALPPTSVRLSKQRLRAMTQPGFDDACVAGIRAQLECYADGEPQ
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEEECCCCHH
RVMAEFLGKRNARESQ
HHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEPVIVERDGDVAIVTLNRPARMNAVNDALRGGLIDALARLNADPAVRALVLAGAGERAF
CCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCEE
CAGQDLDEAAAVTWQQIVPWLNRQRAMYQSVRDLDKPCVAAVRGVAAGAGFQLALCADWR
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEECCE
LTTADSRWGQPEVKAGLASIVGSYLMTLHVGHTHNVQMSLSGELVSGQRAYEIGLVTALH
EECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEECCCCEEEEEEEEEEC
GEAELMGAALARARSLAALPPTSVRLSKQRLRAMTQPGFDDACVAGIRAQLECYADGEPQ
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEEECCCCHH
RVMAEFLGKRNARESQ
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]