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The map label for this gene is lpxB

Identifier: 73541557

GI number: 73541557

Start: 2043956

End: 2045164

Strand: Reverse

Name: lpxB

Synonym: Reut_A1868

Alternate gene names: 73541557

Gene position: 2045164-2043956 (Counterclockwise)

Preceding gene: 73541558

Following gene: 73541556

Centisome position: 53.73

GC content: 64.68

Gene sequence:

>1209_bases
ATGGTCGACGCTGCGATTCGGGGCACATTGCCTGCCGGTACCGGGACCAACGCCAGCCAGCGTGGCACGATTGCCATGGT
CGCCGGCGAAGCTTCAGGCGACCTGCTGGCATCGCTGATGCTGGGCGGGCTTAAGGCCCGCCTCGGCGATACGGTCAGCT
ATGCCGGCATTGGCGGCAAGCGCATGATGACCGAGGGTTTTGTTTCGCAATGGCCGATGGAGACGCTGTCGGTCAATGGC
TACGTCGAGGTGCTGGGCTCGCTGCGCGAGATTCTGGCCACGCGCCGTGCCATCCGTGATTCGCTGCTCGCGAATCCGCC
GCTGTGCTTCATCGGCGTGGATGCGCCGGACTTCAATTTCGGTCTGGAGGTTCCGCTGCGGCGCGCCGGGATTCCGGTGG
TCCATTTCGTCAGCCCGTCGATCTGGGCCTGGCGGGGAGGTCGGATCCGCACCATTGCGCGTGCGGTCGACCACATCCTC
TGCCTGTTCCCGTTTGAGCCCGAGATCTACGCCAAGGCTGGCATTCCGGCGACCTATGTGGGCCACCCGCTGGCCGACGT
GATTCCGATGGTGCCCGATGTCGCAGGCGCGCGTGCGGCATTGGACCTGCCCGCTGGCTGTCGCGTGGTTGCCGTATTGC
CGGGCAGTCGGCAGTCCGAAGTGCGGAACCTCGGTGCGACATTCTTCGCTGCCATGGCGCGGATGCACCGCATGGACCCG
AACCTGGCGTTCGTGCTGCCTGCGGCGAGCGCCCCGTTGCGCGCCATCGTTGAGGAGTTGCATCAGCAGTACCCCGAGCT
TCGCTTGACGATCGTCGACGGTAACTCGCATCAGGCGATGGAAGCGGCCGACGTGGTGCTGCTGGCCAGTGGCACCGCGA
CGCTCGAAGCGGCGTTGTACAAGAAGCCGATGGTGATCTCCTACAAGGTGCCCTGGCTTACTGCGCAGATCATGAAGCGG
CAGGGTTACCTGCCGTATGTGGGCTTGCCGAACATCCTGTCGGGGCGCTTTGTGGTGCCCGAACTGCTGCAGGACGATGC
TACGCCGGAAGCGCTCGCGCGCGAGACGCTGCTGCAGCTCAATGACCAGGGCAATATCGCCTTCCTGTACGAACACTTCA
CGCGCATGCACGAAACGCTCAAGTGCAATACGGCGCAGCTCGCCGCGGATGTGGTCGTCGACCTGATGCGCTCGCGGGGG
CTGGTCTGA

Upstream 100 bases:

>100_bases
CTGGCCCAGGCCGATGCAAGCGCGGCAGAACCGCTGCGCGCGTTCCTCGACTTCATCGCCGCCACCCAGCGCGGCATCGT
GCGCTGAGACTGGCCCGGAC

Downstream 100 bases:

>100_bases
TGGCGCGCGGCAATCTTTCGTCGGCGCAAATGGGGCTTGACCTTGCGCCGGTGGCAGCAAGCGTCCGGTTCCTGTGCGGT
GTGGACGAGGCTGGCCGCGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MVDAAIRGTLPAGTGTNASQRGTIAMVAGEASGDLLASLMLGGLKARLGDTVSYAGIGGKRMMTEGFVSQWPMETLSVNG
YVEVLGSLREILATRRAIRDSLLANPPLCFIGVDAPDFNFGLEVPLRRAGIPVVHFVSPSIWAWRGGRIRTIARAVDHIL
CLFPFEPEIYAKAGIPATYVGHPLADVIPMVPDVAGARAALDLPAGCRVVAVLPGSRQSEVRNLGATFFAAMARMHRMDP
NLAFVLPAASAPLRAIVEELHQQYPELRLTIVDGNSHQAMEAADVVLLASGTATLEAALYKKPMVISYKVPWLTAQIMKR
QGYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQLNDQGNIAFLYEHFTRMHETLKCNTAQLAADVVVDLMRSRG
LV

Sequences:

>Translated_402_residues
MVDAAIRGTLPAGTGTNASQRGTIAMVAGEASGDLLASLMLGGLKARLGDTVSYAGIGGKRMMTEGFVSQWPMETLSVNG
YVEVLGSLREILATRRAIRDSLLANPPLCFIGVDAPDFNFGLEVPLRRAGIPVVHFVSPSIWAWRGGRIRTIARAVDHIL
CLFPFEPEIYAKAGIPATYVGHPLADVIPMVPDVAGARAALDLPAGCRVVAVLPGSRQSEVRNLGATFFAAMARMHRMDP
NLAFVLPAASAPLRAIVEELHQQYPELRLTIVDGNSHQAMEAADVVLLASGTATLEAALYKKPMVISYKVPWLTAQIMKR
QGYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQLNDQGNIAFLYEHFTRMHETLKCNTAQLAADVVVDLMRSRG
LV
>Mature_402_residues
MVDAAIRGTLPAGTGTNASQRGTIAMVAGEASGDLLASLMLGGLKARLGDTVSYAGIGGKRMMTEGFVSQWPMETLSVNG
YVEVLGSLREILATRRAIRDSLLANPPLCFIGVDAPDFNFGLEVPLRRAGIPVVHFVSPSIWAWRGGRIRTIARAVDHIL
CLFPFEPEIYAKAGIPATYVGHPLADVIPMVPDVAGARAALDLPAGCRVVAVLPGSRQSEVRNLGATFFAAMARMHRMDP
NLAFVLPAASAPLRAIVEELHQQYPELRLTIVDGNSHQAMEAADVVLLASGTATLEAALYKKPMVISYKVPWLTAQIMKR
QGYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQLNDQGNIAFLYEHFTRMHETLKCNTAQLAADVVVDLMRSRG
LV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=374, Percent_Identity=39.8395721925134, Blast_Score=274, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_CUPPJ (Q470F0)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296077.1
- ProteinModelPortal:   Q470F0
- GeneID:   3609255
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A1868
- NMPDR:   fig|264198.3.peg.2398
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- BioCyc:   REUT264198:REUT_A1868-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 43360; Mature: 43360

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDAAIRGTLPAGTGTNASQRGTIAMVAGEASGDLLASLMLGGLKARLGDTVSYAGIGGK
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCCH
RMMTEGFVSQWPMETLSVNGYVEVLGSLREILATRRAIRDSLLANPPLCFIGVDAPDFNF
HHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
GLEVPLRRAGIPVVHFVSPSIWAWRGGRIRTIARAVDHILCLFPFEPEIYAKAGIPATYV
CCCCCHHHCCCCEEEECCCCEEEECCCCHHHHHHHHHHEEEEECCCCCCEEECCCCHHHC
GHPLADVIPMVPDVAGARAALDLPAGCRVVAVLPGSRQSEVRNLGATFFAAMARMHRMDP
CCCHHHHHHHCCCCCCCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
NLAFVLPAASAPLRAIVEELHQQYPELRLTIVDGNSHQAMEAADVVLLASGTATLEAALY
CEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCEEEEECCCHHHHHHHH
KKPMVISYKVPWLTAQIMKRQGYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQL
CCCEEEEEECCHHHHHHHHHCCCCCCCCCCHHHCCCEECHHHHCCCCCHHHHHHHHHHHC
NDQGNIAFLYEHFTRMHETLKCNTAQLAADVVVDLMRSRGLV
CCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVDAAIRGTLPAGTGTNASQRGTIAMVAGEASGDLLASLMLGGLKARLGDTVSYAGIGGK
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCCH
RMMTEGFVSQWPMETLSVNGYVEVLGSLREILATRRAIRDSLLANPPLCFIGVDAPDFNF
HHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
GLEVPLRRAGIPVVHFVSPSIWAWRGGRIRTIARAVDHILCLFPFEPEIYAKAGIPATYV
CCCCCHHHCCCCEEEECCCCEEEECCCCHHHHHHHHHHEEEEECCCCCCEEECCCCHHHC
GHPLADVIPMVPDVAGARAALDLPAGCRVVAVLPGSRQSEVRNLGATFFAAMARMHRMDP
CCCHHHHHHHCCCCCCCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
NLAFVLPAASAPLRAIVEELHQQYPELRLTIVDGNSHQAMEAADVVLLASGTATLEAALY
CEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCEEEEECCCHHHHHHHH
KKPMVISYKVPWLTAQIMKRQGYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQL
CCCEEEEEECCHHHHHHHHHCCCCCCCCCCHHHCCCEECHHHHCCCCCHHHHHHHHHHHC
NDQGNIAFLYEHFTRMHETLKCNTAQLAADVVVDLMRSRGLV
CCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA