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The map label for this gene is panC

Identifier: 73540374

GI number: 73540374

Start: 716517

End: 717365

Strand: Reverse

Name: panC

Synonym: Reut_A0668

Alternate gene names: 73540374

Gene position: 717365-716517 (Counterclockwise)

Preceding gene: 73540375

Following gene: 73540372

Centisome position: 18.85

GC content: 66.9

Gene sequence:

>849_bases
ATGAAAGTCATTTCCTCCATCCAAGAGCTGCGTGACCAGTTGCGCGGGCAAAACCGGGTCGCGTTTGTCCCGACCATGGG
CAACCTGCACGAAGGTCACCTGTCGCTGATGCGCCTGGCGCGCCAGCACGGCGATCCGGTGGTGGCATCCATCTTCGTCA
ACCGCCTGCAGTTCGGCCCGAACGAGGACTTCGACAAGTACCCGCGCACGCTGCAGGACGACATCGAAAAGCTGCAGAGC
GAAGGCGTGTACGTGCTGTTCGCGCCGACCGAGCGCGACATGTACCCGGAGCCGCAGGAATACCGCGTGGATCCCCCCCA
CGATCTCGGCGATATCCTGGAAGGCGAGTTCCGCCCGGGCTTCTTCAAGGGCGTCTGCACCGTGGTGATGAAGCTGTTCA
CGGCCGCGCAGCCGCGCGTGGCGGTGTTCGGCAAGAAGGACTACCAGCAGCTCATGATCGTGCGCCGCATGGTCCACCAG
TTCGCGCTGCCGATCGAGATCGTGCCCGCGGAGACCGTGCGTGCCGAGGACGGCCTGGCGCTGTCGTCGCGCAATCGCTA
CCTCACCGAAGCCGAGCGCGCCGAGGCGCCCATGCTTTACCGCACGCTGCACGACGTGCGCGACACCGTGCTGGGCAGCG
ACCGCGCGGCCACCCGGCTGGCCACCGTCGAAGCGGACGCTTGCGCCACCCTGGCGCAGCGCGGCTGGAAGCCCGACTAC
GTGTCGATCCGCAAGCGCAGCAACCTGCAGGCGCCGACGCCCGAGGAATTCGCCGCCGGCGAGCCGCTGGTGGTGCTGAC
GGCTGCCAAGCTCGGCGCCACCCGCCTCATCGACAACCTCGAAATCTGA

Upstream 100 bases:

>100_bases
CCGACAACCGCGAAGAGCCCGGACAGGGTCCGCCGAGACTTGTCGATGCGCCCGCCAGAAGGCGCCAGGATCACCCATAC
CACGACAGCACACCAAGTTC

Downstream 100 bases:

>100_bases
GCCCCGCGGCCAGCGGCCACTTCGCCCAGACAAGAAGAGCAAGCCTTGCGGCTTGCTCTTTGCATTTCAGGCCTCGGCCT
TTTCAGCGCTGCGCGTGCTG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MKVISSIQELRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLQDDIEKLQS
EGVYVLFAPTERDMYPEPQEYRVDPPHDLGDILEGEFRPGFFKGVCTVVMKLFTAAQPRVAVFGKKDYQQLMIVRRMVHQ
FALPIEIVPAETVRAEDGLALSSRNRYLTEAERAEAPMLYRTLHDVRDTVLGSDRAATRLATVEADACATLAQRGWKPDY
VSIRKRSNLQAPTPEEFAAGEPLVVLTAAKLGATRLIDNLEI

Sequences:

>Translated_282_residues
MKVISSIQELRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLQDDIEKLQS
EGVYVLFAPTERDMYPEPQEYRVDPPHDLGDILEGEFRPGFFKGVCTVVMKLFTAAQPRVAVFGKKDYQQLMIVRRMVHQ
FALPIEIVPAETVRAEDGLALSSRNRYLTEAERAEAPMLYRTLHDVRDTVLGSDRAATRLATVEADACATLAQRGWKPDY
VSIRKRSNLQAPTPEEFAAGEPLVVLTAAKLGATRLIDNLEI
>Mature_282_residues
MKVISSIQELRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLQDDIEKLQS
EGVYVLFAPTERDMYPEPQEYRVDPPHDLGDILEGEFRPGFFKGVCTVVMKLFTAAQPRVAVFGKKDYQQLMIVRRMVHQ
FALPIEIVPAETVRAEDGLALSSRNRYLTEAERAEAPMLYRTLHDVRDTVLGSDRAATRLATVEADACATLAQRGWKPDY
VSIRKRSNLQAPTPEEFAAGEPLVVLTAAKLGATRLIDNLEI

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=285, Percent_Identity=44.5614035087719, Blast_Score=219, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6322046, Length=295, Percent_Identity=37.6271186440678, Blast_Score=163, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_CUPPJ (Q474Y3)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_294894.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q474Y3
- SMR:   Q474Y3
- GeneID:   3610657
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A0668
- NMPDR:   fig|264198.3.peg.1157
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   REUT264198:REUT_A0668-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31790; Mature: 31790

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 150-150 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVISSIQELRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGP
CHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
NEDFDKYPRTLQDDIEKLQSEGVYVLFAPTERDMYPEPQEYRVDPPHDLGDILEGEFRPG
CCCHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCH
FFKGVCTVVMKLFTAAQPRVAVFGKKDYQQLMIVRRMVHQFALPIEIVPAETVRAEDGLA
HHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEECCHHHCCCCCCE
LSSRNRYLTEAERAEAPMLYRTLHDVRDTVLGSDRAATRLATVEADACATLAQRGWKPDY
ECCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
VSIRKRSNLQAPTPEEFAAGEPLVVLTAAKLGATRLIDNLEI
HHHHHHCCCCCCCCHHHCCCCCEEEEEEHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVISSIQELRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGP
CHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
NEDFDKYPRTLQDDIEKLQSEGVYVLFAPTERDMYPEPQEYRVDPPHDLGDILEGEFRPG
CCCHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCH
FFKGVCTVVMKLFTAAQPRVAVFGKKDYQQLMIVRRMVHQFALPIEIVPAETVRAEDGLA
HHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEECCHHHCCCCCCE
LSSRNRYLTEAERAEAPMLYRTLHDVRDTVLGSDRAATRLATVEADACATLAQRGWKPDY
ECCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
VSIRKRSNLQAPTPEEFAAGEPLVVLTAAKLGATRLIDNLEI
HHHHHHCCCCCCCCHHHCCCCCEEEEEEHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA