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The map label for this gene is wecA [H]

Identifier: 73540431

GI number: 73540431

Start: 785517

End: 786575

Strand: Direct

Name: wecA [H]

Synonym: Reut_A0725

Alternate gene names: 73540431

Gene position: 785517-786575 (Clockwise)

Preceding gene: 73540430

Following gene: 73540432

Centisome position: 20.64

GC content: 60.72

Gene sequence:

>1059_bases
ATGGTAGCGCTTGTAAGCGCAATGGCGACACTGGTTCTCCGCCCGGTGGCGCATCGTGGCGGCCTGCTGGACCGTCCAGG
CGGACGGAAGCGCCACGGCGGGGACGTGCCGCTGGTGGGTGGCATCGCCATTATGATTGCCGTGTGGGCGGGAGCCATCC
TGTTCATACGCGACCAGAGTCATTATGTGGCGTTGCTGGGCGGCATGACGATTCTGGCCACCGTGGGCGTGGCGGATGAT
CTGCGGGGGATGTCTCCCCTGACCAAGCTGGGTTTCCAGATATTCGCCGCCATCCTGATGACATCTTGGGGCGGCGTGTT
CCTGATGTCGCTGGGCGACCTGATGGGCAAGCGCGAAATCGAACTGGCCAACTGGGGCATTCCGCTGACCCTTTTCGCGG
TCGTGGCCGTCATCAATGCCCTGAACATGATGGACGGCCTGGATGGCTTGGCGGGTGGACTGGCATTCATCACCTTTGGA
TGGCTGGCGTACTTGGCCGGCGAGGTGCACAGCAATTCGGTGCAGCGCTTATGCGTGGTTTTGTGTGGCGCCTTGCTGGG
GTTTCTGTTTTTCAATGCACCCCACCCGTTGCGGGGGGGCAAGCGGGTGTTCCTGGGGGACGCGGGAAGCTTGATGCTAG
GTTTCGCCTTGGCGTGGTTCTCAGTCGAACTGTCTCAGCCGGTCTACAATGCTGGCCAGCACGTGCCCCCGGTAGTCATG
TTGTGGGTGTTCGGGTTCATCCTGATCGATCTGCTTTCGGTGGTGTTGCGTCGTGCAGTGCTGGGGCGCAATCCACTTTC
CGCAGACCGTACTCACCTGCATCACCTGCTGCTGCGCTTAAACGTTTCGCCGCCGCTGGTTGTGCTCATCATTTTGCTCA
GCAATTTGCTATTGGGATTGCTGGGTGTGGCCGGGTGGAAGCTTGGCTTGCCGGAACGTTTCCTGTTCCTTGGATTCGTA
CTGACTGCATTGGCCCATCTTGTGGCCATGCGCAATGCTTCGCGCTTTCTCCGTCGGCTCAGGCGAGTGTTCCGGCGTGC
CGGTCCGAGCGAGCCATGA

Upstream 100 bases:

>100_bases
ATCAAGCTCCTGACCTCCGCAGCCTACTGGGGGTATCGGCTGCTGCCGGCGGTCAGGCAATCATAAAGAGGCAATGTTCG
ATTTCTTCTGGGTACCGTTG

Downstream 100 bases:

>100_bases
ATTTCCCGACATCATTGACTGAATATCGTGAACCTTGGAGAAGCGCACTTGAAACGTGAGGCGACGAGAGTCTCCCCGCT
GGCACCGCTAGCGTGGATGC

Product: glycosyl transferase family protein

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MVALVSAMATLVLRPVAHRGGLLDRPGGRKRHGGDVPLVGGIAIMIAVWAGAILFIRDQSHYVALLGGMTILATVGVADD
LRGMSPLTKLGFQIFAAILMTSWGGVFLMSLGDLMGKREIELANWGIPLTLFAVVAVINALNMMDGLDGLAGGLAFITFG
WLAYLAGEVHSNSVQRLCVVLCGALLGFLFFNAPHPLRGGKRVFLGDAGSLMLGFALAWFSVELSQPVYNAGQHVPPVVM
LWVFGFILIDLLSVVLRRAVLGRNPLSADRTHLHHLLLRLNVSPPLVVLIILLSNLLLGLLGVAGWKLGLPERFLFLGFV
LTALAHLVAMRNASRFLRRLRRVFRRAGPSEP

