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The map label for this gene is gyaR [H]

Identifier: 73540342

GI number: 73540342

Start: 682329

End: 683270

Strand: Reverse

Name: gyaR [H]

Synonym: Reut_A0636

Alternate gene names: 73540342

Gene position: 683270-682329 (Counterclockwise)

Preceding gene: 73540344

Following gene: 73540341

Centisome position: 17.95

GC content: 68.79

Gene sequence:

>942_bases
ATGTCCGCTATCCAGATCCTTCAGGTCGGCCCGCTCGCGCCGCAGACCAATTCCACGCTGCAGGAACGCTTCAGCGCGGC
CGCGCTGTGGCAGCAGGCTGATCCGCTGGCGTGGGCGCGCGAGCACGGCGGCGAGGTGCGCGTGGTGGTGACGTCCGCGC
GCCATGGCTGCACGGCGGCACTGATCGGTGCGCTGCCGAAGCTCGAGGCCATTGTCAGTTTCGGCGTGGGCTATGACTCC
ATCGCACTGGATGCGGCACGCGCACGCGGCATCCAGGTCAGCAATACGCCCGATGTGCTCAACGACTGCGTGGCCGACCT
GGCCTTCGGGCTGCTGATCGACGCGGCGCGCGGCATTGCGCATGGCGACCGCTTCGTGCGTGCGCAGCGCTGGCCGCAAG
GCGGCTTTCCGCTGACCACGAGGGTGTCCGGCAAGAAGCTGGGCATCCTGGGCCTGGGTCGAATCGGCGAGATCGTGGCG
CGCCGGGCCAGCGGCTTCGACATGGAGATCGCGTACCACAACCGCCGCCCGCGCGACGGTGCGCCGTGGCGCTTCGAAGG
CGACCTGAAAGCGCTGGCGGCATGGGCCGACTTCCTCGTGGTGGCCGTTGTCGGCGGCCCGGAAACTGCCGGACTGGTCT
CGCGCGAGGTCATCGACGCGCTGGGTCCCAAGGGCATCCTGGTCAACGTGTCGCGCGGCAGCGTGATCGACGAGGCCGCG
ATGGTCGAGGCGCTGGTTGAAGGCCGGCTCGGCGGCGCGGGACTCGACGTGTTCCGCGACGAACCCAATGTCCCGCCCGC
GCTGCTGGCGCTCGACAATGTCGTGCTGGCACCGCACATGGCCAGCGGCACCCATGAAACGCGCGCTGCCATGACTGCCC
TTACGCTCCAGAATCTGGAAGCGTTCCTGGACACCGGCAAGGTGCTCACTCCGGTCCTGTAA

Upstream 100 bases:

>100_bases
CGGCAGTGGCCGGCAAGATCGTGGGGGCTGCGCTACTATTGCCGGCCTGGGCATACAGCCCGCGCCTCTCCATTCATCGC
TTCCGCTCTCCACACGTTTC

Downstream 100 bases:

>100_bases
CCGACGCTAACCTGCGCCCTATACTGGAAAACGCCGGTTACCAGGCCGGCGTCAGGAGGCGATATGGGACGCAAGTATGT
CGATTGCCGCGACTACCCGA

Product: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSAIQILQVGPLAPQTNSTLQERFSAAALWQQADPLAWAREHGGEVRVVVTSARHGCTAALIGALPKLEAIVSFGVGYDS
IALDAARARGIQVSNTPDVLNDCVADLAFGLLIDAARGIAHGDRFVRAQRWPQGGFPLTTRVSGKKLGILGLGRIGEIVA
RRASGFDMEIAYHNRRPRDGAPWRFEGDLKALAAWADFLVVAVVGGPETAGLVSREVIDALGPKGILVNVSRGSVIDEAA
MVEALVEGRLGGAGLDVFRDEPNVPPALLALDNVVLAPHMASGTHETRAAMTALTLQNLEAFLDTGKVLTPVL

Sequences:

