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The map label for this gene is dacC [H]

Identifier: 73539986

GI number: 73539986

Start: 312438

End: 313637

Strand: Direct

Name: dacC [H]

Synonym: Reut_A0280

Alternate gene names: 73539986

Gene position: 312438-313637 (Clockwise)

Preceding gene: 73539985

Following gene: 73539987

Centisome position: 8.21

GC content: 64.42

Gene sequence:

>1200_bases
ATGCTGAACAGAGCCACGCCGCGCCTAGCGTCCGTCTTTGCCCCCGCCGCCATCGTCGCGGCAGCCACGCTCGCCGCCGC
GCCCGCCGCCGTGCTGGCCCAGGGTGTGCCGATGCCGCAGGTGGCCGCCAAGTCCTGGATGCTGTTCGACGTGACCAGCG
GCCAGGCACTGGCTTCGCAGAACGCGGACCAGCGCATCGAGCCCGCGTCGCTGACCAAGCTGATGACCGCCTACCTGGCG
TTCGAGGCACTGAAGGAAAAGCGTCTGACGCTGGACCAGGCCGTGGTCCCGACCACGCTGGTGCTGAAGGTCAAAAGCGA
TGAATCGCGCATGTTCATCGAGCCCAACAAGCCGGTCAGCGTGCAGGACCTGCTGATGGGCCTGATCGTGCAGTCGGGCA
ACGACGCCGCACTGGCGCTGGCCGAAGCCGTGGGCGGCTCGGAAGAGGGTTTCGTCGCGATGATGAACCGCGAAGCCCAG
CGCATGGGCATGAAGAACACGCACTTCACCAACACCGACGGCATTCCCGACCCGAACCACTACACCACCGCGGTGGATCT
TGCGACGCTGACCACGCGACTGATCCAGGACTTCCCCGAGTACTACGGCATGTACTCGCAGAAGGAGTTCACCTATAACA
AAATCAAGCAGCCGAACCGCAACCGCCTGCTGTATATCGACCCGACCGTCGATGGCGTCAAGACCGGCCACACCAAGTCG
GCCGGCTACTGCCTGATCTCGTCGGCCAAGCGGCCGCTGGCCAATGTGCCGAACGGATCGCGCCGGCTGATTTCGGTCGT
GATCGGCACCACCACCGAACAGGTGCGCACCCAGGAAAGCCTGAAGATCCTCAACTACGGCTTCCAGTTCTTCGACACGC
TGCGCCTGTATGACAAGGGCCAGGTGCTGGCTACGCCGGACATCTACAAGGGCAAGGCCGGCACGGTCAAGATCGGCGTG
CAGAACGAGACCTTCGTCACGGTGCCCAAGGGCACGGGCGGCCGCCTGAAGCCGGTGCTGGAGCGTCAGGAACTGTTGAT
CGCCCCGATCGCCGCCGGCCAGCAGGTGGGCTCGGTGAAGCTGATGGATGGCAACACGAAGGTGGCAGAATTCCCGGTGG
TGGCACTGGAGGAAGTGCCCGAAGCCGGCTTCTTCGGCCGCCTGTGGGACACCATCCGCCTGTGGTTCAAGCGCAAGTGA

Upstream 100 bases:

>100_bases
GATCAAGCAGCTCGTCGTCAACGCGTGGGACCGGTAAGGACGGCCTTGCCCGTAGCCGCTACCGTCTTTCGCGAAATCTA
TCTTGTCGGAAACTGAAAAC

Downstream 100 bases:

>100_bases
TGGGATAGAGCGGTCCGGTGCGCCATCCGTGCGCCGGGCTGCCGGAGATACTGACATGACAGCCGACAATACTGGCGGCG
GCAAACCGGGCGACATTCCG

Product: penicillin-binding protein 6

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MLNRATPRLASVFAPAAIVAAATLAAAPAAVLAQGVPMPQVAAKSWMLFDVTSGQALASQNADQRIEPASLTKLMTAYLA
FEALKEKRLTLDQAVVPTTLVLKVKSDESRMFIEPNKPVSVQDLLMGLIVQSGNDAALALAEAVGGSEEGFVAMMNREAQ
RMGMKNTHFTNTDGIPDPNHYTTAVDLATLTTRLIQDFPEYYGMYSQKEFTYNKIKQPNRNRLLYIDPTVDGVKTGHTKS
AGYCLISSAKRPLANVPNGSRRLISVVIGTTTEQVRTQESLKILNYGFQFFDTLRLYDKGQVLATPDIYKGKAGTVKIGV
QNETFVTVPKGTGGRLKPVLERQELLIAPIAAGQQVGSVKLMDGNTKVAEFPVVALEEVPEAGFFGRLWDTIRLWFKRK

Sequences:

>Translated_399_residues
MLNRATPRLASVFAPAAIVAAATLAAAPAAVLAQGVPMPQVAAKSWMLFDVTSGQALASQNADQRIEPASLTKLMTAYLA
FEALKEKRLTLDQAVVPTTLVLKVKSDESRMFIEPNKPVSVQDLLMGLIVQSGNDAALALAEAVGGSEEGFVAMMNREAQ
RMGMKNTHFTNTDGIPDPNHYTTAVDLATLTTRLIQDFPEYYGMYSQKEFTYNKIKQPNRNRLLYIDPTVDGVKTGHTKS
AGYCLISSAKRPLANVPNGSRRLISVVIGTTTEQVRTQESLKILNYGFQFFDTLRLYDKGQVLATPDIYKGKAGTVKIGV
QNETFVTVPKGTGGRLKPVLERQELLIAPIAAGQQVGSVKLMDGNTKVAEFPVVALEEVPEAGFFGRLWDTIRLWFKRK
>Mature_399_residues
MLNRATPRLASVFAPAAIVAAATLAAAPAAVLAQGVPMPQVAAKSWMLFDVTSGQALASQNADQRIEPASLTKLMTAYLA
FEALKEKRLTLDQAVVPTTLVLKVKSDESRMFIEPNKPVSVQDLLMGLIVQSGNDAALALAEAVGGSEEGFVAMMNREAQ
RMGMKNTHFTNTDGIPDPNHYTTAVDLATLTTRLIQDFPEYYGMYSQKEFTYNKIKQPNRNRLLYIDPTVDGVKTGHTKS
AGYCLISSAKRPLANVPNGSRRLISVVIGTTTEQVRTQESLKILNYGFQFFDTLRLYDKGQVLATPDIYKGKAGTVKIGV
QNETFVTVPKGTGGRLKPVLERQELLIAPIAAGQQVGSVKLMDGNTKVAEFPVVALEEVPEAGFFGRLWDTIRLWFKRK

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=381, Percent_Identity=40.9448818897638, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI87082022, Length=370, Percent_Identity=40.5405405405405, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1786851, Length=404, Percent_Identity=38.6138613861386, Blast_Score=260, Evalue=9e-71,
Organism=Escherichia coli, GI87082054, Length=216, Percent_Identity=31.4814814814815, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 43556; Mature: 43556

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNRATPRLASVFAPAAIVAAATLAAAPAAVLAQGVPMPQVAAKSWMLFDVTSGQALASQ
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHCCEEEEEECCCCHHHHC
NADQRIEPASLTKLMTAYLAFEALKEKRLTLDQAVVPTTLVLKVKSDESRMFIEPNKPVS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEECCCCCCC
VQDLLMGLIVQSGNDAALALAEAVGGSEEGFVAMMNREAQRMGMKNTHFTNTDGIPDPNH
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECHHHHHCCCCCCCCCCCCCCCCCCC
YTTAVDLATLTTRLIQDFPEYYGMYSQKEFTYNKIKQPNRNRLLYIDPTVDGVKTGHTKS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCC
AGYCLISSAKRPLANVPNGSRRLISVVIGTTTEQVRTQESLKILNYGFQFFDTLRLYDKG
CCEEEEECCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QVLATPDIYKGKAGTVKIGVQNETFVTVPKGTGGRLKPVLERQELLIAPIAAGQQVGSVK
CEEECCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHCCCEEEEECCCCCCCCEEE
LMDGNTKVAEFPVVALEEVPEAGFFGRLWDTIRLWFKRK
EECCCCEEECCCCHHHHHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNRATPRLASVFAPAAIVAAATLAAAPAAVLAQGVPMPQVAAKSWMLFDVTSGQALASQ
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHCCEEEEEECCCCHHHHC
NADQRIEPASLTKLMTAYLAFEALKEKRLTLDQAVVPTTLVLKVKSDESRMFIEPNKPVS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEECCCCCCC
VQDLLMGLIVQSGNDAALALAEAVGGSEEGFVAMMNREAQRMGMKNTHFTNTDGIPDPNH
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECHHHHHCCCCCCCCCCCCCCCCCCC
YTTAVDLATLTTRLIQDFPEYYGMYSQKEFTYNKIKQPNRNRLLYIDPTVDGVKTGHTKS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCC
AGYCLISSAKRPLANVPNGSRRLISVVIGTTTEQVRTQESLKILNYGFQFFDTLRLYDKG
CCEEEEECCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QVLATPDIYKGKAGTVKIGVQNETFVTVPKGTGGRLKPVLERQELLIAPIAAGQQVGSVK
CEEECCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHCCCEEEEECCCCCCCCEEE
LMDGNTKVAEFPVVALEEVPEAGFFGRLWDTIRLWFKRK
EECCCCEEECCCCHHHHHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]