Sequences:

>Translated_352_residues
MVALVSAMATLVLRPVAHRGGLLDRPGGRKRHGGDVPLVGGIAIMIAVWAGAILFIRDQSHYVALLGGMTILATVGVADD
LRGMSPLTKLGFQIFAAILMTSWGGVFLMSLGDLMGKREIELANWGIPLTLFAVVAVINALNMMDGLDGLAGGLAFITFG
WLAYLAGEVHSNSVQRLCVVLCGALLGFLFFNAPHPLRGGKRVFLGDAGSLMLGFALAWFSVELSQPVYNAGQHVPPVVM
LWVFGFILIDLLSVVLRRAVLGRNPLSADRTHLHHLLLRLNVSPPLVVLIILLSNLLLGLLGVAGWKLGLPERFLFLGFV
LTALAHLVAMRNASRFLRRLRRVFRRAGPSEP
>Mature_352_residues
MVALVSAMATLVLRPVAHRGGLLDRPGGRKRHGGDVPLVGGIAIMIAVWAGAILFIRDQSHYVALLGGMTILATVGVADD
LRGMSPLTKLGFQIFAAILMTSWGGVFLMSLGDLMGKREIELANWGIPLTLFAVVAVINALNMMDGLDGLAGGLAFITFG
WLAYLAGEVHSNSVQRLCVVLCGALLGFLFFNAPHPLRGGKRVFLGDAGSLMLGFALAWFSVELSQPVYNAGQHVPPVVM
LWVFGFILIDLLSVVLRRAVLGRNPLSADRTHLHHLLLRLNVSPPLVVLIILLSNLLLGLLGVAGWKLGLPERFLFLGFV
LTALAHLVAMRNASRFLRRLRRVFRRAGPSEP

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55) [H]

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=273, Percent_Identity=36.996336996337, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715
- InterPro:   IPR018480 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 37952; Mature: 37952

Theoretical pI: Translated: 11.60; Mature: 11.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVALVSAMATLVLRPVAHRGGLLDRPGGRKRHGGDVPLVGGIAIMIAVWAGAILFIRDQS
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCC
HYVALLGGMTILATVGVADDLRGMSPLTKLGFQIFAAILMTSWGGVFLMSLGDLMGKREI
CHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCE
ELANWGIPLTLFAVVAVINALNMMDGLDGLAGGLAFITFGWLAYLAGEVHSNSVQRLCVV
EHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCGALLGFLFFNAPHPLRGGKRVFLGDAGSLMLGFALAWFSVELSQPVYNAGQHVPPVVM
HHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHH
LWVFGFILIDLLSVVLRRAVLGRNPLSADRTHLHHLLLRLNVSPPLVVLIILLSNLLLGL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LGVAGWKLGLPERFLFLGFVLTALAHLVAMRNASRFLRRLRRVFRRAGPSEP
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVALVSAMATLVLRPVAHRGGLLDRPGGRKRHGGDVPLVGGIAIMIAVWAGAILFIRDQS
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCC
HYVALLGGMTILATVGVADDLRGMSPLTKLGFQIFAAILMTSWGGVFLMSLGDLMGKREI
CHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCE
ELANWGIPLTLFAVVAVINALNMMDGLDGLAGGLAFITFGWLAYLAGEVHSNSVQRLCVV
EHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCGALLGFLFFNAPHPLRGGKRVFLGDAGSLMLGFALAWFSVELSQPVYNAGQHVPPVVM
HHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHH
LWVFGFILIDLLSVVLRRAVLGRNPLSADRTHLHHLLLRLNVSPPLVVLIILLSNLLLGL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LGVAGWKLGLPERFLFLGFVLTALAHLVAMRNASRFLRRLRRVFRRAGPSEP
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]