>Translated_313_residues
MSAIQILQVGPLAPQTNSTLQERFSAAALWQQADPLAWAREHGGEVRVVVTSARHGCTAALIGALPKLEAIVSFGVGYDS
IALDAARARGIQVSNTPDVLNDCVADLAFGLLIDAARGIAHGDRFVRAQRWPQGGFPLTTRVSGKKLGILGLGRIGEIVA
RRASGFDMEIAYHNRRPRDGAPWRFEGDLKALAAWADFLVVAVVGGPETAGLVSREVIDALGPKGILVNVSRGSVIDEAA
MVEALVEGRLGGAGLDVFRDEPNVPPALLALDNVVLAPHMASGTHETRAAMTALTLQNLEAFLDTGKVLTPVL
>Mature_312_residues
SAIQILQVGPLAPQTNSTLQERFSAAALWQQADPLAWAREHGGEVRVVVTSARHGCTAALIGALPKLEAIVSFGVGYDSI
ALDAARARGIQVSNTPDVLNDCVADLAFGLLIDAARGIAHGDRFVRAQRWPQGGFPLTTRVSGKKLGILGLGRIGEIVAR
RASGFDMEIAYHNRRPRDGAPWRFEGDLKALAAWADFLVVAVVGGPETAGLVSREVIDALGPKGILVNVSRGSVIDEAAM
VEALVEGRLGGAGLDVFRDEPNVPPALLALDNVVLAPHMASGTHETRAAMTALTLQNLEAFLDTGKVLTPVL

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=37.2, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI23308577, Length=236, Percent_Identity=35.1694915254237, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI145580578, Length=229, Percent_Identity=29.2576419213974, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4557499, Length=229, Percent_Identity=29.2576419213974, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI61743967, Length=230, Percent_Identity=29.5652173913043, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4557497, Length=230, Percent_Identity=29.5652173913043, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI145580575, Length=232, Percent_Identity=30.1724137931034, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI87082289, Length=301, Percent_Identity=36.8770764119601, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1789279, Length=271, Percent_Identity=32.1033210332103, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787645, Length=274, Percent_Identity=28.4671532846715, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=241, Percent_Identity=31.5352697095436, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI25147481, Length=275, Percent_Identity=26.9090909090909, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324055, Length=312, Percent_Identity=35.2564102564103, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321253, Length=269, Percent_Identity=30.4832713754647, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=306, Percent_Identity=24.5098039215686, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=257, Percent_Identity=26.8482490272374, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=183, Percent_Identity=29.5081967213115, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45552429, Length=248, Percent_Identity=34.2741935483871, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=33.8461538461538, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45551003, Length=260, Percent_Identity=33.8461538461538, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24585514, Length=260, Percent_Identity=33.8461538461538, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574282, Length=260, Percent_Identity=33.8461538461538, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574286, Length=255, Percent_Identity=34.1176470588235, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28571528, Length=254, Percent_Identity=35.4330708661417, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24585516, Length=258, Percent_Identity=29.4573643410853, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI19921140, Length=227, Percent_Identity=31.7180616740088, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI62472511, Length=227, Percent_Identity=29.9559471365639, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646446, Length=227, Percent_Identity=29.9559471365639, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646448, Length=227, Percent_Identity=29.9559471365639, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646452, Length=227, Percent_Identity=29.9559471365639, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646450, Length=227, Percent_Identity=29.9559471365639, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 32995; Mature: 32864

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIQILQVGPLAPQTNSTLQERFSAAALWQQADPLAWAREHGGEVRVVVTSARHGCTAA
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEEECCCCCHHHH
LIGALPKLEAIVSFGVGYDSIALDAARARGIQVSNTPDVLNDCVADLAFGLLIDAARGIA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
HGDRFVRAQRWPQGGFPLTTRVSGKKLGILGLGRIGEIVARRASGFDMEIAYHNRRPRDG
CCHHHHHHHCCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCCC
APWRFEGDLKALAAWADFLVVAVVGGPETAGLVSREVIDALGPKGILVNVSRGSVIDEAA
CCEEECCHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHH
MVEALVEGRLGGAGLDVFRDEPNVPPALLALDNVVLAPHMASGTHETRAAMTALTLQNLE
HHHHHHHCCCCCCCCCEECCCCCCCHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHH
AFLDTGKVLTPVL
HHHHCCCHHCCCC
>Mature Secondary Structure 
SAIQILQVGPLAPQTNSTLQERFSAAALWQQADPLAWAREHGGEVRVVVTSARHGCTAA
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEEECCCCCHHHH
LIGALPKLEAIVSFGVGYDSIALDAARARGIQVSNTPDVLNDCVADLAFGLLIDAARGIA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
HGDRFVRAQRWPQGGFPLTTRVSGKKLGILGLGRIGEIVARRASGFDMEIAYHNRRPRDG
CCHHHHHHHCCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCCC
APWRFEGDLKALAAWADFLVVAVVGGPETAGLVSREVIDALGPKGILVNVSRGSVIDEAA
CCEEECCHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHH
MVEALVEGRLGGAGLDVFRDEPNVPPALLALDNVVLAPHMASGTHETRAAMTALTLQNLE
HHHHHHHCCCCCCCCCEECCCCCCCHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHH
AFLDTGKVLTPVL
HHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA