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The map label for this gene is moxY [H]

Identifier: 73541475

GI number: 73541475

Start: 1948821

End: 1950260

Strand: Reverse

Name: moxY [H]

Synonym: Reut_A1786

Alternate gene names: 73541475

Gene position: 1950260-1948821 (Counterclockwise)

Preceding gene: 73541477

Following gene: 73541474

Centisome position: 51.23

GC content: 69.38

Gene sequence:

>1440_bases
ATGACGATGTCCCGCTTTCTGGCCAGCCGAGCGTTGTGGCTGGCTTGCGCGTGCCTGGGCTGTGCGCTGCTGGGAGCCCT
GTGGCTAGCACGGCAGGCAATCGGCGAAGAGCGCAGCGGCGCAGCCGCGATAGCGCAACTGGTTGCGCGGCTGTCGGCAC
TGCAGGCCGCCGGACCCGCCGAACGCGCGGCGCAGCTCGCTGCGCTGCGCGCCATCAATCAGTCGGCGCGGATGCGCCAT
CTGCGGCTGCACGTCGAGGATGCCGCTGGCCGCGTGCTGGTGGATGCGACACCCAAAGGCGACCTGGTGCACGCAGAAAG
CCAATGGGAGATCCGCGCGCGCGATGGCACCGTCTATCATGCGGCGCTGCGCTGGAACCCGGACAGCGAACTGCGTGAGG
CGCGCGGAGACGTCGTTGGCAACCTGGCCATGCTTGGGGCGTACAGCGTGCTGTTGCTGTGCTGCTTGTCGTGGACGGCG
CGGCGCGCGTTTGCGCCCTTGCAGCAGATCCTCGATGCCATAGGCCACTACGAACGCAAGGACTACAGCGTGCGCCTGCC
CGCCATGCACATCCGCGAACTGGATCAGGTGCGCCGGGCGTTGAATCATCTTGCCGGCGCGCTAGCGCAGCACCAGCTCG
AGCGCCGGGCGCTGAGCCGCAAGCTGCTCGATGCGCAGGAGTGCGAGCGCGCCAGGCTGGCGCGCGAGCTGCACGATGAG
TTCGGCCAGGTGCTGACTGCCATGCGCGCGGACGCCACCTACCTGGTACGCAAGAGCGCGCATGCGCCGATGCTGCAGAT
CGTGGCCAACGATCTGGCCGGGCACTGCGCCCGGATCCAGGACGAAGTCCGCCACCTGTTGCACCGGCTGCGCCCGCATG
GCGGGCAACCCGACGGACGCGTCGCCTGCCTGCCGCGGTTGTTGCAGGACCTGGTCCGGGGCTGGCGCGGACAGCCAGGC
CAGGCGGTGCGGCTCGATTGCGATGTCGACCTGGGCGGCGCCGTGCTGGATCCGGATCTGACCCTCACGCTCTACCGGAT
GACGCAGGAGGCGCTGACCAATGTGATGCGCCATGCCGGCGCCAGCCGCGCGTCGATCTGCATTGTGCGACGCGGCAATG
AAGTCCGCTGGTGCGTGGAAGACGATGGCTCGGGCATAGGCGACATCGCCGCAGCGATGCAGCGCAGCCACGGCTTGCGG
GGCATGCAGGAACGCGCGTGGGCGCATTGCGCCACGCTATGCATCGGGGCTGCGGAGGGCACCGGGGACACGCGCGGCTG
CCGGCTGAGCGCGGCCTTTCCGCTGCCTGCACCAGCGCACGACACGGCGCAGATCCCGCAGATCCCGCCAATCCCGCCAA
TCCCGCCAATCCCGCCAATCCCGCCAATCCCGCCGGTCCCGCCGGTCCCGCAAATTCACCAGGGGAGCCAGCCAGCATGA

Upstream 100 bases:

>100_bases
CAAACTGAGTGCAGGAGCGAGCAGGTTCCATACCGCCCGCGTCGGGAAAACCTCCTGACCTGAGCCCTGCCTGCGCCCCA
TCCTGCGGAGGAGCACCGCC

Downstream 100 bases:

>100_bases
AAACGATCGACGTAGTGATCACCGATGATCACGCAGTGGTGCGCACCGGCTACCGTCGCCTGCTGGAACTGGACGAGGGG
ATGCGTGTGGTGGCGGAGTT

Product: signal transduction histidine kinase, glucose-6-phosphate specific

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MTMSRFLASRALWLACACLGCALLGALWLARQAIGEERSGAAAIAQLVARLSALQAAGPAERAAQLAALRAINQSARMRH
LRLHVEDAAGRVLVDATPKGDLVHAESQWEIRARDGTVYHAALRWNPDSELREARGDVVGNLAMLGAYSVLLLCCLSWTA
RRAFAPLQQILDAIGHYERKDYSVRLPAMHIRELDQVRRALNHLAGALAQHQLERRALSRKLLDAQECERARLARELHDE
FGQVLTAMRADATYLVRKSAHAPMLQIVANDLAGHCARIQDEVRHLLHRLRPHGGQPDGRVACLPRLLQDLVRGWRGQPG
QAVRLDCDVDLGGAVLDPDLTLTLYRMTQEALTNVMRHAGASRASICIVRRGNEVRWCVEDDGSGIGDIAAAMQRSHGLR
GMQERAWAHCATLCIGAAEGTGDTRGCRLSAAFPLPAPAHDTAQIPQIPPIPPIPPIPPIPPIPPVPPVPQIHQGSQPA

Sequences:

>Translated_479_residues
MTMSRFLASRALWLACACLGCALLGALWLARQAIGEERSGAAAIAQLVARLSALQAAGPAERAAQLAALRAINQSARMRH
LRLHVEDAAGRVLVDATPKGDLVHAESQWEIRARDGTVYHAALRWNPDSELREARGDVVGNLAMLGAYSVLLLCCLSWTA
RRAFAPLQQILDAIGHYERKDYSVRLPAMHIRELDQVRRALNHLAGALAQHQLERRALSRKLLDAQECERARLARELHDE
FGQVLTAMRADATYLVRKSAHAPMLQIVANDLAGHCARIQDEVRHLLHRLRPHGGQPDGRVACLPRLLQDLVRGWRGQPG
QAVRLDCDVDLGGAVLDPDLTLTLYRMTQEALTNVMRHAGASRASICIVRRGNEVRWCVEDDGSGIGDIAAAMQRSHGLR
GMQERAWAHCATLCIGAAEGTGDTRGCRLSAAFPLPAPAHDTAQIPQIPPIPPIPPIPPIPPIPPVPPVPQIHQGSQPA
>Mature_478_residues
TMSRFLASRALWLACACLGCALLGALWLARQAIGEERSGAAAIAQLVARLSALQAAGPAERAAQLAALRAINQSARMRHL
RLHVEDAAGRVLVDATPKGDLVHAESQWEIRARDGTVYHAALRWNPDSELREARGDVVGNLAMLGAYSVLLLCCLSWTAR
RAFAPLQQILDAIGHYERKDYSVRLPAMHIRELDQVRRALNHLAGALAQHQLERRALSRKLLDAQECERARLARELHDEF
GQVLTAMRADATYLVRKSAHAPMLQIVANDLAGHCARIQDEVRHLLHRLRPHGGQPDGRVACLPRLLQDLVRGWRGQPGQ
AVRLDCDVDLGGAVLDPDLTLTLYRMTQEALTNVMRHAGASRASICIVRRGNEVRWCVEDDGSGIGDIAAAMQRSHGLRG
MQERAWAHCATLCIGAAEGTGDTRGCRLSAAFPLPAPAHDTAQIPQIPPIPPIPPIPPIPPIPPVPPVPQIHQGSQPA

Specific function: Member of the two-component regulatory system moxY/moxX probably involved in the regulation of the methanol dehydrogenase expression. May function as a membrane-associated protein kinase that phosphorylates moxX in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=208, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082311, Length=244, Percent_Identity=30.7377049180328, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR011712 [H]

Pfam domain/function: PF00672 HAMP; PF07730 HisKA_3 [H]

EC number: 2.7.3.- [C]

Molecular weight: Translated: 52187; Mature: 52056

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS50885 HAMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMSRFLASRALWLACACLGCALLGALWLARQAIGEERSGAAAIAQLVARLSALQAAGPA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHH
ERAAQLAALRAINQSARMRHLRLHVEDAAGRVLVDATPKGDLVHAESQWEIRARDGTVYH
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCEEECCCCEEEEECCCEEEE
AALRWNPDSELREARGDVVGNLAMLGAYSVLLLCCLSWTARRAFAPLQQILDAIGHYERK
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DYSVRLPAMHIRELDQVRRALNHLAGALAQHQLERRALSRKLLDAQECERARLARELHDE
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
FGQVLTAMRADATYLVRKSAHAPMLQIVANDLAGHCARIQDEVRHLLHRLRPHGGQPDGR
HHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
VACLPRLLQDLVRGWRGQPGQAVRLDCDVDLGGAVLDPDLTLTLYRMTQEALTNVMRHAG
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCC
ASRASICIVRRGNEVRWCVEDDGSGIGDIAAAMQRSHGLRGMQERAWAHCATLCIGAAEG
CCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
TGDTRGCRLSAAFPLPAPAHDTAQIPQIPPIPPIPPIPPIPPIPPVPPVPQIHQGSQPA
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TMSRFLASRALWLACACLGCALLGALWLARQAIGEERSGAAAIAQLVARLSALQAAGPA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHH
ERAAQLAALRAINQSARMRHLRLHVEDAAGRVLVDATPKGDLVHAESQWEIRARDGTVYH
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCEEECCCCEEEEECCCEEEE
AALRWNPDSELREARGDVVGNLAMLGAYSVLLLCCLSWTARRAFAPLQQILDAIGHYERK
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DYSVRLPAMHIRELDQVRRALNHLAGALAQHQLERRALSRKLLDAQECERARLARELHDE
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
FGQVLTAMRADATYLVRKSAHAPMLQIVANDLAGHCARIQDEVRHLLHRLRPHGGQPDGR
HHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
VACLPRLLQDLVRGWRGQPGQAVRLDCDVDLGGAVLDPDLTLTLYRMTQEALTNVMRHAG
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCC
ASRASICIVRRGNEVRWCVEDDGSGIGDIAAAMQRSHGLRGMQERAWAHCATLCIGAAEG
CCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
TGDTRGCRLSAAFPLPAPAHDTAQIPQIPPIPPIPPIPPIPPIPPVPPVPQIHQGSQPA
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with a nitrogenous group as acceptor [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8392137 [H]