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The map label for this gene is dtd

Identifier: 73540183

GI number: 73540183

Start: 521667

End: 522137

Strand: Direct

Name: dtd

Synonym: Reut_A0477

Alternate gene names: 73540183

Gene position: 521667-522137 (Clockwise)

Preceding gene: 73540182

Following gene: 73540184

Centisome position: 13.7

GC content: 69.0

Gene sequence:

>471_bases
ATGATCGCACTGATCCAGCGCGTCTCGCAGGCCCGCGTGACGGTCGAGGGCCGCACCACCGGAGAGATTGGCGCCGGGCT
GCTGGCGCTGGTCTGCGCCGAGCGCGGCGACACCGAGGCGCAGGCCGACCGCCTGCTCGCCAAGATGCTGTCCTACCGTG
TGTTTTCGGACGCCGATGGCAAGATGAATCTGCCGGTCCAGAACATGGACGGCAACGGCGGGGCGGGCGGACTGCTGGTC
GTGTCGCAATTCACGCTGGCGGCTGATACCAACAGCGGTACCCGGCCCAGCTTCACGCCGGCGGCATCCCCGGAGGACGG
GCGCCGCCTTTACGGGTATTTCGTCGAGCGCGCGCGTGCATCGCACCCCGATGTGCAGACCGGGGAGTTCGGCGCGATGA
TGCAGGTGAGCCTGACCAACGACGGACCGGTGACGTTCTGGCTGCGCGTGCCGCCGCCGGGGAACGCCTGA

Upstream 100 bases:

>100_bases
CGACCGTCAGCGACAAGGCCGTCAAGGTGGCCGCGGGCACCTACGTGGTGCAGGTCGGCAAGCGCCGCTTTGCCCGCGTG
ACGCTGGCCTGAGGCGGGCG

Downstream 100 bases:

>100_bases
ACCGCAAGGCTATACACCGACAGGCAACAGGAAACCACGGGCCGCGCCGGCGCGGCCGTCCACAGACAGGAGAGACAAAT
GAAACTCTGGAGCAAGTCCT

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MIALIQRVSQARVTVEGRTTGEIGAGLLALVCAERGDTEAQADRLLAKMLSYRVFSDADGKMNLPVQNMDGNGGAGGLLV
VSQFTLAADTNSGTRPSFTPAASPEDGRRLYGYFVERARASHPDVQTGEFGAMMQVSLTNDGPVTFWLRVPPPGNA

Sequences:

>Translated_156_residues
MIALIQRVSQARVTVEGRTTGEIGAGLLALVCAERGDTEAQADRLLAKMLSYRVFSDADGKMNLPVQNMDGNGGAGGLLV
VSQFTLAADTNSGTRPSFTPAASPEDGRRLYGYFVERARASHPDVQTGEFGAMMQVSLTNDGPVTFWLRVPPPGNA
>Mature_156_residues
MIALIQRVSQARVTVEGRTTGEIGAGLLALVCAERGDTEAQADRLLAKMLSYRVFSDADGKMNLPVQNMDGNGGAGGLLV
VSQFTLAADTNSGTRPSFTPAASPEDGRRLYGYFVERARASHPDVQTGEFGAMMQVSLTNDGPVTFWLRVPPPGNA

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=158, Percent_Identity=38.6075949367089, Blast_Score=98, Evalue=3e-21,
Organism=Escherichia coli, GI1790320, Length=150, Percent_Identity=62, Blast_Score=183, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI115533292, Length=148, Percent_Identity=36.4864864864865, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319982, Length=150, Percent_Identity=40.6666666666667, Blast_Score=104, Evalue=8e-24,
Organism=Drosophila melanogaster, GI281361569, Length=157, Percent_Identity=36.3057324840764, Blast_Score=92, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_CUPPJ (Q475S4)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_294703.1
- HSSP:   O66742
- ProteinModelPortal:   Q475S4
- SMR:   Q475S4
- GeneID:   3611386
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A0477
- NMPDR:   fig|264198.3.peg.989
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- ProtClustDB:   PRK05273
- BioCyc:   REUT264198:REUT_A0477-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16545; Mature: 16545

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: ACT_SITE 85-85

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALIQRVSQARVTVEGRTTGEIGAGLLALVCAERGDTEAQADRLLAKMLSYRVFSDADG
CHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
KMNLPVQNMDGNGGAGGLLVVSQFTLAADTNSGTRPSFTPAASPEDGRRLYGYFVERARA
EECCCEECCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
SHPDVQTGEFGAMMQVSLTNDGPVTFWLRVPPPGNA
CCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MIALIQRVSQARVTVEGRTTGEIGAGLLALVCAERGDTEAQADRLLAKMLSYRVFSDADG
CHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
KMNLPVQNMDGNGGAGGLLVVSQFTLAADTNSGTRPSFTPAASPEDGRRLYGYFVERARA
EECCCEECCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
SHPDVQTGEFGAMMQVSLTNDGPVTFWLRVPPPGNA
CCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA