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The map label for this gene is iorB [H]

Identifier: 73541433

GI number: 73541433

Start: 1886555

End: 1888822

Strand: Reverse

Name: iorB [H]

Synonym: Reut_A1744

Alternate gene names: 73541433

Gene position: 1888822-1886555 (Counterclockwise)

Preceding gene: 73541434

Following gene: 73541432

Centisome position: 49.62

GC content: 66.62

Gene sequence:

>2268_bases
ATGAAGCGCAGAGCGTTCCTGTTCGGCGGTATCGGCGCGGCCGGCGCATTGCTGGTCGGCTGGACCGTGCTGCCCGTACG
CCAGCGGCTGACGACGTCGGCGCCGCTGCCAACGGAAGGCACGGAGGTCGCGCTGAACGGATGGCTCAAGATCGATGCGG
ACAACAGCGTCACGATCATGATGTGCCGCTCGGAGATGGGACAGGGCGTGCACACCGGGCTGGCGATGATCCTGGCGGAC
GAACTCGATGCCGACTGGAGCCGCGTGCGCGTGGAAAACGCGCCGCCTGACAAGATCTTCAACAACCTTCAGGTCGTCGT
CGACGGGCTGCCGTTTCATCCCGATGATCACAGGTTTTTCCGCCGGCTTTCGGACCACGTCGCGCGCAAGCTGATGCGCG
AAATTGGCGAGATTGCCACTGGCGGTTCGTCCGGCATCAGCGACCTCTGGATGCCCATGCGCGAGGCCGGCGCCTCGGCG
CGGGCCATGCTGGTGTCCGCGGCAGCGCAGCGCTGGCGCGTGACCGAGGCGGAATGCCGCACGGAAGGCGGCAAGGTGCA
GCAGGGCGCCGCGCGCTCGATGACGTTTGGTGAACTCGCATCCGCAGCGGGACGCGTGCCTTTGCCGGACAAGGTGAAGC
TGAAGGAGCCATCGGCATTTCGCCTGATCGGCCGGCCGTTGCACAGGATCGATGCCGAGCCTAAGACCGATGGGTCGGCC
CGCTTTGGCATCGACGCGTTGCCGCCCAAGCTGCTGTACGCGAGCGTGCTCATGTGCCCGACCGTCGGCGGTCGCGTGAA
GCATGCCGACGTCAGTGCGGCACTCGCGCAGCGCGGCGTCGTGAAGGCCTTTGCGGTGCCGCCGTTCGACGGTGGCTCAG
GCGGCGTGGCGGTCATTGCCGACAACGTGTTTCGCGCGATGCGGGCGCTCGACGCACTGAAGGTTGACTGGGATCCCGGG
CCGGCTGCTGGCCTGACGAGTGCACGCCTGCTGGCGCGGATTACCGCGACGCTGGATCGCGATGATGGCCACGGCTACTA
CACGCGCGGGGATGTCGATGAGGCGCTGCGCGGCGCGGCCAAGGTGGTCAGCGCCGAGTATCGCGCACCATATCTTGCGC
ACGCTGCCGTGGAACCCATTAACTGCACGGTGCTGTATGGCGGCGACGCGGCGACAGTGTGGGTGTCGACGCAGGTGCCT
GGCATTGCGCGCGCCCATGCCGCCAAGATACTGGGTCTGCGGCCGGATCAGGTGGACCTGCAGGTCATGATGCTGGGCGG
AGGCTTCGGGCGCCGGCTGGAAGCGGATTTCGTGTCGCAGGCCGCGGCGATCGCACGCGAGGTCAAGGGGCGGCCCGTGC
AGACCGTCTGGACGCGGGCGCAGGACATGACCCATGACTTCTACCGGCCCGCCTGTGTGTCGCGCTTGCGTGCCGGCATG
GATCGCGACGGGCGGCTGATCAGCTGGCAGGCGCGATCTGCAGGGCAGGCCGTGGTACCGCAGATGCTGGCGCGGGACTT
TGGCTTCCCGCGTATTCCCATCGACAAGACGGCGGCGGAGGGCGCATTCGACCAGCCTTACCGATGGCCGGCAGCGCGGA
TTTCGCATGCGAATGTCGACCTGCCCATACCGGTGGGCTTCTGGCGCTCGGTTGGGCATTCGCACCAGGCTTTCTTCACG
GAGTGCTTTCTCGACGAGGTGGCGGCGGCCGCGGGCAAGGATCCGGTTGCGTTTCGCGCCAGCCTGCTTGGCGAACATCC
GCGCCACCGGGCCGTGCTGGAACGCGTGGCGACCTTGTCGGGATGGGGCAAGCCAATGGCGCGCGCTCCGGATGGCATCG
CGCGGGCACGCGGTGTGGCACTGCACCAGTCATACGGCAGCATCGTCGCGCAAGTGGCTGAGGTGTCCGTCGCGCCCGAC
AAGACGATCCGCGTGCATCGCGTGTTCTGCGTAATCGATTGCGGCATTGCCGTGAATCCCAACCTGATCCGCCAGCAGGC
GGAGAGCGGCATCATATTTGGCTTGTCCGCCGCGCTGTACCAGGAAATCACGTTCGCCGATGGTGTGGTGCAGCAGAAGA
ACTTTCACGACTTTCCGGTCGTGCGCATGACGGATTGCCCGGTCATCGAGACGGACATCATTCCCAGCCAGGAGCCGCCG
CAGGGCACTGGCGAAGTCTGCGCACCGCCGATCGCACCGGCCGTGGCCAATGCGCTGTATACGCTGACCGGCCAGCGCTT
GCGTTCGTTGCCGCTCAAGCTGATCTAG

Upstream 100 bases:

>100_bases
CGCGACGAGATCCGCTGCATTGCGCCGGGCGTGTATCTCGGCAAAGTGTATTGGGACAAGGCTCGCCTGATCGATTTCTG
CCTGGAGTTCTGATCTCGCC

Downstream 100 bases:

>100_bases
TGAAGGAGACCACCATGGCGACCCTGAACGTGAACGACAAGGCCGTCAGCGTTGACGCGGAGCCGGATATGCCGTTGCTA
TGGATCCTGCGCTGCGACCT

Product: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MKRRAFLFGGIGAAGALLVGWTVLPVRQRLTTSAPLPTEGTEVALNGWLKIDADNSVTIMMCRSEMGQGVHTGLAMILAD
ELDADWSRVRVENAPPDKIFNNLQVVVDGLPFHPDDHRFFRRLSDHVARKLMREIGEIATGGSSGISDLWMPMREAGASA
RAMLVSAAAQRWRVTEAECRTEGGKVQQGAARSMTFGELASAAGRVPLPDKVKLKEPSAFRLIGRPLHRIDAEPKTDGSA
RFGIDALPPKLLYASVLMCPTVGGRVKHADVSAALAQRGVVKAFAVPPFDGGSGGVAVIADNVFRAMRALDALKVDWDPG
PAAGLTSARLLARITATLDRDDGHGYYTRGDVDEALRGAAKVVSAEYRAPYLAHAAVEPINCTVLYGGDAATVWVSTQVP
GIARAHAAKILGLRPDQVDLQVMMLGGGFGRRLEADFVSQAAAIAREVKGRPVQTVWTRAQDMTHDFYRPACVSRLRAGM
DRDGRLISWQARSAGQAVVPQMLARDFGFPRIPIDKTAAEGAFDQPYRWPAARISHANVDLPIPVGFWRSVGHSHQAFFT
ECFLDEVAAAAGKDPVAFRASLLGEHPRHRAVLERVATLSGWGKPMARAPDGIARARGVALHQSYGSIVAQVAEVSVAPD
KTIRVHRVFCVIDCGIAVNPNLIRQQAESGIIFGLSAALYQEITFADGVVQQKNFHDFPVVRMTDCPVIETDIIPSQEPP
QGTGEVCAPPIAPAVANALYTLTGQRLRSLPLKLI

Sequences:

>Translated_755_residues
MKRRAFLFGGIGAAGALLVGWTVLPVRQRLTTSAPLPTEGTEVALNGWLKIDADNSVTIMMCRSEMGQGVHTGLAMILAD
ELDADWSRVRVENAPPDKIFNNLQVVVDGLPFHPDDHRFFRRLSDHVARKLMREIGEIATGGSSGISDLWMPMREAGASA
RAMLVSAAAQRWRVTEAECRTEGGKVQQGAARSMTFGELASAAGRVPLPDKVKLKEPSAFRLIGRPLHRIDAEPKTDGSA
RFGIDALPPKLLYASVLMCPTVGGRVKHADVSAALAQRGVVKAFAVPPFDGGSGGVAVIADNVFRAMRALDALKVDWDPG
PAAGLTSARLLARITATLDRDDGHGYYTRGDVDEALRGAAKVVSAEYRAPYLAHAAVEPINCTVLYGGDAATVWVSTQVP
GIARAHAAKILGLRPDQVDLQVMMLGGGFGRRLEADFVSQAAAIAREVKGRPVQTVWTRAQDMTHDFYRPACVSRLRAGM
DRDGRLISWQARSAGQAVVPQMLARDFGFPRIPIDKTAAEGAFDQPYRWPAARISHANVDLPIPVGFWRSVGHSHQAFFT
ECFLDEVAAAAGKDPVAFRASLLGEHPRHRAVLERVATLSGWGKPMARAPDGIARARGVALHQSYGSIVAQVAEVSVAPD
KTIRVHRVFCVIDCGIAVNPNLIRQQAESGIIFGLSAALYQEITFADGVVQQKNFHDFPVVRMTDCPVIETDIIPSQEPP
QGTGEVCAPPIAPAVANALYTLTGQRLRSLPLKLI
>Mature_755_residues
MKRRAFLFGGIGAAGALLVGWTVLPVRQRLTTSAPLPTEGTEVALNGWLKIDADNSVTIMMCRSEMGQGVHTGLAMILAD
ELDADWSRVRVENAPPDKIFNNLQVVVDGLPFHPDDHRFFRRLSDHVARKLMREIGEIATGGSSGISDLWMPMREAGASA
RAMLVSAAAQRWRVTEAECRTEGGKVQQGAARSMTFGELASAAGRVPLPDKVKLKEPSAFRLIGRPLHRIDAEPKTDGSA
RFGIDALPPKLLYASVLMCPTVGGRVKHADVSAALAQRGVVKAFAVPPFDGGSGGVAVIADNVFRAMRALDALKVDWDPG
PAAGLTSARLLARITATLDRDDGHGYYTRGDVDEALRGAAKVVSAEYRAPYLAHAAVEPINCTVLYGGDAATVWVSTQVP
GIARAHAAKILGLRPDQVDLQVMMLGGGFGRRLEADFVSQAAAIAREVKGRPVQTVWTRAQDMTHDFYRPACVSRLRAGM
DRDGRLISWQARSAGQAVVPQMLARDFGFPRIPIDKTAAEGAFDQPYRWPAARISHANVDLPIPVGFWRSVGHSHQAFFT
ECFLDEVAAAAGKDPVAFRASLLGEHPRHRAVLERVATLSGWGKPMARAPDGIARARGVALHQSYGSIVAQVAEVSVAPD
KTIRVHRVFCVIDCGIAVNPNLIRQQAESGIIFGLSAALYQEITFADGVVQQKNFHDFPVVRMTDCPVIETDIIPSQEPP
QGTGEVCAPPIAPAVANALYTLTGQRLRSLPLKLI

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI71773480, Length=394, Percent_Identity=23.3502538071066, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI91823271, Length=288, Percent_Identity=25.3472222222222, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786478, Length=387, Percent_Identity=25.5813953488372, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012368
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 81311; Mature: 81311

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRAFLFGGIGAAGALLVGWTVLPVRQRLTTSAPLPTEGTEVALNGWLKIDADNSVTIM
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCEEEE
MCRSEMGQGVHTGLAMILADELDADWSRVRVENAPPDKIFNNLQVVVDGLPFHPDDHRFF
EECHHHCCCHHHHHHHHHHHHCCCCHHEEEECCCCHHHHHCCCEEEEECCCCCCCHHHHH
RRLSDHVARKLMREIGEIATGGSSGISDLWMPMREAGASARAMLVSAAAQRWRVTEAECR
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHH
TEGGKVQQGAARSMTFGELASAAGRVPLPDKVKLKEPSAFRLIGRPLHRIDAEPKTDGSA
CCCCCCCCCHHHCCCHHHHHHHCCCCCCCCCCEECCCCHHHHHCCHHHHCCCCCCCCCCC
RFGIDALPPKLLYASVLMCPTVGGRVKHADVSAALAQRGVVKAFAVPPFDGGSGGVAVIA
CCCCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEH
DNVFRAMRALDALKVDWDPGPAAGLTSARLLARITATLDRDDGHGYYTRGDVDEALRGAA
HHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
KVVSAEYRAPYLAHAAVEPINCTVLYGGDAATVWVSTQVPGIARAHAAKILGLRPDQVDL
HHHHHHHCCCCHHHHCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCE
QVMMLGGGFGRRLEADFVSQAAAIAREVKGRPVQTVWTRAQDMTHDFYRPACVSRLRAGM
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DRDGRLISWQARSAGQAVVPQMLARDFGFPRIPIDKTAAEGAFDQPYRWPAARISHANVD
CCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
LPIPVGFWRSVGHSHQAFFTECFLDEVAAAAGKDPVAFRASLLGEHPRHRAVLERVATLS
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
GWGKPMARAPDGIARARGVALHQSYGSIVAQVAEVSVAPDKTIRVHRVFCVIDCGIAVNP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCH
NLIRQQAESGIIFGLSAALYQEITFADGVVQQKNFHDFPVVRMTDCPVIETDIIPSQEPP
HHHHHHHHCCEEEEHHHHHHHHHHHHCCHHCCCCCCCCCEEEECCCCEEEECCCCCCCCC
QGTGEVCAPPIAPAVANALYTLTGQRLRSLPLKLI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKRRAFLFGGIGAAGALLVGWTVLPVRQRLTTSAPLPTEGTEVALNGWLKIDADNSVTIM
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCEEEE
MCRSEMGQGVHTGLAMILADELDADWSRVRVENAPPDKIFNNLQVVVDGLPFHPDDHRFF
EECHHHCCCHHHHHHHHHHHHCCCCHHEEEECCCCHHHHHCCCEEEEECCCCCCCHHHHH
RRLSDHVARKLMREIGEIATGGSSGISDLWMPMREAGASARAMLVSAAAQRWRVTEAECR
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHH
TEGGKVQQGAARSMTFGELASAAGRVPLPDKVKLKEPSAFRLIGRPLHRIDAEPKTDGSA
CCCCCCCCCHHHCCCHHHHHHHCCCCCCCCCCEECCCCHHHHHCCHHHHCCCCCCCCCCC
RFGIDALPPKLLYASVLMCPTVGGRVKHADVSAALAQRGVVKAFAVPPFDGGSGGVAVIA
CCCCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEH
DNVFRAMRALDALKVDWDPGPAAGLTSARLLARITATLDRDDGHGYYTRGDVDEALRGAA
HHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
KVVSAEYRAPYLAHAAVEPINCTVLYGGDAATVWVSTQVPGIARAHAAKILGLRPDQVDL
HHHHHHHCCCCHHHHCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCE
QVMMLGGGFGRRLEADFVSQAAAIAREVKGRPVQTVWTRAQDMTHDFYRPACVSRLRAGM
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DRDGRLISWQARSAGQAVVPQMLARDFGFPRIPIDKTAAEGAFDQPYRWPAARISHANVD
CCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
LPIPVGFWRSVGHSHQAFFTECFLDEVAAAAGKDPVAFRASLLGEHPRHRAVLERVATLS
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
GWGKPMARAPDGIARARGVALHQSYGSIVAQVAEVSVAPDKTIRVHRVFCVIDCGIAVNP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCH
NLIRQQAESGIIFGLSAALYQEITFADGVVQQKNFHDFPVVRMTDCPVIETDIIPSQEPP
HHHHHHHHCCEEEEHHHHHHHHHHHHCCHHCCCCCCCCCEEEECCCCEEEECCCCCCCCC
QGTGEVCAPPIAPAVANALYTLTGQRLRSLPLKLI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]