BacMap

Definition	Ralstonia eutropha JMP134 chromosome 1, complete sequence.
Accession	NC_007347
Length	3,806,533

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The map label for this gene is fabG [C]

Identifier: 73541224

GI number: 73541224

Start: 1653205

End: 1653996

Strand: Direct

Name: fabG [C]

Synonym: Reut_A1534

Alternate gene names: 73541224

Gene position: 1653205-1653996 (Clockwise)

Preceding gene: 73541223

Following gene: 73541225

Centisome position: 43.43

GC content: 68.43

Gene sequence:

>792_bases
ATGCTGCTGAAAGACAAGATCGTCATCGTGTCCGGGATCGGTCCCGGACTTGGCGCAAAGCTGGCCGTGGAGGCCGCGCG
CGAAGGCGCGCGCGCCGTGGCCATTGCCGCACGCACCGCGGCGAAGCTGGATGAGGCCCAGGCCCGGATCGACGAACTGG
GCGCCGACTGCGAGGTGCTCAAGGTGGTGACCGACATCACCGAGCGCGCCCAGTGCCGGCAACTGGCCGGCGAGACCCTG
CGCCGCTACGGACGGATCGACGCGCTGGTCAACAGTGCGTTCCAGCACGGCAATTTCCCCGAGCCGATGGAATCCGCCGA
CCTCGACGTCTGGCGCGAGGTGTTCGATACCAACGTGTTCGGCACCATGACGCTGACCCAGGAAGTGGCCGCGCTGATGA
AGCCGCAGGGCGGCGGCGCGATCGTGATGATCAATACGCAGGCCACGCGCAAGCCGATGCCCGGTGAAGGCGGCTACGCG
GCGTCCAAGGGCGCGCTGGCCGTCGCGGTCAAGTATCTGGCGCGCGAACTGGGCCCGTATGGCATCCGCGCCAACAGCAT
CTTCATGGGCTGGATGTGGGGCGCGCCGGTGCAGGGCTATGTGCGCCACGTTGCAGCGGAGCAGGGCATGAGCGAAGATG
CGGTGATTGCCCCCGTCACCGCGCAGATCGCGCTGGGCCGTATGCCGACCGACGACGACTGCGCGCGCGCCGCGCTGTTC
CTGGTGTCGGACTACGCCCGCGCGATCACCGGCGCGTCGCTCGACGCCAACGGCGGCGATTTCATGCCCTGA

Upstream 100 bases:

>100_bases
AGCCAGGCGCAGCTCGAGCGGGATTTCGCCGGCTACCGCGCCCGCCACGTATTGAACACCCGTTAACAGACAGCGCACTG
CGCACCGAGGAGACAACAAC

Downstream 100 bases:

>100_bases
CCGCTGGCCACCGGAAACCTGCCATGACACGCTACTTCGCCTTCAACGGCGACGCCGACGGCCTGTGTGCCCTGCAGCAG
CTGCGCCTGGCCTGTCCCGG

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MLLKDKIVIVSGIGPGLGAKLAVEAAREGARAVAIAARTAAKLDEAQARIDELGADCEVLKVVTDITERAQCRQLAGETL
RRYGRIDALVNSAFQHGNFPEPMESADLDVWREVFDTNVFGTMTLTQEVAALMKPQGGGAIVMINTQATRKPMPGEGGYA
ASKGALAVAVKYLARELGPYGIRANSIFMGWMWGAPVQGYVRHVAAEQGMSEDAVIAPVTAQIALGRMPTDDDCARAALF
LVSDYARAITGASLDANGGDFMP

Sequences:

>Translated_263_residues
MLLKDKIVIVSGIGPGLGAKLAVEAAREGARAVAIAARTAAKLDEAQARIDELGADCEVLKVVTDITERAQCRQLAGETL
RRYGRIDALVNSAFQHGNFPEPMESADLDVWREVFDTNVFGTMTLTQEVAALMKPQGGGAIVMINTQATRKPMPGEGGYA
ASKGALAVAVKYLARELGPYGIRANSIFMGWMWGAPVQGYVRHVAAEQGMSEDAVIAPVTAQIALGRMPTDDDCARAALF
LVSDYARAITGASLDANGGDFMP
>Mature_263_residues
MLLKDKIVIVSGIGPGLGAKLAVEAAREGARAVAIAARTAAKLDEAQARIDELGADCEVLKVVTDITERAQCRQLAGETL
RRYGRIDALVNSAFQHGNFPEPMESADLDVWREVFDTNVFGTMTLTQEVAALMKPQGGGAIVMINTQATRKPMPGEGGYA
ASKGALAVAVKYLARELGPYGIRANSIFMGWMWGAPVQGYVRHVAAEQGMSEDAVIAPVTAQIALGRMPTDDDCARAALF
LVSDYARAITGASLDANGGDFMP

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=257, Percent_Identity=28.4046692607004, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI10190704, Length=262, Percent_Identity=27.8625954198473, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI19923817, Length=265, Percent_Identity=27.5471698113208, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI59889578, Length=203, Percent_Identity=31.5270935960591, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7705925, Length=271, Percent_Identity=28.0442804428044, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI7706318, Length=204, Percent_Identity=30.8823529411765, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI126723191, Length=187, Percent_Identity=28.8770053475936, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI5031737, Length=257, Percent_Identity=24.9027237354086, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI15277342, Length=271, Percent_Identity=28.0442804428044, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI33667109, Length=189, Percent_Identity=27.5132275132275, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI40254992, Length=257, Percent_Identity=29.5719844357977, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4503301, Length=238, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=263, Percent_Identity=29.277566539924, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787905, Length=257, Percent_Identity=30.7392996108949, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1787526, Length=261, Percent_Identity=29.1187739463602, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=27.9245283018868, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786812, Length=271, Percent_Identity=28.4132841328413, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082160, Length=268, Percent_Identity=29.1044776119403, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788459, Length=185, Percent_Identity=31.8918918918919, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=26.8199233716475, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1789378, Length=264, Percent_Identity=27.6515151515151, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI2367175, Length=260, Percent_Identity=28.0769230769231, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=28.8461538461538, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=29.1338582677165, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17562908, Length=185, Percent_Identity=30.8108108108108, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=30.2681992337165, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=266, Percent_Identity=27.8195488721804, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=265, Percent_Identity=29.0566037735849, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=259, Percent_Identity=27.027027027027, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=269, Percent_Identity=27.5092936802974, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=195, Percent_Identity=27.6923076923077, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=25.0965250965251, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=276, Percent_Identity=30.4347826086957, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=26.9662921348315, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=195, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=200, Percent_Identity=28, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17536651, Length=265, Percent_Identity=26.7924528301887, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=273, Percent_Identity=27.1062271062271, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=192, Percent_Identity=30.2083333333333, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=188, Percent_Identity=28.1914893617021, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=192, Percent_Identity=29.1666666666667, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=193, Percent_Identity=26.9430051813472, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=219, Percent_Identity=29.2237442922374, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324126, Length=260, Percent_Identity=24.6153846153846, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=183, Percent_Identity=30.0546448087432, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355319, Length=257, Percent_Identity=30.3501945525292, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI23397609, Length=261, Percent_Identity=32.9501915708812, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28571526, Length=263, Percent_Identity=32.319391634981, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357041, Length=265, Percent_Identity=32.0754716981132, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24644339, Length=265, Percent_Identity=29.0566037735849, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639444, Length=263, Percent_Identity=26.9961977186312, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24643142, Length=258, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27842; Mature: 27842

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKDKIVIVSGIGPGLGAKLAVEAAREGARAVAIAARTAAKLDEAQARIDELGADCEVL
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHH
KVVTDITERAQCRQLAGETLRRYGRIDALVNSAFQHGNFPEPMESADLDVWREVFDTNVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCC
GTMTLTQEVAALMKPQGGGAIVMINTQATRKPMPGEGGYAASKGALAVAVKYLARELGPY
EEHHHHHHHHHHHCCCCCCEEEEEECHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
GIRANSIFMGWMWGAPVQGYVRHVAAEQGMSEDAVIAPVTAQIALGRMPTDDDCARAALF
CEEECEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECHHHHHHCCCCCCCHHHHHHHHH
LVSDYARAITGASLDANGGDFMP
HHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MLLKDKIVIVSGIGPGLGAKLAVEAAREGARAVAIAARTAAKLDEAQARIDELGADCEVL
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHH
KVVTDITERAQCRQLAGETLRRYGRIDALVNSAFQHGNFPEPMESADLDVWREVFDTNVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCC
GTMTLTQEVAALMKPQGGGAIVMINTQATRKPMPGEGGYAASKGALAVAVKYLARELGPY
EEHHHHHHHHHHHCCCCCCEEEEEECHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
GIRANSIFMGWMWGAPVQGYVRHVAAEQGMSEDAVIAPVTAQIALGRMPTDDDCARAALF
CEEECEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECHHHHHHCCCCCCCHHHHHHHHH
LVSDYARAITGASLDANGGDFMP
HHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]