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The map label for this gene is ntpA [H]

Identifier: 73540147

GI number: 73540147

Start: 485538

End: 486029

Strand: Direct

Name: ntpA [H]

Synonym: Reut_A0441

Alternate gene names: 73540147

Gene position: 485538-486029 (Clockwise)

Preceding gene: 73540146

Following gene: 73540148

Centisome position: 12.76

GC content: 64.63

Gene sequence:

>492_bases
ATGTCCATCGGACTCGGTTCCATGCCTTACAAAATCCCTGAATCCGTGCTGGTCGTGATCTACACGCCAGATCTCCAAGT
GCTGTTGCTCGAACGCGCCGACCGGCCGGGCTTCTGGCAGTCCGTGACCGGCAGCCTCGATACCGTCGACGAGCCGCTGG
CGCTCACCGCCGCGCGTGAGGTGTTCGAGGAAACCGGCATCATTGCCGGCGAGCACCAGCTTGCCGACTGGCAGCACACC
ATCGAGTACGAAATCTATCCGCAATGGCGCCACCGCTATGAGGCTGGCGTCACGCGCAATACCGAACACTGGTTCGGGTT
GTGCGTATCGGAACCGCTGCCTGTGACGCTGGCGCCGCGCGAGCACCTGCAGTCGAAATGGCTGCCATGGGAAGTCGCGG
CGCAGCAGTGCTTCTCGAGCAGCAACGCCGAGGCGGTGCGCCAGCTCGCGTGGCGCGTCGCGGGCCGGCCGGCCGTTTGT
GGAGCCGAATGA

Upstream 100 bases:

>100_bases
GGCTGCGCGTCGACCCGATGGACGCCGAGGCACATCGAAACGCCGCCTGAATGCGGGCGGCTATTCGTGGCAAGCGGGCT
AGGCTGCGCTATCCTTGGGG

Downstream 100 bases:

>100_bases
TGAAGTTGCGCGTGGTCACCTACAACATCCATAAAGGCGTGACCGGCATCGCGCGCCGCCCGCGCATCCAGAACGTGCGC
GCGGGGCTGCATGCCATGGA

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MSIGLGSMPYKIPESVLVVIYTPDLQVLLLERADRPGFWQSVTGSLDTVDEPLALTAAREVFEETGIIAGEHQLADWQHT
IEYEIYPQWRHRYEAGVTRNTEHWFGLCVSEPLPVTLAPREHLQSKWLPWEVAAQQCFSSSNAEAVRQLAWRVAGRPAVC
GAE

Sequences:

>Translated_163_residues
MSIGLGSMPYKIPESVLVVIYTPDLQVLLLERADRPGFWQSVTGSLDTVDEPLALTAAREVFEETGIIAGEHQLADWQHT
IEYEIYPQWRHRYEAGVTRNTEHWFGLCVSEPLPVTLAPREHLQSKWLPWEVAAQQCFSSSNAEAVRQLAWRVAGRPAVC
GAE
>Mature_162_residues
SIGLGSMPYKIPESVLVVIYTPDLQVLLLERADRPGFWQSVTGSLDTVDEPLALTAAREVFEETGIIAGEHQLADWQHTI
EYEIYPQWRHRYEAGVTRNTEHWFGLCVSEPLPVTLAPREHLQSKWLPWEVAAQQCFSSSNAEAVRQLAWRVAGRPAVCG
AE

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=148, Percent_Identity=46.6216216216216, Blast_Score=108, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18372; Mature: 18241

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIGLGSMPYKIPESVLVVIYTPDLQVLLLERADRPGFWQSVTGSLDTVDEPLALTAARE
CCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHCCCCCCCCCCHHHHHHHH
VFEETGIIAGEHQLADWQHTIEYEIYPQWRHRYEAGVTRNTEHWFGLCVSEPLPVTLAPR
HHHHCCCCCCCCCCCCCCEEEEEEECHHHHHHHHCCCCCCCCHHEEEEECCCCCEEECCH
EHLQSKWLPWEVAAQQCFSSSNAEAVRQLAWRVAGRPAVCGAE
HHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SIGLGSMPYKIPESVLVVIYTPDLQVLLLERADRPGFWQSVTGSLDTVDEPLALTAARE
CCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHCCCCCCCCCCHHHHHHHH
VFEETGIIAGEHQLADWQHTIEYEIYPQWRHRYEAGVTRNTEHWFGLCVSEPLPVTLAPR
HHHHCCCCCCCCCCCCCCEEEEEEECHHHHHHHHCCCCCCCCHHEEEEECCCCCEEECCH
EHLQSKWLPWEVAAQQCFSSSNAEAVRQLAWRVAGRPAVCGAE
HHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]